Publications 2024

Arlien-Søborg MC, Dal J, Heck A, Stochholm K, Husted E, Feltoft CL, Rasmussen ÅK, Feldt-Rasmussen U, Andreassen M, Klose MC, Nielsen TL, Andersen MS, Christensen LL, Krogh J, Jarlov A, Bollerslev J, Nermoen I, Oksnes M, Dahlqvist P, Olsson T, Berinder K, Hoybye C, Petersson M, Akerman AK, Wahlberg J et al. (2024)
Acromegaly management in the Nordic countries: A Delphi consensus survey
Clin Endocrinol (Oxf), 101 (3), 263-273
DOI 10.1111/cen.15095, PubMed 38865284

Atai S, Knudtzon Andersen M, Wiedmann M, Dahlberg D, Øystese KAB, Bollerslev J, Ringstad G, Heck A (2024)
Unravelling pituitary tumours in medically treated patients with acromegaly: the impact of systematic MRI reassessment
Acta Radiol, 65 (7), 753-758
DOI 10.1177/02841851241246107, PubMed 38659302

Bollerslev J, Heck A (2024)
Precision medicine in Acromegaly: The Potential of Multimodal Therapy
J Clin Endocrinol Metab (in press)
DOI 10.1210/clinem/dgae636, PubMed 39288034

Falch CM, Godang K, Lekva T, Ueland T, Heck A, Bollerslev J, Olarescu NC (2024)
Long-term depot specific changes in adipose tissue after treatment of acromegaly
Eur J Endocrinol, 190 (3), K37-K42
DOI 10.1093/ejendo/lvae016, PubMed 38401530

Heck A, Pretorius M, Lundstam K, Godang K, Hellström M, Ueland T, Bollerslev J (2024)
No effect of surgery on kidney and cardiovascular risk factors in mild primary hyperparathyroidism: secondary analyses from a 10-year randomized controlled trial
Eur J Endocrinol, 191 (3), 354-360
DOI 10.1093/ejendo/lvae109, PubMed 39189547

Jotanovic J, Boldt HB, Burton M, Andersen MS, Bengtsson D, Bontell TO, Ekman B, Engström BE, Feldt-Rasmussen U, Heck A, Jakovcevic A, Jørgensen JOL, Kraljevic I, Kunicki J, Lindsay JR, Losa M, Loughrey PB, Maiter D, Maksymowicz M, Manojlovic-Gacic E, Pahnke J, Petersenn S, Petersson M, Popovic V, Ragnarsson O et al. (2024)
Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Acta Neuropathol, 148 (1), 68
DOI 10.1007/s00401-024-02836-5, PubMed 39580368

Publications 2023

Falch CM, Arlien-Søborg MC, Dal J, Sundaram AYM, Michelsen AE, Ueland T, Olsen LG, Heck A, Bollerslev J, Jørgensen JOL, Olarescu NC (2023)
Gene expression profiling of subcutaneous adipose tissue reveals new biomarkers in acromegaly
Eur J Endocrinol, 188 (3)
DOI 10.1093/ejendo/lvad031, PubMed 36895180

Falch CM, Dupont AK, Olarescu NC, Wiedmann M, Dahlberg D, Bollerslev J, Berg-Johnsen J, Heck A (2023)
Long-term control of acromegaly after pituitary surgery in South-Eastern Norway
Acta Neurochir (Wien), 165 (10), 3003-3010
DOI 10.1007/s00701-023-05772-7, PubMed 37665404

Heck A, Godang K, Lekva T, Markussen KN, De Vincentis S, Ueland T, Bollerslev J (2023)
Endocortical Trabecularization in Acromegaly: The Cause for the Paradoxically Increased Vertebral Fracture Risk?
JBMR Plus, 7 (10), e10787
DOI 10.1002/jbm4.10787, PubMed 37808394

Kolnes AJ, Øystese KAB, Sjöstedt E, Olarescu NC, Heck A, Pahnke J, Dahlberg D, Berg-Johnsen J, Ringstad G, Casar-Borota O, Bollerslev J, Jørgensen AP (2023)
TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
Pituitary, 26 (2), 227-236
DOI 10.1007/s11102-023-01310-x, PubMed 36952069

Lundstam K, Pretorius M, Bollerslev J, Godang K, Fagerland MW, Mollerup C, Fougner SL, Pernow Y, Aas T, Hessman O, Rosén T, Nordenström J, Jansson S, Hellström M, Heck A (2023)
Positive Effect of Parathyroidectomy Compared to Observation on BMD in a Randomized Controlled Trial of Mild Primary Hyperparathyroidism
J Bone Miner Res, 38 (3), 372-380
DOI 10.1002/jbmr.4763, PubMed 36593641

Wiedmann M, Olesrud I, Lashkarivand A, Dheyauldeen S, Heck A, Berg-Johnsen J, Dahlberg D (2023)
Endoscopic four-hands technique for pituitary tumours
Tidsskr Nor Laegeforen, 143 (9)
DOI 10.4045/tidsskr.22.0693, PubMed 37341404

Publications 2022

Bollerslev J, Rejnmark L, Zahn A, Heck A, Appelman-Dijkstra NM, Cardoso L, Hannan FM, Cetani F, Sikjær T, Formenti AM, Björnsdottir S, Schalin-Jantti C, Belaya Z, Gibb FW, Lapauw B, Amrein K, Wicke C, Grasemann C, Krebs M, Ryhänen EM, Makay O, Minisola S, Gaujoux S, Bertocchio JP, Hassan-Smith ZK et al. (2022)
European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: Recommendations of the ESE Educational Program of Parathyroid Disorders
Eur J Endocrinol, 186 (2), R33-R63
DOI 10.1530/EJE-21-1044, PubMed 34863037

Dal J, Rosendal C, Karmisholt J, Feldt-Rasmussen U, Andersen MS, Klose M, Feltoft C, Heck A, Nielsen EH, Jørgensen JOL (2022)
Sex difference in patients with controlled acromegaly-A multicentre survey
Clin Endocrinol (Oxf), 98 (1), 74-81
DOI 10.1111/cen.14750, PubMed 35474467

Falch CM, Olarescu NC, Bollerslev J, Dekkers OM, Heck A (2022)
Trends in incidence and mortality risk for acromegaly in Norway: a cohort study
Endocrine, 80 (1), 152-159
DOI 10.1007/s12020-022-03275-6, PubMed 36525222

Pretorius M, Lundstam K, Heck A, Fagerland MW, Godang K, Mollerup C, Fougner SL, Pernow Y, Aas T, Hessman O, Rosén T, Nordenström J, Jansson S, Hellström M, Bollerslev J (2022)
Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation
Ann Intern Med, 175 (6), 812-819
DOI 10.7326/M21-4416, PubMed 35436153

Publications 2021

Heck A, Winge-Main AK (2021)
Silent, isolated ACTH deficiency in malignant melanoma patients treated with immune checkpoint inhibitors
BMJ Case Rep, 14 (5)
DOI 10.1136/bcr-2021-241981, PubMed 34045201

Lundstam K, Godang K, Pretorius M, Markwardt P, Hellström M, Bollerslev J, Heck A (2021)
The Influence of DXA Hardware, Software, Reference Population and Software Analysis Settings on the Bone Mineral Density and T-Score Relationship
J Clin Densitom, 25 (1), 24-33
DOI 10.1016/j.jocd.2021.07.002, PubMed 34393058

Publications 2020

Pretorius M, Lundstam K, Hellström M, Fagerland MW, Godang K, Mollerup C, Fougner SL, Pernow Y, Aas T, Hessman O, Rosén T, Nordenström J, Jansson S, Heck A, Bollerslev J (2020)
Effects of Parathyroidectomy on Quality of Life: 10 Years of Data From a Prospective Randomized Controlled Trial on Primary Hyperparathyroidism (the SIPH-Study)
J Bone Miner Res, 36 (1), 3-11
DOI 10.1002/jbmr.4199, PubMed 33125769

Publications 2019

Bollerslev J, Heck A, Olarescu NC (2019)
MANAGEMENT OF ENDOCRINE DISEASE: Individualised management of acromegaly
Eur J Endocrinol, 181 (2), R57-R71
DOI 10.1530/EJE-19-0124, PubMed 31100716

Godang K, Lekva T, Normann KR, Olarescu NC, Øystese KAB, Kolnes A, Ueland T, Bollerslev J, Heck A (2019)
Hip Structure Analyses in Acromegaly: Decrease of Cortical Bone Thickness After Treatment: A Longitudinal Cohort Study
JBMR Plus, 3 (12), e10240
DOI 10.1002/jbm4.10240, PubMed 31844828

Publications 2018

Bollerslev J, Pretorius M, Heck A (2018)
Parathyroid hormone independent hypercalcemia in adults
Best Pract Res Clin Endocrinol Metab, 32 (5), 621-638
DOI 10.1016/j.beem.2018.06.005, PubMed 30449545

Godang K, Lundstam K, Mollerup C, Fougner F, Pernow Y, Nordenström J, Rosén T, Jansson S, Hellström M, Bollerslev J, Heck A, The SIPH Study Group (2018)
The effect of surgery on fat mass, lipid and glucose metabolism in mild primary hyperparathyroidism
Endocr Connect, 7 (8), 941-948
DOI 10.1530/EC-18-0259, PubMed 30300532

Publications 2017

Dal J, Klose M, Heck A, Andersen M, Kistorp C, Nielsen EH, Bollerslev J, Feldt-Rasmussen U, Jørgensen JOL (2017)
Targeting either GH or IGF-I during somatostatin analogue treatment in patients with acromegaly: a randomized multicentre study
Eur J Endocrinol, 178 (1), 65-74
DOI 10.1530/EJE-17-0546, PubMed 28993415

Lundstam K, Heck A, Godang K, Mollerup C, Baranowski M, Pernow Y, Aas T, Hessman O, Rosén T, Nordenström J, Jansson S, Hellström M, Bollerslev J, SIPH Study Group (2017)
Effect of Surgery Versus Observation: Skeletal 5-Year Outcomes in a Randomized Trial of Patients With Primary HPT (the SIPH Study)
J Bone Miner Res, 32 (9), 1907-1914
DOI 10.1002/jbmr.3177, PubMed 28543873

Publications 2016

Godang K, Olarescu NC, Bollerslev J, Heck A (2016)
Treatment of acromegaly increases BMD but reduces trabecular bone score: a longitudinal study
Eur J Endocrinol, 175 (2), 155-64
DOI 10.1530/EJE-16-0340, PubMed 27220351

Heck A (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (23-24), 2035
DOI 10.4045/tidsskr.16.0965, PubMed 28004565

Langleite TM, Jensen J, Norheim F, Gulseth HL, Tangen DS, Kolnes KJ, Heck A, Storås T, Grøthe G, Dahl MA, Kielland A, Holen T, Noreng HJ, Stadheim HK, Bjørnerud A, Johansen EI, Nellemann B, Birkeland KI, Drevon CA (2016)
Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men
Arch Physiol Biochem, 122 (4), 167-179
DOI 10.1080/13813455.2016.1202985, PubMed 27477619

Publications 2015

Heck A, Emblem KE, Casar-Borota O, Bollerslev J, Ringstad G (2015)
Quantitative analyses of T2-weighted MRI as a potential marker for response to somatostatin analogs in newly diagnosed acromegaly
Endocrine, 52 (2), 333-43
DOI 10.1007/s12020-015-0766-8, PubMed 26475495

Heck A, Emblem KE, Casar-Borota O, Ringstad G, Bollerslev J (2015)
MRI T2 characteristics in somatotroph adenomas following somatostatin analog treatment in acromegaly
Endocrine, 53 (1), 327-30
DOI 10.1007/s12020-015-0816-2, PubMed 26615593

Lekva T, Berg JP, Lyle R, Heck A, Bollerslev J, Ueland T (2015)
Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas
Neuro Endocrinol Lett, 36 (2), 136-42
PubMed 26071582

Lundstam K, Heck A, Mollerup C, Godang K, Baranowski M, Pernow Y, Varhaug JE, Hessman O, Rosén T, Nordenström J, Jansson S, Hellström M, Bollerslev J, SIPH Study Group (2015)
Effects of parathyroidectomy versus observation on the development of vertebral fractures in mild primary hyperparathyroidism
J Clin Endocrinol Metab, 100 (4), 1359-67
DOI 10.1210/jc.2014-3441, PubMed 25636048

Olarescu NC, Heck A, Godang K, Ueland T, Bollerslev J (2015)
The Metabolic Risk in Patients Newly Diagnosed with Acromegaly Is Related to Fat Distribution and Circulating Adipokines and Improves after Treatment
Neuroendocrinology, 103 (3-4), 197-206
DOI 10.1159/000371818, PubMed 25592241

Publications 2013

Casar-Borota O, Heck A, Schulz S, Nesland JM, Ramm-Pettersen J, Lekva T, Alafuzoff I, Bollerslev J (2013)
Expression of SSTR2a, but not of SSTRs 1, 3, or 5 in somatotroph adenomas assessed by monoclonal antibodies was reduced by octreotide and correlated with the acute and long-term effects of octreotide
J Clin Endocrinol Metab, 98 (11), E1730-9
DOI 10.1210/jc.2013-2145, PubMed 24092823

Lekva T, Berg JP, Heck A, Lyngvi Fougner S, Olstad OK, Ringstad G, Bollerslev J, Ueland T (2013)
Attenuated RORC expression in the presence of EMT progression in somatotroph adenomas following treatment with somatostatin analogs is associated with poor clinical recovery
PLoS One, 8 (6), e66927
DOI 10.1371/journal.pone.0066927, PubMed 23825587

Lekva T, Berg JP, Lyle R, Heck A, Ringstad G, Olstad OK, Michelsen AE, Casar-Borota O, Bollerslev J, Ueland T (2013)
Epithelial splicing regulator protein 1 and alternative splicing in somatotroph adenomas
Endocrinology, 154 (9), 3331-43
DOI 10.1210/en.2013-1051, PubMed 23825128

Publications 2012

Fougner SL, Casar-Borota O, Heck A, Berg JP, Bollerslev J (2012)
Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly
Clin Endocrinol (Oxf), 76 (1), 96-102
DOI 10.1111/j.1365-2265.2011.04163.x, PubMed 21722151

Heck A, Ringstad G, Fougner SL, Casar-Borota O, Nome T, Ramm-Pettersen J, Bollerslev J (2012)
Intensity of pituitary adenoma on T2-weighted magnetic resonance imaging predicts the response to octreotide treatment in newly diagnosed acromegaly
Clin Endocrinol (Oxf), 77 (1), 72-8
DOI 10.1111/j.1365-2265.2011.04286.x, PubMed 22066905

Publications 2007

Heck A, Cappelen T, Følling I (2007)
[Large goiter--diagnosis and treatment]
Tidsskr Nor Laegeforen, 127 (9), 1196-200
PubMed 17479138