Siri Leknes
- Professor; PhD
Publications 2024
Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers
J Psychopharmacol, 2698811241268892 (in press)
DOI 10.1177/02698811241268892, PubMed 39118370
Understanding individual variability in opioid responses: A call to arms
Addict Biol, 29 (6), e13418
DOI 10.1111/adb.13418, PubMed 38853701
Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis
Transl Psychiatry, 14 (1), 379
DOI 10.1038/s41398-024-03088-3, PubMed 39289345
Factors associated with use of opioid rescue medication after surgery
Reg Anesth Pain Med, 49 (4), 265-271
DOI 10.1136/rapm-2023-104412, PubMed 37479238
Publications 2023
Supraphysiological testosterone levels from anabolic steroid use and reduced sensitivity to negative facial expressions in men
Psychopharmacology (Berl), 241 (4), 701-715
DOI 10.1007/s00213-023-06497-2, PubMed 37993638
Publications 2022
Corrigendum to 'Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology' (Br J Anaesth 2020; 124: e29-e33)
Br J Anaesth, 129 (3), 456-457
DOI 10.1016/j.bja.2022.06.011, PubMed 35803756
Stress recovery with social support: A dyadic stress and support task
Psychoneuroendocrinology, 146, 105949
DOI 10.1016/j.psyneuen.2022.105949, PubMed 36240542
Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy
Drug Alcohol Depend, 233, 109361
DOI 10.1016/j.drugalcdep.2022.109361, PubMed 35278786
The partial µ-opioid agonist buprenorphine in autism spectrum disorder: a case report
J Med Case Rep, 16 (1), 152
DOI 10.1186/s13256-022-03384-w, PubMed 35422015
Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade
Neuropsychopharmacology, 48 (2), 299-307
DOI 10.1038/s41386-022-01416-z, PubMed 35978096
Publications 2021
Do endogenous opioids mediate or fine-tune human pain relief?
Pain, 162 (12), 2789-2791
DOI 10.1097/j.pain.0000000000002286, PubMed 34793404
A randomized placebo-controlled intranasal oxytocin study on first impressions and reactions to social rejection
Biol Psychol, 164, 108164
DOI 10.1016/j.biopsycho.2021.108164, PubMed 34331996
'Defrosting' music chills with naltrexone: The role of endogenous opioids for the intensity of musical pleasure
Conscious Cogn, 90, 103105
DOI 10.1016/j.concog.2021.103105, PubMed 33711654
The Role of Mu-Opioids for Reward and Threat Processing in Humans: Bridging the Gap from Preclinical to Clinical Opioid Drug Studies
Curr Addict Rep, 8 (2), 306-318
DOI 10.1007/s40429-021-00366-8, PubMed 34722114
Publications 2020
The effect of intranasal oxytocin on visual processing and salience of human faces
Transl Psychiatry, 10 (1), 318
DOI 10.1038/s41398-020-00991-3, PubMed 32951002
Brightness perception changes related to pupil size
Vision Res, 178, 41-47
DOI 10.1016/j.visres.2020.09.004, PubMed 33113435
Assessment of Anhedonia in Adults With and Without Mental Illness: A Systematic Review and Meta-analysis
JAMA Netw Open, 3 (8), e2013233
DOI 10.1001/jamanetworkopen.2020.13233, PubMed 32789515
Publications 2019
Explaining illness with evil: pathogen prevalence fosters moral vitalism
Proc Biol Sci, 286 (1914), 20191576
DOI 10.1098/rspb.2019.1576, PubMed 31662082
Intact responses to non-drug rewards in long-term opioid maintenance treatment
Neuropsychopharmacology, 44 (8), 1456-1463
DOI 10.1038/s41386-019-0377-9, PubMed 30928994
Anhedonia in chronic pain and prescription opioid misuse
Psychol Med, 50 (12), 1977-1988
DOI 10.1017/S0033291719002010, PubMed 31422776
Anabolic androgenic steroid dependence is associated with impaired emotion recognition
Psychopharmacology (Berl), 236 (9), 2667-2676
DOI 10.1007/s00213-019-05239-7, PubMed 30941469
Flawed methodology undermines conclusions about opioid-induced pleasure: implications for psychopharmacology
Br J Anaesth, 124 (3), e29-e33
DOI 10.1016/j.bja.2019.10.006, PubMed 31753290
Effects of opioid receptor stimulation and blockade on touch pleasantness: a double-blind randomised trial
Soc Cogn Affect Neurosci, 14 (4), 411-422
DOI 10.1093/scan/nsz022, PubMed 30951167
The role of the opioid system in decision making and cognitive control: A review
Cogn Affect Behav Neurosci, 19 (3), 435-458
DOI 10.3758/s13415-019-00710-6, PubMed 30963411
Publications 2018
Opioid-Independent and Opioid-Mediated Modes of Pain Modulation
J Neurosci, 38 (42), 9047-9058
DOI 10.1523/JNEUROSCI.0854-18.2018, PubMed 30201765
The pain modulatory cocktail
Scand J Pain, 2 (3), 105-107
DOI 10.1016/j.sjpain.2011.05.007, PubMed 29913737
Morphine reduced perceived anger from neutral and implicit emotional expressions
Psychoneuroendocrinology, 91, 123-131
DOI 10.1016/j.psyneuen.2018.02.035, PubMed 29550675
Touch targeting C-tactile afferent fibers has a unique physiological pattern: A combined electrodermal and facial electromyography study
Biol Psychol, 140, 55-63
DOI 10.1016/j.biopsycho.2018.11.006, PubMed 30468895
Publications 2017
Opioid Modulation of Value-Based Decision-Making in Healthy Humans
Neuropsychopharmacology, 42 (9), 1833-1840
DOI 10.1038/npp.2017.58, PubMed 28294136
Publications 2016
Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum
Sci Rep, 6, 31693
DOI 10.1038/srep31693, PubMed 27528413
The µ-opioid system promotes visual attention to faces and eyes
Soc Cogn Affect Neurosci, 11 (12), 1902-1909
DOI 10.1093/scan/nsw116, PubMed 27531386
Sweet taste pleasantness is modulated by morphine and naltrexone
Psychopharmacology (Berl), 233 (21-22), 3711-3723
DOI 10.1007/s00213-016-4403-x, PubMed 27538675
The Neurobiology Shaping Affective Touch: Expectation, Motivation, and Meaning in the Multisensory Context
Front Psychol, 6, 1986
DOI 10.3389/fpsyg.2015.01986, PubMed 26779092
Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accident Survivors
Front Psychol, 7, 1173
DOI 10.3389/fpsyg.2016.01173, PubMed 27547195
Publications 2015
Liquid chromatography-mass spectrometry platform for both small neurotransmitters and neuropeptides in blood, with automatic and robust solid phase extraction
Sci Rep, 5, 9308
DOI 10.1038/srep09308, PubMed 25791195
Publications 2014
The Positive Consequences of Pain: A Biopsychosocial Approach
Pers Soc Psychol Rev, 18 (3), 256-279
DOI 10.1177/1088868314527831, PubMed 24727972
The Benefits of Pain
Rev. Philos. Psychol., 5 (1), 57-70
DOI 10.1007/s13164-014-0178-3
State-dependent μ-opioid modulation of social motivation
Front Behav Neurosci, 8, 430
DOI 10.3389/fnbeh.2014.00430, PubMed 25565999
Publications 2013
In touch with your emotions: oxytocin and touch change social impressions while others' facial expressions can alter touch
Psychoneuroendocrinology, 39, 11-20
DOI 10.1016/j.psyneuen.2013.09.017, PubMed 24275000
Placebo improves pleasure and pain through opposite modulation of sensory processing
Proc Natl Acad Sci U S A, 110 (44), 17993-8
DOI 10.1073/pnas.1305050110, PubMed 24127578
Response to the commentary "multiple potential mechanisms for context effects on pain"
Pain, 154 (8), 1485-1486
DOI 10.1016/j.pain.2013.04.002, PubMed 23726676
Publications 2012
The importance of context: when relative relief renders pain pleasant
Pain, 154 (3), 402-410
DOI 10.1016/j.pain.2012.11.018, PubMed 23352758
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Soc Cogn Affect Neurosci, 8 (7), 741-9
DOI 10.1093/scan/nss062, PubMed 22648957
Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects
Proc Natl Acad Sci U S A, 109 (43), 17705-10
DOI 10.1073/pnas.1120201109, PubMed 23045652
Publications 2011
Relief as a reward: hedonic and neural responses to safety from pain
PLoS One, 6 (4), e17870
DOI 10.1371/journal.pone.0017870, PubMed 21490964
Publications 2010
Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness
Biol Psychiatry, 67 (11), 1083-90
DOI 10.1016/j.biopsych.2010.01.014, PubMed 20303069
Publications 2008
Pain relief as an opponent process: a psychophysical investigation
Eur J Neurosci, 28 (4), 794-801
DOI 10.1111/j.1460-9568.2008.06380.x, PubMed 18671736
A common neurobiology for pain and pleasure
Nat Rev Neurosci, 9 (4), 314-20
DOI 10.1038/nrn2333, PubMed 18354400