Børre Fevang
- Group leader, Senior consultant; MD, PhD
Publications 2024
Diagnostics, treatment and outcomes of cardiac sarcoidosis in a Norwegian cohort
Int J Cardiol, 400, 131809
DOI 10.1016/j.ijcard.2024.131809, PubMed 38272129
Chronic HIV Infection Increases Monocyte NLRP3 Inflammasome-Dependent IL-1α and IL-1β Release
Int J Mol Sci, 25 (13)
DOI 10.3390/ijms25137141, PubMed 39000248
Clinical characteristics and factors affecting disease severity in hospitalized tick-borne encephalitis patients in Norway from 2018 to 2022
Eur J Clin Microbiol Infect Dis, 43 (7), 1355-1366
DOI 10.1007/s10096-024-04855-2, PubMed 38801484
Altered Genome-Wide DNA Methylation in the Duodenum of Common Variable Immunodeficiency Patients
J Clin Immunol, 44 (6), 133
DOI 10.1007/s10875-024-01726-5, PubMed 38780872
Publications 2023
Long-term survival after liver transplantation in patients with common variable immunodeficiency
Liver Transpl, 29 (8), 894-899
DOI 10.1097/LVT.0000000000000130, PubMed 36932715
Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review
Front Immunol, 14, 1190235
DOI 10.3389/fimmu.2023.1190235, PubMed 37223103
Treatment of inflammatory complications in common variable immunodeficiency (CVID): current concepts and future perspectives
Expert Rev Clin Immunol, 19 (6), 627-638
DOI 10.1080/1744666X.2023.2198208, PubMed 36996348
Disturbed lipid profile in common variable immunodeficiency - a pathogenic loop of inflammation and metabolic disturbances
Front Immunol, 14, 1199727
DOI 10.3389/fimmu.2023.1199727, PubMed 37545531
Cellular immunity in COVID-19 and other infections in Common variable immunodeficiency
Front Immunol, 14, 1124279
DOI 10.3389/fimmu.2023.1124279, PubMed 37180118
Increased Plasma Levels of Triglyceride-Enriched Lipoproteins Associate with Systemic Inflammation, Lipopolysaccharides, and Gut Dysbiosis in Common Variable Immunodeficiency
J Clin Immunol, 43 (6), 1229-1240
DOI 10.1007/s10875-023-01475-x, PubMed 36995502
COVID-19 patients treated with convalescent plasma
Tidsskr Nor Laegeforen, 143 (11)
DOI 10.4045/tidsskr.22.0577, PubMed 37589359
Publications 2022
Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency
J Clin Immunol, 42 (7), 1553-1563
DOI 10.1007/s10875-022-01318-1, PubMed 35789314
Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2
Viruses, 14 (11)
DOI 10.3390/v14112420, PubMed 36366518
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses
J Allergy Clin Immunol, 151 (3), 767-777
DOI 10.1016/j.jaci.2022.09.029, PubMed 36220400
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency
J Exp Med, 220 (2)
DOI 10.1084/jem.20220275, PubMed 36515678
COVID-19 convalescent plasma from Norwegian blood donors
Tidsskr Nor Laegeforen, 142 (9)
DOI 10.4045/tidsskr.22.0057, PubMed 35699539
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
Front Immunol, 13, 964525
DOI 10.3389/fimmu.2022.964525, PubMed 36159859
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
J Intern Med, 292 (5), 816-828
DOI 10.1111/joim.13549, PubMed 35982589
High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19
J Infect Dis, 226 (12), 2150-2160
DOI 10.1093/infdis/jiac313, PubMed 35876699
Publications 2021
Editorial: Interstitial Lung Disease in Primary Immunodeficiencies
Front Immunol, 12, 699126
DOI 10.3389/fimmu.2021.699126, PubMed 34305936
Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue
Front Immunol, 12, 715102
DOI 10.3389/fimmu.2021.715102, PubMed 34987499
Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency-Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
Front Immunol, 11, 617985
DOI 10.3389/fimmu.2020.617985, PubMed 33584710
Granulomatous-lymphocytic interstitial lung disease: an international research prioritisation
ERJ Open Res, 7 (4)
DOI 10.1183/23120541.00467-2021, PubMed 34881327
Real-World Experiences With Facilitated Subcutaneous Immunoglobulin Substitution in Patients With Hypogammaglobulinemia, Using a Three-Step Ramp-Up Schedule
Front Immunol, 12, 670547
DOI 10.3389/fimmu.2021.670547, PubMed 34012453
A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT
J Clin Immunol, 42 (2), 404-420
DOI 10.1007/s10875-021-01189-y, PubMed 34893945
Altered Plasma Fatty Acids Associate with Gut Microbial Composition in Common Variable Immunodeficiency
J Clin Immunol, 42 (1), 146-157
DOI 10.1007/s10875-021-01146-9, PubMed 34669143
Publications 2020
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
Commentary: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy
Front Immunol, 11, 1921
DOI 10.3389/fimmu.2020.01921, PubMed 32983117
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
[Elevated serum ferritin is not only a sign of liver failure]
Tidsskr Nor Laegeforen, 140 (8)
DOI 10.4045/tidsskr.20.0376, PubMed 32463199
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109
Managing Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders: e-GLILDnet International Clinicians Survey
Front Immunol, 11, 606333
DOI 10.3389/fimmu.2020.606333, PubMed 33324422
Publications 2019
Adverse events with fatal outcome associated with alemtuzumab treatment in multiple sclerosis
BMC Res Notes, 12 (1), 497
DOI 10.1186/s13104-019-4507-6, PubMed 31405369
Selective IgA deficiency in humans is associated with reduced gut microbial diversity
J Allergy Clin Immunol, 143 (5), 1969-1971.e11
DOI 10.1016/j.jaci.2019.01.019, PubMed 30707969
Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency
Sci Rep, 9 (1), 167 (Retracted)
DOI 10.1038/s41598-018-35367-7, PubMed 30655568
Impaired HDL Function Amplifies Systemic Inflammation in Common Variable Immunodeficiency
Sci Rep, 9 (1), 9427
DOI 10.1038/s41598-019-45861-1, PubMed 31263122
Publications 2018
[Not Available]
Tidsskr Nor Laegeforen, 138 (2)
DOI 10.4045/tidsskr.18.0019, PubMed 29357620
Open access- elephant (or polar bear) in the room
Tidsskr. Nor. Laegeforen., 138 (2), 110
Runaway Train: A Leaky Radiosensitive SCID with Skin Lesions and Multiple Lymphomas
Case Reports Immunol, 2018, 2053716
DOI 10.1155/2018/2053716, PubMed 29888014
Malaria and Malnutrition: Kwashiorkor Associated with Low Levels of Parasitaemia
Malar Res Treat, 2018, 7153173
DOI 10.1155/2018/7153173, PubMed 30533212
Autoimmunity and Inflammation in CVID: a Possible Crosstalk between Immune Activation, Gut Microbiota, and Epigenetic Modifications
J Clin Immunol, 39 (1), 30-36
DOI 10.1007/s10875-018-0574-z, PubMed 30465180
Donor-derived strongyloidiasis after organ transplantation in Norway
Transpl Infect Dis, 21 (1), e13008
DOI 10.1111/tid.13008, PubMed 30295406
Soluble markers of neutrophil, T-cell and monocyte activation are associated with disease severity and parasitemia in falciparum malaria
BMC Infect Dis, 18 (1), 670
DOI 10.1186/s12879-018-3593-8, PubMed 30563486
Tenders for HIV medicines are not academically justified
Tidsskr. Nor. Laegeforen., 138 (20), 1912-1913
[Tendering for HIV drugs is not clinically justified]
Tidsskr Nor Laegeforen, 138 (20)
DOI 10.4045/tidsskr.18.0808, PubMed 30539614
Publications 2017
[Not Available]
Tidsskr Nor Laegeforen, 137 (23-24)
DOI 10.4045/tidsskr.17.1010, PubMed 29231632
Open access- elephant (or polar bear) in the room
Tidsskr. Nor. Laegeforen., 137 (23-24), 1860
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency
PLoS One, 12 (10), e0185708
DOI 10.1371/journal.pone.0185708, PubMed 28973009
CVID and Celiac Disease
Am J Gastroenterol, 112 (2), 393
DOI 10.1038/ajg.2016.551, PubMed 28154406
Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
Sci Rep, 7, 39710
DOI 10.1038/srep39710, PubMed 28054583
Erratum: Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia
Sci Rep, 7, 42569
DOI 10.1038/srep42569, PubMed 28240280
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239
A Young, Immunocompetent Woman with Small Bowel and Hepatic Mucormycosis Successfully Treated with Aggressive Surgical Debridements and Antifungal Therapy
Case Rep Infect Dis, 2017, 4173246
DOI 10.1155/2017/4173246, PubMed 29435377
Publications 2016
[Atypical mycobacteria and Lady Windermere]
Tidsskr Nor Laegeforen, 136 (14-15), 1227
DOI 10.4045/tidsskr.16.0235, PubMed 27554564
Liver transplantation in patients with primary antibody deficiency
J Allergy Clin Immunol, 139 (5), 1708-1710.e2
DOI 10.1016/j.jaci.2016.10.025, PubMed 27931972
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am J Gastroenterol, 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329, PubMed 27527747
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction
Mol Genet Genomic Med, 4 (6), 604-616
DOI 10.1002/mgg3.237, PubMed 27896283
Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders
J Allergy Clin Immunol, 139 (1), 232-245
DOI 10.1016/j.jaci.2016.05.042, PubMed 27577878
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
Clin Immunol, 175, 69-74
DOI 10.1016/j.clim.2016.11.014, PubMed 27919819
Publications 2015
IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells
J Immunol, 195 (6), 2601-11
DOI 10.4049/jimmunol.1500250, PubMed 26276871
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells
Nat Commun, 6, 6804
DOI 10.1038/ncomms7804, PubMed 25891430
Publications 2013
Lung disease, T-cells and inflammation in common variable immunodeficiency disorders
Scand J Clin Lab Invest, 73 (6), 514-22
DOI 10.3109/00365513.2013.819523, PubMed 23957371
Retinoic acid improves defective TLR9/RP105-induced immune responses in common variable immunodeficiency-derived B cells
J Immunol, 191 (7), 3624-33
DOI 10.4049/jimmunol.1300213, PubMed 24006462
Publications 2012
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-73
DOI 10.1016/j.atherosclerosis.2012.06.071, PubMed 22840692
Publications 2010
Profound perturbation: immunopathological mechanisms in common variable immunodeficiency
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 889, 1 b. (flere pag.)
BIBSYS 100281206, ISBN 978-82-8072-344-4
Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors
Ann Allergy Asthma Immunol, 104 (6), 503-10
DOI 10.1016/j.anai.2010.04.015, PubMed 20568383
Publications 2009
Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy
AIDS, 23 (1), 135-8
DOI 10.1097/QAD.0b013e32831cf595, PubMed 19050397
Enhanced levels of urokinase plasminogen activator and its soluble receptor in common variable immunodeficiency
Clin Immunol, 131 (3), 438-46
DOI 10.1016/j.clim.2009.01.007, PubMed 19232508
Publications 2008
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure
Eur J Heart Fail, 10 (4), 352-9
DOI 10.1016/j.ejheart.2008.02.010, PubMed 18353719
Chemokines and common variable immunodeficiency; possible contribution of the fractalkine system (CX3CL1/CX3CR1) to chronic inflammation
Clin Immunol, 130 (2), 151-61
DOI 10.1016/j.clim.2008.09.002, PubMed 18938112
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins
Cardiovasc Res, 79 (1), 195-203
DOI 10.1093/cvr/cvn071, PubMed 18339644
Publications 2007
Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis--possible role in vascular inflammation
Rheumatology (Oxford), 46 (9), 1422-7
DOI 10.1093/rheumatology/kem168, PubMed 17616549
Publications 2006
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
DOI 10.1161/01.ATV.0000255581.38523.7c, PubMed 17170367