Kari Otterdal
- Senior researcher; PhD
- +47 23 07 36 25
Publications 2024
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome
Infection, 52 (4), 1357-1365
DOI 10.1007/s15010-024-02192-2, PubMed 38502427
C-C Motif Ligand 7 (CCL7) and C-C Motif Chemokine Receptor 3 (CCR3) dysregulation in patients with scrub typhus and association with mortality
J Infect Dis (in press)
DOI 10.1093/infdis/jiae401, PubMed 39190223
Publications 2023
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation
Gastroenterology, 166 (4), 667-679
DOI 10.1053/j.gastro.2023.11.283, PubMed 37995866
Publications 2021
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front Immunol, 12, 715102
DOI 10.3389/fimmu.2021.715102, PubMed 34987499
IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria
BMC Infect Dis, 21 (1), 1073
DOI 10.1186/s12879-021-06751-y, PubMed 34663245
Secreted Wnt antagonists in scrub typhus
PLoS Negl Trop Dis, 15 (4), e0009185
DOI 10.1371/journal.pntd.0009185, PubMed 33914733
Publications 2020
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
Infection, 48 (3), 367-373
DOI 10.1007/s15010-020-01399-3, PubMed 32077073
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med, 289 (4), 523-531
DOI 10.1111/joim.13178, PubMed 32976665
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
BMC Infect Dis, 20 (1), 65
DOI 10.1186/s12879-020-4783-8, PubMed 31964363
Publications 2019
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Sci Immunol, 4 (40)
DOI 10.1126/sciimmunol.aaw0336, PubMed 31628160
Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages
Atherosclerosis, 296, 74-82
DOI 10.1016/j.atherosclerosis.2019.12.008, PubMed 31870625
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9 (1), 9427
DOI 10.1038/s41598-019-45861-1, PubMed 31263122
Publications 2018
Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression
Am J Transplant, 19 (4), 1050-1060
DOI 10.1111/ajt.15141, PubMed 30312541
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria
BMC Infect Dis, 18 (1), 670
DOI 10.1186/s12879-018-3593-8, PubMed 30563486
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J Am Heart Assoc, 7 (2)
DOI 10.1161/JAHA.117.006479, PubMed 29330254
Publications 2017
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387, PubMed 29176764
Publications 2016
LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro
Diabetologia, 59 (10), 2134-44
DOI 10.1007/s00125-016-4036-y, PubMed 27421726
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Clin Microbiol Infect, 22 (8), 734.e1-6
DOI 10.1016/j.cmi.2016.05.010, PubMed 27217049
Publications 2015
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria
J Infect Dis, 212 (11), 1835-40
DOI 10.1093/infdis/jiv283, PubMed 25980034
Increased Serum Levels of LIGHT/TNFSF14 in Nonalcoholic Fatty Liver Disease: Possible Role in Hepatic Inflammation
Clin Transl Gastroenterol, 6 (7), e95
DOI 10.1038/ctg.2015.23, PubMed 26133108
Publications 2014
Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality
PLoS Negl Trop Dis, 8 (2), e2648
DOI 10.1371/journal.pntd.0002648, PubMed 24516677
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BMC Infect Dis, 14, 70
DOI 10.1186/1471-2334-14-70, PubMed 24507453
Cytokine network in adults with falciparum Malaria and HIV-1: increased IL-8 and IP-10 levels are associated with disease severity
PLoS One, 9 (12), e114480
DOI 10.1371/journal.pone.0114480, PubMed 25503583
Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus
J Infect, 69 (5), 462-9
DOI 10.1016/j.jinf.2014.06.018, PubMed 24995849
Increased serum and bone matrix levels of the secreted Wnt antagonist DKK-1 in patients with growth hormone deficiency in response to growth hormone treatment
J Clin Endocrinol Metab, 100 (2), 736-43
DOI 10.1210/jc.2014-2912, PubMed 25459913
Publications 2012
A complex interaction between Rickettsia conorii and Dickkopf-1--potential role in immune evasion mechanisms in endothelial cells
PLoS One, 7 (9), e43638
DOI 10.1371/journal.pone.0043638, PubMed 23028464
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707
DOI 10.2217/CLP.12.71
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673, PubMed 22815786
Publications 2011
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation
Diabetes, 60 (5), 1544-51
DOI 10.2337/db10-1493, PubMed 21464440
Cellular sources and inducers of cytokines present in acute wound fluid
Wound Repair Regen, 19 (3), 337-47
DOI 10.1111/j.1524-475X.2011.00668.x, PubMed 21371163
Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy
J Thromb Haemost, 9 (5), 1075-7
DOI 10.1111/j.1538-7836.2011.04242.x, PubMed 21324059
Increased serum and bone matrix levels of transforming growth factor {beta}1 in patients with GH deficiency in response to GH treatment
Eur J Endocrinol, 165 (3), 393-400
DOI 10.1530/EJE-11-0442, PubMed 21653735
Publications 2010
Activated platelets and atherosclerosis
Expert Rev Cardiovasc Ther, 8 (9), 1297-307
DOI 10.1586/erc.10.92, PubMed 20828352
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Ann Med, 43 (2), 90-103
DOI 10.3109/07853890.2010.523711, PubMed 21039303
Publications 2009
Treatment with the PPARgamma agonist rosiglitazone downregulates interleukin-1 receptor antagonist in individuals with metabolic syndrome
Eur J Endocrinol, 162 (2), 267-73
DOI 10.1530/EJE-09-0706, PubMed 19926782
CXCL16 in HIV infection - a link between inflammation and viral replication
Eur J Clin Invest, 39 (11), 1017-24
DOI 10.1111/j.1365-2362.2009.02207.x, PubMed 19674076
The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis
Thromb Haemost, 102 (4), 704-10
DOI 10.1160/TH08-10-0665, PubMed 19806256
Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis
Arterioscler Thromb Vasc Biol, 29 (8), 1228-34
DOI 10.1161/ATVBAHA.109.189761, PubMed 19498175
Publications 2008
Chemokines and cardiovascular risk
Arterioscler Thromb Vasc Biol, 28 (11), 1909-19
DOI 10.1161/ATVBAHA.107.161240, PubMed 18669888
The complex role of T-cell-based immunity in atherosclerosis
Curr Atheroscler Rep, 10 (3), 236-43
DOI 10.1007/s11883-008-0037-8, PubMed 18489852
A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins
Arterioscler Thromb Vasc Biol, 28 (5), 1005-11
DOI 10.1161/ATVBAHA.108.162305, PubMed 18276907
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
Eur J Heart Fail, 10 (4), 352-9
DOI 10.1016/j.ejheart.2008.02.010, PubMed 18353719
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever
J Infect, 58 (1), 68-75
DOI 10.1016/j.jinf.2008.11.008, PubMed 19091423
Atherosclerotic plaque stability--what determines the fate of a plaque?
Prog Cardiovasc Dis, 51 (3), 183-94
DOI 10.1016/j.pcad.2008.09.001, PubMed 19026853
Smoking and Inflammation: Their Synergistic Roles in Chronic Disease
Curr. Cardiovascu. Risk Rep., 2 (6), 446-451
DOI 10.1007/s12170-008-0079-z
The antiatherogenic function of HDL is impaired in hyperhomocysteinemic subjects
J Nutr, 138 (11), 2070-5
DOI 10.3945/jn.108.090704, PubMed 18936200
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis
Circ Res, 104 (1), 60-8
DOI 10.1161/CIRCRESAHA.108.188078, PubMed 19023130
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc Res, 79 (1), 195-203
DOI 10.1093/cvr/cvn071, PubMed 18339644
Publications 2007
Platelet-mediated inflammation: involvement of the tumor necrosis factor superfamily ligands CD40L and LIGHT
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 474, 1 b. (flere pag.)
BIBSYS 07040934x, ISBN 978-82-8072-695-7
Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation
Am J Respir Crit Care Med, 177 (2), 202-7
DOI 10.1164/rccm.200703-506OC, PubMed 17962639
Publications 2006
Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets
J Immunol, 177 (4), 2699-706
DOI 10.4049/jimmunol.177.4.2699, PubMed 16888032
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes
Blood, 108 (3), 928-35
DOI 10.1182/blood-2005-09-010629, PubMed 16861346
Triglyceride-rich HDL3 from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux
J Nutr, 136 (4), 877-81
DOI 10.1093/jn/136.4.877, PubMed 16549444
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation
J Am Coll Cardiol, 48 (8), 1591-9
DOI 10.1016/j.jacc.2006.06.060, PubMed 17045893
Publications 2005
Altered composition of HDL3 in FH subjects causing a HDL subfraction with less atheroprotective function
Clin Chim Acta, 359 (1-2), 171-8
DOI 10.1016/j.cccn.2005.03.050, PubMed 15936009
Soluble CD40 ligand in acute and chronic heart failure
Eur Heart J, 26 (11), 1101-7
DOI 10.1093/eurheartj/ehi132, PubMed 15716285
Publications 2004
Soluble CD40 ligand in pulmonary arterial hypertension: possible pathogenic role of the interaction between platelets and endothelial cells
Circulation, 110 (8), 999-1005
DOI 10.1161/01.CIR.0000139859.68513.FC, PubMed 15302794
Release of soluble CD40 ligand after platelet activation: studies on the solubilization phase
Thromb Res, 114 (3), 167-77
DOI 10.1016/j.thromres.2004.05.007, PubMed 15342213
Potential anti-inflammatory role of activin A in acute coronary syndromes
J Am Coll Cardiol, 44 (2), 369-75
DOI 10.1016/j.jacc.2004.03.069, PubMed 15261933
Publications 2003
Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets
Circulation, 107 (21), 2670-6
DOI 10.1161/01.CIR.0000070542.18001.87, PubMed 12742982
Publications 2001
Platelet shape change induced by the peptide YFLLRNP
Thromb Res, 103 (5), 411-20
DOI 10.1016/s0049-3848(01)00334-6, PubMed 11553373
Publications 2000
Persistently elevated levels of von Willebrand factor antigen in HIV infection. Downregulation during highly active antiretroviral therapy
Thromb Haemost, 84 (2), 183-7
PubMed 10959687
Publications 1998
Studier av blodplatenes formforandring ved påvirkning av peptidet YFLLRNP
K. Otterdal, Oslo, 102 s.
BIBSYS 980358426