Mathis Korseberg Stokke
- Group leader, Professor I UiO, Senior consultant; MD, PhD
Mathis Korseberg Stokke is group leader for Research group for Translational arrhythmology and electrophysiology at Institute for Experimental Medical Research. He is Professor I at the University of Oslo, and senior consultant at the Arrhythmia unit of the Department of Cardiology, Oslo University Hospital Rikshospitalet.
Stokke did his PhD at IEMR in collaboration with David Eisners` research group at the University of Manchester, UK, and defended his thesis entitled SERCA2-RyR2 interplay at the heart of Ca2+ wave development in 2011. He continued his research at IEMR as a Postdoctoral fellow and supervisor, and spent his second period as a Postdoctoral fellow at the Department of Cardiology, OUS Rikshospitalet.
From 2008-2019, Stokke was part of the administration of the Center for Heart Failure Research, and acted as head of CHFR in 2018-2019. He has been Deputy Director of NORHEART – The Norwegian PhD School of Heart Research since 2013.
Publications 2024
Editorial for "MRI Assessment of Myocardial Deformation for Risk Stratification of Major Arrhythmic Events in Patients with Non-Ischemic Cardiomyopathy Eligible for Primary Prevention Implantable Cardioverter Defibrillators"
J Magn Reson Imaging, 60 (5), 1987-1988
DOI 10.1002/jmri.29300, PubMed 38358060
Neutrophil Extracellular Traps in ST-Segment Elevation Myocardial Infarction: Reduced by Tocilizumab and Associated With Infarct Size
JACC Adv, 3 (9), 101193
DOI 10.1016/j.jacadv.2024.101193, PubMed 39247678
Lessons on the non-linear path of medical progress and biological complexity from mouse models of the Brugada syndrome
Europace, 26 (6)
DOI 10.1093/europace/euae152, PubMed 38874401
Publications 2023
Beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice
Am J Physiol Heart Circ Physiol, 324 (6), H881-H892
DOI 10.1152/ajpheart.00701.2022, PubMed 37115627
Cardiac dysfunction in mixed connective tissue disease: a nationwide observational study
Rheumatol Int, 43 (6), 1055-1065
DOI 10.1007/s00296-023-05308-3, PubMed 36933069
Myocardial oxidative stress is increased in early reperfusion, but systemic antioxidative therapy does not prevent ischemia-reperfusion arrhythmias in pigs
Front Cardiovasc Med, 10, 1223496
DOI 10.3389/fcvm.2023.1223496, PubMed 37823177
Recurrent malignant ventricular arrhythmias and paresthesia-a mystery revealed as aconitine poisoning: a case report
J Med Case Rep, 17 (1), 554
DOI 10.1186/s13256-023-04304-2, PubMed 38129927
Utility of the Inferior Axis and Left Bundle Branch Block Pattern for Categorization of Patients With Premature Ventricular Complexes Before Catheter Ablation
Am J Cardiol, 201, 148-149
DOI 10.1016/j.amjcard.2023.06.013, PubMed 37385167
Publications 2022
Exercise training during childhood and adolescence is associated with favorable diastolic function in hypertrophic cardiomyopathy
Int J Cardiol, 364, 65-71
DOI 10.1016/j.ijcard.2022.06.042, PubMed 35714718
One step closer to myocardial physiology: From PV loop analysis to state-of-the-art myocardial imaging
Acta Physiol (Oxf), 234 (2), e13759
DOI 10.1111/apha.13759, PubMed 34978759
Lumican accumulates with fibrillar collagen in fibrosis in hypertrophic cardiomyopathy
ESC Heart Fail, 10 (2), 858-871
DOI 10.1002/ehf2.14234, PubMed 36444917
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload
Commun Biol, 5 (1), 1392
DOI 10.1038/s42003-022-04361-1, PubMed 36539599
Publications 2021
Right ventricular involvement in hypertrophic cardiomyopathy: evidence and implications from current literature
Scand Cardiovasc J, 55 (4), 195-204
DOI 10.1080/14017431.2021.1901979, PubMed 33759664
Exercise Training Stabilizes RyR2-Dependent Ca2+ Release in Post-infarction Heart Failure
Front Cardiovasc Med, 7, 623922
DOI 10.3389/fcvm.2020.623922, PubMed 33569394
Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
Front Physiol, 12, 744730
DOI 10.3389/fphys.2021.744730, PubMed 34712150
CaMKII inhibition has dual effects on spontaneous Ca2+ release and Ca2+ alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation
Am J Physiol Heart Circ Physiol, 321 (2), H446-H460
DOI 10.1152/ajpheart.00011.2021, PubMed 34270372
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1
Physiol Rep, 9 (18), e15030
DOI 10.14814/phy2.15030, PubMed 34558218
Publications 2020
Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Circ Arrhythm Electrophysiol, 13 (3), e007471
DOI 10.1161/CIRCEP.119.007471, PubMed 32063070
Coupling of the Na+/K+-ATPase to Ankyrin B controls Na+/Ca2+ exchanger activity in cardiomyocytes
Cardiovasc Res, 116 (1), 78-90
DOI 10.1093/cvr/cvz087, PubMed 30949686
Absence of ECG Task Force Criteria does not rule out structural changes in genotype positive ARVC patients
Int J Cardiol, 317, 152-158
DOI 10.1016/j.ijcard.2020.05.095, PubMed 32504717
Reply to: TFC ECG in arrhythmogenic cardiomyopathy: Inadequate mixture of criteria?
Int J Cardiol, 323, 203
DOI 10.1016/j.ijcard.2020.08.050, PubMed 32810539
Publications 2019
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777
Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry
Europace, 21 (11), 1670-1677
DOI 10.1093/europace/euz221, PubMed 31504477
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765
Potassium infusion increases the likelihood of conversion of recent-onset atrial fibrillation-A single-blinded, randomized clinical trial
Am Heart J, 221, 114-124
DOI 10.1016/j.ahj.2019.12.014, PubMed 31986288
Publications 2018
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100, PubMed 30399185
The Mitral Annulus Disjunction Arrhythmic Syndrome
J Am Coll Cardiol, 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070, PubMed 30261961
Cardiac electrical and mechanical alterations - united in the long QT syndrome
Int J Cardiol, 274, 190-191
DOI 10.1016/j.ijcard.2018.09.048, PubMed 30236503
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC Clin Electrophysiol, 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010, PubMed 29929667
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017, PubMed 30031702
Publications 2017
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594
DOI 10.1002/ehf2.12180, PubMed 29154430
Publications 2016
Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front Physiol, 7, 197
DOI 10.3389/fphys.2016.00197, PubMed 27313537
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Cardiovasc Res, 111 (3), 295-306
DOI 10.1093/cvr/cvw095, PubMed 27161030
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887, PubMed 27096943
Publications 2014
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299
Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1
Am J Cardiol, 113 (11), 1829-33
DOI 10.1016/j.amjcard.2014.03.012, PubMed 24837260
Publications 2013
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation
Cardiovasc Res, 98 (2), 315-25
DOI 10.1093/cvr/cvt037, PubMed 23417043
Publications 2012
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium
Physiology (Bethesda), 27 (5), 308-23
DOI 10.1152/physiol.00021.2012, PubMed 23026754
From global to local: a new understanding of cardiac electromechanical coupling
Tidsskr Nor Laegeforen, 132 (12-13), 1457-60
DOI 10.4045/tidsskr.11.1353, PubMed 22766818
Publications 2011
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content
Cardiovasc Res, 90 (3), 503-12
DOI 10.1093/cvr/cvr013, PubMed 21242164
Publications 2010
Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice
Am J Physiol Heart Circ Physiol, 299 (5), H1671-8
DOI 10.1152/ajpheart.01155.2009, PubMed 20802136
Publications 2009
Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes
Cardiovasc Res, 86 (1), 63-71
DOI 10.1093/cvr/cvp401, PubMed 20019150