Victor Greiff

  • Group leader
  • +47 966 90 757
 

Publications 2021

Akbar R, Robert PA, Pavlović M, Jeliazkov JR, Snapkov I, Slabodkin A, Weber CR, Scheffer L, Miho E, Haff IH, Haug DTT, Lund-Johansen F, Safonova Y, Sandve GK, Greiff V (2021)
A compact vocabulary of paratope-epitope interactions enables predictability of antibody-antigen binding
Cell Rep, 34 (11), 108856
DOI 10.1016/j.celrep.2021.108856, PubMed 33730590

Amoriello R, Chernigovskaya M, Greiff V, Carnasciali A, Massacesi L, Barilaro A, Repice AM, Biagioli T, Aldinucci A, Muraro PA, Laplaud DA, Lossius A, Ballerini C (2021)
TCR repertoire diversity in Multiple Sclerosis: High-dimensional bioinformatics analysis of sequences from brain, cerebrospinal fluid and peripheral blood
EBioMedicine, 68, 103429
DOI 10.1016/j.ebiom.2021.103429, PubMed 34127432

Laustsen AH, Greiff V, Karatt-Vellatt A, Muyldermans S, Jenkins TP (2021)
Animal Immunization, in Vitro Display Technologies, and Machine Learning for Antibody Discovery
Trends Biotechnol (in press)
DOI 10.1016/j.tibtech.2021.03.003, PubMed 33775449

Mathew NR, Jayanthan JK, Smirnov IV, Robinson JL, Axelsson H, Nakka SS, Emmanouilidi A, Czarnewski P, Yewdell WT, Schön K, Lebrero-Fernández C, Bernasconi V, Rodin W, Harandi AM, Lycke N, Borcherding N, Yewdell JW, Greiff V, Bemark M, Angeletti D (2021)
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
Cell Rep, 35 (12), 109286
DOI 10.1016/j.celrep.2021.109286, PubMed 34161770

Mester S, Evers M, Meyer S, Nilsen J, Greiff V, Sandlie I, Leusen J, Andersen JT (2021)
Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
MAbs, 13 (1), 1893888
DOI 10.1080/19420862.2021.1893888, PubMed 33691596

Mikocziova I, Greiff V, Sollid LM (2021)
Immunoglobulin germline gene variation and its impact on human disease
Genes Immun, 22 (4), 205-217
DOI 10.1038/s41435-021-00145-5, PubMed 34175903

Öjlert ÅK, Nebdal D, Snapkov I, Olsen V, Kidman J, Greiff V, Chee J, Helland Å (2021)
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor
Mol Oncol
DOI 10.1002/1878-0261.13082, PubMed 34402187

Peng K, Safonova Y, Shugay M, Popejoy AB, Rodriguez OL, Breden F, Brodin P, Burkhardt AM, Bustamante C, Cao-Lormeau VM, Corcoran MM, Duffy D, Fuentes-Guajardo M, Fujita R, Greiff V, Jönsson VD, Liu X, Quintana-Murci L, Rossetti M, Xie J, Yaari G, Zhang W, Abedalthagafi MS, Adekoya KO, Ahmed RA et al. (2021)
Diversity in immunogenomics: the value and the challenge
Nat Methods, 18 (6), 588-591
DOI 10.1038/s41592-021-01169-5, PubMed 34002093

Robert PA, Kunze-Schumacher H, Greiff V, Krueger A (2021)
Modeling the Dynamics of T-Cell Development in the Thymus
Entropy (Basel), 23 (4)
DOI 10.3390/e23040437, PubMed 33918050

Snapkov I, Chernigovskaya M, Sinitcyn P, Lê Quý K, Nyman TA, Greiff V (2021)
Progress and challenges in mass spectrometry-based analysis of antibody repertoires
Trends Biotechnol (in press)
DOI 10.1016/j.tibtech.2021.08.006, PubMed 34535228

Publications 2020

Amoriello R, Greiff V, Aldinucci A, Bonechi E, Carnasciali A, Peruzzi B, Repice AM, Mariottini A, Saccardi R, Mazzanti B, Massacesi L, Ballerini C (2020)
The TCR Repertoire Reconstitution in Multiple Sclerosis: Comparing One-Shot and Continuous Immunosuppressive Therapies
Front Immunol, 11, 559
DOI 10.3389/fimmu.2020.00559, PubMed 32328061

Fallet B, Hao Y, Florova M, Cornille K, de Los Aires AV, Girelli Zubani G, Ertuna YI, Greiff V, Menzel U, Hammad K, Merkler D, Reddy ST, Weill JC, Reynaud CA, Pinschewer DD (2020)
Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses
Cell Rep, 30 (4), 1013-1026.e7
DOI 10.1016/j.celrep.2019.12.023, PubMed 31995746

Kräutler NJ, Yermanos A, Pedrioli A, Welten SPM, Lorgé D, Greczmiel U, Bartsch I, Scheuermann J, Kiefer JD, Eyer K, Menzel U, Greiff V, Neri D, Stadler T, Reddy ST, Oxenius A (2020)
Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection
Cell Rep, 30 (4), 997-1012.e6
DOI 10.1016/j.celrep.2019.12.088, PubMed 31995768

Li H, Limenitakis JP, Greiff V, Yilmaz B, Schären O, Urbaniak C, Zünd M, Lawson MAE, Young ID, Rupp S, Heikenwälder M, McCoy KD, Hapfelmeier S, Ganal-Vonarburg SC, Macpherson AJ (2020)
Mucosal or systemic microbiota exposures shape the B cell repertoire
Nature, 584 (7820), 274-278
DOI 10.1038/s41586-020-2564-6, PubMed 32760003

Riedel R, Addo R, Ferreira-Gomes M, Heinz GA, Heinrich F, Kummer J, Greiff V, Schulz D, Klaeden C, Cornelis R, Menzel U, Kröger S, Stervbo U, Köhler R, Haftmann C, Kühnel S, Lehmann K, Maschmeyer P, McGrath M, Naundorf S, Hahne S, Sercan-Alp Ö, Siracusa F, Stefanowski J, Weber M et al. (2020)
Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow
Nat Commun, 11 (1), 2570
DOI 10.1038/s41467-020-16464-6, PubMed 32444631

Smakaj E, Babrak L, Ohlin M, Shugay M, Briney B, Tosoni D, Galli C, Grobelsek V, D'Angelo I, Olson B, Reddy S, Greiff V, Trück J, Marquez S, Lees W, Miho E (2020)
Benchmarking immunoinformatic tools for the analysis of antibody repertoire sequences
Bioinformatics, 36 (6), 1731-1739
DOI 10.1093/bioinformatics/btz845, PubMed 31873728

Weber CR, Akbar R, Yermanos A, Pavlović M, Snapkov I, Sandve GK, Reddy ST, Greiff V (2020)
immuneSIM: tunable multi-feature simulation of B- and T-cell receptor repertoires for immunoinformatics benchmarking
Bioinformatics, 36 (11), 3594-3596
DOI 10.1093/bioinformatics/btaa158, PubMed 32154832

Yermanos A, Dounas A, Greiff V, Stadler T, Oxenius A, Reddy ST (2020)
Inter- and intraspecies comparison of phylogenetic fingerprints and sequence diversity of immunoglobulin variable genes
Immunogenetics, 72 (5), 279-294
DOI 10.1007/s00251-020-01164-8, PubMed 32367185

Yermanos A, Kräutler NJ, Pedrioli A, Menzel U, Greiff V, Stadler T, Oxenius A, Reddy ST (2020)
IgM Antibody Repertoire Fingerprints in Mice Are Personalized but Robust to Viral Infection Status
Front Cell Infect Microbiol, 10, 254
DOI 10.3389/fcimb.2020.00254, PubMed 32547966

Publications 2019

Bartolomé-Casado R, Landsverk OJB, Chauhan SK, Richter L, Phung D, Greiff V, Risnes LF, Yao Y, Neumann RS, Yaqub S, Øyen O, Horneland R, Aandahl EM, Paulsen V, Sollid LM, Qiao SW, Baekkevold ES, Jahnsen FL (2019)
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737

Brown AJ, Snapkov I, Akbar R, Pavlovic M, Miho E, Sandve GK, Greiff V (2019)
Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires
Mol. Syst. Des. Eng., 4 (4), 701-736
DOI 10.1039/c9me00071b

Chain B, Greiff V, Textor J, Yaari G (2019)
Editorial: Methods and Applications of Computational Immunology
Front Immunol, 10, 2818
DOI 10.3389/fimmu.2019.02818, PubMed 31849986

Miho E, Roškar R, Greiff V, Reddy ST (2019)
Large-scale network analysis reveals the sequence space architecture of antibody repertoires
Nat Commun, 10 (1), 1321
DOI 10.1038/s41467-019-09278-8, PubMed 30899025

Ohlin M, Scheepers C, Corcoran M, Lees WD, Busse CE, Bagnara D, Thörnqvist L, Bürckert JP, Jackson KJL, Ralph D, Schramm CA, Marthandan N, Breden F, Scott J, Matsen Iv FA, Greiff V, Yaari G, Kleinstein SH, Christley S, Sherkow JS, Kossida S, Lefranc MP, van Zelm MC, Watson CT, Collins AM (2019)
Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming
Front Immunol, 10, 435
DOI 10.3389/fimmu.2019.00435, PubMed 30936866

Tomescu-Baciu A, Johansen JN, Holmøy T, Greiff V, Stensland M, de Souza GA, Vartdal F, Lossius A (2019)
Persistence of intrathecal oligoclonal B cells and IgG in multiple sclerosis
J Neuroimmunol, 333, 576966
DOI 10.1016/j.jneuroim.2019.576966, PubMed 31153015

Publications 2018

Mason DM, Weber CR, Parola C, Meng SM, Greiff V, Kelton WJ, Reddy ST (2018)
High-throughput antibody engineering in mammalian cells by CRISPR/Cas9-mediated homology-directed mutagenesis
Nucleic Acids Res, 46 (14), 7436-7449
DOI 10.1093/nar/gky550, PubMed 29931269

Miho E, Yermanos A, Weber CR, Berger CT, Reddy ST, Greiff V (2018)
Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires
Front Immunol, 9, 224
DOI 10.3389/fimmu.2018.00224, PubMed 29515569

Publications 2017

Greiff V, Menzel U, Miho E, Weber C, Riedel R, Cook S, Valai A, Lopes T, Radbruch A, Winkler TH, Reddy ST (2017)
Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development
Cell Rep, 19 (7), 1467-1478
DOI 10.1016/j.celrep.2017.04.054, PubMed 28514665

Greiff V, Weber CR, Palme J, Bodenhofer U, Miho E, Menzel U, Reddy ST (2017)
Learning the High-Dimensional Immunogenomic Features That Predict Public and Private Antibody Repertoires
J Immunol, 199 (8), 2985-2997
DOI 10.4049/jimmunol.1700594, PubMed 28924003

Yermanos A, Greiff V, Krautler NJ, Menzel U, Dounas A, Miho E, Oxenius A, Stadler T, Reddy ST (2017)
Comparison of methods for phylogenetic B-cell lineage inference using time-resolved antibody repertoire simulations (AbSim)
Bioinformatics, 33 (24), 3938-3946
DOI 10.1093/bioinformatics/btx533, PubMed 28968873

Publications 2015

Berger CT, Greiff V, Mehling M, Fritz S, Meier MA, Hoenger G, Conen A, Recher M, Battegay M, Reddy ST, Hess C (2015)
Influenza vaccine response profiles are affected by vaccine preparation and preexisting immunity, but not HIV infection
Hum Vaccin Immunother, 11 (2), 391-6
DOI 10.1080/21645515.2015.1008930, PubMed 25692740

Greiff V, Bhat P, Cook SC, Menzel U, Kang W, Reddy ST (2015)
A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status
Genome Med, 7 (1), 49
DOI 10.1186/s13073-015-0169-8, PubMed 26140055

Greiff V, Miho E, Menzel U, Reddy ST (2015)
Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires
Trends Immunol, 36 (11), 738-749
DOI 10.1016/j.it.2015.09.006, PubMed 26508293

Publications 2014

Greiff V, Menzel U, Haessler U, Cook SC, Friedensohn S, Khan TA, Pogson M, Hellmann I, Reddy ST (2014)
Quantitative assessment of the robustness of next-generation sequencing of antibody variable gene repertoires from immunized mice
BMC Immunol, 15, 40
DOI 10.1186/s12865-014-0040-5, PubMed 25318652

Menzel U, Greiff V, Khan TA, Haessler U, Hellmann I, Friedensohn S, Cook SC, Pogson M, Reddy ST (2014)
Comprehensive evaluation and optimization of amplicon library preparation methods for high-throughput antibody sequencing
PLoS One, 9 (5), e96727
DOI 10.1371/journal.pone.0096727, PubMed 24809667

Publications 2012

Greiff V, Redestig H, Lück J, Bruni N, Valai A, Hartmann S, Rausch S, Schuchhardt J, Or-Guil M (2012)
A minimal model of peptide binding predicts ensemble properties of serum antibodies
BMC Genomics, 13, 79
DOI 10.1186/1471-2164-13-79, PubMed 22353141

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