Mathis Korseberg Stokke

  • Group leader, Professor I UiO, Senior consultant; MD, PhD

Mathis Korseberg Stokke is group leader for Research group for Translational arrhythmology and electrophysiology at Institute for Experimental Medical Research. He is Professor I at the University of Oslo, and senior consultant at the Arrhythmia unit of the Department of Cardiology, Oslo University Hospital Rikshospitalet.

Stokke did his PhD at IEMR in collaboration with David Eisners` research group at the University of Manchester, UK, and defended his thesis entitled SERCA2-RyR2 interplay at the heart of Ca2+ wave development in 2011. He continued his research at IEMR as a Postdoctoral fellow and supervisor, and spent his second period as a Postdoctoral fellow at the Department of Cardiology, OUS Rikshospitalet.

From 2008-2019, Stokke was part of the administration of the Center for Heart Failure Research, and acted as head of CHFR in 2018-2019. He has been Deputy Director of NORHEART – The Norwegian PhD School of Heart Research since 2013.

 

Publications 2021

Berger SG, Sjaastad I, Stokke MK (2021)
Right ventricular involvement in hypertrophic cardiomyopathy: evidence and implications from current literature
Scand. Cardiovasc. J., 55 (4), 195-204
DOI 10.1080/14017431.2021.1901979

Danielsen TK, Sadredini M, Manotheepan R, Aronsen JM, Frisk M, Hansen MH, Andressen KW, Hougen K, Levy FO, Louch WE, Sejersted OM, Sjaastad I, Stokke MK (2021)
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front. Cardiovasc. Med., 7, 623922
DOI 10.3389/fcvm.2020.623922

Edwards AG, Mork H, Stokke MK, Lipsett DB, Sjaastad I, Richard S, Sejersted OM, Louch WE (2021)
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front. Physiol., 12, 744730
DOI 10.3389/fphys.2021.744730

Sadredini M, Hansen MH, Frisk M, Louch WE, Lehnart SE, Sjaastad I, Stokke MK (2021)
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am. J. Physiol.-Heart Circul. Physiol., 321 (2), H446-H460
DOI 10.1152/ajpheart.00011.2021

Sadredini M, Manotheepan R, Lehnart SE, Anderson ME, Sjaastad I, Stokke MK (2021)
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1
PHYSIOL. REP., 9 (18), e15030
DOI 10.14814/phy2.15030

Stokke MK, Castrini AI, Aneq MA, Jensen HK, Madsen T, Hansen J, Bundgaard H, Gilljam T, Platonov PG, Svendsen JH, Edvardsena T, Haugaa KH (2021)
Reply to: TFC ECG in arrhythmogenic cardiomyopathy: Inadequate mixture of criteria?
Int. J. Cardiol., 323, 203
DOI 10.1016/j.ijcard.2020.08.050

Publications 2020

Lieve KVV, Dusi V, van der Werf C, Bos JM, Lane CM, Stokke MK, Roston TM, Djupsjobacka A, Wada Y, Denjoy I, Bundgaard H, Noguer FRI, Semsarian C, Robyns T, Hofman N, Tanck MW, van den Berg MP, Kammeraad JAE, Krahn AD, Clur SAB, Sacher F, Till J, Skinner JR, Tfelt-Hansen J, Probst V et al. (2020)
Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Circ.-Arrhythmia Electrophysiol., 13 (3), e007471
DOI 10.1161/CIRCEP.119.007471

Skogestad J, Aronsen JM, Tovsrud N, Wanichawan P, Hougen K, Stokke MK, Carlson CR, Sjaastad I, Sejersted OM, Swift F (2020)
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc. Res., 116 (1), 78-90
DOI 10.1093/cvr/cvz087

Stokke MK, Castrini AI, Aneq MA, Jensen HK, Madsen T, Hansen J, Bundgaard H, Gilljam T, Platonov PG, Svendsen JH, Edvardsen T, Haugaa KH (2020)
Absence of ECG Task Force Criteria does not rule out structural changes in genotype positive ARVC patients
Int. J. Cardiol., 317, 152-158
DOI 10.1016/j.ijcard.2020.05.095

Tazmini K, Fraz MSA, Nymo SH, Stokke MK, Louch WE, Oie E (2020)
Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial
Am. Heart J., 221, 114-124
DOI 10.1016/j.ahj.2019.12.014

Publications 2019

Castrini AI, Lie OH, Leren IS, Estensen ME, Stokke MK, Klaeboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur. Heart J.-Cardiovasc. Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061

Conte G, Belhassen B, Lambiase P, Ciconte G, de Asmundis C, Arbelo E, Schaer B, Frontera A, Burri H, Calo' L, Letsas KP, Leyva F, Porter B, Saenen J, Zaca V, Berne P, Ammann P, Zardini M, Luani B, Rordorf R, Brugada GS, Medeiros-Domingo A, Geller JC, de Potter T, Stokke MK et al. (2019)
Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry
Europace, 21 (11), 1670-1677
DOI 10.1093/europace/euz221

Haugaa KH, Stokke MK (2019)
Cardiac electrical and mechanical alterations - united in the long QT syndrome
Int. J. Cardiol., 274, 190-191
DOI 10.1016/j.ijcard.2018.09.048

Ottesen AH, Carlson CR, Eken OS, Sadredini M, Myhre PL, Shen X, Dalhus B, Laver DR, Lunde PK, Kurola J, Lunde M, Hoff JE, Godang K, Sjaastad I, Pettila V, Stridsberg M, Lehnart SE, Edwards AG, Lunde IG, Omland T, Stokke MK, Christensen G, Rosjo H, Louch WE (2019)
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ.-Arrhythmia Electrophysiol., 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045

Publications 2018

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK (2018)
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100

Dejgaard LA, Skjolsvik ET, Lie OH, Ribe M, Stokke MK, Hegbom F, Scheirlynck ES, Gjertsen E, Andresen K, Helle-Valle TM, Hopp E, Edvardsen T, Haugaa KH (2018)
The Mitral Annulus Disjunction Arrhythmic Syndrome
J. Am. Coll. Cardiol., 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070

Lie OH, Dejgaard LA, Saberniak J, Rootwelt C, Stokke MK, Edvardsen T, Haugaa KH (2018)
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC-Clin. Electrophysiol., 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010

Lie OH, Rootwelt-Norberg C, Dejgaard LA, Leren IS, Stokke MK, Edvardsen T, Haugaa KH (2018)
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy A Primary Prevention Cohort Study
JACC-Cardiovasc. Imag., 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017

Publications 2017

Lie OH, Saberniak J, Dejgaard LA, Stokke MK, Hegbom F, Anfinsen OG, Edvardsen T, Haugaa KH (2017)
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail., 4 (4), 585-594
DOI 10.1002/ehf2.12180

Publications 2016

Logantha SJRJ, Stokke MK, Atkinson AJ, Kharche SR, Parveen S, Saeed Y, Sjaastad I, Sejersted OM, Dobrzynski H (2016)
Ca2+-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front. Physiol., 7, 197
DOI 10.3389/fphys.2016.00197

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK (2016)
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Cardiovasc. Res., 111 (3), 295-306
DOI 10.1093/cvr/cvw095

Sadredini M, Danielsen TK, Aronsen JM, Manotheepan R, Hougen K, Sjaastad I, Stokke MK (2016)
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887

Publications 2015

Aronsen JM, Skogestad J, Lewalle A, Louch WE, Hougen K, Stokke MK, Swift F, Niederer S, Smith NP, Sejersted OM, Sjaastad I (2015)
Hypokalaemia induces Ca2+ overload and Ca2+ waves in ventricular myocytes by reducing Na+, K+-ATPase alpha(2) activity
J. Physiol.-London, 593 (6), 1509-1521
DOI 10.1113/jphysiol.2014.279893

Publications 2014

Manotheepan R, Saberniak J, Danielsen TK, Edvardsen T, Sjaastad I, Haugaa KH, Stokke MK (2014)
Effects of Individualized Exercise Training in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Am. J. Cardiol., 113 (11), 1829-1833
DOI 10.1016/j.amjcard.2014.03.012

Publications 2013

Stokke MK, Tovsrud N, Louch WE, Oyehaug L, Hougen K, Sejersted OM, Swift F, Sjaastad I (2013)
I-CaL inhibition prevents arrhythmogenic Ca2+ waves caused by abnormal Ca2+ sensitivity of RyR or SR Ca2+ accumulation
Cardiovasc. Res., 98 (2), 315-325
DOI 10.1093/cvr/cvt037

Publications 2012

Louch WE, Stokke MK, Sjaastad I, Christensen G, Sejersted OM (2012)
No Rest for the Weary: Diastolic Calcium Homeostasis in the Normal and Failing Myocardium
Physiology, 27 (5), 308-323
DOI 10.1152/physiol.00021.2012

Publications 2011

Stokke MK, Briston SJ, Jolle GF, Manzoor I, Louch WE, Oyehaug L, Christensen G, Eisner DA, Trafford AW, Sejersted OM, Sjaastad I (2011)
Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content
Cardiovasc. Res., 90 (3), 503-512
DOI 10.1093/cvr/cvr013

Publications 2010

Hougen K, Aronsen JM, Stokke MK, Enger U, Nygard S, Andersson KB, Christensen G, Sejersted OM, Sjaastad I (2010)
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alpha MHC-MerCreMer) mice
Am. J. Physiol.-Heart Circul. Physiol., 299 (5), H1671-H1678
DOI 10.1152/ajpheart.01155.2009

Stokke MK, Hougen K, Sjaastad I, Louch WE, Briston SJ, Enger UH, Andersson KB, Christensen G, Eisner DA, Sejersted OM, Trafford AW (2010)
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc. Res., 86 (1), 63-71
DOI 10.1093/cvr/cvp401