Publications 2025

Resell M, Rabben HL, Sharma A, Hagen L, Hoang L, Skogaker NT, Aarvik A, Bjåstad EK, Svensson MK, Amrutkar M, Verbeke CS, Batra SK, Qvigstad G, Wang TC, Rustgi A, Chen D, Zhao CM (2025)
Proteomics profiling of research models for studying pancreatic ductal adenocarcinoma
Sci Data, 12 (1), 266
DOI 10.1038/s41597-025-04522-x, PubMed 39953055

Xia Y, Caputo M, Andersson E, Asiedu B, Zhang J, Hou W, Amrutkar M, Cansby E, Gul N, Gemmink A, Myers C, Aghajan M, Booten S, Hoy AJ, Härtlova A, Lindahl P, Ståhlberg A, Schaart G, Hesselink MKC, Peter A, Murray S, Mahlapuu M (2025)
Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma
Cell Mol Gastroenterol Hepatol, 19 (7), 101485 (in press)
DOI 10.1016/j.jcmgh.2025.101485, PubMed 40024534

Publications 2024

Amrutkar M, Guttorm SJT, Finstadsveen AV, Labori KJ, Eide L, Rootwelt H, Elgstøen KBP, Gladhaug IP, Verbeke CS (2024)
Global metabolomic profiling of tumor tissue and paired serum samples to identify biomarkers for response to neoadjuvant FOLFIRINOX treatment of human pancreatic cancer
Mol Oncol, 19 (2), 391-411
DOI 10.1002/1878-0261.13759, PubMed 39545923

Caputo M, Andersson E, Xia Y, Hou W, Cansby E, Erikson M, Lind DE, Hallberg B, Amrutkar M, Mahlapuu M (2024)
Genetic Ablation of STE20-Type Kinase MST4 Does Not Alleviate Diet-Induced MASLD Susceptibility in Mice
Int J Mol Sci, 25 (4)
DOI 10.3390/ijms25042446, PubMed 38397122

Lencioni G, Gregori A, Toledo B, Rebelo R, Immordino B, Amrutkar M, Xavier CPR, Kocijančič A, Pandey DP, Perán M, Castaño JP, Walsh N, Giovannetti E (2024)
Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems
Semin Cancer Biol, 106-107, 217-233
DOI 10.1016/j.semcancer.2024.09.002, PubMed 39299411

Publications 2023

Amrutkar M, Berg K, Balto A, Skilbrei MG, Finstadsveen AV, Aasrum M, Gladhaug IP, Verbeke CS (2023)
Pancreatic stellate cell-induced gemcitabine resistance in pancreatic cancer is associated with LDHA- and MCT4-mediated enhanced glycolysis
Cancer Cell Int, 23 (1), 9
DOI 10.1186/s12935-023-02852-7, PubMed 36658582

Li Y, Amrutkar M, Finstadsveen AV, Dalen KT, Verbeke CS, Gladhaug IP (2023)
Fatty acids abrogate the growth-suppressive effects induced by inhibition of cholesterol flux in pancreatic cancer cells
Cancer Cell Int, 23 (1), 276
DOI 10.1186/s12935-023-03138-8, PubMed 37978383

Publications 2022

Amrutkar M, Verbeke CS, Finstadsveen AV, Dorg L, Labori KJ, Gladhaug IP (2022)
Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
Mol Oncol, 17 (1), 59-81
DOI 10.1002/1878-0261.13344, PubMed 36400567

Publications 2021

Amrutkar M, Gladhaug IP (2021)
Stellate Cells Aid Growth-Permissive Metabolic Reprogramming and Promote Gemcitabine Chemoresistance in Pancreatic Cancer
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040601, PubMed 33546284

Caputo M, Kurhe Y, Kumari S, Cansby E, Amrutkar M, Scandalis E, Booten SL, Ståhlman M, Borén J, Marschall HU, Aghajan M, Mahlapuu M (2021)
Silencing of STE20-type kinase MST3 in mice with antisense oligonucleotide treatment ameliorates diet-induced nonalcoholic fatty liver disease
FASEB J, 35 (5), e21567
DOI 10.1096/fj.202002671RR, PubMed 33891332

Sántha P, Lenggenhager D, Finstadsveen A, Dorg L, Tøndel K, Amrutkar M, Gladhaug IP, Verbeke C (2021)
Morphological Heterogeneity in Pancreatic Cancer Reflects Structural and Functional Divergence
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040895, PubMed 33672734

Publications 2020

Amrutkar M, Larsen EK, Aasrum M, Finstadsveen AV, Andresen PA, Verbeke CS, Gladhaug IP (2020)
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor
Cells, 9 (1)
DOI 10.3390/cells9010227, PubMed 31963309

Amrutkar M, Vethe NT, Verbeke CS, Aasrum M, Finstadsveen AV, Sántha P, Gladhaug IP (2020)
Differential Gemcitabine Sensitivity in Primary Human Pancreatic Cancer Cells and Paired Stellate Cells Is Driven by Heterogenous Drug Uptake and Processing
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123628, PubMed 33287390

Publications 2019

Amrutkar M, Aasrum M, Verbeke CS, Gladhaug IP (2019)
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
BMC Cancer, 19 (1), 596
DOI 10.1186/s12885-019-5803-1, PubMed 31208372

Cansby E, Kulkarni NM, Magnusson E, Kurhe Y, Amrutkar M, Nerstedt A, Ståhlman M, Sihlbom C, Marschall HU, Borén J, Blüher M, Mahlapuu M (2019)
Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans
FASEB J, 33 (9), 9974-9989
DOI 10.1096/fj.201900356RR, PubMed 31173506

Lenggenhager D, Amrutkar M, Sántha P, Aasrum M, Löhr JM, Gladhaug IP, Verbeke CS (2019)
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293

Publications 2018

Cansby E, Magnusson E, Nuñez-Durán E, Amrutkar M, Pedrelli M, Parini P, Hoffmann J, Ståhlman M, Howell BW, Marschall HU, Borén J, Mahlapuu M (2018)
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia
Arterioscler Thromb Vasc Biol, 38 (8), 1723-1737
DOI 10.1161/ATVBAHA.118.311241, PubMed 29930001

Cansby E, Nuñez-Durán E, Magnusson E, Amrutkar M, Booten SL, Kulkarni NM, Svensson LT, Borén J, Marschall HU, Aghajan M, Mahlapuu M (2018)
Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease
Cell Mol Gastroenterol Hepatol, 7 (3), 597-618
DOI 10.1016/j.jcmgh.2018.12.004, PubMed 30576769

Sütt S, Cansby E, Paul A, Amrutkar M, Nuñez-Durán E, Kulkarni NM, Ståhlman M, Borén J, Laurencikiene J, Howell BW, Enerbäck S, Mahlapuu M (2018)
STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue
J Endocrinol, 238 (3), 187-202
DOI 10.1530/JOE-18-0182, PubMed 29794231

Publications 2017

Amrutkar M, Gladhaug IP (2017)
Pancreatic Cancer Chemoresistance to Gemcitabine
Cancers (Basel), 9 (11)
DOI 10.3390/cancers9110157, PubMed 29144412

Nuñez-Durán E, Aghajan M, Amrutkar M, Sütt S, Cansby E, Booten SL, Watt A, Ståhlman M, Stefan N, Häring HU, Staiger H, Borén J, Marschall HU, Mahlapuu M (2017)
Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice
Hepatol Commun, 2 (1), 69-83
DOI 10.1002/hep4.1128, PubMed 29404514

Publications 2016

Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M (2016)
STK25 is a critical determinant in nonalcoholic steatohepatitis
FASEB J, 30 (10), 3628-3643
DOI 10.1096/fj.201600562R, PubMed 27421788

Chursa U, Nuñez-Durán E, Cansby E, Amrutkar M, Sütt S, Ståhlman M, Olsson BM, Borén J, Johansson ME, Bäckhed F, Johansson BR, Sihlbom C, Mahlapuu M (2016)
Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle
Diabetologia, 60 (3), 553-567
DOI 10.1007/s00125-016-4171-5, PubMed 27981357

Publications 2015

Amrutkar M, Cansby E, Chursa U, Nuñez-Durán E, Chanclón B, Ståhlman M, Fridén V, Mannerås-Holm L, Wickman A, Smith U, Bäckhed F, Borén J, Howell BW, Mahlapuu M (2015)
Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model
Diabetes, 64 (8), 2791-804
DOI 10.2337/db15-0060, PubMed 25845663

Amrutkar M, Cansby E, Nuñez-Durán E, Pirazzi C, Ståhlman M, Stenfeldt E, Smith U, Borén J, Mahlapuu M (2015)
Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH
FASEB J, 29 (4), 1564-76
DOI 10.1096/fj.14-264937, PubMed 25609431

Amrutkar M, Kern M, Nuñez-Durán E, Ståhlman M, Cansby E, Chursa U, Stenfeldt E, Borén J, Blüher M, Mahlapuu M (2015)
Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans
Diabetologia, 59 (2), 341-53
DOI 10.1007/s00125-015-3801-7, PubMed 26553096

Publications 2014

Cansby E, Nerstedt A, Amrutkar M, Durán EN, Smith U, Mahlapuu M (2014)
Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained
Mol Cell Endocrinol, 393 (1-2), 143-51
DOI 10.1016/j.mce.2014.06.014, PubMed 24976178

Publications 2013

Cansby E, Amrutkar M, Mannerås Holm L, Nerstedt A, Reyahi A, Stenfeldt E, Borén J, Carlsson P, Smith U, Zierath JR, Mahlapuu M (2013)
Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet
FASEB J, 27 (9), 3660-71
DOI 10.1096/fj.13-228494, PubMed 23729594

Nerstedt A, Cansby E, Amrutkar M, Smith U, Mahlapuu M (2013)
Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes
Mol Cell Endocrinol, 375 (1-2), 68-78
DOI 10.1016/j.mce.2013.05.013, PubMed 23707791