Lars Wik

  • Senior researcher, Senior Physician; MD, PhD
  • +47 23 02 62 14

Senior Consultant of Anaesthesiology and Senior Researcher at Oslo University Hospital and NAKOS. Since 1985 Dr Wik has been active in conducting clinical and experimental research into mechanical Cardiopulmonary Resuscitation (CPR). Together with Professor Steen he established the experimental cardiac arrest program at the Institute of Experimental Medical Research at Ullevål University Hospital in the beginning of 1990’s and were crucial for implementing randomized clinical outcome studies utilizing the infrastructure of the prehospital Emergency Medicine Service and Hospitals in the Oslo area. Several studies have changed the International CPR Guidelines. The combination of studies exploring different experimental CPR methods in the animal lab, didactic CPR performance, clinical outcome and hemodynamic studies of patients is unique and document a broad approach to save more lives. Dr Wik was the Principal Investigator (PI) for the International Circulation Improving Resuscitation Care (CIRC) randomized controlled trial and led several clinical outcome studies (The SISTER study, CPR before defibrillation, IV Yes/No,) that have changed CPR Guidelines. Innovative studies related to avalanche and trauma have also documented how to save more lives. During the last years Dr Wik has been the PI for the first mechanical clinical active compression decompression studies (LUCAS 2 AD studies). During the last few years he has been influential in designing and performing randomized studies regarding use of biosensors and signal processing in prehospital care.   

Dr Wik’s work has generated contributions to about 130 publications in top ranked journals resulting in several invitations worldwide to present at congresses. 

Dr Wik actively practices clinical pre-hospital emergency medicine (last 40 years), regular shifts at Oslo University Hospital Anaesthesia department, and conducts advanced research on cardiac arrest and trauma while working with the rapid response car in Oslo. Dr Wik also holds several patents related to Emergency Medicine technology licensed to International Manufactories. 

Lars Wik - Cristin

Lars Wik | ResearchGate

 

Publications 2022

Berve PO, Hardig BM, Skalhegg T, Kongsgaard H, Kramer-Johansen J, Wik L (2022)
Clinical paper Mechanical active compression-decompression versus standard mechanical cardiopulmonary resuscitation: A randomised haemodynamic out-of-hospital cardiac arrest study
Resuscitation, 170, 1-10
DOI 10.1016/j.resuscitation.2021.10.026

Publications 2021

Elola A, Aramendi E, Irusta U, Berve PO, Wik L (2021)
Multimodal Algorithms for the Classification of Circulation States During Out-of-Hospital Cardiac Arrest
IEEE Trans. Biomed. Eng., 68 (6), 1913-1922
DOI 10.1109/TBME.2020.3030216

Publications 2020

Eftestol T, Stokka SE, Kvaloy JT, Rad AB, Irusta U, Aramendi E, Alonso E, Nordseth T, Skogvoll E, Wik L, Kramer-Johansen J (2020)
A Probabilistic Function to Model the Relationship between Quality of Chest Compressions and the Physiological Response for Patients in Cardiac Arrest
COMPUT CARDIOL CONF, 73
DOI 10.22489/CinC.2020.073

Isasi I, Irusta U, Aramendi E, Eftestol T, Kramer-Johansen J, Wik L (2020)
Rhythm Analysis during Cardiopulmonary Resuscitation Using Convolutional Neural Networks
Entropy, 22 (6), 595
DOI 10.3390/e22060595

Isasi I, Irusta U, Aramendi E, Olsen JA, Wik L (2020)
Detection of Shockable Rhythms Using Convolutional Neural Networks During Chest Compressions Provided by a Load Distributing Band
COMPUT CARDIOL CONF, 45
DOI 10.22489/CinC.2020.045

Lasa H, Irusta U, Eftestol T, Aramendi E, Rad AB, Kramer-Johansen J, Wik L (2020)
Multimodal Biosignal Analysis Algorithm for the Classification of Cardiac Rhythms During Resuscitation
COMPUT CARDIOL CONF, 347
DOI 10.22489/CinC.2020.347

Nas J, Kleinnibbelink G, Hannink G, Navarese EP, van Royen N, de Boer MJ, Wik L, Bonnes JL, Brouwer MA (2020)
Diagnostic performance of the basic and advanced life support termination of resuscitation rules: A systematic review and diagnostic meta-analysis
Resuscitation, 148, 3-13
DOI 10.1016/j.resuscitation.2019.12.016

Publications 2019

Berve PO, Irusta U, Kramer-Johansen J, Skalhegg T, Kongsgard HW, Brunborg C, Aramendi E, Wik L (2019)
Transthoracic Impedance Measured with Defibrillator PadsNew Interpretations of Signal Change Induced by Ventilations
J. Clin. Med., 8 (5), 724
DOI 10.3390/jcm8050724

Isasi I, Irusta U, Elola A, Aramendi E, Eftestol T, Kramer-Johansen J, Wik L (2019)
A Robust Machine Learning Architecture for a Reliable ECG Rhythm Analysis during CPR
IEEE ENG MED BIO, 1903-1907

Isasi I, Irusta U, Rad AB, Aramendi E, Zabihi M, Eftestol T, Kramer-Johansen J, Wik L (2019)
Automatic Cardiac Rhythm Classification With Concurrent Manual Chest Compressions
IEEE Access, 7, 115147-115159
DOI 10.1109/ACCESS.2019.2935096

Olsen JA, Brunborg C, Steinberg M, Persse D, Sterz F, Lozano M, Westfall M, van Grunsven PM, Lerner EB, Wik L (2019)
Survival to hospital discharge with biphasic fixed 360 joules versus 200 escalating to 360 joules defibrillation strategies in out-of-hospital cardiac arrest of presumed cardiac etiology
Resuscitation, 136, 112-118
DOI 10.1016/j.resuscitation.2019.01.020

Picon A, Irusta U, Alvarez-Gila A, Aramendi E, Alonso-Atienza F, Figuera C, Ayala U, Garrote E, Wik L, Kramer-Johansen J, Eftestol T (2019)
Mixed convolutional and long short-term memory network for the detection of lethal ventricular arrhythmia
PLoS One, 14 (5), e0216756
DOI 10.1371/journal.pone.0216756

Skjeflo GW, Skogvoll E, Loennechen JP, Olasveengen TM, Wik L, Nordseth T (2019)
The effect of intravenous adrenaline on electrocardiographic changes during resuscitation in patients with initial pulseless electrical activity in out of hospital cardiac arrest
Resuscitation, 136, 119-125
DOI 10.1016/j.resuscitation.2019.01.021

Publications 2018

Isasi I, Rad AB, Irusta U, Zabihi M, Aramendi E, Eftestol T, Kramer-Johansen J, Wik L (2018)
ECG Rhythm Analysis During Manual Chest Compressions Using an Artefact Removal Filter and Random Forest Classifiers
COMPUT CARDIOL CONF, 45
DOI 10.22489/CinC.2018.202

Rad AB, Eftestol T, Irusta U, Kvaloy JT, Wik L, Kramer-Johansen J, Katsaggelos AK, Engan K (2018)
An automatic system for the comprehensive retrospective analysis of cardiac rhythms in resuscitation episodes
Resuscitation, 122, 6-12
DOI 10.1016/j.resuscitation.2017.11.035

Steinberg MT, Olsen JA, Eriksen M, Neset A, Norseng PA, Kramer-Johansen J, Hardig BM, Wik L (2018)
Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest
Scand. J. Trauma Resusc. Emerg. Med., 26, 31
DOI 10.1186/s13049-018-0496-z

Publications 2017

Nurnberger A, Herkner H, Sterz F, Olsen JA, Lozano M, van Grunsven PM, Lerner EB, Persse D, Malzer R, Brouwer MA, Westfall M, Souders CM, Travis DT, Herken UR, Wik L (2017)
Observed survival benefit of mild therapeutic hypothermia reanalysing the Circulation Improving Resuscitation Care trial
Eur. J. Clin. Invest., 47 (6), 439-446
DOI 10.1111/eci.12759

Ottestad W, Bredmose PB, Berve PO, Stave H, Farstad G, Wik L, Sandberg M (2017)
Prehospital thoracotomy for traumatic cardiac arrest
Tidsskr. Nor. Laegeforen., 137 (3), 169

Ottestad W, Bredmose PB, Berve PO, Stave H, Farstad G, Wik L, Sandberg M (2017)
Ethics and aesthetics in prehospital thoracotomy
Tidsskr. Nor. Laegeforen., 137 (9), 603-604

Rad AB, Eftestol T, Engan K, Irusta U, Kvaloy JT, Kramer-Johansen J, Wik L, Katsaggelos AK (2017)
ECG-Based Classification of Resuscitation Cardiac Rhythms for Retrospective Data Analysis
IEEE Trans. Biomed. Eng., 64 (10), 2411-2418
DOI 10.1109/TBME.2017.2688380

Thomassen O, Skaiaa SC, Assmuss J, Osteras O, Heltne JK, Wik L, Brattebo G (2017)
Mountain rescue cardiopulmonary resuscitation: a comparison between manual and mechanical chest compressions during manikin cardio resuscitation
Emerg. Med. J., 34 (9), 573-577
DOI 10.1136/emermed-2016-206323

Publications 2016

Figuera C, Irusta U, Morgado E, Aramendi E, Ayala U, Wik L, Kramer-Johansen J, Eftestol T, Alonso-Atienza F (2016)
Machine Learning Techniques for the Detection of Shockable Rhythms in Automated External Defibrillators
PLoS One, 11 (7), e0159654
DOI 10.1371/journal.pone.0159654

Kjellemo H, Hansen AE, Oines DA, Nilsen TO, Wik L (2016)
PEDIATRIC CARDIAC ARREST DUE TO TRAUMA
Prehosp. Emerg. Care, 20 (3), 425-431
DOI 10.3109/10903127.2015.1111479

Ottestad W, Bredmose PB, Berve PO, Stave H, Farstad G, Wik L, Sandberg M (2016)
Prehospital thoracotomy for traumatic cardiac arrest
Tidsskr. Nor. Laegeforen., 136 (23-24), 1964-1965
DOI 10.4045/tidsskr.16.0798

Rad AB, Engan K, Katsaggelos AK, Kvaloy JT, Wik L, Kramer-Johansen J, Irusta U, Eftestol T (2016)
Automatic cardiac rhythm interpretation during resuscitation
Resuscitation, 102, 44-50
DOI 10.1016/j.resuscitation.2016.01.015

Steinberg MT, Olsen JA, Brunborg C, Persse D, Sterz F, Lozano M, Westfall M, Travis DT, Lerner EB, Wik L (2016)
Defibrillation success during different phases of the mechanical chest compression cycle
Resuscitation, 103, 99-105
DOI 10.1016/j.resuscitation.2016.01.031

Wik L (2016)
Near-infrared spectroscopy during cardiopulmonary resuscitation and after restoration of spontaneous circulation: a valid technology?
Curr. Opin. Crit. Care, 22 (3), 191-198
DOI 10.1097/MCC.0000000000000301

Wik L, Olsen JA, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, Travis DT, Herken UR, Lerner EB (2016)
Why do some studies find that CPR fraction is not a predictor of survival?
Resuscitation, 104, 59-62
DOI 10.1016/j.resuscitation.2016.04.013

Publications 2015

Gonzalez-Otero DM, de Gauna SR, Ruiz J, Daya MR, Wik L, Russell JK, Kramer-Johansen J, Eftestol T, Alonso E, Ayala U (2015)
Chest compression rate feedback based on transthoracic impedance
Resuscitation, 93, 82-88
DOI 10.1016/j.resuscitation.2015.05.027

Olsen JA, Brunborg C, Steinberg M, Persse D, Sterz F, Lozano M, Mark WI, Travis DT, Lerner EB, Brouwer MA, Wik L (2015)
Pre-shock chest compression pause effects on termination of ventricular fibrillation/tachycardia and return of organized rhythm within mechanical and manual cardiopulmonary resuscitation
Resuscitation, 93, 158-163
DOI 10.1016/j.resuscitation.2015.04.023

Steinberg MT, Olsen JA, Brunborg C, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, van Grunsven PM, Travis DT, Lerner EB, Wik L (2015)
Minimizing pre-shock chest compression pauses in a cardiopulmonary resuscitation cycle by performing an earlier rhythm analysis
Resuscitation, 87, 33-37
DOI 10.1016/j.resuscitation.2014.11.012

Wik L, Rubertsson S (2015)
Automatic mechanical chest compressions during cardiopulmonary resuscitation: What is the evidence for its use?
Resuscitation, 94, A8
DOI 10.1016/j.resuscitation.2015.06.014

Publications 2014

Hardeland C, Olasveengen TM, Lawrence R, Garrison D, Lorem T, Farstad G, Wik L (2014)
Comparison of Medical Priority Dispatch (MPD) and Criteria Based Dispatch (CBD) relating to cardiac arrest calls
Resuscitation, 85 (5), 612-616
DOI 10.1016/j.resuscitation.2014.01.029

Wik L, Olsen JA, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, Malzer R, van Grunsven PM, Travis DT, Whitehead A, Herken UR, Lerner EB (2014)
Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial
Resuscitation, 85 (6), 741-748
DOI 10.1016/j.resuscitation.2014.03.005

Wik L, Olsen JA, Persse D, Sterz F, Lozano M, Brouwer MA, Westfall M, Souders CM, Malzer R, van Grunsven PM, Travis DT, Whitehead A, Herken UR, Lerner EB (2014)
Manual vs. integrated automatic load-distributing band CPR with equal survival after out of hospital cardiac arrest. The randomized CIRC trial (vol 85, pg 741, 2014)
Resuscitation, 85 (9), 1306
DOI 10.1016/j.resuscitation.2014.06.017

Publications 2013

Neset A, Nordseth T, Kramer-Johansen J, Wik L, Olasveengen TM (2013)
Effects of adrenaline on rhythm transitions in out-of-hospital cardiac arrest
Acta Anaesthesiol. Scand., 57 (10), 1260-1267
DOI 10.1111/aas.12184

Publications 2012

Nordseth T, Olasveengen TM, Kvaloy JT, Wik L, Steen PA, Skogvoll E (2012)
Dynamic effects of adrenaline (epinephrine) in out-of-hospital cardiac arrest with initial pulseless electrical activity (PEA)
Resuscitation, 83 (8), 946-952
DOI 10.1016/j.resuscitation.2012.02.031

Olasveengen TM, Wik L, Sunde K, Steen PA (2012)
Outcome when adrenaline (epinephrine) was actually given vs. not given - post hoc analysis of a randomized clinical trial
Resuscitation, 83 (3), 327-332
DOI 10.1016/j.resuscitation.2011.11.011

Publications 2011

Kramer-Johansen J, Pytte M, Tomlinson AE, Sunde K, Dorph E, Svendsen JVH, Eriksen M, Stromme TA, Wik L (2011)
Mechanical chest compressions with trapezoidal waveform improve haemodynamics during cardiac arrest
Resuscitation, 82 (2), 213-218
DOI 10.1016/j.resuscitation.2010.10.009

Lerner EB, Persse D, Souders CM, Sterz F, Malzer R, Lozano M, Westfall M, Brouwer MA, van Grunsven PM, Whitehead A, Olsen JA, Herken UR, Wik L (2011)
Design of the Circulation Improving Resuscitation Care (CIRC) Trial: A new state of the art design for out-of-hospital cardiac arrest research
Resuscitation, 82 (3), 294-299
DOI 10.1016/j.resuscitation.2010.11.013

Publications 2010

Lorem T, Steen PA, Wik L (2010)
High school students as ambassadors of CPR-A model for reaching the most appropriate target population?
Resuscitation, 81 (1), 78-81
DOI 10.1016/j.resuscitation.2009.09.030

Lund-Kordahl I, Olasveengen TM, Lorem T, Samdal M, Wik L, Sunde K (2010)
Improving outcome after out-of-hospital cardiac arrest by strengthening weak links of the local Chain of Survival; quality of advanced life support and post-resuscitation care
Resuscitation, 81 (4), 422-426
DOI 10.1016/j.resuscitation.2009.12.020

Tomte O, Sjaastad I, Wik L, Kuzovlev A, Eriksen M, Norseng PA, Sunde K (2010)
Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest
Resuscitation, 81 (4), 488-492
DOI 10.1016/j.resuscitation.2009.12.028

Publications 2009

Olasveengen TM, Eftestol T, Gundersen K, Wik L, Sunde K (2009)
Acute ischemic heart disease alters ventricular fibrillation waveform characteristics in out-of hospital cardiac arrest
Resuscitation, 80 (4), 412-417
DOI 10.1016/j.resuscitation.2009.01.012

Olasveengen TM, Samdal M, Steen PA, Wik L, Sunde K (2009)
Progressing from initial non-shockable rhythms to a shockable rhythm is associated with improved outcome after out-of-hospital cardiac arrest
Resuscitation, 80 (1), 24-29
DOI 10.1016/j.resuscitation.2008.09.003

Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik L (2009)
Intravenous Drug Administration During Out-of-Hospital Cardiac Arrest A Randomized Trial
JAMA-J. Am. Med. Assoc., 302 (20), 2222-2229
DOI 10.1001/jama.2009.1729

Tomte O, Sunde K, Lorem T, Auestad B, Souders C, Jensen J, Wik L (2009)
Advanced life support performance with manual and mechanical chest compressions in a randomized, multicentre manikin study
Resuscitation, 80 (10), 1152-1157
DOI 10.1016/j.resuscitation.2009.07.001

Publications 2008

Lorem T, Palm A, Wik L (2008)
Impact of a self-instruction CPR kit on 7th graders' and adults' skills and CPR performance
Resuscitation, 79 (1), 103-108
DOI 10.1016/j.resuscitation.2008.04.030

Olasveengen TM, Steen P, Wik L (2008)
Comprehensive evaluation for quality of prehospital CPR - Reply
Resuscitation, 78 (1), 99
DOI 10.1016/j.resuscitation.2007.12.002

Olasveengen TM, Wik L, Steen PA (2008)
Quality of cardiopulmonary resuscitation before and during transport in out-of-hospital cardiac arrest
Resuscitation, 76 (2), 185-190
DOI 10.1016/j.resuscitation.2007.07.001

Pytte M, Dorph E, Sunde K, Kramer-Johansen J, Wik L, Steen PA (2008)
Arterial blood gases during basic life support of human cardiac arrest victims
Resuscitation, 77 (1), 35-38
DOI 10.1016/j.resuscitation.2007.10.005

Stecher FS, Olsen JA, Stickney RE, Wik L (2008)
Transthoracic impedance used to evaluate performance of cardiopulmonary resuscitation during out of hospital cardiac arrest
Resuscitation, 79 (3), 432-437
DOI 10.1016/j.resuscitation.2008.08.007

Publications 2007

Asveengen TM, Wik L, Kramer-Johansen J, Sunde K, Pytte M, Steen PA (2007)
Is CPR quality improving? A retrospective study of out-of-hospital cardiac arrest
Resuscitation, 75 (2), 260-266
DOI 10.1016/j.resuscitation.2007.04.016

Bollig G, Steen PA, Wik L (2007)
Standard versus over-the-head cardiopulmonary resuscitation during simulated advanced life support
Prehosp. Emerg. Care, 11 (4), 443-447
DOI 10.1080/00207450701537050

Grogaard HK, Wik L, Eriksen M, Brekke M, Sunde K (2007)
Continuous mechanical chest compressions during cardiac arrest to facilitate restoration of coronary circulation with percutaneous coronary intervention
J. Am. Coll. Cardiol., 50 (11), 1093-1094
DOI 10.1016/j.jacc.2007.05.028

Kramer-Johansen J, Edelson DP, Abella BS, Becker LB, Wik L, Steen PA (2007)
Pauses in chest compression and inappropriate shocks: A comparison of manual and semi-automatic defibrillation attempts
Resuscitation, 73 (2), 212-220
DOI 10.1016/j.resuscitation.2006.09.006

Odegaard S, Kramer-Johansen J, Bromley A, Myklebust H, Nysaether J, Wik L, Steen PA (2007)
Chest compressions by ambulance personnel on chests with variable stiffness: Abilities and attitudes
Resuscitation, 74 (1), 127-134
DOI 10.1016/j.resuscitation.2006.12.006

Olasveengen TM, Tomlinson AE, Wik L, Sunde K, Steen PA, Myklebust H, Kramer-Johansen J (2007)
A failed attempt to improve quality of out-of-hospital CPR through performance evaluation
Prehosp. Emerg. Care, 11 (4), 427-433
DOI 10.1080/10903120701536628

Publications 2006

Bollig G, Lovhaug SW, Sagen O, Svendsen MV, Steen PA, Wik L (2006)
Airway management by paramedics using endotracheal intubation with a laryngoscope versus the oesophageal tracheal Combitube (TM) and EasyTube (TM) on manikins: A randomised experimental trial
Resuscitation, 71 (1), 107-111
DOI 10.1016/j.resuscitation.2006.02.016

Edelson DP, Abella BS, Kramer-Johansen J, Wik L, Myklebust H, Barry AM, Merchant RM, Hoek TL, Steen PA, Becker LB (2006)
Effects of compression depth and pre-shock pauses predict defibrillation failure during cardiac arrest
Resuscitation, 71 (2), 137-145
DOI 10.1016/j.resuscitation.2006.04.008

Kramer-Johansen J, Myklebust H, Wik L, Fellows B, Svensson L, Sorebo H, Steen PA (2006)
Quality of out-of-hospital cardiopulmonary resuscitation with real time automated feedback: A prospective interventional study
Resuscitation, 71 (3), 283-292
DOI 10.1016/j.resuscitation.2006.05.011

Kramer-Johansen J, Sunde K, Pytte M, Wik L, Steen PA (2006)
Reconfirmation algorithms should be the standard of care in automated external defibrillators
Resuscitation, 70 (3), 474-475
DOI 10.1016/j.resuscitation.2006.04.010

Odegaard S, Saether E, Steen PA, Wik L (2006)
Quality of lay person CPR performance with compression: ventilation ratios 15 : 2, 30 : 2 or continuous chest compressions without ventilations on manikins
Resuscitation, 71 (3), 335-340
DOI 10.1016/j.resuscitation.2006.05.012

Pytte M, Kramer-Johansen J, Eilevstjonn J, Eriksen M, Stromme TA, Godang K, Wik L, Steen PA, Sunde K (2006)
Haemodynamic effects of adrenaline (epinephrine) depend on chest compression quality during cardiopulmonary resuscitation in pigs
Resuscitation, 71 (3), 369-378
DOI 10.1016/j.resuscitation.2006.05.003