Øyvind Haugen Lie

  • MD, PhD

Øyvind Haugen Lie, MD, PhD, Department of Cardiology, Rikshospitalet, Oslo University Hospital

Øyvind Haugen Lie successfully defended his PhD thesis "Risk stratification and management of patients with right ventricular arrhythmias" in December 2018. His supervisors were Associate Professor Kristina Hermann Haugaa, MD, PhD and Professor Thor Edvardsen, MD, PhD.

During his fellowship Lie was awarded with Prof. J. Roelandt’s Young Investigator Award for best original work in clinical science at the 2017 EuroEcho-Imaging Congress.  The award was given in recognition of the work “Harmful effects of exercise intensity and exercise duration in patients with arrhythmogenic cardiomyopathy”.

Lie also won the best poster prize in the session for “Diagnostic and therapeutical strategies for cardiac disease” at the annual Center for Heart Failure Research Symposium two years in a row. He was give the prize in recognition of the work “How many are too many – Frequent premature ventricular contractions and left ventricular function” and "V-3 QRS-duration of premature ventricular contractions relates to ventricular tachycardia in patients with outflow tract arrhythmia", respectively.

Lie, together with his colleagues, discovered that the threshold ectopy burden associated with impaired left ventricular function was lower than previously assumed when accurate and sensitive echocardiographic tools were used. Patients with frequent premature ventricular contractions of right ventricular outflow tract origin may contract an ectopy-induced cardiomyopathy, those with more than 8000 premature ventricular contractions per 24 hours may benefit from antiarrhythmic therapy.

Higher exercise intensity is a strong and independent marker of adverse outcome in patients with arrhythmogenic cardiomyopathy, irrespective of longer exercise duration. Together with ECG-abnormalities and subtle left ventricular contraction abnormalities, information on exercise intensity at study entry yielded precise risk stratification that may be useful in the challenging selection of patients with arrhythmogenic cardiomyopathy who may benefit from a primary preventive implantable cardioverter-defibrillator.
 

Publications 2019

Cadrin-Tourigny J, Bosman LP, Nozza A, Wang W, Tadros R, Bhonsale A, Bourfiss M, Fortier A, Lie ØH, Saguner AM, Svensson A, Andorin A, Tichnell C, Murray B, Zeppenfeld K, van den Berg MP, Asselbergs FW, Wilde AAM, Krahn AD, Talajic M, Rivard L, Chelko S, Zimmerman SL, Kamel IR, Crosson JE et al. (2019)
A new prediction model for ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy
Eur Heart J, 40 (23), 1850-1858
DOI 10.1093/eurheartj/ehz103, PubMed 30915475

Castrini AI, Lie ØH, Leren IS, Estensen ME, Stokke MK, Klæboe LG, Edvardsen T, Haugaa KH (2019)
Number of pregnancies and subsequent phenotype in a cross-sectional cohort of women with arrhythmogenic cardiomyopathy
Eur Heart J Cardiovasc Imaging, 20 (2), 192-198
DOI 10.1093/ehjci/jey061, PubMed 29659777

Chivulescu M, Lie ØH, Popescu BA, Skulstad H, Edvardsen T, Jurcut RO, Haugaa KH (2019)
High penetrance and similar disease progression in probands and in family members with arrhythmogenic cardiomyopathy
Eur Heart J (in press)
DOI 10.1093/eurheartj/ehz570, PubMed 31504415

Dejgaard LA, Lie ØH, Helle-Valle TM, Edvardsen T, Haugaa KH (2019)
Reply: Arrhythmic Mitral Annulus Disjunction and Mitral Valve Prolapse: Components of the Same Clinical Spectrum?
J Am Coll Cardiol, 73 (6), 739-740
DOI 10.1016/j.jacc.2018.12.008, PubMed 30765047

Haugaa KH, Lie ØH (2019)
Cardiac amyloidosis: can imaging shed light on mechanisms and prognosis?
Eur Heart J Cardiovasc Imaging, 20 (5), 500-501
DOI 10.1093/ehjci/jez009, PubMed 30726891

Klaeboe LG, Brekke PH, Lie ØH, Aaberge L, Haugaa KH, Edvardsen T (2019)
Classical mechanical dyssynchrony is rare in transcatheter aortic valve implantation-induced left bundle branch block
Eur Heart J Cardiovasc Imaging, 20 (3), 271-278
DOI 10.1093/ehjci/jey127, PubMed 30247533

Platonov PG, Haugaa KH, Bundgaard H, Svensson A, Gilljam T, Hansen J, Madsen T, Holst AG, Carlson J, Lie ØH, Kvistholm Jensen M, Edvardsen T, Jensen HK, Svendsen JH (2019)
Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillator Therapy in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy
Am J Cardiol, 123 (7), 1156-1162
DOI 10.1016/j.amjcard.2018.12.049, PubMed 30678832

Scheirlynck E, Dejgaard LA, Skjølsvik E, Lie OH, Motoc A, Hopp E, Tanaka K, Ueland T, Ribe M, Collet C, Edvardsen T, Droogmans S, Cosyns B, Haugaa KH (2019)
Increased levels of sST2 in patients with mitral annulus disjunction and ventricular arrhythmias
Open Heart, 6 (1), e001016
DOI 10.1136/openhrt-2019-001016, PubMed 31168386

Scheirlynck E, Van Malderen S, Motoc A, Lie ØH, de Asmundis C, Sieira J, Chierchia GB, Brugada P, Cosyns B, Droogmans S (2019)
Contraction alterations in Brugada syndrome; association with life-threatening ventricular arrhythmias
Int J Cardiol, 299, 147-152
DOI 10.1016/j.ijcard.2019.06.074, PubMed 31281045

Scheirlynck E, Van Malderen S, Motoc A, Lie ØH, de Asmundis C, Sieira J, Chierchia GB, Brugada P, Cosyns B, Droogmans S (2019)
Speckle tracking echocardiography data in Brugada syndrome patients
Data Brief, 25, 104330
DOI 10.1016/j.dib.2019.104330, PubMed 31453301

Publications 2018

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2018)
Vigorous exercise in patients with hypertrophic cardiomyopathy
Int J Cardiol, 250, 157-163
DOI 10.1016/j.ijcard.2017.07.015, PubMed 29169752

Dejgaard LA, Skjølsvik ET, Lie ØH, Ribe M, Stokke MK, Hegbom F, Scheirlynck ES, Gjertsen E, Andresen K, Helle-Valle TM, Hopp E, Edvardsen T, Haugaa KH (2018)
The Mitral Annulus Disjunction Arrhythmic Syndrome
J Am Coll Cardiol, 72 (14), 1600-1609
DOI 10.1016/j.jacc.2018.07.070, PubMed 30261961

Haugaa KH, Lie ØH (2018)
Reveal the Concealed: The Quest for Early Disease Detection in Family Members at Risk of Developing Arrhythmogenic Cardiomyopathy
JACC Cardiovasc Imaging, 12 (3), 456-457
DOI 10.1016/j.jcmg.2018.02.007, PubMed 29550321

Lie ØH, Dejgaard LA, Saberniak J, Rootwelt C, Stokke MK, Edvardsen T, Haugaa KH (2018)
Harmful Effects of Exercise Intensity and Exercise Duration in Patients With Arrhythmogenic Cardiomyopathy
JACC Clin Electrophysiol, 4 (6), 744-753
DOI 10.1016/j.jacep.2018.01.010, PubMed 29929667

Lie ØH, Rootwelt-Norberg C, Dejgaard LA, Leren IS, Stokke MK, Edvardsen T, Haugaa KH (2018)
Prediction of Life-Threatening Ventricular Arrhythmia in Patients With Arrhythmogenic Cardiomyopathy: A Primary Prevention Cohort Study
JACC Cardiovasc Imaging, 11 (10), 1377-1386
DOI 10.1016/j.jcmg.2018.05.017, PubMed 30031702

Rootwelt-Norberg C, Lie ØH, Dejgaard LA, Chivulescu M, Leren IS, Edvardsen T, Haugaa KH (2018)
Life-threatening arrhythmic presentation in patients with arrhythmogenic cardiomyopathy before and after entering the genomic era; a two-decade experience from a large volume center
Int J Cardiol, 279, 79-83
DOI 10.1016/j.ijcard.2018.12.066, PubMed 30638987

Publications 2017

Chivulescu M, Haugaa K, Lie ØH, Edvardsen T, Ginghină C, Popescu BA, Jurcut R (2017)
Right ventricular remodeling in athletes and in arrhythmogenic cardiomyopathy
Scand Cardiovasc J, 52 (1), 13-19
DOI 10.1080/14017431.2017.1416158, PubMed 29254378

Dejgaard LA, Haland TF, Lie OH, Ribe M, Bjune T, Leren IS, Berge KE, Edvardsen T, Haugaa KH (2017)
Data on exercise and cardiac imaging in a patient cohort with hypertrophic cardiomyopathy
Data Brief, 15, 30-39
DOI 10.1016/j.dib.2017.08.018, PubMed 28971120

Lie ØH, Saberniak J, Dejgaard LA, Stokke MK, Hegbom F, Anfinsen OG, Edvardsen T, Haugaa KH (2017)
Lower than expected burden of premature ventricular contractions impairs myocardial function
ESC Heart Fail, 4 (4), 585-594
DOI 10.1002/ehf2.12180, PubMed 29154430

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