Siri Leknes

  • Professor; PhD

Publications 2024

Leknes S, Eikemo M, Løseth G (2024)
Understanding individual variability in opioid responses: A call to arms
Addict Biol, 29 (6), e13418
DOI 10.1111/adb.13418, PubMed 38853701

Meier IM, Eikemo M, Trøstheim M, Buen K, Jensen E, Gurandsrud Karlsen S, Reme SE, Berna C, Leknes S, Ernst G (2024)
Factors associated with use of opioid rescue medication after surgery
Reg Anesth Pain Med, 49 (4), 265-271
DOI 10.1136/rapm-2023-104412, PubMed 37479238

Publications 2023

Scarth M, Hauger LE, Thorsby PM, Leknes S, Hullstein IR, Westlye LT, Bjørnebekk A (2023)
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men
Psychopharmacology (Berl), 241 (4), 701-715
DOI 10.1007/s00213-023-06497-2, PubMed 37993638

Publications 2022

Leknes S, Atlas LY (2022)
Corrigendum to 'Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology' (Br J Anaesth 2020; 124: e29-e33)
Br J Anaesth, 129 (3), 456-457
DOI 10.1016/j.bja.2022.06.011, PubMed 35803756

Løseth GE, Eikemo M, Trøstheim M, Meier IM, Bjørnstad H, Asratian A, Pazmandi C, Tangen VW, Heilig M, Leknes S (2022)
Stress recovery with social support: A dyadic stress and support task
Psychoneuroendocrinology, 146, 105949
DOI 10.1016/j.psyneuen.2022.105949, PubMed 36240542

Parisi A, Landicho HL, Hudak J, Leknes S, Froeliger B, Garland EL (2022)
Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy
Drug Alcohol Depend, 233, 109361
DOI 10.1016/j.drugalcdep.2022.109361, PubMed 35278786

Skoglund C, Leknes S, Heilig M (2022)
The partial µ-opioid agonist buprenorphine in autism spectrum disorder: a case report
J Med Case Rep, 16 (1), 152
DOI 10.1186/s13256-022-03384-w, PubMed 35422015

Trøstheim M, Eikemo M, Haaker J, Frost JJ, Leknes S (2022)
Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade
Neuropsychopharmacology, 48 (2), 299-307
DOI 10.1038/s41386-022-01416-z, PubMed 35978096

Publications 2021

Eikemo M, Løseth GE, Leknes S (2021)
Do endogenous opioids mediate or fine-tune human pain relief?
Pain, 162 (12), 2789-2791
DOI 10.1097/j.pain.0000000000002286, PubMed 34793404

Henningsson S, Leknes S, Asperholm M, Eikemo M, Westberg L (2021)
A randomized placebo-controlled intranasal oxytocin study on first impressions and reactions to social rejection
Biol Psychol, 164, 108164
DOI 10.1016/j.biopsycho.2021.108164, PubMed 34331996

Laeng B, Garvija L, Løseth G, Eikemo M, Ernst G, Leknes S (2021)
'Defrosting' music chills with naltrexone: The role of endogenous opioids for the intensity of musical pleasure
Conscious Cogn, 90, 103105
DOI 10.1016/j.concog.2021.103105, PubMed 33711654

Meier IM, Eikemo M, Leknes S (2021)
The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies
Curr Addict Rep, 8 (2), 306-318
DOI 10.1007/s40429-021-00366-8, PubMed 34722114

Publications 2020

Hovey D, Martens L, Laeng B, Leknes S, Westberg L (2020)
The effect of intranasal oxytocin on visual processing and salience of human faces
Transl Psychiatry, 10 (1), 318
DOI 10.1038/s41398-020-00991-3, PubMed 32951002

Sulutvedt U, Zavagno D, Lubell J, Leknes S, de Rodez Benavent SA, Laeng B (2020)
Brightness perception changes related to pupil size
Vision Res, 178, 41-47
DOI 10.1016/j.visres.2020.09.004, PubMed 33113435

Trøstheim M, Eikemo M, Meir R, Hansen I, Paul E, Kroll SL, Garland EL, Leknes S (2020)
Assessment of Anhedonia in Adults With and Without Mental Illness: A Systematic Review and Meta-analysis
JAMA Netw Open, 3 (8), e2013233
DOI 10.1001/jamanetworkopen.2020.13233, PubMed 32789515

Publications 2019

Bastian B, Vauclair CM, Loughnan S, Bain P, Ashokkumar A, Becker M, Bilewicz M, Collier-Baker E, Crespo C, Eastwick PW, Fischer R, Friese M, Gómez Á, Guerra VM, Guevara JLC, Hanke K, Hooper N, Huang LL, Junqi S, Karasawa M, Kuppens P, Leknes S, Peker M, Pelay C, Pina A et al. (2019)
Explaining illness with evil: pathogen prevalence fosters moral vitalism
Proc Biol Sci, 286 (1914), 20191576
DOI 10.1098/rspb.2019.1576, PubMed 31662082

Eikemo M, Lobmaier PP, Pedersen ML, Kunøe N, Matziorinis AM, Leknes S, Sarfi M (2019)
Intact responses to non-drug rewards in long-term opioid maintenance treatment
Neuropsychopharmacology, 44 (8), 1456-1463
DOI 10.1038/s41386-019-0377-9, PubMed 30928994

Garland EL, Trøstheim M, Eikemo M, Ernst G, Leknes S (2019)
Anhedonia in chronic pain and prescription opioid misuse
Psychol Med, 50 (12), 1977-1988
DOI 10.1017/S0033291719002010, PubMed 31422776

Hauger LE, Sagoe D, Vaskinn A, Arnevik EA, Leknes S, Jørstad ML, Bjørnebekk A (2019)
Anabolic androgenic steroid dependence is associated with impaired emotion recognition
Psychopharmacology (Berl), 236 (9), 2667-2676
DOI 10.1007/s00213-019-05239-7, PubMed 30941469

Leknes S, Atlas LY (2019)
Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology
Br J Anaesth, 124 (3), e29-e33
DOI 10.1016/j.bja.2019.10.006, PubMed 31753290

Løseth GE, Eikemo M, Leknes S (2019)
Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial
Soc Cogn Affect Neurosci, 14 (4), 411-422
DOI 10.1093/scan/nsz022, PubMed 30951167

van Steenbergen H, Eikemo M, Leknes S (2019)
The role of the opioid system in decision making and cognitive control: A review
Cogn Affect Behav Neurosci, 19 (3), 435-458
DOI 10.3758/s13415-019-00710-6, PubMed 30963411

Publications 2018

Berna C, Leknes S, Ahmad AH, Mhuircheartaigh RN, Goodwin GM, Tracey I (2018)
Opioid-Independent and Opioid-Mediated Modes of Pain Modulation
J Neurosci, 38 (42), 9047-9058
DOI 10.1523/JNEUROSCI.0854-18.2018, PubMed 30201765

Leknes S (2018)
The pain modulatory cocktail
Scand J Pain, 2 (3), 105-107
DOI 10.1016/j.sjpain.2011.05.007, PubMed 29913737

Løseth GE, Eikemo M, Isager P, Holmgren J, Laeng B, Vindenes V, Hjørnevik T, Leknes S (2018)
Morphine reduced perceived anger from neutral and implicit emotional expressions
Psychoneuroendocrinology, 91, 123-131
DOI 10.1016/j.psyneuen.2018.02.035, PubMed 29550675

Ree A, Mayo LM, Leknes S, Sailer U (2018)
Touch targeting C-tactile afferent fibers has a unique physiological pattern: A combined electrodermal and facial electromyography study
Biol Psychol, 140, 55-63
DOI 10.1016/j.biopsycho.2018.11.006, PubMed 30468895

Publications 2017

Eikemo M, Biele G, Willoch F, Thomsen L, Leknes S (2017)
Opioid Modulation of Value-Based Decision-Making in Healthy Humans
Neuropsychopharmacology, 42 (9), 1833-1840
DOI 10.1038/npp.2017.58, PubMed 28294136

Publications 2016

Brandtzaeg OK, Johnsen E, Roberg-Larsen H, Seip KF, MacLean EL, Gesquiere LR, Leknes S, Lundanes E, Wilson SR (2016)
Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum
Sci Rep, 6, 31693
DOI 10.1038/srep31693, PubMed 27528413

Chelnokova O, Laeng B, Løseth G, Eikemo M, Willoch F, Leknes S (2016)
The µ-opioid system promotes visual attention to faces and eyes
Soc Cogn Affect Neurosci, 11 (12), 1902-1909
DOI 10.1093/scan/nsw116, PubMed 27531386

Eikemo M, Løseth GE, Johnstone T, Gjerstad J, Willoch F, Leknes S (2016)
Sweet taste pleasantness is modulated by morphine and naltrexone
Psychopharmacology (Berl), 233 (21-22), 3711-3723
DOI 10.1007/s00213-016-4403-x, PubMed 27538675

Ellingsen DM, Leknes S, Løseth G, Wessberg J, Olausson H (2016)
The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context
Front Psychol, 6, 1986
DOI 10.3389/fpsyg.2015.01986, PubMed 26779092

Nilsen AS, Blix I, Leknes S, Ekeberg Ø, Skogstad L, Endestad T, Østberg BC, Heir T (2016)
Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accident Survivors
Front Psychol, 7, 1173
DOI 10.3389/fpsyg.2016.01173, PubMed 27547195

Publications 2015

Johnsen E, Leknes S, Wilson SR, Lundanes E (2015)
Liquid chromatography-mass spectrometry platform for both small neurotransmitters and neuropeptides in blood, with automatic and robust solid phase extraction
Sci Rep, 5, 9308
DOI 10.1038/srep09308, PubMed 25791195

Publications 2014

Bastian B, Jetten J, Hornsey MJ, Leknes S (2014)
The Positive Consequences of Pain: A Biopsychosocial Approach
Pers Soc Psychol Rev, 18 (3), 256-279
DOI 10.1177/1088868314527831, PubMed 24727972

Leknes S, Bastian B (2014)
The Benefits of Pain
Rev. Philos. Psychol., 5 (1), 57-70
DOI 10.1007/s13164-014-0178-3

Loseth GE, Ellingsen DM, Leknes S (2014)
State-dependent μ-opioid modulation of social motivation
Front Behav Neurosci, 8, 430
DOI 10.3389/fnbeh.2014.00430, PubMed 25565999

Publications 2013

Ellingsen DM, Wessberg J, Chelnokova O, Olausson H, Laeng B, Leknes S (2013)
In touch with your emotions: oxytocin and touch change social impressions while others' facial expressions can alter touch
Psychoneuroendocrinology, 39, 11-20
DOI 10.1016/j.psyneuen.2013.09.017, PubMed 24275000

Ellingsen DM, Wessberg J, Eikemo M, Liljencrantz J, Endestad T, Olausson H, Leknes S (2013)
Placebo improves pleasure and pain through opposite modulation of sensory processing
Proc Natl Acad Sci U S A, 110 (44), 17993-8
DOI 10.1073/pnas.1305050110, PubMed 24127578

Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I (2013)
Response to the commentary "multiple potential mechanisms for context effects on pain"
Pain, 154 (8), 1485-1486
DOI 10.1016/j.pain.2013.04.002, PubMed 23726676

Publications 2012

Leknes S, Berna C, Lee MC, Snyder GD, Biele G, Tracey I (2012)
The importance of context: when relative relief renders pain pleasant
Pain, 154 (3), 402-410
DOI 10.1016/j.pain.2012.11.018, PubMed 23352758

Leknes S, Wessberg J, Ellingsen DM, Chelnokova O, Olausson H, Laeng B (2012)
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Soc Cogn Affect Neurosci, 8 (7), 741-9
DOI 10.1093/scan/nss062, PubMed 22648957

Wanigasekera V, Lee MC, Rogers R, Kong Y, Leknes S, Andersson J, Tracey I (2012)
Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects
Proc Natl Acad Sci U S A, 109 (43), 17705-10
DOI 10.1073/pnas.1120201109, PubMed 23045652

Publications 2011

Leknes S, Lee M, Berna C, Andersson J, Tracey I (2011)
Relief as a reward: hedonic and neural responses to safety from pain
PLoS One, 6 (4), e17870
DOI 10.1371/journal.pone.0017870, PubMed 21490964

Publications 2010

Berna C, Leknes S, Holmes EA, Edwards RR, Goodwin GM, Tracey I (2010)
Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness
Biol Psychiatry, 67 (11), 1083-90
DOI 10.1016/j.biopsych.2010.01.014, PubMed 20303069

Publications 2008

Leknes S, Brooks JC, Wiech K, Tracey I (2008)
Pain relief as an opponent process: a psychophysical investigation
Eur J Neurosci, 28 (4), 794-801
DOI 10.1111/j.1460-9568.2008.06380.x, PubMed 18671736

Leknes S, Tracey I (2008)
A common neurobiology for pain and pleasure
Nat Rev Neurosci, 9 (4), 314-20
DOI 10.1038/nrn2333, PubMed 18354400

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