Knut Erik Hovda
- Consultant; MD, PhD
- +47 23 01 59 22
Publications 2024
Can endogenous ethylene glycol production occur in humans? A detailed investigation of adult monozygotic twin sisters
Clin Toxicol (Phila), 1-9 (in press)
DOI 10.1080/15563650.2024.2401076, PubMed 39327950
Antidotes for poisoning by alcohols that form toxic metabolites
Br J Clin Pharmacol (in press)
DOI 10.1111/bcp.16232, PubMed 39234820
Clinical effects of cannabis compared to synthetic cannabinoid receptor agonists (SCRAs): a retrospective cohort study of presentations with acute toxicity to European hospitals between 2013 and 2020
Clin Toxicol (Phila), 62 (6), 378-384
DOI 10.1080/15563650.2024.2346125, PubMed 38934347
Publications 2023
Determinants of Admission to Critical Care Following Acute Recreational Drug Toxicity: A Euro-DEN Plus Study
J Clin Med, 12 (18)
DOI 10.3390/jcm12185970, PubMed 37762912
[The Norwegian Poisons Information Centre provides safe treatment and saves lives]
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.22.0816, PubMed 36718899
Self-discharge during treatment for acute recreational drug toxicity: an observational study from emergency departments in seven European countries
Int J Emerg Med, 16 (1), 86
DOI 10.1186/s12245-023-00566-1, PubMed 38030969
Publications 2022
Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review
Clin Toxicol (Phila), 60 (7), 784-797
DOI 10.1080/15563650.2022.2049810, PubMed 35311442
Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014-2019
Clin Toxicol (Phila), 60 (12), 1318-1327
DOI 10.1080/15563650.2022.2137524, PubMed 36322684
Poisoning with central stimulant drugs: an observational study from Oslo, Norway
Int J Emerg Med, 15 (1), 54
DOI 10.1186/s12245-022-00457-x, PubMed 36175843
An enzymatic assay with formate oxidase for point-of-care diagnosis of methanol poisoning
Basic Clin Pharmacol Toxicol, 131 (6), 547-554
DOI 10.1111/bcpt.13789, PubMed 36083569
A cross-sectional multicenter linkage study of hospital admissions and mortality due to methanol poisoning in Iranian adults during the COVID-19 pandemic
Sci Rep, 12 (1), 9741
DOI 10.1038/s41598-022-14007-1, PubMed 35697919
Severity of emergency department presentations due to acute drug toxicity in Europe: a longitudinal analysis over a 6-year period (2014-2019) stratified by sex
Eur J Emerg Med, 30 (1), 21-31
DOI 10.1097/MEJ.0000000000000978, PubMed 36350710
The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures
Clin Toxicol (Phila), 60 (7), 798-807
DOI 10.1080/15563650.2022.2049811, PubMed 35323087
Peppermint protocol: first results for gas chromatography-ion mobility spectrometry
J Breath Res, 16 (3)
DOI 10.1088/1752-7163/ac6ca0, PubMed 35508103
Differences in clinical features associated with cannabis intoxication in presentations to European emergency departments according to patient age and sex
Clin Toxicol (Phila), 60 (8), 912-919
DOI 10.1080/15563650.2022.2060116, PubMed 35404194
Publications 2021
Osmolal and anion gaps after acute self-poisoning with agricultural formulations of the organophosphorus insecticides profenofos and diazinon: A pilot study
Basic Clin Pharmacol Toxicol, 130 (2), 320-327
DOI 10.1111/bcpt.13686, PubMed 34796663
Substances, poisonings and A&E clinics
Tidsskr Nor Laegeforen, 141 (7)
DOI 10.4045/tidsskr.21.0133, PubMed 33950646
Formate test for bedside diagnosis of methanol poisoning
Basic Clin Pharmacol Toxicol, 129 (1), 86-88
DOI 10.1111/bcpt.13597, PubMed 33915025
A survey of the antidote preparedness in Norwegian hospitals
Eur J Hosp Pharm, 29 (6), 319-323
DOI 10.1136/ejhpharm-2020-002544, PubMed 33483361
Fomepizole dosing during continuous renal replacement therapy - an observational study
Clin Toxicol (Phila), 60 (4), 451-457
DOI 10.1080/15563650.2021.1980581, PubMed 34585641
Impact of pregabalin co-use in patients presenting with acute heroin toxicity to the European Drug Emergencies Network Plus project
Eur J Emerg Med, 28 (2), 144-146
DOI 10.1097/MEJ.0000000000000738, PubMed 33674514
Variation of drugs involved in acute drug toxicity presentations based on age and sex: an epidemiological approach based on European emergency departments
Clin Toxicol (Phila), 59 (10), 896-904
DOI 10.1080/15563650.2021.1884693, PubMed 33724118
Rhabdomyolysis related to acute recreational drug toxicity-A Euro-DEN study
PLoS One, 16 (3), e0246297
DOI 10.1371/journal.pone.0246297, PubMed 33705425
Publications 2020
Ventilatory support for hypoxaemic intensive care patients with COVID-19
Tidsskr Nor Laegeforen, 140 (11)
DOI 10.4045/tidsskr.20.0445, PubMed 32815344
[T.M. Gundem and colleagues respond]
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0650, PubMed 32900164
Double trouble: methanol outbreak in the wake of the COVID-19 pandemic in Iran-a cross-sectional assessment
Crit Care, 24 (1), 402
DOI 10.1186/s13054-020-03140-w, PubMed 32646475
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes
Basic Clin Pharmacol Toxicol, 127 (1), 47-51
DOI 10.1111/bcpt.13389, PubMed 31977139
Acute toxicity related to misuse (nonmedical use) of tramadol: Experience of the European Drug Emergencies Network Plus
Br J Clin Pharmacol, 87 (4), 1668-1675
DOI 10.1111/bcp.14408, PubMed 32503085
MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014-2017
Clin Toxicol (Phila), 59 (2), 131-137
DOI 10.1080/15563650.2020.1784914, PubMed 32677861
Publications 2019
Clinical relevance of ethanol coingestion in patients with GHB/GBL intoxication
Toxicol Lett, 314, 37-42
DOI 10.1016/j.toxlet.2019.07.001, PubMed 31301370
Consensus statements on the approach to patients in a methanol poisoning outbreak
Clin Toxicol (Phila), 57 (12), 1129-1136
DOI 10.1080/15563650.2019.1636992, PubMed 31328583
Methanol content in homemade alcohol from a province in North Vietnam
Drug Alcohol Rev, 38 (5), 537-542
DOI 10.1111/dar.12937, PubMed 31095796
Epidemiology, clinical features and management of patients presenting to European emergency departments with acute cocaine toxicity: comparison between powder cocaine and crack cocaine cases
Clin Toxicol (Phila), 57 (8), 718-726
DOI 10.1080/15563650.2018.1549735, PubMed 30696283
Gender differences in acute recreational drug toxicity: a case series from Oslo, Norway
BMC Emerg Med, 19 (1), 29
DOI 10.1186/s12873-019-0244-3, PubMed 31035940
Seizures as a complication of recreational drug use: Analysis of the Euro-DEN Plus data-set
Neurotoxicology, 73, 183-187
DOI 10.1016/j.neuro.2019.04.003, PubMed 30974132
Poor Identification of Emergency Department Acute Recreational Drug Toxicity Presentations Using Routine Hospital Coding Systems: the Experience in Denmark, Switzerland and the UK
J Med Toxicol, 15 (2), 112-120
DOI 10.1007/s13181-018-0687-z, PubMed 30603897
Publications 2018
The Hypothesis of Circulus Hypoxicus and Its Clinical Relevance in Patients With Methanol Poisoning - An Observational Study of 35 Patients
Basic Clin Pharmacol Toxicol, 123 (6), 749-755
DOI 10.1111/bcpt.13074, PubMed 29923671
Acute recreational drug toxicity: Comparison of self-reports and results of immunoassay and additional analytical methods in a multicenter European case series
Medicine (Baltimore), 97 (5), e9784
DOI 10.1097/MD.0000000000009784, PubMed 29384873
Presentations to the emergency department with non-medical use of benzodiazepines and Z-drugs: profiling and relation to sales data
Eur J Clin Pharmacol, 75 (1), 77-85
DOI 10.1007/s00228-018-2550-1, PubMed 30244371
Emergencies related to recreational drug abuse in Spain compared to emergencies attended in 3 European areas
Emergencias, 30 (6), 385-394
PubMed 30638341
Concurrent Use of Benzodiazepine by Heroin Users-What Are the Prevalence and the Risks Associated with This Pattern of Use?
J Med Toxicol, 15 (1), 4-11
DOI 10.1007/s13181-018-0674-4, PubMed 30066312
Publications 2017
Intoxication by gamma hydroxybutyrate and related analogues: Clinical characteristics and comparison between pure intoxication and that combined with other substances of abuse
Toxicol Lett, 277, 84-91
DOI 10.1016/j.toxlet.2017.05.030, PubMed 28579487
Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway
Clin Toxicol (Phila), 55 (7), 636-644
DOI 10.1080/15563650.2017.1312002, PubMed 28406320
Reply to "Letter in response to efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning"
Clin Toxicol (Phila), 55 (4), 306-307
DOI 10.1080/15563650.2017.1284338, PubMed 28206824
Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks
Ann Intensive Care, 7 (1), 77
DOI 10.1186/s13613-017-0300-7, PubMed 28730555
Publications 2016
Antidotes for poisoning by alcohols that form toxic metabolites
Br J Clin Pharmacol, 81 (3), 505-15
DOI 10.1111/bcp.12824, PubMed 26551875
The Methanol Poisoning Outbreaks in Libya 2013 and Kenya 2014
PLoS One, 11 (3), e0152676
DOI 10.1371/journal.pone.0152676, PubMed 27030969
Correction: The Methanol Poisoning Outbreaks in Libya 2013 and Kenya 2014
PLoS One, 11 (6), e0157256
DOI 10.1371/journal.pone.0157256, PubMed 27257672
Psychosis associated with acute recreational drug toxicity: a European case series
BMC Psychiatry, 16, 293
DOI 10.1186/s12888-016-1002-7, PubMed 27538886
Erratum to: Psychosis associated with acute recreational drug toxicity: a European case series
BMC Psychiatry, 16 (1), 405
DOI 10.1186/s12888-016-1066-4, PubMed 27852244
Review of European- Drug Emergencies Network ( Euro- DEN) training package for non- specialist workers to assess acute recreational drug and new psychoactive substance toxicity in night- time economy environments
Drug-Educ. Prev. Policy, 23 (1), 73-77
DOI 10.3109/09687637.2015.1081379
Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning
Clin Toxicol (Phila), 55 (2), 123-132
DOI 10.1080/15563650.2016.1250901, PubMed 27817225
Use of Out-of-Hospital Ethanol Administration to Improve Outcome in Mass Methanol Outbreaks
Ann Emerg Med, 68 (1), 52-61
DOI 10.1016/j.annemergmed.2016.01.010, PubMed 26875060
Publications 2015
A young woman who drank Strep test reagents
Tidsskr Nor Laegeforen, 135 (22), 2067-70
DOI 10.4045/tidsskr.15.0190, PubMed 26627296
Presentations to the Emergency Department Following Cannabis use--a Multi-Centre Case Series from Ten European Countries
J Med Toxicol, 11 (4), 415-21
DOI 10.1007/s13181-014-0460-x, PubMed 25652342
Acute recreational drug and new psychoactive substance toxicity in Europe: 12 months data collection from the European Drug Emergencies Network (Euro-DEN)
Clin Toxicol (Phila), 53 (9), 893-900
DOI 10.3109/15563650.2015.1088157, PubMed 26503789
A novel bedside diagnostic test for methanol poisoning using dry chemistry for formate
Scand J Clin Lab Invest, 75 (7), 610-4
DOI 10.3109/00365513.2015.1066847, PubMed 26203958
Long-term visual damage after acute methanol poisonings: Longitudinal cross-sectional study in 50 patients
Clin Toxicol (Phila), 53 (9), 884-92
DOI 10.3109/15563650.2015.1086488, PubMed 26364866
Fomepizole versus ethanol in the treatment of acute methanol poisoning: Comparison of clinical effectiveness in a mass poisoning outbreak
Clin Toxicol (Phila), 53 (8), 797-806
DOI 10.3109/15563650.2015.1059946, PubMed 26109326
Publications 2014
Current European data collection on emergency department presentations with acute recreational drug toxicity: gaps and national variations
Clin Toxicol (Phila), 52 (10), 1005-12
DOI 10.3109/15563650.2014.976792, PubMed 25361166
The European Drug Emergencies Network (Euro-DEN)
Clin Toxicol (Phila), 52 (4), 239-41
DOI 10.3109/15563650.2014.898771, PubMed 24654801
Intermittent hemodialysis is superior to continuous veno-venous hemodialysis/hemodiafiltration to eliminate methanol and formate during treatment for methanol poisoning
Kidney Int, 86 (1), 199-207
DOI 10.1038/ki.2014.60, PubMed 24621917
Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features
Clin Toxicol (Phila), 52 (10), 1013-24
DOI 10.3109/15563650.2014.974106, PubMed 25345388
Publications 2013
Pre-hospital management and outcome of acute poisonings by ambulances in Yekaterinburg, Russia
Clin Toxicol (Phila), 51 (8), 752-60
DOI 10.3109/15563650.2013.827707, PubMed 23937527
Five-year mortality after acute poisoning treated in ambulances, an emergency outpatient clinic and hospitals in Oslo
Scand J Trauma Resusc Emerg Med, 21, 65
DOI 10.1186/1757-7241-21-65, PubMed 23965589
Response to the letter "Risk assessment of methanol poisoning in outbreaks not applicable to isolated cases"
Clin Toxicol (Phila), 51 (2), 120
DOI 10.3109/15563650.2013.764430, PubMed 23339630
Publications 2012
A one-year observational study of all hospitalized acute poisonings in Oslo: complications, treatment and sequelae
Scand J Trauma Resusc Emerg Med, 20, 49
DOI 10.1186/1757-7241-20-49, PubMed 22828054
A one-year observational study of all hospitalized and fatal acute poisonings in Oslo: epidemiology, intention and follow-up
BMC Public Health, 12, 858
DOI 10.1186/1471-2458-12-858, PubMed 23046743
Outpatient treatment of acute poisonings in Oslo: poisoning pattern, factors associated with hospitalization, and mortality
Scand J Trauma Resusc Emerg Med, 20, 1
DOI 10.1186/1757-7241-20-1, PubMed 22217253
Risk factors related to poor outcome after methanol poisoning and the relation between outcome and antidotes--a multicenter study
Clin Toxicol (Phila), 50 (9), 823-31
DOI 10.3109/15563650.2012.728224, PubMed 22992104
Publications 2011
Studies on ethylene glycol poisoning: one patient - 154 admissions
Clin Toxicol (Phila), 49 (6), 478-84
DOI 10.3109/15563650.2011.590140, PubMed 21824058
[Living conditions and pattern of acute poisonings in Oslo]
Tidsskr Nor Laegeforen, 131 (15), 1424-8
DOI 10.4045/tidsskr.10.0531, PubMed 21844943
Publications 2010
Suicidal intention, psychosocial factors and referral to further treatment: a one-year cross-sectional study of self-poisoning
BMC Psychiatry, 10, 58
DOI 10.1186/1471-244X-10-58, PubMed 20653986
Fatal poisonings in Oslo: a one-year observational study
BMC Emerg Med, 10, 13
DOI 10.1186/1471-227X-10-13, PubMed 20525396
Publications 2009
Repetition of acute poisoning in Oslo: 1-year prospective study
Br J Psychiatry, 194 (1), 73-9
DOI 10.1192/bjp.bp.107.048322, PubMed 19118331
Renal toxicity of ethylene glycol results from internalization of calcium oxalate crystals by proximal tubule cells
Toxicol Lett, 192 (3), 365-72
DOI 10.1016/j.toxlet.2009.11.013, PubMed 19931368
Methanol poisoning and long term sequelae - a six years follow-up after a large methanol outbreak
BMC Clin Pharmacol, 9, 5
DOI 10.1186/1472-6904-9-5, PubMed 19327138
Publications 2008
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (II): clinical outcome
Clin Toxicol (Phila), 46 (1), 42-9
DOI 10.1080/15563650701210048, PubMed 18167036
Clinical assessment compared to laboratory screening in acutely poisoned patients
Hum Exp Toxicol, 27 (1), 73-9
DOI 10.1177/0960327107087800, PubMed 18480152
Pre-hospital treatment of acute poisonings in Oslo
BMC Emerg Med, 8, 15
DOI 10.1186/1471-227X-8-15, PubMed 19025643
Acute poisonings treated in hospitals in Oslo: a one-year prospective study (I): pattern of poisoning
Clin Toxicol (Phila), 46 (1), 35-41
DOI 10.1080/15563650601185969, PubMed 18167035
Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning
Hum Exp Toxicol, 27 (7), 539-46
DOI 10.1177/0960327108095992, PubMed 18829729
Publications 2007
Extremely slow formate elimination in severe methanol poisoning: a fatal case report
Clin Toxicol (Phila), 45 (5), 516-21
DOI 10.1080/15563650701354150, PubMed 17503258
Methanol mass poisoning in Estonia: outbreak in 154 patients
Clin Toxicol (Phila), 45 (2), 152-7
DOI 10.1080/15563650600956329, PubMed 17364632
Acute child poisonings in Oslo: a 2-year prospective study
Acta Paediatr, 96 (9), 1355-9
DOI 10.1111/j.1651-2227.2007.00420.x, PubMed 17718791
Publications 2006
Clinical vs. laboratory identification of drugs of abuse in patients admitted for acute poisoning
Clin Toxicol (Phila), 44 (2), 127-34
DOI 10.1080/15563650500514384, PubMed 16615667
Use of the osmolal gap to guide the start and duration of dialysis in methanol poisoning
Scand J Urol Nephrol, 40 (1), 70-4
DOI 10.1080/00365590500190755, PubMed 16452060
Publications 2005
Methanol poisoning: clinical features, diagnosis, treatment and prognosis
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 315, 1 b. (flere pag.)
BIBSYS 051507005, ISBN 82-8080-148-0
Methanol and formate kinetics during treatment with fomepizole
Clin Toxicol (Phila), 43 (4), 221-7
PubMed 16035197
Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases
Clin Nephrol, 64 (3), 190-7
DOI 10.5414/cnp64190, PubMed 16175943
Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs
J Intern Med, 258 (2), 181-90
DOI 10.1111/j.1365-2796.2005.01521.x, PubMed 16018795
Increased serum formate in the diagnosis of methanol poisoning
J Anal Toxicol, 29 (6), 586-8
DOI 10.1093/jat/29.6.586, PubMed 16168185
Publications 2004
Anion and osmolal gaps in the diagnosis of methanol poisoning: clinical study in 28 patients
Intensive Care Med, 30 (9), 1842-6
DOI 10.1007/s00134-004-2373-7, PubMed 15241587
[Diagnosis in metabolic acidosis of unknown origin]
Tidsskr Nor Laegeforen, 124 (24), 3203-5
PubMed 15608766
[Methanol poisoning in Norway 2002]
Tidsskr Nor Laegeforen, 124 (24), 3199-202
PubMed 15608765
Publications 2003
Conventional and diffusion-weighted MRI in the evaluation of methanol poisoning
Acta Radiol, 44 (6), 691-5
DOI 10.1080/02841850312331287779, PubMed 14616218
Publications 1998
[Gamma-hydroxybutyrate--an endogenous substance and an intoxicant]
Tidsskr Nor Laegeforen, 118 (28), 4390-3
PubMed 9889613
[Ecstasy--cool dope with long-lasting effects?]
Tidsskr Nor Laegeforen, 118 (28), 4384-7
PubMed 9889612