Publications 2025

Fragoso-Bargas N, Mcbride NS, Lee-Ødegård S, Lawlor DA, Yousefi PD, Moen GH, Opsahl JO, Jenum AK, Franks PW, Prasad RB, Qvigstad E, Birkeland KI, Richardsen KR, Sommer C (2025)
Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes
BMC Genomics, 26 (1), 62
DOI 10.1186/s12864-025-11262-0, PubMed 39844050

Fragoso-Bargas N, Mcbride NS, Lee-Ødegård S, Lawlor DA, Yousefi PD, Moen GH, Opsahl JO, Jenum AK, Franks PW, Prasad RB, Qvigstad E, Birkeland KI, Richardsen KR, Sommer C (2025)
Correction: Epigenome-wide association study of objectively measured physical activity in peripheral blood leukocytes
BMC Genomics, 26 (1), 142
DOI 10.1186/s12864-025-11311-8, PubMed 39948463

Waage CW, Jenum AK, Mdala I, Lee-Ødegård S, Braend AM, Sletner L, Berg JP, Birkeland KI (2025)
Diabetes and prediabetes among women universally screened for gestational diabetes: a multi-ethnic, population-based, prospective study with eleven years follow-up
BMC Public Health, 25 (1), 1264
DOI 10.1186/s12889-025-22493-x, PubMed 40181282

Publications 2024

Borgen TT, Lee-Ødegård S, Eriksen BF, Eriksen EF (2024)
Intermittent dosing of zoledronic acid based on bone turnover marker assessment reduces vertebral and non-vertebral fractures
JBMR Plus, 8 (7), ziae072
DOI 10.1093/jbmrpl/ziae072, PubMed 38939827

Grannes H, Sharma A, Suntharalingam A, Michelsen AE, Aukrust P, Ueland T, Birkeland KI, Gregersen I, Lee-Ødegård S, Halvorsen B (2024)
Plasma soluble TIM-3 is increased in normoglycemic South Asian women compared to Nordic women after gestational diabetes mellitus and associated with markers of metaflammation
Heliyon, 10 (22), e40339
DOI 10.1016/j.heliyon.2024.e40339, PubMed 39641064

Kvist AAS, Sharma A, Sommer C, Qvigstad E, Gulseth HL, Sollid ST, Nermoen I, Sattar N, Gill J, Tannæs TM, Birkeland KI, Lee-Ødegård S (2024)
Adipose Tissue Insulin Resistance in South Asian and Nordic Women after Gestational Diabetes Mellitus
Metabolites, 14 (5)
DOI 10.3390/metabo14050288, PubMed 38786765

Lee-Ødegård S, Gundersen TE, Drevon CA (2024)
Effect of a plant extract of fenugreek (Trigonella foenum-graecum) on testosterone in blood plasma and saliva in a double blind randomized controlled intervention study
PLoS One, 19 (9), e0310170
DOI 10.1371/journal.pone.0310170, PubMed 39288153

Lee-Ødegård S, Hjorth M, Olsen T, Moen GH, Daubney E, Evans DM, Hevener AL, Lusis AJ, Zhou M, Seldin MM, Allayee H, Hilser J, Viken JK, Gulseth H, Norheim F, Drevon CA, Birkeland KI (2024)
Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis
Elife, 13
DOI 10.7554/eLife.96535, PubMed 39190027

Lee-Ødegård S, Valderhaug T, Myhre PL, Tonstad S (2024)
[Not Available]
Tidsskr Nor Laegeforen, 144
DOI 10.4045/tidsskr.24.0133, PubMed 38738570

Linares-Pineda TM, Fragoso-Bargas N, Picón MJ, Molina-Vega M, Jenum AK, Sletner L, Lee-Ødegård S, Opsahl JO, Moen GH, Qvigstad E, Prasad RB, Birkeland KI, Morcillo S, Sommer C (2024)
DNA methylation risk score for type 2 diabetes is associated with gestational diabetes
Cardiovasc Diabetol, 23 (1), 68
DOI 10.1186/s12933-024-02151-z, PubMed 38350951

Olsen T, Stolt E, Øvrebø B, Elshorbagy A, Tore EC, Lee-Ødegård S, Troensegaard H, Johannessen H, Doeland B, Vo AAD, Dahl AF, Svendsen K, Thoresen M, Refsum H, Rising R, Barvíková K, van Greevenbroek M, Kožich V, Retterstøl K, Vinknes KJ (2024)
Dietary sulfur amino acid restriction in humans with overweight and obesity: a translational randomized controlled trial
J Transl Med, 22 (1), 40
DOI 10.1186/s12967-023-04833-w, PubMed 38195568

Olsen T, Vinknes KJ, Barvíková K, Stolt E, Lee-Ødegård S, Troensegaard H, Johannessen H, Elshorbagy A, Sokolová J, Krijt J, Křížková M, Ditrói T, Nagy P, Øvrebø B, Refsum H, Thoresen M, Retterstøl K, Kožich V (2024)
Dietary sulfur amino acid restriction in humans with overweight and obesity: Evidence of an altered plasma and urine sulfurome, and a novel metabolic signature that correlates with loss of fat mass and adipose tissue gene expression
Redox Biol, 73, 103192
DOI 10.1016/j.redox.2024.103192, PubMed 38776754

Opsahl JO, Fragoso-Bargas N, Lee Y, Carlsen EØ, Lekanova N, Qvigstad E, Sletner L, Jenum AK, Lee-Ødegård S, Prasad RB, Birkeland KI, Moen GH, Sommer C (2024)
Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain
Int J Obes (Lond), 48 (4), 584-593
DOI 10.1038/s41366-024-01458-x, PubMed 38219005

Sharma A, Birkeland KI, Nermoen I, Sommer C, Qvigstad E, Lee-Ødegård S, Sveen KA, Sattar N, Sollid ST, Omland T, Myhre PL (2024)
N-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus
Cardiovasc Diabetol, 23 (1), 284
DOI 10.1186/s12933-024-02349-1, PubMed 39097697

Viken JK, Olsen T, Drevon CA, Hjorth M, Birkeland KI, Norheim F, Lee-Ødegård S (2024)
Intra-Individual Variations in How Insulin Sensitivity Responds to Long-Term Exercise: Predictions by Machine Learning Based on Large-Scale Serum Proteomics
Metabolites, 14 (6)
DOI 10.3390/metabo14060335, PubMed 38921470

Publications 2023

Elshorbagy A, Bastani NE, Lee-Ødegård S, Øvrebø B, Haj-Yasein N, Svendsen K, Turner C, Refsum H, Vinknes KJ, Olsen T (2023)
Correction to: The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression
Amino Acids, 55 (4), 547-548
DOI 10.1007/s00726-023-03244-x, PubMed 36795350

Fragoso-Bargas N, Elliott HR, Lee-Ødegård S, Opsahl JO, Sletner L, Jenum AK, Drevon CA, Qvigstad E, Moen GH, Birkeland KI, Prasad RB, Sommer C (2023)
Cross-Ancestry DNA Methylation Marks of Insulin Resistance in Pregnancy: An Integrative Epigenome-Wide Association Study
Diabetes, 72 (3), 415-426
DOI 10.2337/db22-0504, PubMed 36534481

Fragoso-Bargas N, Page CM, Joubert BR, London SJ, Lee-Ødegård S, Opsahl JO, Sletner L, Jenum AK, Qvigstad E, Prasad RB, Moen GH, Birkeland KI, Sommer C (2023)
Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes
Epigenomics, 15 (1), 39-52
DOI 10.2217/epi-2022-0427, PubMed 36974632

Jersin RÅ, Sri Priyanka Tallapragada D, Skartveit L, Bjune MS, Muniandy M, Lee-Ødegård S, Heinonen S, Alvarez M, Birkeland KI, André Drevon C, Pajukanta P, McCann A, Pietiläinen KH, Claussnitzer M, Mellgren G, Dankel SN (2023)
Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism
J Clin Endocrinol Metab, 108 (9), 2217-2229
DOI 10.1210/clinem/dgad148, PubMed 36916878

Lee S, Norheim F, Langleite TM, Gulseth HL, Birkeland KI, Drevon CA (2023)
Correction to: Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight
Diabetologia, 66 (2), 410
DOI 10.1007/s00125-022-05841-z, PubMed 36445395

Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S et al. (2023)
Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice
Cell Rep, 42 (5), 112499
DOI 10.1016/j.celrep.2023.112499, PubMed 37178122

Sommer C, Vangberg KG, Moen GH, Evans DM, Lee-Ødegård S, Blom-Høgestøl IK, Sletner L, Jenum AK, Drevon CA, Gulseth HL, Birkeland KI (2023)
Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans
J Clin Endocrinol Metab, 108 (5), 1110-1119
DOI 10.1210/clinem/dgac699, PubMed 36459457

Publications 2022

Bjerkreim BA, Hammerstad SS, Gulseth HL, Berg TJ, Lee-Ødegård S, Eriksen EF (2022)
Thyroid Signaling Biomarkers in Female Symptomatic Hypothyroid Patients on Liothyronine versus Levothyroxine Monotherapy: A Randomized Crossover Trial
J Thyroid Res, 2022, 6423023
DOI 10.1155/2022/6423023, PubMed 35572853

Bjerkreim BA, Hammerstad SS, Gulseth HL, Berg TJ, Omdal LJ, Lee-Ødegård S, Eriksen EF (2022)
Effect of Liothyronine Treatment on Quality of Life in Female Hypothyroid Patients With Residual Symptoms on Levothyroxine Therapy: A Randomized Crossover Study
Front Endocrinol (Lausanne), 13, 816566
DOI 10.3389/fendo.2022.816566, PubMed 35273566

Doncheva AI, Romero S, Ramirez-Garrastacho M, Lee S, Kolnes KJ, Tangen DS, Olsen T, Drevon CA, Llorente A, Dalen KT, Hjorth M (2022)
Extracellular vesicles and microRNAs are altered in response to exercise, insulin sensitivity and overweight
Acta Physiol (Oxf), 236 (4), e13862
DOI 10.1111/apha.13862, PubMed 36377504

Elshorbagy A, Bastani NE, Lee-Ødegård S, Øvrebø B, Haj-Yasein N, Svendsen K, Turner C, Refsum H, Vinknes KJ, Olsen T (2022)
The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression
Amino Acids, 55 (3), 313-323
DOI 10.1007/s00726-022-03229-2, PubMed 36542145

Lee-Ødegård S, Olsen T, Norheim F, Drevon CA, Birkeland KI (2022)
Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance
Metabolites, 12 (3)
DOI 10.3390/metabo12030208, PubMed 35323652

Lee-Ødegård S, Ueland T, Thorsby PM, Aukrust P, Michelsen AE, Halvorsen B, Drevon CA, Birkeland KI (2022)
Fetuin-A mediates the difference in adipose tissue insulin resistance between young adult pakistani and norwegian patients with type 2 diabetes
BMC Endocr Disord, 22 (1), 208
DOI 10.1186/s12902-022-01127-y, PubMed 35978354

Sharma A, Lee-Ødegård S, Qvigstad E, Sommer C, Sattar N, Gill JMR, Gulseth HL, Sollid ST, Nermoen I, Birkeland KI (2022)
β-Cell Function, Hepatic Insulin Clearance, and Insulin Sensitivity in South Asian and Nordic Women After Gestational Diabetes Mellitus
Diabetes, 71 (12), 2530-2538
DOI 10.2337/db22-0622, PubMed 36112815

Publications 2021

Bjerkreim BA, Hammerstad SS, Gulseth HL, Berg TJ, Lee-Ødegård S, Rangberg A, Jonassen CM, Budge H, Morris D, Law J, Symonds M, Eriksen EF (2021)
Effect of Liothyronine Treatment on Dermal Temperature and Activation of Brown Adipose Tissue in Female Hypothyroid Patients: A Randomized Crossover Study
Front Endocrinol (Lausanne), 12, 785175
DOI 10.3389/fendo.2021.785175, PubMed 34867829

Bleskestad KB, Nordheim E, Lindahl JP, Midtvedt K, Pihlstrøm HK, Horneland R, Lee S, Åsberg A, Jenssen TG, Birkeland KI (2021)
Insulin secretion and action after pancreas transplantation. A retrospective single-center study
Scand J Clin Lab Invest, 81 (5), 365-370
DOI 10.1080/00365513.2021.1926535, PubMed 34075856

Fragoso-Bargas N, Opsahl JO, Kiryushchenko N, Böttcher Y, Lee-Ødegård S, Qvigstad E, Richardsen KR, Waage CW, Sletner L, Jenum AK, Prasad RB, Groop LC, Moen GH, Birkeland KI, Sommer C (2021)
Cohort profile: Epigenetics in Pregnancy (EPIPREG) - population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes
PLoS One, 16 (8), e0256158
DOI 10.1371/journal.pone.0256158, PubMed 34388220

Tallay E, Lindberg SK, Lee-Ødegård S, Bjordal J, Fraser AN, Madsen JE, Fjalestad T (2021)
External validity in a multicenter randomized clinical trial of proximal humeral fractures: the DelPhi trial
Eur J Orthop Surg Traumatol, 32 (2), 317-323
DOI 10.1007/s00590-021-02982-6, PubMed 33880653

Publications 2020

Hansen AMB, Wium C, Lee S, Tierney AC, McCarthy D, Roche HM, Drevon CA, Birkeland KI, Gulseth HL (2020)
Substantial inter-individual variations in insulin secretion and sensitivity across the glucometabolic spectrum
Scand J Clin Lab Invest, 80 (4), 282-290
DOI 10.1080/00365513.2020.1730433, PubMed 32134347

Lee S, Gulseth HL, Langleite TM, Norheim F, Olsen T, Refsum H, Jensen J, Birkeland KI, Drevon CA (2020)
Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men
Diabetologia, 64 (2), 410-423
DOI 10.1007/s00125-020-05296-0, PubMed 33123769

Lee Y, Haftorn KL, Denault WRP, Nustad HE, Page CM, Lyle R, Lee-Ødegård S, Moen GH, Prasad RB, Groop LC, Sletner L, Sommer C, Magnus MC, Gjessing HK, Harris JR, Magnus P, Håberg SE, Jugessur A, Bohlin J (2020)
Blood-based epigenetic estimators of chronological age in human adults using DNA methylation data from the Illumina MethylationEPIC array
BMC Genomics, 21 (1), 747
DOI 10.1186/s12864-020-07168-8, PubMed 33109080

Olsen T, Øvrebø B, Haj-Yasein N, Lee S, Svendsen K, Hjorth M, Bastani NE, Norheim F, Drevon CA, Refsum H, Vinknes KJ (2020)
Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study
J Transl Med, 18 (1), 122
DOI 10.1186/s12967-020-02288-x, PubMed 32160926

Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M et al. (2020)
Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling
Sci Transl Med, 12 (555)
DOI 10.1126/scitranslmed.aax8096, PubMed 32759275

Publications 2019

Blakstad EW, Korpela K, Lee S, Nakstad B, Moltu SJ, Strømmen K, Rønnestad AE, Brække K, Iversen PO, de Vos WM, Drevon CA (2019)
Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants
Pediatr Res, 86 (3), 323-332
DOI 10.1038/s41390-019-0412-x, PubMed 31086354

Lee S, Kolset SO, Birkeland KI, Drevon CA, Reine TM (2019)
Acute exercise increases syndecan-1 and -4 serum concentrations
Glycoconj J, 36 (2), 113-125
DOI 10.1007/s10719-019-09869-z, PubMed 30949875

Lee S, Norheim F, Langleite TM, Gulseth HL, Birkeland KI, Drevon CA (2019)
Effects of long-term exercise on plasma adipokine levels and inflammation-related gene expression in subcutaneous adipose tissue in sedentary dysglycaemic, overweight men and sedentary normoglycaemic men of healthy weight
Diabetologia, 62 (6), 1048-1064
DOI 10.1007/s00125-019-4866-5, PubMed 31011777

Publications 2018

Lee S, Norheim F, Gulseth HL, Langleite TM, Aker A, Gundersen TE, Holen T, Birkeland KI, Drevon CA (2018)
Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men
Sci Rep, 8 (1), 6531
DOI 10.1038/s41598-018-24976-x, PubMed 29695812

Lee S, Norheim F, Gulseth HL, Langleite TM, Aker A, Gundersen TE, Holen T, Birkeland KI, Drevon CA (2018)
Author Correction: Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men
Sci Rep, 8 (1), 7885
DOI 10.1038/s41598-018-26061-9, PubMed 29760520

Lee S, Olsen T, Vinknes KJ, Refsum H, Gulseth HL, Birkeland KI, Drevon CA (2018)
Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men
Nutrients, 11 (1)
DOI 10.3390/nu11010010, PubMed 30577516

Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL (2018)
The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle
Mol Metab, 21, 51-67
DOI 10.1016/j.molmet.2018.11.012, PubMed 30591411

Sommer C, Lee S, Gulseth HL, Jensen J, Drevon CA, Birkeland KI (2018)
Soluble Leptin Receptor Predicts Insulin Sensitivity and Correlates With Upregulation of Metabolic Pathways in Men
J Clin Endocrinol Metab, 103 (3), 1024-1032
DOI 10.1210/jc.2017-02126, PubMed 29300960

Publications 2017

Lee S, Norheim F, Gulseth HL, Langleite TM, Kolnes KJ, Tangen DS, Stadheim HK, Gilfillan GD, Holen T, Birkeland KI, Jensen J, Drevon CA (2017)
Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise
Physiol Rep, 5 (5)
DOI 10.14814/phy2.13183, PubMed 28270597

Pourteymour S, Eckardt K, Holen T, Langleite T, Lee S, Jensen J, Birkeland KI, Drevon CA, Hjorth M (2017)
Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines
Mol Metab, 6 (4), 352-365
DOI 10.1016/j.molmet.2017.01.007, PubMed 28377874

Pourteymour S, Hjorth M, Lee S, Holen T, Langleite TM, Jensen J, Birkeland KI, Drevon CA, Eckardt K (2017)
Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise
Physiol Rep, 5 (19)
DOI 10.14814/phy2.13459, PubMed 28989118

Publications 2016

Lee S, Norheim F, Langleite TM, Noreng HJ, Storås TH, Afman LA, Frost G, Bell JD, Thomas EL, Kolnes KJ, Tangen DS, Stadheim HK, Gilfillan GD, Gulseth HL, Birkeland KI, Jensen J, Drevon CA, Holen T, NutriTech Consortium (2016)
Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging
Physiol Rep, 4 (21)
DOI 10.14814/phy2.13019, PubMed 27821717

Publications 2015

Albrecht E, Norheim F, Thiede B, Holen T, Ohashi T, Schering L, Lee S, Brenmoehl J, Thomas S, Drevon CA, Erickson HP, Maak S (2015)
Irisin - a myth rather than an exercise-inducible myokine
Sci Rep, 5, 8889
DOI 10.1038/srep08889, PubMed 25749243

Hjorth M, Norheim F, Meen AJ, Pourteymour S, Lee S, Holen T, Jensen J, Birkeland KI, Martinov VN, Langleite TM, Eckardt K, Drevon CA, Kolset SO (2015)
The effect of acute and long-term physical activity on extracellular matrix and serglycin in human skeletal muscle
Physiol Rep, 3 (8)
DOI 10.14814/phy2.12473, PubMed 26290530

Pourteymour S, Lee S, Langleite TM, Eckardt K, Hjorth M, Bindesbøll C, Dalen KT, Birkeland KI, Drevon CA, Holen T, Norheim F (2015)
Perilipin 4 in human skeletal muscle: localization and effect of physical activity
Physiol Rep, 3 (8)
DOI 10.14814/phy2.12481, PubMed 26265748

Publications 2014

Kanzleiter T, Rath M, Görgens SW, Jensen J, Tangen DS, Kolnes AJ, Kolnes KJ, Lee S, Eckel J, Schürmann A, Eckardt K (2014)
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Biochem Biophys Res Commun, 450 (2), 1089-94
DOI 10.1016/j.bbrc.2014.06.123, PubMed 24996176

Li Y, Lee S, Langleite T, Norheim F, Pourteymour S, Jensen J, Stadheim HK, Storås TH, Davanger S, Gulseth HL, Birkeland KI, Drevon CA, Holen T (2014)
Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention
Physiol Rep, 2 (11)
DOI 10.14814/phy2.12187, PubMed 25413318

Norheim F, Hjorth M, Langleite TM, Lee S, Holen T, Bindesbøll C, Stadheim HK, Gulseth HL, Birkeland KI, Kielland A, Jensen J, Dalen KT, Drevon CA (2014)
Regulation of angiopoietin-like protein 4 production during and after exercise
Physiol Rep, 2 (8)
DOI 10.14814/phy2.12109, PubMed 25138789