Sverre Holm

  • Deputy Group Leader; PhD
  • +47 230 73624
 

Original articles

Kong XY, Vik ES, Nawaz MS, Berges N, Dahl TB, Vågbø C, Suganthan R, Segers F, Holm S, Quiles-Jiménez A, Gregersen I, Fladeby C, Aukrust P, Bjørås M, Klungland A, Halvorsen B, Alseth I (2020)
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res (in press)
DOI 10.1093/nar/gkaa115, PubMed 32083667

Esmonde H, Holm S (2020)
Fractional derivative modelling of adhesive cure
Appl. Math. Model., 77, 1041-1053

Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M et al. (2019)
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis (in press)
DOI 10.1016/j.atherosclerosis.2019.12.008, PubMed 31870625

Holm S (2019)
DISPERSION ANALYSIS FOR WAVE EQUATIONS WITH FRACTIONAL LAPLACIAN LOSS OPERATORS
Fract. Calc. Appl. Anal., 22 (6), 1596-1606

Chandrasekaran SN, Holm S (2019)
A multiple relaxation interpretation of the extended Biot model
J Acoust Soc Am, 146 (1), 330
DOI 10.1121/1.5116139, PubMed 31370628

Holm S, Oma I, Hagve TA, Saatvedt K, Brosstad F, Mikkelsen K, Rydningen H, Risnes I, Almdahl SM, Ueland T, Aukrust P, Halvorsen B, Hollan I (2019)
Levels of Lipoprotein (a) in patients with coronary artery disease with and without inflammatory rheumatic disease: a cross-sectional study
BMJ Open, 9 (5), e030651
DOI 10.1136/bmjopen-2019-030651, PubMed 31079089

Patz S, Fovargue D, Schregel K, Nazari N, Palotai M, Barbone PE, Fabry B, Hammers A, Holm S, Kozerke S, Nordsletten D, Sinkus R (2019)
Imaging localized neuronal activity at fast time scales through biomechanics
Sci Adv, 5 (4), eaav3816
DOI 10.1126/sciadv.aav3816, PubMed 31001585

Kvam J, Holm S, Angelsen BAJ (2019)
Exploiting Ballou's rule for better tissue classification
J Acoust Soc Am, 145 (4), 2103
DOI 10.1121/1.5096533, PubMed 31046352

Evensen KB, Paulat K, Prieur F, Holm S, Eide PK (2018)
Utility of the Tympanic Membrane Pressure Waveform for Non-invasive Estimation of The Intracranial Pressure Waveform
Sci Rep, 8 (1), 15776
DOI 10.1038/s41598-018-34083-6, PubMed 30361489

Sinkus R, Lambert S, Abd-Elmoniem KZ, Morse C, Heller T, Guenthner C, Ghanem AM, Holm S, Gharib AM (2018)
Rheological determinants for simultaneous staging of hepatic fibrosis and inflammation in patients with chronic liver disease
NMR Biomed, 31 (10), e3956
DOI 10.1002/nbm.3956, PubMed 30059174

Holm S (2018)
Comment on "High resolution coherence analysis between planetary and climate oscillations"
Adv. Space Res., 62 (2), 326-333

Evensen KB, O'Rourke M, Prieur F, Holm S, Eide PK (2018)
Non-invasive Estimation of the Intracranial Pressure Waveform from the Central Arterial Blood Pressure Waveform in Idiopathic Normal Pressure Hydrocephalus Patients
Sci Rep, 8 (1), 4714
DOI 10.1038/s41598-018-23142-7, PubMed 29549286

Skarpengland T, Skjelland M, Kong XY, Skagen K, Holm S, Otterdal K, Dahl CP, Krohg-Sørensen K, Sagen EL, Bjerkeli V, Aamodt AH, Abbas A, Gregersen I, Aukrust P, Halvorsen B, Dahl TB (2018)
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J Am Heart Assoc, 7 (2)
DOI 10.1161/JAHA.117.006479, PubMed 29330254

Gregersen I, Sandanger Ø, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sørensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B (2017)
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387, PubMed 29176764

Holm S (2017)
Spring-damper equivalents of the fractional, poroelastic, and poroviscoelastic models for elastography
NMR Biomed, 31 (10), e3854
DOI 10.1002/nbm.3854, PubMed 29178340

Holm S, Holm MB (2017)
Restrictions on wave equations for passive media
J Acoust Soc Am, 142 (4), 1888
DOI 10.1121/1.5006059, PubMed 29092559

Espada S, Stavik B, Holm S, Sagen EL, Bjerkeli V, Skjelland M, Dahl TB, Espevik T, Kanse S, Sandset PM, Skretting G, Halvorsen B (2017)
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages
Biochem Biophys Res Commun, 491 (2), 442-448
DOI 10.1016/j.bbrc.2017.07.070, PubMed 28712870

Rindal OMH, Aakhus S, Holm S, Austeng A (2017)
Hypothesis of Improved Visualization of Microstructures in the Interventricular Septum with Ultrasound and Adaptive Beamforming
Ultrasound Med Biol, 43 (10), 2494-2499
DOI 10.1016/j.ultrasmedbio.2017.05.023, PubMed 28689675

Stavik B, Holm S, Espada S, Iversen N, Sporsheim B, Bjerkeli V, Dahl TB, Sandset PM, Skjelland M, Espevik T, Skretting G, Halvorsen B (2017)
Increased expression of TFPI in human carotid stenosis
Thromb Res, 155, 31-37
DOI 10.1016/j.thromres.2017.04.024, PubMed 28482260

Bermudez B, Dahl TB, Medina I, Groeneweg M, Holm S, Montserrat-de la Paz S, Rousch M, Otten J, Herias V, Varela LM, Ranheim T, Yndestad A, Ortega-Gomez A, Abia R, Nagy L, Aukrust P, Muriana FJG, Halvorsen B, Biessen EAL (2017)
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
Arterioscler Thromb Vasc Biol, 37 (6), 1157-1167
DOI 10.1161/ATVBAHA.116.308187, PubMed 28408371

Prieur F, Rindal OMH, Holm S, Austeng A (2017)
Influence of the Delay-Multiply-And-Sum beamformer on the ultrasound image amplitude
IEEE INT ULTRA SYM

Bergh TF, Hajizovic I, Holm S (2017)
ACOUSTIC IMAGING OF SPARSE SOURCES WITH ORTHOGONAL MATCHING PURSUIT AND CLUSTERING OF BASIS VECTORS
INT CONF ACOUST SPEE, 6030-6034

Chen W, Fang J, Pang G, Holm S (2017)
Fractional biharmonic operator equation model for arbitrary frequency-dependent scattering attenuation in acoustic wave propagation
J Acoust Soc Am, 141 (1), 244
DOI 10.1121/1.4973865, PubMed 28147566

Chandrasekaran SN, Holm S, Prieur F (2017)
Focused ultrasound setup for the study of acoustic radiation force induced biological effects in cells
IEEE INT ULTRA SYM

Pandey V, Holm S (2016)
Connecting the grain-shearing mechanism of wave propagation in marine sediments to fractional order wave equations
J Acoust Soc Am, 140 (6), 4225
DOI 10.1121/1.4971289, PubMed 28039990

Lunde NN, Holm S, Dahl TB, Elyouncha I, Sporsheim B, Gregersen I, Abbas A, Skjelland M, Espevik T, Solberg R, Johansen HT, Halvorsen B (2016)
Increased levels of legumain in plasma and plaques from patients with carotid atherosclerosis
Atherosclerosis, 257, 216-223
DOI 10.1016/j.atherosclerosis.2016.11.026, PubMed 27940038

Pandey V, Holm S (2016)
Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity
Phys Rev E, 94 (3-1), 032606
DOI 10.1103/PhysRevE.94.032606, PubMed 27739858

Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kuśnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, Folkersen L, Krohg-Sørensen K, Holm S, Bjørås M, Aukrust P, Halvorsen B (2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939

Pilely K, Rosbjerg A, Genster N, Gal P, Pál G, Halvorsen B, Holm S, Aukrust P, Bakke SS, Sporsheim B, Nervik I, Niyonzima N, Bartels ED, Stahl GL, Mollnes TE, Espevik T, Garred P (2016)
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
J Immunol, 196 (12), 5064-74
DOI 10.4049/jimmunol.1502595, PubMed 27183610

Otterdal K, Portillo A, Astrup E, Ludviksen J, Davì G, Holm S, Santilli F, Vitale G, Raoult D, Olano JP, Schjalm C, Halvorsen B, Oteo JA, Mollnes TE, Aukrust P, Nilsson PH (2016)
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202

Pandey V, Nasholm SP, Holm S (2016)
SPATIAL DISPERSION OF ELASTIC WAVES IN A BAR CHARACTERIZED BY TEMPERED NONLOCAL ELASTICITY
Fract. Calc. Appl. Anal., 19 (2), 498-515

Skagen K, Trøseid M, Ueland T, Holm S, Abbas A, Gregersen I, Kummen M, Bjerkeli V, Reier-Nilsen F, Russell D, Svardal A, Karlsen TH, Aukrust P, Berge RK, Hov JE, Halvorsen B, Skjelland M (2016)
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis
Atherosclerosis, 247, 64-9
DOI 10.1016/j.atherosclerosis.2016.01.033, PubMed 26868510

Stavik B, Espada S, Cui XY, Iversen N, Holm S, Mowinkel MC, Halvorsen B, Skretting G, Sandset PM (2016)
EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
Biochim Biophys Acta, 1862 (4), 670-678
DOI 10.1016/j.bbadis.2016.01.017, PubMed 26826018

Bergh TE, Hafizovicz I, Holm S (2016)
Multi-Speaker Voice Activity Detection Using a Camera-assisted Microphone Array
INT CONF SYST SIGNAL, 327-330

Holm S, Pandey V (2016)
Wave propagation in marine sediments expressed by fractional wave and diffusion equations
2016 IEEE/OES CHINA OCEAN ACOUSTICS SYMPOSIUM (COA)

Palmer CL, Rindal OMH, Holm S, Austeng A (2016)
Realtime plane-wave software beamforming with an iPhone
IEEE INT ULTRA SYM

Rindal OMH, Austeng A, Torp H, Holm S, Rodriguez-Molares A (2016)
The dynamic range of adaptive beamformers
IEEE INT ULTRA SYM

Halvorsen B, Espeland MZ, Andersen GØ, Yndestad A, Sagen EL, Rashidi A, Knudsen EC, Skjelland M, Skagen KR, Krohg-Sørensen K, Holm S, Ritschel V, Holven KB, Biessen EA, Aukrust P, Dahl TB (2015)
Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages
Atherosclerosis, 243 (1), 204-10
DOI 10.1016/j.atherosclerosis.2015.09.010, PubMed 26402139

Lambert SA, Näsholm SP, Nordsletten D, Michler C, Juge L, Serfaty JM, Bilston L, Guzina B, Holm S, Sinkus R (2015)
Bridging Three Orders of Magnitude: Multiple Scattered Waves Sense Fractal Microscopic Structures via Dispersion
Phys Rev Lett, 115 (9), 094301
DOI 10.1103/PhysRevLett.115.094301, PubMed 26371655

Otterdal K, Haukeland JW, Yndestad A, Dahl TB, Holm S, Segers FM, Gladhaug IP, Konopski Z, Damås JK, Halvorsen B, Aukrust P (2015)
Increased Serum Levels of LIGHT/TNFSF14 in Nonalcoholic Fatty Liver Disease: Possible Role in Hepatic Inflammation
Clin Transl Gastroenterol, 6, e95
DOI 10.1038/ctg.2015.23, PubMed 26133108

Abbas A, Gregersen I, Holm S, Daissormont I, Bjerkeli V, Krohg-Sørensen K, Skagen KR, Dahl TB, Russell D, Almås T, Bundgaard D, Alteheld LH, Rashidi A, Dahl CP, Michelsen AE, Biessen EA, Aukrust P, Halvorsen B, Skjelland M (2015)
Interleukin 23 levels are increased in carotid atherosclerosis: possible role for the interleukin 23/interleukin 17 axis
Stroke, 46 (3), 793-9
DOI 10.1161/STROKEAHA.114.006516, PubMed 25649806

Holm S (2015)
Four ways to justify temporal memory operators in the lossy wave equation
IEEE INT ULTRA SYM

Halvorsen B, Holm S, Yndestad A, Scholz H, Sagen EL, Nebb H, Holven KB, Dahl TB, Aukrust P (2014)
Interleukin-10 increases reverse cholesterol transport in macrophages through its bidirectional interaction with liver X receptor α
Biochem Biophys Res Commun, 450 (4), 1525-30
DOI 10.1016/j.bbrc.2014.07.036, PubMed 25035925

Parolini C, Vik R, Busnelli M, Bjørndal B, Holm S, Brattelid T, Manzini S, Ganzetti GS, Dellera F, Halvorsen B, Aukrust P, Sirtori CR, Nordrehaug JE, Skorve J, Berge RK, Chiesa G (2014)
A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in ApoE-deficient mice
PLoS One, 9 (5), e97598
DOI 10.1371/journal.pone.0097598, PubMed 24840793

Halvorsen B, Smedbakken LM, Michelsen AE, Skjelland M, Bjerkeli V, Sagen EL, Taskén K, Bendz B, Gullestad L, Holm S, Biessen EA, Aukrust P (2014)
Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13
Atherosclerosis, 234 (2), 352-9
DOI 10.1016/j.atherosclerosis.2014.03.021, PubMed 24732574

Halvorsen B, Dahl TB, Smedbakken LM, Singh A, Michelsen AE, Skjelland M, Krohg-Sørensen K, Russell D, Höpken UE, Lipp M, Damås JK, Holm S, Yndestad A, Biessen EA, Aukrust P (2014)
Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells
Cardiovasc Res, 102 (1), 148-56
DOI 10.1093/cvr/cvu036, PubMed 24518141

Abbas A, Aukrust P, Russell D, Krohg-Sørensen K, Almås T, Bundgaard D, Bjerkeli V, Sagen EL, Michelsen AE, Dahl TB, Holm S, Ueland T, Skjelland M, Halvorsen B (2014)
Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis
PLoS One, 9 (1), e84935
DOI 10.1371/journal.pone.0084935, PubMed 24400123

Vik R, Busnelli M, Parolini C, Bjørndal B, Holm S, Bohov P, Halvorsen B, Brattelid T, Manzini S, Ganzetti GS, Dellera F, Nygård OK, Aukrust P, Sirtori CR, Chiesa G, Berge RK (2013)
An immunomodulating fatty acid analogue targeting mitochondria exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in apoe(-/-) mice
PLoS One, 8 (12), e81963
DOI 10.1371/journal.pone.0081963, PubMed 24324736

Gregersen I, Skjelland M, Holm S, Holven KB, Krogh-Sørensen K, Russell D, Askevold ET, Dahl CP, Ørn S, Gullestad L, Mollnes TE, Ueland T, Aukrust P, Halvorsen B (2013)
Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis
PLoS One, 8 (8), e72769
DOI 10.1371/journal.pone.0072769, PubMed 24023645

Eide PK, Holm S, Sorteberg W (2012)
Simultaneous monitoring of static and dynamic intracranial pressure parameters from two separate sensors in patients with cerebral bleeds: comparison of findings
Biomed Eng Online, 11, 66
DOI 10.1186/1475-925X-11-66, PubMed 22958653

Smedbakken LM, Halvorsen B, Daissormont I, Ranheim T, Michelsen AE, Skjelland M, Sagen EL, Folkersen L, Krohg-Sørensen K, Russell D, Holm S, Ueland T, Fevang B, Hedin U, Yndestad A, Gullestad L, Hansson GK, Biessen EA, Aukrust P (2012)
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-73
DOI 10.1016/j.atherosclerosis.2012.06.071, PubMed 22840692

Abbas A, Aukrust P, Dahl TB, Bjerkeli V, Sagen EB, Michelsen A, Russell D, Krohg-Sørensen K, Holm S, Skjelland M, Halvorsen B (2012)
High levels of S100A12 are associated with recent plaque symptomatology in patients with carotid atherosclerosis
Stroke, 43 (5), 1347-53
DOI 10.1161/STROKEAHA.111.642256, PubMed 22382154

Diego C, Hernandez A, Jimenez A, Holm S, Aparicio J (2012)
Effect of CDMA techniques with Kasami codes on ultrasound-image quality parameters
IEEE IMTC P, 1833-1837

Dahl T, Ranheim T, Holm S, Berge R, Aukrust P, Halvorsen B (2011)
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages
Eur J Clin Invest, 41 (10), 1098-104
DOI 10.1111/j.1365-2362.2011.02515.x, PubMed 21426336

Holm S, Ueland T, Dahl TB, Michelsen AE, Skjelland M, Russell D, Nymo SH, Krohg-Sørensen K, Clausen OP, Atar D, Januzzi JL, Aukrust P, Jensen JK, Halvorsen B (2011)
Fatty Acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke
PLoS One, 6 (12), e28785
DOI 10.1371/journal.pone.0028785, PubMed 22174896

Michelsen AE, Rathcke CN, Skjelland M, Holm S, Ranheim T, Krohg-Sørensen K, Klingvall MF, Brosstad F, Oie E, Vestergaard H, Aukrust P, Halvorsen B (2010)
Increased YKL-40 expression in patients with carotid atherosclerosis
Atherosclerosis, 211 (2), 589-95
DOI 10.1016/j.atherosclerosis.2010.02.035, PubMed 20347092

Holm S, Voshol PJ, Gustafsson JA, Nebb HI (2010)
LXRbeta deficient mice have reduced hepatic insulin clearance during hyperinsulinemic euglucemic clamp
Biochem Biophys Res Commun, 392 (3), 436-41
DOI 10.1016/j.bbrc.2010.01.042, PubMed 20079709

Holm S, Nilsen CIC (2010)
Robust ultrasonic indoor positioning using transmitter arrays
INT C INDOOR POSIT

Anthonisen EH, Berven L, Holm S, Nygård M, Nebb HI, Grønning-Wang LM (2009)
Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose
J Biol Chem, 285 (3), 1607-15
DOI 10.1074/jbc.M109.082685, PubMed 19933273

Review articles

Cai W, Chen W, Fang J, Holm S (2018)
A Survey on Fractional Derivative Modeling of Power-Law Frequency-Dependent Viscous Dissipative and Scattering Attenuation in Acoustic Wave Propagation
Appl. Mech. Rev., 70 (3), 030802

Gregersen I, Holm S, Dahl TB, Halvorsen B, Aukrust P (2015)
A focus on inflammation as a major risk factor for atherosclerotic cardiovascular diseases
Expert Rev Cardiovasc Ther, 14 (3), 391-403
DOI 10.1586/14779072.2016.1128828, PubMed 26641944

Dahl TB, Bermudez B, Ranheim T, Otterdal K, Holm S, Biessen EAL, Halvorsen B, Aukrust P (2012)
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707

Dahl TB, Holm S, Aukrust P, Halvorsen B (2012)
Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology
Annu Rev Nutr, 32, 229-43
DOI 10.1146/annurev-nutr-071811-150746, PubMed 22462624

Other articles

Chandrasekaran SN, Holm S (2019)
Erratum: A multiple relaxation interpretation of the extended Biot model [J. Acoust. Soc. Am. 146, 330-339 (2019)]
J Acoust Soc Am, 146 (6), 4322
DOI 10.1121/1.5139414, PubMed 31893747

Holm S, Holm MB (2018)
Erratum: Restrictions on wave equations for passive media [J. Acoust. Soc. Am. 142, 1888-1896 (2017)]
J Acoust Soc Am, 143 (5), 2580
DOI 10.1121/1.5036745, PubMed 29857703

Pandey V, Holm S (2018)
Publisher's Note: Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity [Phys. Rev. E 94, 032606 (2016)]
Phys Rev E, 97 (5-2), 059901
DOI 10.1103/PhysRevE.97.059901, PubMed 29906881

Holm S (2014)
On the alleged coherence between the global temperature and the sun's movement (vol 110, pg 23, 2014)
J. Atmos. Sol.-Terr. Phys., 119, 230-231

Theses

Holm S (2010)
Liver X receptor: physiological regulation at the crossroads of glucose andlipid metabolism
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 963, 1 b. (flere pag.)
BIBSYS 101287658, ISBN 978-82-8072-542-4

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