Satish Arora

  • MD; PhD
  • +47 970 07 305

Satish Arora successfully defended his thesis "Immunological and non-immunological markers of cardiac allograft vasculopathy amongst heart transplant recipients" in May 2010.

Coronary disease often occurs in patients who are heart transplanted. The cause of the development of the disease is unknown, but chronic inflammation probably plays an important role.
The disease is difficult to detect, but physician and researcher Satish Arora has shown that simple blood tests can help in diagnosis.

Dr. Arora and his colleagues investigated the importance of elevated C-reactive protein (CRP) and other inflammatory markers for the development of coronary disease. Reduced renal function as well as previously undergone disease caused by a parasite (Toxoplasma gondii) can also be easily determined by blood sampling and the association with the development of coronary disease and later outcomes is considered in more detail.

Arora shows that different blood tests can be used to determine if a heart transplant patient is particularly at risk of developing coronary disease. Early detection of this disease is important and may result in more intensive follow-up and treatment, thus increasing the chance of survival after heart transplant.

 

Original articles

Bergh N, Gude E, Bartfay SE, K Andreassen A, Arora S, Dahlberg P, Dellgren G, Gullestad L, Gustafsson F, Karasson K, Rådegran G, Bollano E, Andersson B (2020)
Invasive haemodynamics in de novo everolimus vs. calcineurin inhibitor heart transplant recipients
ESC Heart Fail (in press)
DOI 10.1002/ehf2.12608, PubMed 32059083

Nelson LM, Andreassen AK, Arora S, Andersson B, Gude E, Eiskjaer H, Rådegran G, Dellgren G, Gullestad L, Gustafsson F (2020)
Mild acute cellular rejection and development of cardiac allograft vasculopathy assessed by intravascular ultrasound and coronary angiography in heart transplant recipients-a SCHEDULE trial substudy
Transpl Int
DOI 10.1111/tri.13577, PubMed 31958178

Gustafsson F, Andreassen AK, Andersson B, Eiskjær H, Rådegran G, Gude E, Jansson K, Solbu D, Karason K, Arora S, Dellgren G, Gullestad L, SCHEDULE (Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance) Investigators* (2020)
Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients: Long-term Follow-up From the Randomized SCHEDULE Study
Transplantation, 104 (1), 154-164
DOI 10.1097/TP.0000000000002702, PubMed 30893292

Trøseid M, Mayerhofer CCK, Broch K, Arora S, Svardal A, Hov JR, Andreassen AK, Gude E, Karason K, Dellgren G, Berge RK, Gullestad L, Aukrust P, Ueland T (2019)
The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection
J Heart Lung Transplant, 38 (10), 1097-1103
DOI 10.1016/j.healun.2019.06.003, PubMed 31301965

Arora S, Ofstad AP, Ulimoen GR, Birkeland KI, Endresen K, Gullestad L, Johansen OE (2019)
Asymptomatic coronary artery disease in a Norwegian cohort with type 2 diabetes: a prospective angiographic study with intravascular ultrasound evaluation
Cardiovasc Diabetol, 18 (1), 26
DOI 10.1186/s12933-019-0832-2, PubMed 30851727

Norum HM, Michelsen AE, Lekva T, Arora S, Otterdal K, Olsen MB, Kong XY, Gude E, Andreassen AK, Solbu D, Karason K, Dellgren G, Gullestad L, Aukrust P, Ueland T (2018)
Circulating delta-like Notch ligand 1 is correlated with cardiac allograft vasculopathy and suppressed in heart transplant recipients on everolimus-based immunosuppression
Am J Transplant, 19 (4), 1050-1060
DOI 10.1111/ajt.15141, PubMed 30312541

Arora S, Andreassen AK, Karason K, Gustafsson F, Eiskjær H, Bøtker HE, Rådegran G, Gude E, Ioanes D, Solbu D, Dellgren G, Ueland T, Aukrust P, Gullestad L, SCHEDULE (Scandinavian Heart Transplant Everolimus De Novo Study With Early Calcineurin Inhibitors Avoidance) Investigators (2018)
Effect of Everolimus Initiation and Calcineurin Inhibitor Elimination on Cardiac Allograft Vasculopathy in De Novo Heart Transplant Recipients
Circ Heart Fail, 11 (9), e004050
DOI 10.1161/CIRCHEARTFAILURE.117.004050, PubMed 30354362

Relbo Authen A, Grov I, Karason K, Gustafsson F, Eiskjaer H, Rådegran G, Gude E, Jansson K, Dellgren G, Solbu D, Arora S, Andreassen AK, Gullestad L (2017)
Effect of everolimus vs calcineurin inhibitors on quality of life in heart transplant recipients during a 3-year follow-up: Results of a randomized controlled trial (SCHEDULE)
Clin Transplant, 31 (9)
DOI 10.1111/ctr.13038, PubMed 28640529

Bürker BS, Gullestad L, Gude E, Relbo Authen A, Grov I, Hol PK, Andreassen AK, Arora S, Dew MA, Fiane AE, Haraldsen IR, Malt UF, Andersson S (2017)
Cognitive function after heart transplantation: Comparing everolimus-based and calcineurin inhibitor-based regimens
Clin Transplant, 31 (4)
DOI 10.1111/ctr.12927, PubMed 28185318

Yardley M, Gullestad L, Bendz B, Bjørkelund E, Rolid K, Arora S, Nytrøen K (2016)
Long-term effects of high-intensity interval training in heart transplant recipients: A 5-year follow-up study of a randomized controlled trial
Clin Transplant, 31 (1)
DOI 10.1111/ctr.12868, PubMed 27865004

Mirza K, Gustafsson F, Gullestad L, Arora S, Andersen C (2016)
Effect of everolimus initiation and early calcineurin inhibitor withdrawal on myocardial FOXP3+ regulatory T cells in heart transplantation
Transpl Immunol, 38, 75-7
DOI 10.1016/j.trim.2016.05.004, PubMed 27260644

Solberg OG, Stavem K, Ragnarsson A, Ioanes D, Arora S, Endresen K, Benth JŠ, Gullestad L, Gude E, Andreassen AK, Aaberge L (2016)
Index of microvascular resistance after early conversion from calcineurin inhibitor to everolimus in heart transplantation: A sub-study to a 1-year randomized trial
J Heart Lung Transplant, 35 (8), 1010-7
DOI 10.1016/j.healun.2016.03.002, PubMed 27113960

Nytrøen K, Yardley M, Rolid K, Bjørkelund E, Karason K, Wigh JP, Dall CH, Arora S, Aakhus S, Lunde K, Solberg OG, Gustafsson F, Prescott EI, Gullestad L (2015)
Design and rationale of the HITTS randomized controlled trial: Effect of High-intensity Interval Training in de novo Heart Transplant Recipients in Scandinavia
Am Heart J, 172, 96-105
DOI 10.1016/j.ahj.2015.10.011, PubMed 26856221

Nytrøen K, Rustad LA, Erikstad I, Aukrust P, Ueland T, Lekva T, Gude E, Wilhelmsen N, Hervold A, Aakhus S, Gullestad L, Arora S (2013)
Effect of high-intensity interval training on progression of cardiac allograft vasculopathy
J Heart Lung Transplant, 32 (11), 1073-80
DOI 10.1016/j.healun.2013.06.023, PubMed 23906899

Sarvari SI, Gjesdal O, Gude E, Arora S, Andreassen AK, Gullestad L, Geiran O, Edvardsen T (2012)
Early postoperative left ventricular function by echocardiographic strain is a predictor of 1-year mortality in heart transplant recipients
J Am Soc Echocardiogr, 25 (9), 1007-14
DOI 10.1016/j.echo.2012.05.010, PubMed 22727199

Arora S, Aarones M, Aakhus S, Skaardal R, Aass H, Aukrust P, Kongsgaard E, Gullestad L (2012)
Peak oxygen uptake during cardiopulmonary exercise testing determines response to cardiac resynchronization therapy
J Cardiol, 60 (3), 228-35
DOI 10.1016/j.jjcc.2012.03.004, PubMed 22542140

Arora S, Gude E, Sigurdardottir V, Mortensen SA, Eiskjær H, Riise G, Mared L, Bjørtuft O, Ekmehag B, Jansson K, Simonsen S, Aukrust P, Solbu D, Iversen M, Gullestad L (2012)
Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate
J Heart Lung Transplant, 31 (3), 259-65
DOI 10.1016/j.healun.2011.12.010, PubMed 22333403

Arora S, Ueland T, Wennerblom B, Sigurdadottir V, Eiskjær H, Bøtker HE, Ekmehag B, Jansson K, Mortensen SA, Saunamaki K, Simonsen S, Gude E, Bendz B, Solbu D, Aukrust P, Gullestad L (2011)
Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial
Transplantation, 92 (2), 235-43
DOI 10.1097/TP.0b013e31822057f1, PubMed 21677600

Gude E, Andreassen AK, Arora S, Gullestad L, Grov I, Hartmann A, Leivestad T, Fiane AE, Geiran OR, Vardal M, Simonsen S (2010)
Acute renal failure early after heart transplantation: risk factors and clinical consequences
Clin Transplant, 24 (6), E207-13
DOI 10.1111/j.1399-0012.2010.01225.x, PubMed 20184627

Arora S, Gunther A, Wennerblom B, Ueland T, Andreassen AK, Gude E, Endresen K, Geiran O, Wilhelmsen N, Andersen R, Aukrust P, Gullestad L (2010)
Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component
Am J Transplant, 10 (6), 1428-36
DOI 10.1111/j.1600-6143.2010.03118.x, PubMed 20486911

Gude E, Gullestad L, Arora S, Simonsen S, Hoel I, Hartmann A, Holdaas H, Fiane AE, Geiran OR, Andreassen AK (2010)
Benefit of early conversion from CNI-based to everolimus-based immunosuppression in heart transplantation
J Heart Lung Transplant, 29 (6), 641-7
DOI 10.1016/j.healun.2010.01.005, PubMed 20304681

Gude E, Simonsen S, Geiran OR, Fiane AE, Gullestad L, Arora S, Relbo A, Andreassen AK (2009)
Pulmonary hypertension in heart transplantation: discrepant prognostic impact of pre-operative compared with 1-year post-operative right heart hemodynamics
J Heart Lung Transplant, 29 (2), 216-23
DOI 10.1016/j.healun.2009.08.021, PubMed 19837606

Arora S, Aukrust P, Ueland T, Broch K, Simonsen S, Gude E, Fiane AE, Geiran O, Wergeland R, Andreassen AK, Gullestad L (2009)
Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality
Eur J Heart Fail, 11 (10), 1005-13
DOI 10.1093/eurjhf/hfp115, PubMed 19737803

Arora S, Aukrust P, Andreassen A, Simonsen S, Gude E, Grov I, Geiran O, Fiane A, Gullestad L (2009)
The prognostic importance of modifiable risk factors after heart transplantation
Am Heart J, 158 (3), 431-6
DOI 10.1016/j.ahj.2009.05.036, PubMed 19699867

Gjesdal O, Gude E, Arora S, Leivestad T, Andreassen AK, Gullestad L, Aaberge L, Brunvand H, Edvardsen T, Geiran OR, Simonsen S (2009)
Intra-aortic balloon counterpulsation as a bridge to heart transplantation does not impair long-term survival
Eur J Heart Fail, 11 (7), 709-14
DOI 10.1093/eurjhf/hfp078, PubMed 19515719

Arora S, Nicholls SJ (2008)
Atherosclerotic plaque reduction: blood pressure, dyslipidemia, atherothrombosis
Drugs Today (Barc), 44 (9), 711-8
DOI 10.1358/dot.2008.44.9.1263999, PubMed 19137125

Arora S, Jenum PA, Aukrust P, Rollag H, Andreassen AK, Simonsen S, Gude E, Fiane AE, Geiran O, Gullestad L (2007)
Pre-transplant Toxoplasma gondii seropositivity among heart transplant recipients is associated with an increased risk of all-cause and cardiac mortality
J Am Coll Cardiol, 50 (20), 1967-72
DOI 10.1016/j.jacc.2007.07.068, PubMed 17996562

Arora S, Andreassen A, Simonsen S, Gude E, Dahl C, Skaardal R, Hoel I, Geiran O, Gullestad L (2007)
Prognostic importance of renal function 1 year after heart transplantation for all-cause and cardiac mortality and development of allograft vasculopathy
Transplantation, 84 (2), 149-54
DOI 10.1097/01.tp.0000268810.61393.2c, PubMed 17667805

Arora S, Gullestad L, Wergeland R, Simonsen S, Holm T, Hognestad A, Ueland T, Geiran O, Andreassen A (2007)
Probrain natriuretic peptide and C-reactive protein as markers of acute rejection, allograft vasculopathy, and mortality in heart transplantation
Transplantation, 83 (10), 1308-15
DOI 10.1097/01.tp.0000263338.39555.21, PubMed 17519779

Review articles

Arora S, Gullestad L (2014)
The challenge of allograft vasculopathy in cardiac transplantation
Curr Opin Organ Transplant, 19 (5), 508-14
DOI 10.1097/MOT.0000000000000112, PubMed 25144667

Other articles

Arora S, Jenum PA, Aukrust P, Rollag H, Andreassen AK, Simonsen S, Guide E, Fiane AE, Geiran O, Gullestad L (2008)
Pre-transplant Toxoplasma gondii seropositivlty among heart transplant recipients and mortality - Reply
J. Am. Coll. Cardiol., 51 (18), 1827-1828

Theses

Arora S (2010)
Immunological and non-immunological markers of cardiac allograft vasculopathy amongst heart transplant recipients
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 934, 1 b. (flere pag.)
BIBSYS 101142978, ISBN 978-82-8072-360-4

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