Trine Ranheim
- Researcher; PhD
Publications 2024
Extracellular matrix remodelling pathway in peripheral blood mononuclear cells from severe COVID-19 patients: an explorative study
Front Immunol, 15, 1379570
DOI 10.3389/fimmu.2024.1379570, PubMed 38957465
Publications 2023
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
J Clin Immunol, 43 (6), 1229-1240
DOI 10.1007/s10875-023-01475-x, PubMed 36995502
Publications 2022
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
Front Immunol, 13, 964525
DOI 10.3389/fimmu.2022.964525, PubMed 36159859
Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
Front Immunol, 13, 870811
DOI 10.3389/fimmu.2022.870811, PubMed 35432387
Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology
Platelets, 33 (4), 640-644
DOI 10.1080/09537104.2022.2042238, PubMed 35225150
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations
J Intern Med, 291 (6), 801-812
DOI 10.1111/joim.13458, PubMed 35212063
Publications 2021
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns
J Intern Med, 290 (3), 677-692
DOI 10.1111/joim.13310, PubMed 34080738
Publications 2020
YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis
Circ Heart Fail, 13 (10), e006643
DOI 10.1161/CIRCHEARTFAILURE.119.006643, PubMed 32962417
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482
Publications 2019
Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
Open Heart, 6 (2), e001098
DOI 10.1136/openhrt-2019-001098, PubMed 31798913
NLRP3 Inflammasome: A Novel Player in Metabolically Induced Inflammation-Potential Influence on the Myocardium
J Cardiovasc Pharmacol, 74 (4), 276-284
DOI 10.1097/FJC.0000000000000704, PubMed 31584530
NLRP3 Inflammasome Promotes Myocardial Remodeling During Diet-Induced Obesity
Front Immunol, 10, 1621
DOI 10.3389/fimmu.2019.01621, PubMed 31379826
Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts
Front Immunol, 10, 1285
DOI 10.3389/fimmu.2019.01285, PubMed 31244838
Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes
J Immunol, 203 (6), 1598-1608
DOI 10.4049/jimmunol.1801382, PubMed 31427442
Neuromodulatory Effect of NLRP3 and ASC in Neonatal Hypoxic Ischemic Encephalopathy
Neonatology, 115 (4), 355-362
DOI 10.1159/000497200, PubMed 30909283
Publications 2018
NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Am J Physiol Endocrinol Metab, 315 (5), E912-E923
DOI 10.1152/ajpendo.00461.2017, PubMed 30016155
Publications 2017
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
Arterioscler Thromb Vasc Biol, 37 (6), 1157-1167
DOI 10.1161/ATVBAHA.116.308187, PubMed 28408371
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840
Publications 2016
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
J Am Heart Assoc, 5 (5)
DOI 10.1161/JAHA.115.003031, PubMed 27207962
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim Biophys Acta Mol Cell Biol Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003, PubMed 27845246
Publications 2015
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am J Physiol Lung Cell Mol Physiol, 309 (4), L378-87
DOI 10.1152/ajplung.00342.2014, PubMed 26071556
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem Biophys Res Commun, 469 (4), 1012-20
DOI 10.1016/j.bbrc.2015.12.051, PubMed 26706279
Publications 2014
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BMC Infect Dis, 14, 70
DOI 10.1186/1471-2334-14-70, PubMed 24507453
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172, PubMed 25398010
Toll-like receptor 9 mediated responses in cardiac fibroblasts
PLoS One, 9 (8), e104398
DOI 10.1371/journal.pone.0104398, PubMed 25126740
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension
PLoS One, 9 (8), e104407
DOI 10.1371/journal.pone.0104407, PubMed 25126943
Publications 2013
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury
Cardiovasc Res, 99 (1), 164-74
DOI 10.1093/cvr/cvt091, PubMed 23580606
A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Reply
Cardiovasc Res, 99 (1), 226-7
DOI 10.1093/cvr/cvt130, PubMed 23708737
Publications 2012
Secreted Wnt modulators in symptomatic aortic stenosis
J Am Heart Assoc, 1 (6), e002261
DOI 10.1161/JAHA.112.002261, PubMed 23316316
Increased circulating mitochondrial DNA after myocardial infarction
Int J Cardiol, 158 (1), 132-4
DOI 10.1016/j.ijcard.2012.04.047, PubMed 22578950
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707
DOI 10.2217/CLP.12.71
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673, PubMed 22815786
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-73
DOI 10.1016/j.atherosclerosis.2012.06.071, PubMed 22840692
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038, PubMed 22427939
Publications 2011
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages
Eur J Clin Invest, 41 (10), 1098-104
DOI 10.1111/j.1365-2362.2011.02515.x, PubMed 21426336
Publications 2010
Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease
J Clin Endocrinol Metab, 95 (6), 3039-47
DOI 10.1210/jc.2009-2148, PubMed 20392873
Increased YKL-40 expression in patients with carotid atherosclerosis
Atherosclerosis, 211 (2), 589-95
DOI 10.1016/j.atherosclerosis.2010.02.035, PubMed 20347092
Publications 2009
Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C
Atherosclerosis, 209 (1), 163-6
DOI 10.1016/j.atherosclerosis.2009.08.039, PubMed 19765707
Nonsense-mediated decay of human LDL receptor mRNA
Scand J Clin Lab Invest, 69 (3), 409-17
DOI 10.1080/00365510802707163, PubMed 19148831
Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses
Mol Genet Metab, 96 (4), 245-52
DOI 10.1016/j.ymgme.2008.12.014, PubMed 19208450
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR
Acta Biochim Biophys Sin (Shanghai), 41 (3), 246-55
DOI 10.1093/abbs/gmp008, PubMed 19280064
Publications 2008
Characterization of novel mutations in the catalytic domain of the PCSK9 gene
J Intern Med, 263 (4), 420-31
DOI 10.1111/j.1365-2796.2007.01915.x, PubMed 18266662
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
FEBS J, 275 (16), 4121-33
DOI 10.1111/j.1742-4658.2008.06553.x, PubMed 18631360
Berberine decreases PCSK9 expression in HepG2 cells
Atherosclerosis, 201 (2), 266-73
DOI 10.1016/j.atherosclerosis.2008.02.004, PubMed 18355829
Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
J Cell Physiol, 217 (2), 459-67
DOI 10.1002/jcp.21519, PubMed 18570182
Publications 2007
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
BMC Cell Biol, 8, 9
DOI 10.1186/1471-2121-8-9, PubMed 17328821
4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor
FEBS J, 274 (8), 1881-93
DOI 10.1111/j.1742-4658.2007.05735.x, PubMed 17408384
Publications 2006
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
Hum Mol Genet, 15 (9), 1551-8
DOI 10.1093/hmg/ddl077, PubMed 16571601
Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene
Scand J Clin Lab Invest, 66 (4), 317-28
DOI 10.1080/00365510600672775, PubMed 16777760
[Lox-1--an actor in cardiovascular disease?]
Tidsskr Nor Laegeforen, 126 (6), 753-5
PubMed 16541167
Model system for phenotypic characterization of sequence variations in the LDL receptor gene
Clin Chem, 52 (8), 1469-79
DOI 10.1373/clinchem.2006.068627, PubMed 16740646
Analysis of alternatively spliced isoforms of human LDL receptor mRNA
Clin Chim Acta, 373 (1-2), 151-7
DOI 10.1016/j.cca.2006.05.031, PubMed 16828075
Publications 2005
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression
Am J Physiol Endocrinol Metab, 290 (2), E326-33
DOI 10.1152/ajpendo.00020.2005, PubMed 16144822
Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus
Mol Nutr Food Res, 49 (3), 274-84
DOI 10.1002/mnfr.200400109, PubMed 15704241
Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress
J Biol Chem, 281 (1), 468-76
DOI 10.1074/jbc.M507071200, PubMed 16257961
Publications 2004
Adiponectin is reduced in gestational diabetes mellitus in normal weight women
Acta Obstet Gynecol Scand, 83 (4), 341-7
DOI 10.1111/j.0001-6349.2004.00413.x, PubMed 15005780
Publications 2003
Experimental infection of Atlantic halibut Hippoglossus hippoglossus with nodavirus: tissue distribution and immune response
Dis Aquat Organ, 53 (3), 211-21
DOI 10.3354/dao053211, PubMed 12691192
[The importance of adipose tissue for development of obesity and diabetes mellitus type 2]
Tidsskr Nor Laegeforen, 123 (3), 311-4
PubMed 12640896
Augmented PLA2 activity in pre-eclamptic decidual tissue--a key player in the pathophysiology of 'acute atherosis' in pre-eclampsia?
Placenta, 24 (10), 965-73
DOI 10.1016/s0143-4004(03)00175-9, PubMed 14580379
Publications 2002
Reduced secretion of triacylglycerol in CaCo-2 cells transfected with intestinal fatty acid-binding protein
Lipids, 37 (1), 61-8
DOI 10.1007/s11745-002-0864-8, PubMed 11876264
Pathological changes in juvenile Atlantic halibut Hippoglossus hippoglossus persistently infected with nodavirus
Dis Aquat Organ, 50 (3), 161-9
DOI 10.3354/dao050161, PubMed 12219972
Pathological changes in juvenile Atlantic halibut Hippoglossus hippoglossus persistently infected with nodavirus
Dis. Aquat. Org., 50 (3), 161-169
Publications 2001
8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells
Hypertension, 37 (4), 1184-90
DOI 10.1161/01.hyp.37.4.1184, PubMed 11304522
VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery
Acta Obstet Gynecol Scand, 80 (2), 93-8
DOI 10.1034/j.1600-0412.2001.080002093.x, PubMed 11167201
Publications 2000
8-Iso-prostaglandin f(2alpha) reduces trophoblast invasion and matrix metalloproteinase activity
Hypertension, 35 (6), 1307-13
DOI 10.1161/01.hyp.35.6.1307, PubMed 10856282
Publications 1999
Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture
Adv Exp Med Biol, 466, 205-10
DOI 10.1007/0-306-46818-2_24, PubMed 10709646
Stimulation of serglycin and CD44 mRNA expression in endothelial cells exposed to TNF-alpha and IL-1alpha
Biochim Biophys Acta, 1428 (2-3), 225-32
DOI 10.1016/s0304-4165(99)00096-3, PubMed 10434040
Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia
Am J Obstet Gynecol, 181 (5 Pt 1), 1211-5
DOI 10.1016/s0002-9378(99)70110-9, PubMed 10561647
Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
Am J Obstet Gynecol, 180 (3 Pt 1), 587-92
DOI 10.1016/s0002-9378(99)70259-0, PubMed 10076133
Publications 1998
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts
J Lipid Res, 39 (4), 901-12
PubMed 9555953
Publications 1997
Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice
Arterioscler Thromb Vasc Biol, 17 (11), 3286-93
DOI 10.1161/01.atv.17.11.3286, PubMed 9409324
Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells
Arterioscler Thromb Vasc Biol, 17 (10), 2140-9
DOI 10.1161/01.atv.17.10.2140, PubMed 9351383
Cafestol (a coffee lipid) decreases uptake of low-density lipoprotein (LDL) in human skin fibroblasts and liver cells
Ann N Y Acad Sci, 827, 158-62
DOI 10.1111/j.1749-6632.1997.tb51830.x, PubMed 9329750
Publications 1995
Tetradecylthioacetic acid (a 3-thia fatty acid) decreases triacylglycerol secretion in CaCo-2 cells
J Lipid Res, 36 (3), 535-43
PubMed 7775865
Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells
J Lipid Res, 36 (10), 2079-89
PubMed 8576635
Publications 1994
Lipid metabolism in cultured intestinal cells: effect of eicosapentaenoic acid (20:5, n-3), tetradecylthioacetic acid and a coffee lipid (cafestol) on the lipid metabolism in CaCo-2 cells
Institute for Nutrition Research, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 95032423x, ISBN 82-91061-58-0
Effect of chronic incubation of CaCo-2 cells with eicosapentaenoic acid (20:5, n-3) and oleic acid (18:1, n-9) on triacylglycerol production
Biochem J, 303 ( Pt 1) (Pt 1), 155-61
DOI 10.1042/bj3030155, PubMed 7945235
Fatty acid uptake and metabolism in CaCo-2 cells: eicosapentaenoic acid (20:5(n-3)) and oleic acid (18:1(n-9)) presented in association with micelles or albumin
Biochim Biophys Acta, 1212 (3), 295-304
DOI 10.1016/0005-2760(94)90203-8, PubMed 8199200
Publications 1992
Influence of eicosapentaenoic acid (20:5, n-3) on secretion of lipoproteins in CaCo-2 cells
J Lipid Res, 33 (9), 1281-93
PubMed 1402397
Publications 1990
Characteristics of a human intestinal adenocarcinoma cellline (CACO-2) in relation to metabolism of eicosapentaenoic acid (20:5, n-3) and oleic acid (18:1, n-9)
Institute for Nutrition Research, University of Oslo ; Bekkestua : Stabekk høgskole, Oslo, 43 s.
BIBSYS 971595380
Publications 1988
Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
Br J Cancer, 58 (3), 306-13
DOI 10.1038/bjc.1988.209, PubMed 3179182