Publications 2021

Fevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K (2021)
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front. Immunol., 12, 715102
DOI 10.3389/fimmu.2021.715102

Hoel H, Heggelund L, Reikvam DH, Stiksrud B, Ueland T, Michelsen AE, Otterdal K, Muller KE, Lind A, Muller F, Dudman S, Aukrust P, Dyrhol-Riise AM, Holter JC, Troseid M (2021)
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J. Intern. Med., 289 (4), 523-531
DOI 10.1111/joim.13178

Otterdal K, Berg A, Michelsen AE, Yndestad A, Patel S, Gregersen I, Halvorsen B, Ueland T, Langeland N, Aukrust P (2021)
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
BMC Infect. Dis., 21 (1), 1073
DOI 10.1186/s12879-021-06751-y

Ueland T, Astrup E, Otterdal K, Lekva T, Janardhanan J, Prakash JAJ, Thomas K, Michelsen AE, Aukrust P, Varghese GM, Damas JK (2021)
Secreted Wnt antagonists in scrub typhus
Plos Neglect. Trop. Dis., 15 (4), e0009185
DOI 10.1371/journal.pntd.0009185

Publications 2020

Berg A, Patel S, Tellevik MG, Haanshuus CG, Dalen I, Otterdal K, Ueland T, Moyo SJ, Aukrust P, Langeland N (2020)
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
Infection, 48 (3), 367-373
DOI 10.1007/s15010-020-01399-3

Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Goncalves I, Nilsson J, Grenegard M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M et al. (2020)
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Troseid M, Halvorsen B, Aukrust P, Fevang B, Jorgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front. Immunol., 11, 574500
DOI 10.3389/fimmu.2020.574500

Otterdal K, Berg A, Michelsen AE, Patel S, Gregersen I, Sagen EL, Halvorsen B, Yndestad A, Ueland T, Langeland N, Aukrust P (2020)
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
BMC Infect. Dis., 20 (1), 65
DOI 10.1186/s12879-020-4783-8

Publications 2019

Knackstedt SL, Georgiadou A, Apel F, Abu-Abed U, Moxon CA, Cunnington AJ, Raupach B, Cunningham D, Langhorne J, Kruger R, Barrera V, Harding SP, Berg A, Patel S, Otterdal K, Mordmuller B, Schwarzer E, Brinkmann V, Zychlinsky A, Amulic B (2019)
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Sci. Immunol., 4 (40), eaaw0336
DOI 10.1126/sciimmunol.aaw0336

Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jorgensen SF (2019)
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9, 9427
DOI 10.1038/s41598-019-45861-1

Norum HM, Michelsen AE, Lekva T, Arora S, Otterdal K, Olsen MB, Kong XY, Gude E, Andreassen AK, Solbu D, Karason K, Dellgren G, Gullestad L, Aukrust P, Ueland T (2019)
Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression
Am. J. Transplant., 19 (4), 1050-1060
DOI 10.1111/ajt.15141

Publications 2018

Otterdal K, Berg A, Michelsen AE, Patel S, Tellevik MG, Haanshuus CG, Fevang B, Aukrust P, Langeland N, Ueland T (2018)
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria
BMC Infect. Dis., 18, 670
DOI 10.1186/s12879-018-3593-8

Skarpengland T, Skjelland M, Kong XY, Skagen K, Holm S, Otterdal K, Dahl CP, Krohg-Sorensen K, Sagen EL, Bjerkeli V, Aamodt AH, Abbas A, Gregersen I, Aukrust P, Halvorsen B, Dahl TB (2018)
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J. Am. Heart Assoc., 7 (2), e006479
DOI 10.1161/JAHA.117.006479

Publications 2017

Gregersen I, Sandanger O, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sorensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B (2017)
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387

Publications 2016

Halvorsen B, Santilli F, Scholz H, Sahraoui A, Gulseth HL, Wium C, Lattanzio S, Formoso G, Di Fulvio P, Otterdal K, Retterstol K, Holven KB, Gregersen I, Stavik B, Bjerkeli V, Michelsen AE, Ueland T, Liani R, Davi G, Aukrust P (2016)
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-2144
DOI 10.1007/s00125-016-4036-y

Otterdal K, Portillo A, Astrup E, Ludviksen J, Davi G, Holm S, Santilli F, Vitale G, Raoult D, Olano JP, Schjalm C, Halvorsen B, Oteo JA, Mollnes TE, Aukrust P, Nilsson PH (2016)
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006

Otterdal K, Portillo A, Astrup E, Ludviksen JK, Schjalm C, Raoult D, Olano JP, Halvorsen B, Oteo JA, Aukrust P, Mollnes TE, Nilsson PH (2016)
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Clin. Microbiol. Infect., 22 (8), 734.e1
DOI 10.1016/j.cmi.2016.05.010

Publications 2015

Berg A, Otterdal K, Patel S, Gonca M, David C, Dalen I, Nymo S, Nilsson M, Nordling S, Magnusson PU, Ueland T, Prato M, Giribaldi G, Mollnes TE, Aukrust P, Langeland N, Nilsson PH (2015)
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
J. Infect. Dis., 212 (11), 1835-1840
DOI 10.1093/infdis/jiv283

Otterdal K, Haukeland JWI, Yndestad A, Dahl TB, Holm S, Segers FM, Gladhaug IP, Konopski Z, Damas JKR, Halvorsen B, Aukrust P (2015)
Increased Serum Levels of LIGHT/TNFSF14 in Nonalcoholic Fatty Liver Disease: Possible Role in Hepatic Inflammation
Clin. Transl. Gastroenterol., 6, e95
DOI 10.1038/ctg.2015.23

Ueland T, Olarescu NC, Jorgensen AP, Otterdal K, Aukrust P, Godang K, Lekva T, Bollerslev J (2015)
Increased Serum and Bone Matrix Levels of the Secreted Wnt Antagonist DKK-1 in Patients With Growth Hormone Deficiency in Response to Growth Hormone Treatment
J. Clin. Endocrinol. Metab., 100 (2), 736-743
DOI 10.1210/jc.2014-2912

Publications 2014

Astrup E, Janardhanan J, Otterdal K, Ueland T, Prakash JAJ, Lekva T, Strand OA, Abraham OC, Thomas K, Damas JK, Mathews P, Mathai D, Aukrust P, Varghese GM (2014)
Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality
Plos Neglect. Trop. Dis., 8 (2), e2648
DOI 10.1371/journal.pntd.0002648

Astrup E, Ranheim T, Damas JK, Davi G, Santilli F, Jensenius M, Vitale G, Aukrust P, Olano JP, Otterdal K (2014)
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BMC Infect. Dis., 14, 70
DOI 10.1186/1471-2334-14-70

Berg A, Patel S, Gonca M, David C, Otterdal K, Ueland T, Dalen I, Kvaloy JT, Mollnes TE, Aukrust P, Langeland N (2014)
Cytokine Network in Adults with Falciparum Malaria and HIV-1: Increased IL-8 and IP-10 Levels Are Associated with Disease Severity
PLoS One, 9 (12), e114480
DOI 10.1371/journal.pone.0114480

Otterdal K, Janardhanan J, Astrup E, Ueland T, Prakash JAJ, Lekva T, Abraham OC, Thomas K, Damas JK, Mathews P, Mathai D, Aukrust P, Varghese GM (2014)
Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus
J. Infect., 69 (5), 462-469
DOI 10.1016/j.jinf.2014.06.018

Publications 2012

Astrup E, Lekva T, Davi G, Otterdal K, Santilli F, Oie E, Halvorsen B, Damas JK, Raoult D, Vitale G, Olano JP, Ueland T, Aukrust P (2012)
A Complex Interaction between Rickettsia conorii and Dickkopf-1-Potential Role in Immune Evasion Mechanisms in Endothelial Cells
PLoS One, 7 (9), e43638
DOI 10.1371/journal.pone.0043638

Dahl TB, Bermudez B, Ranheim T, Otterdal K, Holm S, Biessen EAL, Halvorsen B, Aukrust P (2012)
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707
DOI 10.2217/CLP.12.71

Hol J, Otterdal K, Breland UM, Stang E, Pedersen TM, Hagelsteen K, Ranheim T, Kasprzycka M, Halvorsen B, Haraldsen G, Aukrust P (2012)
Statins Affect the Presentation of Endothelial Chemokines by Targeting to Multivesicular Bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673

Publications 2011

Aukrust P, Sandberg WJ, Otterdal K, Vinge LE, Gullestad L, Yndestad A, Halvorsen B, Ueland T (2011)
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Ann. Med., 43 (2), 90-103
DOI 10.3109/07853890.2010.523711

Grimstad O, Sandanger O, Ryan L, Otterdal K, Damaas JK, Pukstad B, Espevik T (2011)
Cellular sources and inducers of cytokines present in acute wound fluid
Wound Repair Regen., 19 (3), 337-347
DOI 10.1111/j.1524-475X.2011.00668.x

Landro L, Ueland T, Otterdal K, Froland SS, Aukrust P (2011)
Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy
J. Thromb. Haemost., 9 (5), 1075-1077
DOI 10.1111/j.1538-7836.2011.04242.x

Ueland T, Lekva T, Otterdal K, Dahl TB, Olarescu NC, Jorgensen AP, Fougner KJ, Brixen K, Aukrust P, Bollerslev J (2011)
Increased serum and bone matrix levels of transforming growth factor beta 1 in patients with GH deficiency in response to GH treatment
Eur. J. Endocrinol., 165 (3), 393-400
DOI 10.1530/EJE-11-0442

Publications 2010

Aukrust P, Halvorsen B, Ueland T, Michelsen AE, Skjelland M, Gullestad L, Yndestad A, Otterdal K (2010)
Activated platelets and atherosclerosis
Expert Rev. Cardiovasc. Ther., 8 (9), 1297-1307
DOI 10.1586/ERC.10.92

Halvorsen B, Heggen E, Ueland T, Smith C, Sandberg WJ, Damas JK, Otterdal K, Tonstad S, Aukrust P (2010)
Treatment with the PPAR gamma agonist rosiglitazone downregulates interleukin-1 receptor antagonist in individuals with metabolic syndrome
Eur. J. Endocrinol., 162 (2), 267-273
DOI 10.1530/EJE-09-0706

Publications 2009

Damas JK, Davi G, Jensenius M, Santilli F, Otterdal K, Ueland T, Flo TH, Lien E, Espevik T, Froland SS, Vitale G, Raoult D, Aukrust P (2009)
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever
J. Infect., 58 (1), 68-75
DOI 10.1016/j.jinf.2008.11.008

Landro L, Damas JK, Halvorsen B, Fevang B, Ueland T, Otterdal K, Heggelund L, Froland SS, Aukrust P (2009)
CXCL16 in HIV infection - a link between inflammation and viral replication
Eur. J. Clin. Invest., 39 (11), 1017-1024
DOI 10.1111/j.1365-2362.2009.02207.x

Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P (2009)
Inflammatory Interaction Between LIGHT and Proteinase-Activated Receptor-2 in Endothelial Cells Potential Role in Atherogenesis
Circ.Res., 104 (1), 60-U192
DOI 10.1161/CIRCRESAHA.108.188078

Sandberg WJ, Otterdal K, Gullestad L, Halvorsen B, Ragnarsson A, Froland SS, Damas JK, Oie E, Aukrust P, Hansson GK, Yndestad A (2009)
The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis
Thromb. Haemost., 102 (4), 704-710
DOI 10.1160/TH08-10-0665

Ueland T, Otterdal K, Lekva T, Halvorsen B, Gabrielsen A, Sandberg WJ, Paulsson-Berne G, Pedersen TM, Folkersen L, Gullestad L, Oie E, Hansson GK, Aukrust P (2009)
Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis
Arterioscler. Thromb. Vasc. Biol., 29 (8), 1228-1234
DOI 10.1161/ATVBAHA.109.189761

Publications 2008

Aukrust P, Halvorsen B, Yndestad A, Ueland T, Oie E, Otterdal K, Gullestad L, Damas JK (2008)
Chemokines and Cardiovascular Risk
Arterioscler. Thromb. Vasc. Biol., 28 (11), 1909-1919
DOI 10.1161/ATVBAHA.107.161240

Aukrust P, Otterdal K, Yndestad A, Sandberg WJ, Smith C, Ueland T, Oie E, Damas JK, Gullestad L, Halvorsen B (2008)
The Complex Role of T-Cell-Based Immunity in Atherosclerosis
Curr. Atherosclerol. Rep., 10 (3), 236-243
DOI 10.1007/s11883-008-0037-8

Breland UM, Halvorsen B, Hol J, Oie E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, Sandberg WJ, Froland SS, Haraldsen G, Gullestad L, Damas JK, Hansson GK, Aukrust P (2008)
A potential role of the CXC chemokine GRO alpha in atherosclerosis and plaque destabilization - Downregulatory effects of statins
Arterioscler. Thromb. Vasc. Biol., 28 (5), 1005-1011
DOI 10.1161/ATVBAHA.108.162305

Halvorsen B, Otterdal K, Dahl TB, Skjelland M, Gullestad L, Oie E, Aukrust P (2008)
Atherosclerotic Plaque Stability-What Determines the Fate of a Plaque?
Prog. Cardiovasc. Dis., 51 (3), 183-194
DOI 10.1016/j.pcad.2008.09.001

Halvorsen B, Otterdal K, Tonstad S, Aukrust P (2008)
Smoking and Inflammation: Their Synergistic Roles in Chronic Disease
Curr. Cardiovascu. Risk Rep., 2 (6), 446-451
DOI 10.1007/s12170-008-0079-z

Holven KB, Aukrust P, Retterstol K, Otterdal K, Bjerkeli V, Ose L, Nenseter MS, Halvorsen B (2008)
The Antiatherogenic Function of HDL Is Impaired in Hyperhomocysteinemic Subjects
J. Nutr., 138 (11), 2070-2075
DOI 10.3945/jn.108.090704

Otterdal K, Andreassen AK, Yndestad A, Oie E, Sandberg WJ, Dahl CP, Pedersen TM, Ueland T, Gullestad L, Brosstad FR, Aukrust P, Damas JK (2008)
Raised LIGHT levels in pulmonary arterial hypertension potential role in thrombus formation
Am. J. Respir. Crit. Care Med., 177 (2), 202-207
DOI 10.1164/rccm.200703-506OC

Smith C, Halvorsen B, Otterdal K, Waehre T, Yndestad A, Fevang B, Sandberg WJ, Breland UM, Froland SS, Oie E, Gullestad L, Damas JK, Aukrust P (2008)
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res., 79 (1), 195-203
DOI 10.1093/cvr/cvn071

Publications 2007

Otterdal K (2007)
Platelet-mediated inflammation: involvement of the tumor necrosis factor superfamily ligands CD40L and LIGHT
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 474, 1 b. (flere pag.)
BIBSYS 07040934x, ISBN 978-82-8072-695-7

Publications 2006

Damas JK, Jensenius M, Ueland T, Otterdal K, Yndestad A, Froland SS, Rolain JM, Myrvang B, Raoult D, Aukrust P (2006)
Increased levels of soluble CD40L in African tick bite fever: Possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets
J. Immunol., 177 (4), 2699-2706
DOI 10.4049/jimmunol.177.4.2699

Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P (2006)
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes
Blood, 108 (3), 928-935
DOI 10.1182/blood-2005-09-010629

Ottestad HO, Halvorsen B, Balstad TR, Otterdal K, Borge GI, Brosstad F, Myhre AM, Ose L, Nenseter MS, Holven KB (2006)
Triglyceride-rich HDL3 from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux
J. Nutr., 136 (4), 877-881
DOI 10.1093/jn/136.4.877

Smith C, Damas JK, Otterdal K, Oie E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Froland SS, Hansson GK, Aukrust P (2006)
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes - Possible role of platelet-mediated vascular inflammation
J. Am. Coll. Cardiol., 48 (8), 1591-1599
DOI 10.1016/j.jacc.2006.06.060

Publications 2005

Balstad TR, Holven KB, Ottestad IO, Otterdal K, Halvorsen B, Myhre AM, Ose L, Nenseter MS (2005)
Altered composition of HDL3 in FH subjects causing a HDL subfraction with less atheroprotective function
Clin. Chim. Acta, 359 (1-2), 171-178
DOI 10.1016/j.cccn.2005.03.050

Ueland T, Aukrust P, Yndestad A, Otterdal K, Froland SS, Dickstein K, Kjekshus J, Gullestad L, Damais JK (2005)
Soluble CD40 ligand in acute and chronic heart failure
Eur. Heart J., 26 (11), 1101-1107
DOI 10.1093/eurheartj/ehi132

Publications 2004

Damas JK, Otterdal K, Yndestad A, Aass H, Solum NO, Froland SS, Simonsen S, Aukrust P, Andreassen AK (2004)
Soluble CD40 ligand in pulmonary arterial hypertension - Possible pathogenic role of the interaction between platelets and endothelial cells
Circulation, 110 (8), 999-1005
DOI 10.1161/01.CIR.0000139859.68513.FC

Otterdal K, Pedersen TM, Solum NO (2004)
Release of soluble CD40 ligand after platelet activation - Studies on the solubilization phase
Thromb. Res., 114 (3), 167-177
DOI 10.1016/j.thromres.2004.05.007

Smith C, Yndestad A, Halvorsen B, Ueland T, Waehre T, Otterdal K, Scholz H, Endresen K, Gullestad L, Froland SS, Damas JK, Aukrust P (2004)
Potential anti-inflammatory role of activin A in acute coronary syndromes
J. Am. Coll. Cardiol., 44 (2), 369-375
DOI 10.1016/j.jacc.2004.03.069

Publications 2003

Damas JK, Waehre T, Yndestad A, Otterdal K, Hognestad A, Solum NO, Gullestad L, Froland SS, Aukrust P (2003)
Interleukin-7-mediated inflammation in unstable angina - Possible role of chemokines and platelets
Circulation, 107 (21), 2670-2676
DOI 10.1161/01.CIR.0000070542.18001.87

Publications 2001

Otterdal K, Pedersen TM, Solum NO (2001)
Platelet shape change induced by the peptide YFLLRNP
Thromb. Res., 103 (5), 411-420
DOI 10.1016/S0049-3848(01)00334-6

Publications 2000

Aukrust P, Bjornsen S, Lunden B, Otterdal K, Ng EC, Ameln W, Ueland T, Muller F, Solum NO, Brosstad F, Froland SS (2000)
Persistently elevated levels of von Willebrand factor antigen in HIV infection - Downregulation during highly active antiretroviral therapy
Thromb. Haemost., 84 (2), 183-187

Publications 1998

Otterdal K (1998)
Studier av blodplatenes formforandring ved påvirkning av peptidet YFLLRNP
K. Otterdal, Oslo, 102 s.
BIBSYS 980358426