Paul Hoff Backe

  • Postdoc PhD
Structure group
 

Publications 2019

Rydning SL, Koht J, Sheng Y, Sowa P, Hjorthaug HS, Wedding IM, Erichsen AK, Hovden IA, Backe PH, Tallaksen CME, Vigeland MD, Selmer KK (2019)
Biallelic POLR3A variants confirmed as a frequent cause of hereditary ataxia and spastic paraparesis
Brain, 142 (4), e12
DOI 10.1093/brain/awz041, PubMed 30847471

Publications 2018

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe PH, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, Loon BV (2018)
Publisher Correction: Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep, 8 (1), 6010
DOI 10.1038/s41598-018-24189-2, PubMed 29651030

Makrythanasis P, Maroofian R, Stray-Pedersen A, Musaev D, Zaki MS, Mahmoud IG, Selim L, Elbadawy A, Jhangiani SN, Coban Akdemir ZH, Gambin T, Sorte HS, Heiberg A, McEvoy-Venneri J, James KN, Stanley V, Belandres D, Guipponi M, Santoni FA, Ahangari N, Tara F, Doosti M, Iwaszkiewicz J, Zoete V, Backe PH et al. (2018)
Biallelic variants in KIF14 cause intellectual disability with microcephaly
Eur J Hum Genet, 26 (3), 330-339
DOI 10.1038/s41431-017-0088-9, PubMed 29343805

Publications 2017

Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe PH, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B (2017)
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep, 7 (1), 15050
DOI 10.1038/s41598-017-15380-y, PubMed 29118367

Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK (2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1031-1040
DOI 10.1093/hmg/ddw391, PubMed 28007905

Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK (2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1217-1218
DOI 10.1093/hmg/ddx072, PubMed 28334853

Publications 2016

Jaradat SA, Al-Qa'qa' K, Amayreh W, Backe PH, Al-Hawamdeh A, Karam M, Alzoubi B, Deebajah H, Al Rababah B (2016)
Molecular analysis of maple syrup urine disease in Jordanian families
Meta Gene, 10, 81-85

Jaradat SA, Jubran B, Alzoubi F, Backe PH, Bader HM, Haddad H (2016)
Molecular Analysis of the GJB2 Gene in Iraqi Patients with Sensorineural Non-Syndromic Hearing Loss
Jordan Medical Journal, 50 (3), 145-155
PublikaID 236

Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, Abrahamsen TG, Kittang OB, Øverland T, Jhangiani SN, Muzny DM, Vigeland MD, Samarakoon P, Gambin T, Akdemir ZH, Gibbs RA, Rødningen OK, Lyle R, Lupski JR, Stray-Pedersen A (2016)
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction
Mol Genet Genomic Med, 4 (6), 604-616
DOI 10.1002/mgg3.237, PubMed 27896283

Publications 2015

Fjaer R, Brodtkorb E, Øye AM, Sheng Y, Vigeland MD, Kvistad KA, Backe PH, Selmer KK (2015)
Generalized epilepsy in a family with basal ganglia calcifications and mutations in SLC20A2 and CHRNB2
Eur J Med Genet, 58 (11), 624-8
DOI 10.1016/j.ejmg.2015.10.005, PubMed 26475232

Lundin KE, Hamasy A, Backe PH, Moens LN, Falk-Sörqvist E, Elgstøen KB, Mørkrid L, Bjørås M, Granert C, Norlin AC, Nilsson M, Christensson B, Stenmark S, Smith CI (2015)
Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene
Clin Immunol, 161 (2), 366-72
DOI 10.1016/j.clim.2015.10.002, PubMed 26482871

Publications 2014

Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, Sasa GS, Krance RA, Martinez CA, Abraham SM, Speckmann C, Ehl S, Hall P, Forbes LR, Merckoll E, Westvik J et al. (2014)
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Publications 2013

Backe PH, Simm R, Laerdahl JK, Dalhus B, Fagerlund A, Okstad OA, Rognes T, Alseth I, Kolstø AB, Bjørås M (2013)
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
DOI 10.1016/j.jsb.2013.04.007, PubMed 23623903

Backe PH, Ytre-Arne M, Røhr AK, Brodtkorb E, Fowler B, Rootwelt H, Bjørås M, Mørkrid L (2013)
Novel Deletion Mutation Identified in a Patient with Late-Onset Combined Methylmalonic Acidemia and Homocystinuria, cblC Type
JIMD Rep, 11, 79-85
DOI 10.1007/8904_2013_225, PubMed 23580368

Publications 2012

Bliksrud YT, Brodtkorb E, Backe PH, Woldseth B, Rootwelt H (2012)
Hereditary tyrosinaemia type I in Norway: incidence and three novel small deletions in the fumarylacetoacetase gene
Scand J Clin Lab Invest, 72 (5), 369-73
DOI 10.3109/00365513.2012.676210, PubMed 22554029

Hereng TH, Backe PH, Kahmann J, Scheich C, Bjørås M, Skålhegg BS, Rosendal KR (2012)
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2
J Struct Biol, 178 (3), 300-10
DOI 10.1016/j.jsb.2012.03.013, PubMed 22504716

Payne CM, Baban J, Horn SJ, Backe PH, Arvai AS, Dalhus B, Bjørås M, Eijsink VG, Sørlie M, Beckham GT, Vaaje-Kolstad G (2012)
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases
J Biol Chem, 287 (43), 36322-30
DOI 10.1074/jbc.M112.402149, PubMed 22952223

Ranneberg-Nilsen T, Rollag H, Slettebakk R, Backe PH, Olsen Ø, Luna L, Bjørås M (2012)
The chromatin remodeling factor SMARCB1 forms a complex with human cytomegalovirus proteins UL114 and UL44
PLoS One, 7 (3), e34119
DOI 10.1371/journal.pone.0034119, PubMed 22479537

Søberg K, Larsen AC, Diskar M, Backe PH, Bjørås M, Jahnsen T, Laerdahl JK, Rognes T, Herberg FW, Skålhegg BS (2012)
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA)
PLoS One, 7 (4), e34838
DOI 10.1371/journal.pone.0034838, PubMed 22514673

Publications 2011

Dalhus B, Forsbring M, Helle IH, Vik ES, Forstrøm RJ, Backe PH, Alseth I, Bjørås M (2011)
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
DOI 10.1016/j.str.2010.09.023, PubMed 21220122

Publications 2010

Brodtkorb E, Strand J, Backe PH, Lund AM, Bjørås M, Rootwelt T, Rootwelt H, Woldseth B, Eide L (2010)
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
DOI 10.1016/j.ymgme.2010.04.017, PubMed 20570198

Görbitz CH, Backe PH (2010)
L-isoleucyl-L-asparagine 1.094-hydrate: a hybrid hydrogen-bonding pattern
Acta Crystallogr C, 66 (Pt 7), o349-52
DOI 10.1107/S0108270110020895, PubMed 20603563

Publications 2009

Dalhus B, Arvai AS, Rosnes I, Olsen ØE, Backe PH, Alseth I, Gao H, Cao W, Tainer JA, Bjørås M (2009)
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
DOI 10.1038/nsmb.1538, PubMed 19136958

Dalhus B, Laerdahl JK, Backe PH, Bjørås M (2009)
DNA base repair--recognition and initiation of catalysis
FEMS Microbiol Rev, 33 (6), 1044-78
DOI 10.1111/j.1574-6976.2009.00188.x, PubMed 19659577

Publications 2007

Dalhus B, Helle IH, Backe PH, Alseth I, Rognes T, Bjørås M, Laerdahl JK (2007)
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
DOI 10.1093/nar/gkm039, PubMed 17395642

Publications 2005

Backe PH, Messias AC, Ravelli RB, Sattler M, Cusack S (2005)
X-ray crystallographic and NMR studies of the third KH domain of hnRNP K in complex with single-stranded nucleic acids
Structure, 13 (7), 1055-67
DOI 10.1016/j.str.2005.04.008, PubMed 16004877

Publications 2004

Backe PH, Ravelli RB, Garman E, Cusack S (2004)
Crystallization, microPIXE and preliminary crystallographic analysis of the complex between the third KH domain of hnRNP K and single-stranded DNA
Acta Crystallogr D Biol Crystallogr, 60 (Pt 4), 784-7
DOI 10.1107/S0907444904002628, PubMed 15039586

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