Publications 2021

Awoyemi A, Mayerhofer C, Felix AS, Hov JR, Moscavitch SD, Lappegard KT, Hovland A, Halvorsen S, Halvorsen B, Gregersen I, Svardal A, Berge RK, Hansen SH, Gotz A, Holm K, Aukrust P, Akra S, Seljeflot I, Solheim S, Lorenzo A, Gullestad L, Troseid M, Broch K (2021)
Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial
EBioMedicine, 70, 103511
DOI 10.1016/j.ebiom.2021.103511

Holm S, Kared H, Michelsen AE, Kong XY, Dahl TB, Schultz NH, Nyman TA, Fladeby C, Seljeflot I, Ueland T, Stensland M, Mjaaland S, Goll GL, Nissen-Meyer LS, Aukrust P, Skagen K, Gregersen I, Skjelland M, Holme PA, Munthe LA, Halvorsen B (2021)
Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia
Eur. Heart J., 42 (39), 4064-4072
DOI 10.1093/eurheartj/ehab506

Karlsen TR, Kong XY, Holm S, Quiles-Jimenez A, Dahl TB, Yang K, Sagen EL, Skarpengland T, Ogaard JSD, Holm K, Vestad B, Olsen MB, Aukrust P, Bjoras M, Hov JR, Halvorsen B, Gregersen I (2021)
NEIL3-deficiency increases gut permeability and contributes to a pro-atherogenic metabolic phenotype
Sci Rep, 11 (1), 19749
DOI 10.1038/s41598-021-98820-0

Kong XY, Huse C, Yang K, Ogaard J, Berges N, Vik ES, Nawaz MS, Quiles-Jimenez A, Abbas A, Gregersen I, Holm S, Bjerkli V, Rashidi A, Fladeby C, Suganthan R, Sagen EL, Skjelland M, Lang AN, Boe SO, Bjoras M, Aukrust P, Alseth I, Halvorsen B, Dahl TB (2021)
Endonuclease V Regulates Atherosclerosis Through C-C Motif Chemokine Ligand 2-Mediated Monocyte Infiltration
J. Am. Heart Assoc., 10 (14), e020656
DOI 10.1161/JAHA.120.020656

Otterdal K, Berg A, Michelsen AE, Yndestad A, Patel S, Gregersen I, Halvorsen B, Ueland T, Langeland N, Aukrust P (2021)
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
BMC Infect. Dis., 21 (1), 1073
DOI 10.1186/s12879-021-06751-y

Quiles-Jimenez A, Gregersen I, Segers FM, Skarpengland T, Kroustallaki P, Yang K, Kong XY, Lauritzen KH, Olsen MB, Karlsen TR, Nyman TA, Sagen EL, Bjerkeli V, Suganthan R, Nygard S, Scheffler K, Prins J, Van der Veer E, Ogaard JDS, Floisand Y, Jorgensen HF, Holven KB, Biessen EA, Nilsen H, Dahl TB et al. (2021)
DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development
Atherosclerosis, 324, 123-132
DOI 10.1016/j.atherosclerosis.2021.02.023

Publications 2020

Gregersen I, Michelsen AE, Lunde NN, Akerblom A, Lakic TG, Skjelland M, Skagen KR, Becker RC, Lindback J, Himmelmann A, Solberg R, Johansen HT, James SK, Siegbahn A, Storey RF, Kontny F, Aukrust P, Ueland T, Wallentin L, Halvorsen B (2020)
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial
J. Am. Heart Assoc., 9 (17), e016360
DOI 10.1161/JAHA.120.016360

Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vagbo C, Suganthan R, Segers F, Holm S, Quiles-Jimenez A, Gregersen I, Fladeby C, Aukrust P, Bjoras M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res., 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115

Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Goncalves I, Nilsson J, Grenegard M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M et al. (2020)
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008

Niyonzima N, Bakke SS, Gregersen I, Holm S, Sandanger O, Orrem HL, Sporsheim B, Ryan L, Kong XY, Dahl TB, Skjelland M, Sorensen KK, Rokstad AM, Yndestad A, Latz E, Gullestad L, Andersen GO, Damas JK, Aukrust P, Mollnes TE, Halvorsen B, Espevik T (2020)
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985

Olsen MB, Gregersen I (2020)
The role of the immune system in severe covid-19
Tidsskr. Nor. Laegeforen., 140 (18), 1821

Otterdal K, Berg A, Michelsen AE, Patel S, Gregersen I, Sagen EL, Halvorsen B, Yndestad A, Ueland T, Langeland N, Aukrust P (2020)
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
BMC Infect. Dis., 20 (1), 65
DOI 10.1186/s12879-020-4783-8

Quiles-Jimenez A, Gregersen I, de Sousa MML, Abbas A, Kong XY, Alseth I, Holm S, Dahl TB, Skagen K, Skjelland M, Aukrust P, Bjoras M, Halvorsen B (2020)
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem. Biophys. Res. Commun., 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057

Publications 2019

Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Oie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J, Yndestad A (2019)
Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction
EBioMedicine, 46, 264-273
DOI 10.1016/j.ebiom.2019.07.024

Gregersen I, Hoibraaten E, Holven KB, Lovdahl L, Ueland T, Mowinckel MC, Dahl TB, Aukrust P, Halvorsen B, Sandset PM (2019)
Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women
Thromb. Res., 184, 1-7
DOI 10.1016/j.thromres.2019.10.005

Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jorgensen SF (2019)
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9, 9427
DOI 10.1038/s41598-019-45861-1

Publications 2018

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damas JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GO, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE (2018)
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front. Immunol., 9, 2035
DOI 10.3389/fimmu.2018.02035

Skarpengland T, Skjelland M, Kong XY, Skagen K, Holm S, Otterdal K, Dahl CP, Krohg-Sorensen K, Sagen EL, Bjerkeli V, Aamodt AH, Abbas A, Gregersen I, Aukrust P, Halvorsen B, Dahl TB (2018)
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J. Am. Heart Assoc., 7 (2), e006479
DOI 10.1161/JAHA.117.006479

Publications 2017

Gregersen I, Sandanger O, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sorensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B (2017)
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387

Lunde NN, Holm S, Dahl TB, Elyouncha I, Sporsheim B, Gregersen I, Abbas A, Skjelland M, Espevik T, Solberg R, Johansen HT, Halvorsen B (2017)
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis
Atherosclerosis, 257, 216-223
DOI 10.1016/j.atherosclerosis.2016.11.026

Publications 2016

Gregersen I, Holm S, Dahl TB, Halvorsen B, Aukrust P (2016)
A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases
Expert Rev. Cardiovasc. Ther., 14 (3), 391-403
DOI 10.1586/14779072.2016.1128828

Halvorsen B, Santilli F, Scholz H, Sahraoui A, Gulseth HL, Wium C, Lattanzio S, Formoso G, Di Fulvio P, Otterdal K, Retterstol K, Holven KB, Gregersen I, Stavik B, Bjerkeli V, Michelsen AE, Ueland T, Liani R, Davi G, Aukrust P (2016)
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-2144
DOI 10.1007/s00125-016-4036-y

Skagen K, Troseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JER, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-69
DOI 10.1016/j.atherosclerosis.2016.01.033

Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kusnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, Folkersen L, Krohg-Sorensen K, Holm S, Bjoras M, Aukrust P, Halvorsen B (2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic. Biol. Med., 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Ostlie I, Otten JJT, Luna L, Ketelhuth DFJ, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjorndal B, Svardal AM, Iversen PO, Hedin U, Nygard S, Olstad OK, Krohg-Sorensen K, Slupphaug G, Eide L, Kusnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337

Publications 2015

Abbas A, Gregersen I, Holm S, Daissormont I, Bjerkeli V, Krohg-Sorensen K, Skagen KR, Dahl TB, Russell D, Almas T, Bundgaard D, Alteheld LH, Rashidi A, Dahl CP, Michelsen AE, Biessen EA, Aukrust P, Halvorsen B, Skjelland M (2015)
Interleukin 23 Levels Are Increased in Carotid Atherosclerosis Possible Role for the Interleukin 23/Interleukin 17 Axis
Stroke, 46 (3), 793-+
DOI 10.1161/STROKEAHA.114.006516

Publications 2013

Gregersen I, Skjelland M, Holm S, Holven KB, Krogh-Sorensen K, Russell D, Askevold ET, Dahl CP, Orn S, Gullestad L, Mollnes TE, Ueland T, Aukrust P, Halvorsen B (2013)
Increased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosis
PLoS One, 8 (8), e72769
DOI 10.1371/journal.pone.0072769