Trine Ranheim
- Researcher; PhD
Publications 2021
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns
J. Intern. Med., 290 (3), 677-692
DOI 10.1111/joim.13310
Publications 2020
YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis
Circ.-Heart Fail., 13 (10), e006643
DOI 10.1161/CIRCHEARTFAILURE.119.006643
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1
Publications 2019
Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
Open Heart, 6 (2), UNSP e001098
DOI 10.1136/openhrt-2019-001098
NLRP3 Inflammasome: A Novel Player in Metabolically Induced Inflammation-Potential Influence on the Myocardium
J. Cardiovasc. Pharmacol., 74 (4), 276-284
DOI 10.1097/FJC.0000000000000704
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front. Immunol., 10, 1621
DOI 10.3389/fimmu.2019.01621
Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1 beta Expression in Primary Mouse Cardiac Fibroblasts
Front. Immunol., 10, 1285
DOI 10.3389/fimmu.2019.01285
Low Cellular NAD(+) Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J. Immunol., 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200
Publications 2018
NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Am. J. Physiol.-Endocrinol. Metab., 315 (5), E912-E923
DOI 10.1152/ajpendo.00461.2017
Publications 2017
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J. Mol. Med., 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPAR gamma-Dependent Monocyte Differentiation and Function
Arterioscler. Thromb. Vasc. Biol., 37 (6), 1157-+
DOI 10.1161/ATVBAHA.116.308187
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediat. Inflamm., 2017, 9450439
DOI 10.1155/2017/9450439
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003
Publications 2016
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem. Biophys. Res. Commun., 469 (4), 1012-1020
DOI 10.1016/j.bbrc.2015.12.051
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
J. Am. Heart Assoc., 5 (5), e003031
DOI 10.1161/JAHA.115.003031
Publications 2015
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am. J. Physiol.-Lung Cell. Mol. Physiol., 309 (4), L378-L387
DOI 10.1152/ajplung.00342.2014
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715
Publications 2014
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BMC Infect. Dis., 14, 70
DOI 10.1186/1471-2334-14-70
The Homeostatic Chemokine CCL21 Predicts Mortality in Aortic Stenosis Patients and Modulates Left Ventricular Remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172
Toll-Like Receptor 9 Mediated Responses in Cardiac Fibroblasts
PLoS One, 9 (8), e104398
DOI 10.1371/journal.pone.0104398
Toll-Like Receptor 9-Activation during Onset of Myocardial Ischemia Does Not Influence Infarct Extension
PLoS One, 9 (8), e104407
DOI 10.1371/journal.pone.0104407
Publications 2013
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury
Cardiovasc. Res., 99 (1), 164-174
DOI 10.1093/cvr/cvt091
A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Reply
Cardiovasc. Res., 99 (1), 226-227
DOI 10.1093/cvr/cvt130
Publications 2012
Secreted Wnt Modulators in Symptomatic Aortic Stenosis
J. Am. Heart Assoc., 1 (6), e002261
DOI 10.1161/JAHA.112.002261
Increased circulating mitochondrial DNA after myocardial infarction
Int. J. Cardiol., 158 (1), 132-134
DOI 10.1016/j.ijcard.2012.04.047
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707
DOI 10.2217/CLP.12.71
Statins Affect the Presentation of Endothelial Chemokines by Targeting to Multivesicular Bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-273
DOI 10.1016/j.atherosclerosis.2012.06.071
The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038
Publications 2011
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages
Eur. J. Clin. Invest., 41 (10), 1098-1104
DOI 10.1111/j.1365-2362.2011.02515.x
Publications 2010
Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C
Atherosclerosis, 209 (1), 163-166
DOI 10.1016/j.atherosclerosis.2009.08.039
Intracellular Nicotinamide Phosphoribosyltransferase Protects against Hepatocyte Apoptosis and Is Down-Regulated in Nonalcoholic Fatty Liver Disease
J. Clin. Endocrinol. Metab., 95 (6), 3039-3047
DOI 10.1210/jc.2009-2148
Increased YKL-40 expression in patients with carotid atherosclerosis
Atherosclerosis, 211 (2), 589-595
DOI 10.1016/j.atherosclerosis.2010.02.035
Publications 2009
Nonsense-mediated decay of human LDL receptor mRNA
Scand. J. Clin. Lab. Invest., 69 (3), PII 910664994-417
DOI 10.1080/00365510802707163
Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses
Mol. Genet. Metab., 96 (4), 245-252
DOI 10.1016/j.ymgme.2008.12.014
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR
Acta Biochim. Biophys. Sin., 41 (3), 246-255
DOI 10.1093/abbs/gmp008
Publications 2008
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
FEBS J., 275 (16), 4121-4133
DOI 10.1111/j.1742-4658.2008.06553.x
Characterization of novel mutations in the catalytic domain of the PCSK9 gene
J. Intern. Med., 263 (4), 420-431
DOI 10.1111/j.1365-2796.2007.01915.x
Berberine decreases PCSK9 expression in HepG2 cells
Atherosclerosis, 201 (2), 266-273
DOI 10.1016/j.atherosclerosis.2008.02.004
Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
J. Cell. Physiol., 217 (2), 459-467
DOI 10.1002/jcp.21519
Publications 2007
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
BMC Cell Biol., 8, 9
DOI 10.1186/1471-2121-8-9
4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor
FEBS J., 274 (8), 1881-1893
DOI 10.1111/j.1742-4658.2007.05735.x
Publications 2006
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
Hum. Mol. Genet., 15 (9), 1551-1558
DOI 10.1093/hmg/ddl077
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression
Am. J. Physiol.-Endocrinol. Metab., 290 (2), E326-E333
DOI 10.1152/ajpendo.00020.2005
Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene
Scand. J. Clin. Lab. Invest., 66 (4), 317-328
DOI 10.1080/00365510600672775
Model system for phenotypic characterization of sequence variations in the LDL receptor gene
Clin. Chem., 52 (8), 1469-1479
DOI 10.1373/clinchem.2006.068627
Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress
J. Biol. Chem., 281 (1), 468-476
DOI 10.1074/jbc.M507071200
Analysis of alternatively spliced isoforms of human LDL receptor mRNA
Clin. Chim. Acta, 373 (1-2), 151-157
DOI 10.1016/j.cca.2006.05.031
Publications 2005
Coffee consumption and human health - beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus
Mol. Nutr. Food Res., 49 (3), 274-284
DOI 10.1002/mnfr.200400109
Publications 2004
Exflagellation of microgametocytes in Plasmodium vivax malaria: A diagnostic conundrum
Med. Princ. Pract., 13 (5), 298-300
DOI 10.1159/000079533
Adiponectin is reduced in gestational diabetes mellitus in normal weight women
Acta Obstet. Gynecol. Scand., 83 (4), 341-347
DOI 10.1111/j.0001-6349.2004.00413.x
Publications 2003
Experimental infection of Atlantic halibut Hippoglossus hippoglossus with nodavirus: tissue distribution and immune response
Dis. Aquat. Org., 53 (3), 211-221
DOI 10.3354/dao053211
Augmented PLA(2) activity in pre-eclamptic decidual tissue - A key player in the pathophysiology of 'acute atherosis' in pre-eclampsia?
Placenta, 24 (10), 965-973
DOI 10.1016/S0143-4004(03)00175-9
Publications 2002
Reduced secretion of triacylglycerol in CaCo-2 cells transfected with intestinal fatty acid-binding protein
Lipids, 37 (1), 61-68
DOI 10.1007/s11745-002-0864-8
Pathological changes in juvenile Atlantic halibut Hippoglossus hippoglossus persistently infected with nodavirus
Dis. Aquat. Org., 50 (3), 161-169
Publications 2001
8-iso-prostaglandin F-2 alpha increases expression of LOX-1 in JAR cells
Hypertension, 37 (4), 1184-1190
DOI 10.1161/01.HYP.37.4.1184
VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery
Acta Obstet. Gynecol. Scand., 80 (2), 93-98
DOI 10.1034/j.1600-0412.2001.080002093.x
Publications 2000
8-Iso-prostaglandin F-2 alpha reduces trophoblast invasion and matrix metalloproteinase activity
Hypertension, 35 (6), 1307-1313
DOI 10.1161/01.HYP.35.6.1307
Publications 1999
Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture
Adv.Exp.Med.Biol., 466, 205-210
Stimulation of serglycin and CD44 mRNA expression in endothelial cells exposed to TNF-alpha and IL-1 alpha
Biochim. Biophys. Acta-Gen. Subj., 1428 (2-3), 225-232
DOI 10.1016/S0304-4165(99)00096-3
Elevated level of free 8-iso-prostaglandin F-2 alpha in the decidua basalis of women with preeclampsia
Am. J. Obstet. Gynecol., 181 (5), 1211-1215
DOI 10.1016/S0002-9378(99)70110-9
Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
Am. J. Obstet. Gynecol., 180 (3), 587-592
DOI 10.1016/S0002-9378(99)70259-0
Publications 1998
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts
J. Lipid Res., 39 (4), 901-912
Publications 1997
Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells
Arterioscler. Thromb. Vasc. Biol., 17 (10), 2140-2149
DOI 10.1161/01.ATV.17.10.2140
Cafestol (a coffee lipid) decreases uptake of low-density lipoprotein (LDL) in human skin fibroblasts and liver cells
Ann.NY Acad.Sci., 827, 158-162
DOI 10.1111/j.1749-6632.1997.tb51830.x
Publications 1995
TETRADECYLTHIOACETIC ACID (A 3-THIA FATTY-ACID) DECREASES TRIACYLGLYCEROL SECRETION IN CACO-2 CELLS
J. Lipid Res., 36 (3), 535-543
EFFECT OF A COFFEE LIPID (CAFESTOL) ON REGULATION OF LIPID-METABOLISM IN CACO-2 CELLS
J. Lipid Res., 36 (10), 2079-2089
Publications 1994
Lipid metabolism in cultured intestinal cells: effect of eicosapentaenoic acid (20:5, n-3), tetradecylthioacetic acid and a coffee lipid (cafestol) on the lipid metabolism in CaCo-2 cells
Institute for Nutrition Research, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 95032423x, ISBN 82-91061-58-0
FATTY-ACID UPTAKE AND METABOLISM IN CACO-2 CELLS - EICOSAPENTAENOIC ACID (20/5(N-3)) AND OLEIC ACID(18/1(N-9)) PRESENTED IN ASSOCIATION WITH MICELLES OR ALBUMIN
Biochim. Biophys. Acta-Lipids Lipid Metab., 1212 (3), 295-304
DOI 10.1016/0005-2760(94)90203-8
EFFECT OF CHRONIC INCUBATION OF CACO-2 CELLS WITH EICOSAPENTAENOIC ACID (20/5, N-3) AND OLEIC-ACID (18/1, N-9) ON TRIACYLGLYCEROL PRODUCTION
Biochem. J., 303, 155-161
DOI 10.1042/bj3030155
Publications 1992
INFLUENCE OF EICOSAPENTAENOIC ACID (20-5, N-3) ON SECRETION OF LIPOPROTEINS IN CACO-2 CELLS
J. Lipid Res., 33 (9), 1281-1293
Publications 1990
Characteristics of a human intestinal adenocarcinoma cellline (CACO-2) in relation to metabolism of eicosapentaenoic acid (20:5, n-3) and oleic acid (18:1, n-9)
Institute for Nutrition Research, University of Oslo ; Bekkestua : Stabekk høgskole, Oslo, 43 s.
BIBSYS 971595380
Publications 1988
RELATIONSHIP BETWEEN CHANGES IN ANTIGEN EXPRESSION AND PROTEIN-SYNTHESIS IN HUMAN-MELANOMA CELLS AFTER HYPERTHERMIA AND PHOTODYNAMIC TREATMENT
Br. J. Cancer, 58 (3), 306-313
DOI 10.1038/bjc.1988.209