Olav Sundnes

  • Senior dermatologist, Associate Professor, Research group leader; MD, PhD

Research topics: Atopic dermatitis, immunology, keratinocyte biology, Sturge-Weber syndrome

 

Publications 2021

Fjaer R, Marciniak K, Sundnes O, Hjorthaug H, Sheng Y, Hammarstrom C, Sitek JC, Vigeland MD, Backe PH, Oye AM, Fosse JH, Stav-Noraas TE, Uchiyama Y, Matsumoto N, Comi A, Pevsner J, Haraldsen G, Selmer KK (2021)
A novel somatic mutation in GNB2 provides new insights to the pathogenesis of Sturge-Weber syndrome
Hum. Mol. Genet., 30 (21), 1919-1931
DOI 10.1093/hmg/ddab144

Gatti F, Mia S, Hammarstrom C, Frerker N, Fosby B, Wang JB, Pietka W, Sundnes O, Hol J, Kasprzycka M, Haraldsen G (2021)
Nuclear IL-33 restrains the early conversion of fibroblasts to an extracellular matrix-secreting phenotype
Sci Rep, 11 (1), 108
DOI 10.1038/s41598-020-80509-5

Gjersvik P, Sundnes O (2021)
This is how biological drugs get their name
Tidsskr. Nor. Laegeforen., 141 (3), 284-285

Lossius AH, Berents TL, Saetre F, Nilsen HR, Bradley M, Asad S, Haraldsen G, Sundnes O, Holm JO (2021)
Early transcriptional changes after UVB treatment in atopic dermatitis includes inverse regulation of IL-36 gamma and IL-37
Exp. Dermatol., 30 (2), 249-261
DOI 10.1111/exd.14217

Lossius AH, Sundnes O, Ingham AC, Edslev SM, Bjornholt JV, Lilje B, Bradley M, Asad S, Haraldsen G, Skytt-Andersen P, Holm JO, Berents TL (2021)
Shifts in the Skin Microbiota after UVB Treatment in Adult Atopic Dermatitis
Dermatology
DOI 10.1159/000515236

Nast A, Smith C, Spuls PI, Valle GA, Bata-Csorgo Z, Boonen H, De Jong E, Garcia-Doval I, Gisondi P, Kaur-Knudsen D, Mahil S, Malkonen T, Maul JT, Mburu S, Mrowietz U, Reich K, Remenyik E, Ronholt KM, Sator PG, Schmitt-Egenolf M, Sikora M, Stromer K, Sundnes O, Trigos D, Van der Kraaij G et al. (2021)
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations
J. Eur. Acad. Dermatol. Venereol., 35 (2), 281-317
DOI 10.1111/jdv.16926

Sundnes O, Ottestad W, Schjalm C, Lundback P, Poulsen LL, Mollnes TE, Haraldsen G, Eken T (2021)
Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study
Mol. Med., 27 (1), 29
DOI 10.1186/s10020-021-00288-1

Publications 2020

Nast A, Smith C, Spuls PI, Valle GA, Bata-Csorgo Z, Boonen H, De Jong E, Garcia-Doval I, Gisondi P, Kaur-Knudsen D, Mahil S, Malkonen T, Maul JT, Mburu S, Mrowietz U, Reich K, Remenyik E, Ronholt KM, Sator PG, Schmitt-Egenolf M, Sikora M, Stromer K, Sundnes O, Trigos D, Van der Kraaij G et al. (2020)
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 1: treatment and monitoring recommendations
J. Eur. Acad. Dermatol. Venereol., 34 (11), 2461-2498
DOI 10.1111/jdv.16915

Pietka W, Sundnes O, Hammarstrom C, Zucknick M, Khnykin D, Haraldsen G (2020)
Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice
Sci Rep, 10 (1), 6451
DOI 10.1038/s41598-020-63410-z

Publications 2019

Pietka W, Khnykin D, Bertelsen V, Lossius AH, Stav-Noraas TE, Fosse JH, Galtung HK, Haraldsen G, Sundnes O (2019)
Hypo-osmotic Stress Drives IL-33 Production in Human Keratinocytes-An Epidermal Homeostatic Response
J. Invest. Dermatol., 139 (1), 81-90
DOI 10.1016/j.jid.2018.07.023

Publications 2018

Poulsen LL, Edelmann RJ, Kruger S, Dieguez-Hurtado R, Shah A, Stav-Noraas TE, Renzi A, Szymanska M, Wang JB, Ehling M, Benedito R, Kasprzycka M, Baekkevold E, Sundnes O, Midwood KS, Scott H, Collas P, Siebel CW, Adams RH, Haraldsen G, Sundlisaeter E, Hol J (2018)
Inhibition of Endothelial NOTCH1 Signaling Attenuates Inflammation by Reducing Cytokine-Mediated Histone Acetylation at Inflammatory Enhancers
Arterioscler. Thromb. Vasc. Biol., 38 (4), 854-869
DOI 10.1161/ATVBAHA.117.310388

Publications 2017

Ngcungcu T, Oti M, Sitek JC, Haukanes BI, Linghu B, Bruccoleri R, Stokowy T, Oakeley EJ, Yang F, Zhu J, Sultan M, Schalkwijk J, van Vlijmen-Willems IMJJ, von der Lippe C, Brunner HG, Ersland KM, Grayson W, Buechmann-Moller S, Sundnes O, Nirmala N, Morgan TM, van Bokhoven H, Steen VM, Hull PR, Szustakowski J et al. (2017)
Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families
Am. J. Hum. Genet., 100 (5), 737-750
DOI 10.1016/j.ajhg.2017.03.012

Stav-Noraas TE, Edelmann RJ, Poulsen LL, Sundnes O, Phung D, Kuchler AM, Muller F, Kamen AA, Haraldsen G, Kaarbo M, Hol J (2017)
Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery
J. Immunol., 198 (8), 3318-3325
DOI 10.4049/jimmunol.1600054

Publications 2016

Gundersen MD, Goll R, Hol J, Olsen T, Rismo R, Sorbye SW, Sundnes O, Haraldsen G, Florholmen J (2016)
Loss of interleukin 33 expression in colonic crypts - a potential marker for disease remission in ulcerative colitis
Sci Rep, 6, 35403
DOI 10.1038/srep35403

Publications 2015

Schrumpf E, Tan C, Karlsen TH, Sponheim J, Bjorkstrom NK, Sundnes O, Alfsnes K, Kaser A, Jefferson DM, Ueno Y, Eide TJ, Haraldsen G, Zeissig S, Exley MA, Blumberg RS, Melum E (2015)
The biliary epithelium presents antigens to and activates natural killer T cells
Hepatology, 62 (4), 1249-1259
DOI 10.1002/hep.27840

Sundnes O, Pietka W, Loos T, Sponheim J, Rankin AL, Pflanz S, Bertelsen V, Sitek JC, Hol J, Haraldsen G, Khnykin D (2015)
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences
J. Invest. Dermatol., 135 (7), 1771-1780
DOI 10.1038/jid.2015.85

Publications 2014

Tveita AA, Schjesvold FH, Sundnes O, Haabeth OAW, Haraldsen G, Bogen B (2014)
Indirect CD4(+) T-cell-mediated elimination of MHC IINEG tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells
Eur. J. Immunol., 44 (9), 2625-2637
DOI 10.1002/eji.201444659

Publications 2013

Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skanland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang JB, Kuchler AM, Tasken K, Haraldsen G, Hol J (2013)
Interleukin-33 Drives a Proinflammatory Endothelial Activation That Selectively Targets Nonquiescent Cells
Arterioscler. Thromb. Vasc. Biol., 33 (2), E47-+
DOI 10.1161/ATVBAHA.112.253427