Børre Fevang

  • Group leader, Senior consultant; MD, PhD
 

Publications 2021

Fevang B, Warnatz K, Hurst JR (2021)
Editorial: Interstitial Lung Disease in Primary Immunodeficiencies
Front. Immunol., 12, 699126
DOI 10.3389/fimmu.2021.699126

Fevang B, Wyller VBB, Mollnes TE, Pedersen M, Asprusten TT, Michelsen A, Ueland T, Otterdal K (2021)
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front. Immunol., 12, 715102
DOI 10.3389/fimmu.2021.715102

Fraz MSA, Moe N, Revheim ME, Stavrinou ML, Durheim MT, Nordoy I, Macpherson ME, Aukrust P, Jorgensen SF, Aalokken TM, Fevang B (2021)
Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and F-18-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
Front. Immunol., 11, 617985
DOI 10.3389/fimmu.2020.617985

Hustad NB, Degerud HM, Hjelmerud I, Fraz MSA, Nordoy I, Troseid M, Fevang B, Aukrust P, Jorgensen SF (2021)
Real-World Experiences With Facilitated Subcutaneous Immunoglobulin Substitution in Patients With Hypogammaglobulinemia, Using a Three-Step Ramp-Up Schedule
Front. Immunol., 12, 670547
DOI 10.3389/fimmu.2021.670547

Jorgensen SF, Buechner J, Myhre AE, Galteland E, Spetalen S, Kulseth MA, Sorte HS, Holla OL, Lundman E, Alme C, Heier I, Flaegstad T, Floisand Y, Benneche A, Fevang B, Aukrust P, Stray-Pedersen A, Gedde-Dahl T, Nordoy I (2021)
A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT
J. Clin. Immunol.
DOI 10.1007/s10875-021-01189-y

Skarpengland T, Macpherson ME, Hov JR, Kong XY, Bohov P, Halvorsen B, Fevang B, Berge RK, Aukrust P, Jorgensen SF (2021)
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J. Clin. Immunol.
DOI 10.1007/s10875-021-01146-9

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jorgensen MJ, Barratt-Due A, Skeie LG, Nordoy I, Fraz MSA, Quist-Paulsen E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Muller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2021)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J. Allergy Clin. Immunol., 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007

Publications 2020

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Trand T, Gjolberg TT, Skeie LG, Hesstvedt L, Ormasen V, Fevang B, Austad C, Muller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Muller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc. Natl. Acad. Sci. U. S. A., 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117

Jorgensen SF, Fevang B, Aukrust P (2020)
Commentary: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy
Front. Immunol., 11, 1921
DOI 10.3389/fimmu.2020.01921

Macpherson ME, Hov JR, Ueland T, Dahl TB, Kummen M, Otterdal K, Holm K, Berge RK, Mollnes TE, Troseid M, Halvorsen B, Aukrust P, Fevang B, Jorgensen SF (2020)
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front. Immunol., 11, 574500
DOI 10.3389/fimmu.2020.574500

van de Ven AAJM, Alfaro TM, Robinson A, Baumann U, Bergeron A, Burns SO, Condliffe AM, Fevang B, Gennery AR, Haerynck F, Jacob J, Jolles S, Malphettes M, Meignin V, Milota T, van Montfrans J, Prasse A, Quinti I, Renzoni E, Stolz D, Warnatz K, Hurst JR, ERS e-GLILDnet Clinical Res Collab (2020)
Managing Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders: e-GLILDnet International Clinicians Survey
Front. Immunol., 11, 606333
DOI 10.3389/fimmu.2020.606333

Publications 2019

Holmoy T, Fevang B, Olsen DB, Spigset O, Bo L (2019)
Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis
BMC Res. Notes, 12 (1), 497
DOI 10.1186/s13104-019-4507-6

Jorgensen SF, Fevang B, Aukrust P (2019)
Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications
J. Clin. Immunol., 39 (1), 30-36
DOI 10.1007/s10875-018-0574-z

Jorgensen SF, Holm K, Macpherson ME, Storm-Larsen C, Kummen M, Fevang B, Aukrust P, Hov JR (2019)
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J. Allergy Clin. Immunol., 143 (5), 1969-+
DOI 10.1016/j.jaci.2019.01.019

Macpherson ME, Halvorsen B, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jorgensen SF (2019)
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9, 9427
DOI 10.1038/s41598-019-45861-1

Nordheim E, Storro MO, Natvik AK, Kro GB, Midtvedt K, Reisaeter AV, Hagness M, Fevang B, Pettersen FO (2019)
Donor-derived strongyloidiasis after organ transplantation in Norway
Transpl. Infect. Dis., 21 (1), e13008
DOI 10.1111/tid.13008

Publications 2018

Fevang B (2018)
Open access- elephant (or polar bear) in the room
Tidsskr. Nor. Laegeforen., 138 (2), 110

Fevang B, Fagerli UM, Sorte H, Aarset H, Hov H, Langmyr M, Keil TM, Bjorge E, Aukrust P, Stray-Pedersen A, Gedde-Dahl T (2018)
Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas
Case Rep. Immunol., 2018, 2053716
DOI 10.1155/2018/2053716

Otterdal K, Berg A, Michelsen AE, Patel S, Tellevik MG, Haanshuus CG, Fevang B, Aukrust P, Langeland N, Ueland T (2018)
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria
BMC Infect. Dis., 18, 670
DOI 10.1186/s12879-018-3593-8

Troseid M, Nordoy I, Fevang B, Aukrust P (2018)
Tenders for HIV medicines are not academically justified
Tidsskr. Nor. Laegeforen., 138 (20), 1912-1913

Publications 2017

Fevang B (2017)
Open access- elephant (or polar bear) in the room
Tidsskr. Nor. Laegeforen., 137 (23-24), 1860

Holm KL, Syljuasen RG, Hasvold G, Alsoe L, Nilsen H, Ivanauskiene K, Collas P, Shaposhnikov S, Collins A, Indrevaer RL, Aukrust P, Fevang B, Blomhoff HK (2017)
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708

Jorgensen SF, Macpherson ME, Bjoro K, Karlsen TH, Reims HM, Grzyb K, Fosby B, Fevang B, Aukrust P, Nordoy I (2017)
Liver transplantation in patients with primary antibody deficiency
J. Allergy Clin. Immunol., 139 (5), 1708-+
DOI 10.1016/j.jaci.2016.10.025

Jorgensen SF, Reims HM, Aukrust P, Lundin KEA, Fevang B (2017)
CVID and Celiac Disease
Am. J. Gastroenterol., 112 (2), 393
DOI 10.1038/ajg.2016.551

Stray-Pedersen A, Sorte HS, Samarakoon P, Gambin T, Chinn IK, Akdemir ZHC, Erichsen HC, Forbes LR, Gu S, Yuan B, Jhangiani SN, Muzny DM, Rodningen OK, Sheng Y, Nicholas SK, Noroski LM, Seeborg FO, Davis CM, Canter DL, Mace EM, Vece TJ, Allen CE, Abhyankar HA, Boone PM, Beck CR et al. (2017)
Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders
J. Allergy Clin. Immunol., 139 (1), 232-245
DOI 10.1016/j.jaci.2016.05.042

Stuchly J, Kanderova V, Vlkova M, Hermanova I, Slamova L, Pelak O, Taraldsrud E, Jilek D, Kralickova P, Fevang B, Trkova M, Hrusak O, Fronkova E, Sediva A, Litzman J, Kalina T (2017)
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
Sci Rep, 7, 39710
DOI 10.1038/srep39710

Taraldsrud E, Aukrust P, Jorgensen S, Lingjaerde OC, Olweus J, Myklebust JH, Fevang B (2017)
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
Clin. Immunol., 175, 69-74
DOI 10.1016/j.clim.2016.11.014

Taraldsrud E, Fevang B, Jorgensen SF, Moltu K, Hilden V, Tasken K, Aukrust P, Myklebust JH, Olweus J (2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J. Autoimmun., 81, 110-119
DOI 10.1016/j.jaut.2017.04.004

Vikum D, Nordoy I, Andersen CT, Fevang B, Line PD, Kolrud FK, Aukrust P, Buanes T (2017)
A Young, Immunocompetent Woman with Small Bowel and Hepatic Mucormycosis Successfully Treated with Aggressive Surgical Debridements and Antifungal Therapy
Case Rep. Infect. Dis., 2017, 4173246
DOI 10.1155/2017/4173246

Publications 2016

Falkenberg-Jensen B, Aalokken TM, Fevang B (2016)
Atypical mycobacteria and Lady Windermere syndrome
Tidsskr. Nor. Laegeforen., 136 (14-15), 1227
DOI 10.4045/tidsskr.16.0235

Jorgensen SF, Reims HM, Frydenlund D, Holm K, Paulsen V, Michelsen AE, Jorgensen KK, Osnes LT, Bratlie J, Eide TJ, Dahl CP, Holter E, Tronstad RR, Hanevik K, Brattbakk HR, Kaveh F, Fiskerstrand T, Kran AMB, Ueland T, Karlsen TH, Aukrust P, Lundin KEA, Fevang B (2016)
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am. J. Gastroenterol., 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329

Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, Abrahamsen TG, Kittang OB, Overland T, Jhangiani SN, Muzny DM, Vigeland MD, Samarakoon P, Gambin T, Akdemir ZHC, Gibbs RA, Rodningen OK, Lyle R, Lupski JR, Stray-Pedersen A (2016)
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction
Mol. Genet. Genom. Med., 4 (6), 604-616
DOI 10.1002/mgg3.237

Publications 2015

Indrevaer RL, Moskaug JO, Paur I, Bohn SK, Jorgensen SF, Blomhoff R, Aukrust P, Fevang B, Blomhoff HK (2015)
IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells
J. Immunol., 195 (6), 2601-2611
DOI 10.4049/jimmunol.1500250

Li J, Jorgensen SF, Maggadottir SM, Bakay M, Warnatz K, Glessner J, Pandey R, Salzer U, Schmidt RE, Perez E, Resnick E, Goldacker S, Buchta M, Witte T, Padyukov L, Videm V, Folseraas T, Atschekzei F, Elder JT, Nair RP, Winkelmann J, Gieger C, Nothen MM, Buning C, Brand S et al. (2015)
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat. Commun., 6, 6804
DOI 10.1038/ncomms7804

Publications 2013

Gregersen S, Holm AM, Fevang B, Ueland T, Sikkeland LIB, Aalokken TM, Mynarek G, Kongerud J, Aukrust P, Johansen B, Froland SS (2013)
Lung disease, T-cells and inflammation in common variable immunodeficiency disorders
Scand. J. Clin. Lab. Invest., 73 (6), 514-522
DOI 10.3109/00365513.2013.819523

Indrevaer RL, Holm KL, Aukrust P, Osnes LT, Naderi EH, Fevang B, Blomhoff HK (2013)
Retinoic Acid Improves Defective TLR9/RP105-Induced Immune Responses in Common Variable Immunodeficiency-Derived B Cells
J. Immunol., 191 (7), 3624-3633
DOI 10.4049/jimmunol.1300213

Publications 2012

Smedbakken LM, Halvorsen B, Daissormont I, Ranheim T, Michelsen AE, Skjelland M, Sagen EL, Folkersen L, Krohg-Sorensen K, Russell D, Holm S, Ueland T, Fevang B, Hedin U, Yndestad A, Gullestad L, Hansson GK, Biessen EA, Aukrust P (2012)
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-273
DOI 10.1016/j.atherosclerosis.2012.06.071

Publications 2010

Fevang B (2010)
Profound perturbation: immunopathological mechanisms in common variable immunodeficiency
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 889, 1 b. (flere pag.)
BIBSYS 100281206, ISBN 978-82-8072-344-4

Gregersen S, Aalokken TM, Mynarek G, Fevang B, Holm AM, Ueland T, Aukrust P, Kongerud J, Johansen B, Froland SS (2010)
Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors
Ann. Allergy Asthma Immunol., 104 (6), 503-510
DOI 10.1016/j.anai.2010.04.015

Publications 2009

Damas JK, Landro L, Fevang B, Heggelund L, Froland SS, Aukrust P (2009)
Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy
Aids, 23 (1), 135-138
DOI 10.1097/QAD.0b013e32831cf595

Fevang B, Eugen-Olsen J, Yndestad A, Brosstad F, Beiske K, Aukrust P, Froland SS (2009)
Enhanced levels of urokinase plasminogen activator and its soluble receptor in common variable immunodeficiency
Clin. Immunol., 131 (3), 438-446
DOI 10.1016/j.clim.2009.01.007

Fevang B, Yndestad A, Damas JK, Bjerkeli V, Ueland T, Holm AM, Beiske K, Aukrust P, Froland SS (2009)
Chemokines and common variable immunodeficiency; possible contribution of the fractalkine system (CX3CL1/CX3CR1) to chronic inflammation
Clin. Immunol., 130 (2), 151-161
DOI 10.1016/j.clim.2008.09.002

Publications 2008

Dahl CP, Gullestad L, Fevang B, Holm AM, Landro L, Vinge LE, Fiane AE, Sandberg WJ, Otterdal K, Froland SS, Damas JK, Halvorsen B, Aukrust P, Oie E, Yndestad A (2008)
Increased expression of LIGHT/TNFSF 14 and its receptors in experimental and clinical heart failure
Eur. J. Heart Fail., 10 (4), 352-359
DOI 10.1016/j.ejheart.2008.02.010

Smith C, Halvorsen B, Otterdal K, Waehre T, Yndestad A, Fevang B, Sandberg WJ, Breland UM, Froland SS, Oie E, Gullestad L, Damas JK, Aukrust P (2008)
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc. Res., 79 (1), 195-203
DOI 10.1093/cvr/cvn071

Publications 2007

Bjerkeli V, Damas JK, Fevang B, Holter JC, Aukrust P, Froland SS (2007)
Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis-possible role in vascular inflammation
RHEUMATOLOGY, 46 (9), 1422-1427
DOI 10.1093/rheumatology/kem168

Damas JK, Smith C, Oie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AKL, Sandberg WJ, Kjekshus J, Tasken K, Froland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P (2007)
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis - Possible pathogenic role in plaque destabilization
Arterioscler. Thromb. Vasc. Biol., 27 (3), 614-620
DOI 10.1161/01.ATV.0000255581.38523.7c