Anna Isotta Castrini

  • Cardiologist, PhD fellow; MD

Anna Isotta Castrini, MD, is cardiologist and PhD fellow at last year at Department of Cardiology, OUS, Rikshospitalet. She is supervised by Prof. Kristina Haugaa, Dr. Øyvind Lie, MD, PhD and Dr. Mette Estensen MD, PhD. Inherited cardiomyopathies are the main topic of her PhD project, with focus on effect of pregnancy on disease’s penetrance and progression. With the research group, she published two important papers on the effect of pregnancy in arrhythmogenic cardiomyopathy and Lamin A/C cardiomyopathy, recently included in the European guidelines for management of cardiomyopathies. During her research fellowship, Dr. Castrini was awarded by “Best poster Price” during the Annual Symposium for Heart Research.

Dr. Castrini has a special interest for echocardiography and she is certified by the European Association
for Cardiovascular Imaging for trans-thoracic echocardiography in adults.

 

Publications 2025

Monopoli G, Haas D, Singh A, Aabel EW, Ribe M, Castrini AI, Hasselberg NE, Bugge C, Five C, Haugaa K, Forsch N, Thambawita V, Balaban G, Maleckar MM (2025)
DeepValve: The first automatic detection pipeline for the mitral valve in Cardiac Magnetic Resonance imaging
192 (Pt A), 110211
DOI 10.1016/j.compbiomed.2025.110211, PubMed 40311468

Aaserud LT, Rootwelt-Norberg C, Olsen PAS, Five CK, Castrini AI, Aabel EW, Haugaa KH, Lie ØH (2025)
Disease Progression in Exercise-Induced Arrhythmogenic Cardiomyopathy Compared With Arrhythmogenic Right Ventricular Cardiomyopathy
18 (8), 853-863
DOI 10.1016/j.jcmg.2025.03.018, PubMed 40637652

Publications 2024

Five CK, Hasselberg NE, Chivulescu M, Rootwelt-Norberg C, Ribe MP, Dejgaard LA, Castrini AI, Aabel EW, Haugaa KH (2024)
Prediction of severe ventricular arrhythmias in patients with mitral valve prolapse by exercise ECG
21 (11), 2339-2340
DOI 10.1016/j.hrthm.2024.04.076, PubMed 38663787

Myklebust L, Monopoli G, Balaban G, Aabel EW, Ribe M, Castrini AI, Hasselberg NE, Bugge C, Five C, Haugaa K, Maleckar MM, Arevalo H (2024)
Stretch of the papillary insertion triggers reentrant arrhythmia: an in silico patient study
15, 1447938
DOI 10.3389/fphys.2024.1447938, PubMed 39224207

Sabbag A, Aabel EW, Castrini AI, Siontis KC, Laredo M, Nizard J, Duthoit G, Asirvatham S, Sehrawat O, Kirkels FP, van Rosendael PJ, Beinart R, Acha MR, Peichl P, Lim HS, Sohns C, Martins R, Font J, Truong NNK, Estensen M, Haugaa KH (2024)
Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum
45 (20), 1831-1839
DOI 10.1093/eurheartj/ehae224, PubMed 38740526

Publications 2023

Five CK, Hasselberg NE, Aaserud LT, Castrini AI, Vlaisavljevic K, Lie Ø, Rootwelt-Norberg C, Aabel EW, Haugaa KH (2023)
Lifetime exercise dose and ventricular arrhythmias in patients with mitral valve prolapse
25 (10)
DOI 10.1093/europace/euad309, PubMed 37851515

Haugaa KH, Castrini AI (2023)
Sudden cardiac death in the young-Can illicit drug use explain the unexplained?
20 (10), 1356-1357
DOI 10.1016/j.hrthm.2023.06.014, PubMed 37352948

Kirkels FP, Rootwelt-Norberg C, Bosman LP, Aabel EW, Muller SA, Castrini AI, Taha K, van Osta N, Lie ØH, Asselbergs FW, Lumens J, Te Riele ASJM, Hasselberg NE, Cramer MJ, Haugaa KH, Teske AJ (2023)
The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy
24 (12), 1710-1718
DOI 10.1093/ehjci/jead174, PubMed 37474315

Kirkels FP, van Osta N, Rootwelt-Norberg C, Chivulescu M, van Loon T, Aabel EW, Castrini AI, Lie ØH, Asselbergs FW, Delhaas T, Cramer MJ, Teske AJ, Haugaa KH, Lumens J (2023)
Monitoring of Myocardial Involvement in Early Arrhythmogenic Right Ventricular Cardiomyopathy Across the Age Spectrum
82 (9), 785-797
DOI 10.1016/j.jacc.2023.05.065, PubMed 37612010

Publications 2022

Castrini AI, Skjølsvik E, Estensen ME, Almaas VM, Skulstad H, Lyseggen E, Edvardsen T, Lie ØH, Picard KCI, Lakdawala NK, Haugaa KH (2022)
Pregnancy and Progression of Cardiomyopathy in Women With LMNA Genotype-Positive
11 (8), e024960
DOI 10.1161/JAHA.121.024960, PubMed 35434999

Sidhu K, Castrini AI, Parikh V, Reza N, Owens A, Tremblay-Gravel M, Wheeler MT, Mestroni L, Taylor M, Graw S, Gigli M, Merlo M, Paldino A, Sinagra G, Judge DP, Ramos H, Mesubi O, Brown E, Turnbull S, Kumar S, Roy D, Tedrow UB, Ngo L, Haugaa K, Lakdawala NK (2022)
The response to cardiac resynchronization therapy in LMNA cardiomyopathy
24 (4), 685-693
DOI 10.1002/ejhf.2463, PubMed 35229420

Skjølsvik ET, Haugen Lie Ø, Chivulescu M, Ribe M, Castrini AI, Broch K, Pripp AH, Edvardsen T, Haugaa KH (2022)
Progression of cardiac disease in patients with lamin A/C mutations
23 (4), 543-550
DOI 10.1093/ehjci/jeab057, PubMed 33824984

Publications 2021

Rootwelt-Norberg C, Lie ØH, Chivulescu M, Castrini AI, Sarvari SI, Lyseggen E, Almaas VM, Bogsrud MP, Edvardsen T, Haugaa KH (2021)
Sex differences in disease progression and arrhythmic risk in patients with arrhythmogenic cardiomyopathy
23 (7), 1084-1091
DOI 10.1093/europace/euab077, PubMed 33829244

Publications 2020

Platonov PG, Castrini AI, Svensson A, Christiansen MK, Gilljam T, Bundgaard H, Madsen T, Heliö T, Christensen AH, Åström MA, Carlson J, Edvardsen T, Jensen HK, Haugaa KH, Svendsen JH (2020)
Pregnancies, ventricular arrhythmias, and substrate progression in women with arrhythmogenic right ventricular cardiomyopathy in the Nordic ARVC Registry
22 (12), 1873-1879
DOI 10.1093/europace/euaa136, PubMed 32681178

Stokke MK, Castrini AI, Aneq MÅ, Jensen HK, Madsen T, Hansen J, Bundgaard H, Gilljam T, Platonov PG, Svendsen JH, Edvardsen T, Haugaa KH (2020)
Absence of ECG Task Force Criteria does not rule out structural changes in genotype positive ARVC patients
317, 152-158
DOI 10.1016/j.ijcard.2020.05.095, PubMed 32504717

Stokke MK, Castrini AI, Aneq MÅ, Jensen HK, Madsen T, Hansen J, Bundgaard H, Gilljam T, Platonov PG, Svendsen JH, Edvardsen T, Haugaa KH (2020)
Reply to: TFC ECG in arrhythmogenic cardiomyopathy: Inadequate mixture of criteria?
323, 203
DOI 10.1016/j.ijcard.2020.08.050, PubMed 32810539

Publications 2019

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

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