Lars Wik
- Senior researcher, Senior Physician; MD, PhD
- +47 23 02 62 14
Senior Consultant of Anaesthesiology and Senior Researcher at Oslo University Hospital and NAKOS. Since 1985 Dr Wik has been active in conducting clinical and experimental research into mechanical Cardiopulmonary Resuscitation (CPR). Together with Professor Steen he established the experimental cardiac arrest program at the Institute of Experimental Medical Research at Ullevål University Hospital in the beginning of 1990’s and were crucial for implementing randomized clinical outcome studies utilizing the infrastructure of the prehospital Emergency Medicine Service and Hospitals in the Oslo area. Several studies have changed the International CPR Guidelines. The combination of studies exploring different experimental CPR methods in the animal lab, didactic CPR performance, clinical outcome and hemodynamic studies of patients is unique and document a broad approach to save more lives. Dr Wik was the Principal Investigator (PI) for the International Circulation Improving Resuscitation Care (CIRC) randomized controlled trial and led several clinical outcome studies (The SISTER study, CPR before defibrillation, IV Yes/No,) that have changed CPR Guidelines. Innovative studies related to avalanche and trauma have also documented how to save more lives. During the last years Dr Wik has been the PI for the first mechanical clinical active compression decompression studies (LUCAS 2 AD studies). During the last few years he has been influential in designing and performing randomized studies regarding use of biosensors and signal processing in prehospital care.
Dr Wik’s work has generated contributions to about 130 publications in top ranked journals resulting in several invitations worldwide to present at congresses.
Dr Wik actively practices clinical pre-hospital emergency medicine (last 40 years), regular shifts at Oslo University Hospital Anaesthesia department, and conducts advanced research on cardiac arrest and trauma while working with the rapid response car in Oslo. Dr Wik also holds several patents related to Emergency Medicine technology licensed to International Manufactories.
Publications 2022
Clinical paper Mechanical active compression-decompression versus standard mechanical cardiopulmonary resuscitation: A randomised haemodynamic out-of-hospital cardiac arrest study
Resuscitation, 170, 1-10
DOI 10.1016/j.resuscitation.2021.10.026
Publications 2021
Multimodal Algorithms for the Classification of Circulation States During Out-of-Hospital Cardiac Arrest
IEEE Trans. Biomed. Eng., 68 (6), 1913-1922
DOI 10.1109/TBME.2020.3030216
Publications 2020
A Probabilistic Function to Model the Relationship between Quality of Chest Compressions and the Physiological Response for Patients in Cardiac Arrest
COMPUT CARDIOL CONF, 73
DOI 10.22489/CinC.2020.073
Rhythm Analysis during Cardiopulmonary Resuscitation Using Convolutional Neural Networks
Entropy, 22 (6), 595
DOI 10.3390/e22060595
Detection of Shockable Rhythms Using Convolutional Neural Networks During Chest Compressions Provided by a Load Distributing Band
COMPUT CARDIOL CONF, 45
DOI 10.22489/CinC.2020.045
Multimodal Biosignal Analysis Algorithm for the Classification of Cardiac Rhythms During Resuscitation
COMPUT CARDIOL CONF, 347
DOI 10.22489/CinC.2020.347
Diagnostic performance of the basic and advanced life support termination of resuscitation rules: A systematic review and diagnostic meta-analysis
Resuscitation, 148, 3-13
DOI 10.1016/j.resuscitation.2019.12.016
Publications 2019
Transthoracic Impedance Measured with Defibrillator PadsNew Interpretations of Signal Change Induced by Ventilations
J. Clin. Med., 8 (5), 724
DOI 10.3390/jcm8050724
A Robust Machine Learning Architecture for a Reliable ECG Rhythm Analysis during CPR
IEEE ENG MED BIO, 1903-1907
Automatic Cardiac Rhythm Classification With Concurrent Manual Chest Compressions
IEEE Access, 7, 115147-115159
DOI 10.1109/ACCESS.2019.2935096
Survival to hospital discharge with biphasic fixed 360 joules versus 200 escalating to 360 joules defibrillation strategies in out-of-hospital cardiac arrest of presumed cardiac etiology
Resuscitation, 136, 112-118
DOI 10.1016/j.resuscitation.2019.01.020
Mixed convolutional and long short-term memory network for the detection of lethal ventricular arrhythmia
PLoS One, 14 (5), e0216756
DOI 10.1371/journal.pone.0216756
The effect of intravenous adrenaline on electrocardiographic changes during resuscitation in patients with initial pulseless electrical activity in out of hospital cardiac arrest
Resuscitation, 136, 119-125
DOI 10.1016/j.resuscitation.2019.01.021
Publications 2018
ECG Rhythm Analysis During Manual Chest Compressions Using an Artefact Removal Filter and Random Forest Classifiers
COMPUT CARDIOL CONF, 45
DOI 10.22489/CinC.2018.202
An automatic system for the comprehensive retrospective analysis of cardiac rhythms in resuscitation episodes
Resuscitation, 122, 6-12
DOI 10.1016/j.resuscitation.2017.11.035
Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest
Scand. J. Trauma Resusc. Emerg. Med., 26, 31
DOI 10.1186/s13049-018-0496-z
Publications 2017
Observed survival benefit of mild therapeutic hypothermia reanalysing the Circulation Improving Resuscitation Care trial
Eur. J. Clin. Invest., 47 (6), 439-446
DOI 10.1111/eci.12759
Prehospital thoracotomy for traumatic cardiac arrest
Tidsskr. Nor. Laegeforen., 137 (3), 169
Ethics and aesthetics in prehospital thoracotomy
Tidsskr. Nor. Laegeforen., 137 (9), 603-604
ECG-Based Classification of Resuscitation Cardiac Rhythms for Retrospective Data Analysis
IEEE Trans. Biomed. Eng., 64 (10), 2411-2418
DOI 10.1109/TBME.2017.2688380
Mountain rescue cardiopulmonary resuscitation: a comparison between manual and mechanical chest compressions during manikin cardio resuscitation
Emerg. Med. J., 34 (9), 573-577
DOI 10.1136/emermed-2016-206323
Publications 2016
Machine Learning Techniques for the Detection of Shockable Rhythms in Automated External Defibrillators
PLoS One, 11 (7), e0159654
DOI 10.1371/journal.pone.0159654
PEDIATRIC CARDIAC ARREST DUE TO TRAUMA
Prehosp. Emerg. Care, 20 (3), 425-431
DOI 10.3109/10903127.2015.1111479
Prehospital thoracotomy for traumatic cardiac arrest
Tidsskr. Nor. Laegeforen., 136 (23-24), 1964-1965
DOI 10.4045/tidsskr.16.0798
Automatic cardiac rhythm interpretation during resuscitation
Resuscitation, 102, 44-50
DOI 10.1016/j.resuscitation.2016.01.015
Defibrillation success during different phases of the mechanical chest compression cycle
Resuscitation, 103, 99-105
DOI 10.1016/j.resuscitation.2016.01.031
Near-infrared spectroscopy during cardiopulmonary resuscitation and after restoration of spontaneous circulation: a valid technology?
Curr. Opin. Crit. Care, 22 (3), 191-198
DOI 10.1097/MCC.0000000000000301
Why do some studies find that CPR fraction is not a predictor of survival?
Resuscitation, 104, 59-62
DOI 10.1016/j.resuscitation.2016.04.013
Publications 2015
Chest compression rate feedback based on transthoracic impedance
Resuscitation, 93, 82-88
DOI 10.1016/j.resuscitation.2015.05.027
Pre-shock chest compression pause effects on termination of ventricular fibrillation/tachycardia and return of organized rhythm within mechanical and manual cardiopulmonary resuscitation
Resuscitation, 93, 158-163
DOI 10.1016/j.resuscitation.2015.04.023
Minimizing pre-shock chest compression pauses in a cardiopulmonary resuscitation cycle by performing an earlier rhythm analysis
Resuscitation, 87, 33-37
DOI 10.1016/j.resuscitation.2014.11.012
Automatic mechanical chest compressions during cardiopulmonary resuscitation: What is the evidence for its use?
Resuscitation, 94, A8
DOI 10.1016/j.resuscitation.2015.06.014
Publications 2014
Comparison of Medical Priority Dispatch (MPD) and Criteria Based Dispatch (CBD) relating to cardiac arrest calls
Resuscitation, 85 (5), 612-616
DOI 10.1016/j.resuscitation.2014.01.029
Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
Resuscitation, 85 (6), 741-748
DOI 10.1016/j.resuscitation.2014.03.005
Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial (vol 85, pg 741, 2014)
Resuscitation, 85 (9), 1306
DOI 10.1016/j.resuscitation.2014.06.017
Publications 2013
Effects of adrenaline on rhythm transitions in out-of-hospital cardiac arrest
Acta Anaesthesiol. Scand., 57 (10), 1260-1267
DOI 10.1111/aas.12184
Publications 2012
Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA)
Resuscitation, 83 (8), 946-952
DOI 10.1016/j.resuscitation.2012.02.031
Outcome when adrenaline (epinephrine) was actually given vs. not given - post hoc analysis of a randomized clinical trial
Resuscitation, 83 (3), 327-332
DOI 10.1016/j.resuscitation.2011.11.011
Publications 2011
Mechanical chest compressions with trapezoidal waveform improve haemodynamics during cardiac arrest
Resuscitation, 82 (2), 213-218
DOI 10.1016/j.resuscitation.2010.10.009
Design of the Circulation Improving Resuscitation Care (CIRC) Trial: A new state of the art design for out-of-hospital cardiac arrest research
Resuscitation, 82 (3), 294-299
DOI 10.1016/j.resuscitation.2010.11.013
Publications 2010
High school students as ambassadors of CPR-A model for reaching the most appropriate target population?
Resuscitation, 81 (1), 78-81
DOI 10.1016/j.resuscitation.2009.09.030
Improving outcome after out-of-hospital cardiac arrest by strengthening weak links of the local Chain of Survival; quality of advanced life support and post-resuscitation care
Resuscitation, 81 (4), 422-426
DOI 10.1016/j.resuscitation.2009.12.020
Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest
Resuscitation, 81 (4), 488-492
DOI 10.1016/j.resuscitation.2009.12.028
Publications 2009
Acute ischemic heart disease alters ventricular fibrillation waveform characteristics in out-of hospital cardiac arrest
Resuscitation, 80 (4), 412-417
DOI 10.1016/j.resuscitation.2009.01.012
Progressing from initial non-shockable rhythms to a shockable rhythm is associated with improved outcome after out-of-hospital cardiac arrest
Resuscitation, 80 (1), 24-29
DOI 10.1016/j.resuscitation.2008.09.003
Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest A Randomized Trial
JAMA-J. Am. Med. Assoc., 302 (20), 2222-2229
DOI 10.1001/jama.2009.1729
Advanced life support performance with manual and mechanical chest compressions in a randomized, multicentre manikin study
Resuscitation, 80 (10), 1152-1157
DOI 10.1016/j.resuscitation.2009.07.001
Publications 2008
Impact of a self-instruction CPR kit on 7th graders' and adults' skills and CPR performance
Resuscitation, 79 (1), 103-108
DOI 10.1016/j.resuscitation.2008.04.030
Comprehensive evaluation for quality of prehospital CPR - Reply
Resuscitation, 78 (1), 99
DOI 10.1016/j.resuscitation.2007.12.002
Quality of cardiopulmonary resuscitation before and during transport in out-of-hospital cardiac arrest
Resuscitation, 76 (2), 185-190
DOI 10.1016/j.resuscitation.2007.07.001
Arterial blood gases during basic life support of human cardiac arrest victims
Resuscitation, 77 (1), 35-38
DOI 10.1016/j.resuscitation.2007.10.005
Transthoracic impedance used to evaluate performance of cardiopulmonary resuscitation during out of hospital cardiac arrest
Resuscitation, 79 (3), 432-437
DOI 10.1016/j.resuscitation.2008.08.007
Publications 2007
Is CPR quality improving? A retrospective study of out-of-hospital cardiac arrest
Resuscitation, 75 (2), 260-266
DOI 10.1016/j.resuscitation.2007.04.016
Standard versus over-the-head cardiopulmonary resuscitation during simulated advanced life support
Prehosp. Emerg. Care, 11 (4), 443-447
DOI 10.1080/00207450701537050
Continuous mechanical chest compressions during cardiac arrest to facilitate restoration of coronary circulation with percutaneous coronary intervention
J. Am. Coll. Cardiol., 50 (11), 1093-1094
DOI 10.1016/j.jacc.2007.05.028
Pauses in chest compression and inappropriate shocks: A comparison of manual and semi-automatic defibrillation attempts
Resuscitation, 73 (2), 212-220
DOI 10.1016/j.resuscitation.2006.09.006
Chest compressions by ambulance personnel on chests with variable stiffness: Abilities and attitudes
Resuscitation, 74 (1), 127-134
DOI 10.1016/j.resuscitation.2006.12.006
A failed attempt to improve quality of out-of-hospital CPR through performance evaluation
Prehosp. Emerg. Care, 11 (4), 427-433
DOI 10.1080/10903120701536628
Publications 2006
Airway management by paramedics using endotracheal intubation with a laryngoscope versus the oesophageal tracheal Combitube (TM) and EasyTube (TM) on manikins: A randomised experimental trial
Resuscitation, 71 (1), 107-111
DOI 10.1016/j.resuscitation.2006.02.016
Effects of compression depth and pre-shock pauses predict defibrillation failure during cardiac arrest
Resuscitation, 71 (2), 137-145
DOI 10.1016/j.resuscitation.2006.04.008
Quality of out-of-hospital cardiopulmonary resuscitation with real time automated feedback: A prospective interventional study
Resuscitation, 71 (3), 283-292
DOI 10.1016/j.resuscitation.2006.05.011
Reconfirmation algorithms should be the standard of care in automated external defibrillators
Resuscitation, 70 (3), 474-475
DOI 10.1016/j.resuscitation.2006.04.010
Quality of lay person CPR performance with compression: ventilation ratios 15 : 2, 30 : 2 or continuous chest compressions without ventilations on manikins
Resuscitation, 71 (3), 335-340
DOI 10.1016/j.resuscitation.2006.05.012
Haemodynamic effects of adrenaline (epinephrine) depend on chest compression quality during cardiopulmonary resuscitation in pigs
Resuscitation, 71 (3), 369-378
DOI 10.1016/j.resuscitation.2006.05.003