Bjørn Dalhus
- Research scientist; PhD
- +47 230 70 908
Publications 2023
A homozygous POLR1A variant causes leukodystrophy and affects protein homeostasis
Brain, 146 (8), 3513-3527
DOI 10.1093/brain/awad086, PubMed 36917474
Publications 2022
Affinity maturation of TCR-like antibodies using phage display guided by structural modeling
Protein Eng Des Sel, 35
DOI 10.1093/protein/gzac005, PubMed 35871543
Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST)
Methods Mol Biol, 2528, 239-251
DOI 10.1007/978-1-0716-2477-7_15, PubMed 35704195
Publications 2021
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Commun Biol, 4 (1), 876
DOI 10.1038/s42003-021-02400-x, PubMed 34267321
Synthesis and Evaluation of Fused Pyrimidines as E. coli Thymidylate Monophosphate Kinase Inhibitors
ChemistrySelect, 6 (45), 12852-12857
DOI 10.1002/slct.202103796
AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR
Circ Res, 130 (1), 27-44
DOI 10.1161/CIRCRESAHA.120.317976, PubMed 34814703
CdgL is a degenerate nucleotide cyclase domain protein affecting flagellin synthesis and motility in Bacillus thuringiensis
Res Microbiol, 172 (4-5), 103850
DOI 10.1016/j.resmic.2021.103850, PubMed 34082027
Publications 2020
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390
An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics
Sci Transl Med, 12 (565)
DOI 10.1126/scitranslmed.abb0580, PubMed 33055243
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072
Author Correction: Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus
Sci Rep, 10 (1), 6287
DOI 10.1038/s41598-020-62786-2, PubMed 32269252
Publications 2019
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323
Publisher Correction: Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 10 (1), 1991
DOI 10.1038/s41467-019-10070-x, PubMed 31024006
Additive manufacturing of laminar flow cells for single-molecule experiments
Sci Rep, 9 (1), 16784
DOI 10.1038/s41598-019-53151-z, PubMed 31727950
Structural and Thermodynamic Signatures of Ligand Binding to the Enigmatic Chitinase D of Serratia proteamaculans
J Phys Chem B, 123 (10), 2270-2279
DOI 10.1021/acs.jpcb.8b11448, PubMed 30789732
Secretoneurin Is an Endogenous Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor That Attenuates Ca2+-Dependent Arrhythmia
Circ Arrhythm Electrophysiol, 12 (4), e007045
DOI 10.1161/CIRCEP.118.007045, PubMed 30943765
Publications 2018
Breaking the speed limit with multimode fast scanning of DNA by Endonuclease V
Nat Commun, 9 (1), 5381
DOI 10.1038/s41467-018-07797-4, PubMed 30568191
Hb Oslo [β42(CD1)Phe→Ile; HBB: c.127T>A]: A Novel Unstable Hemoglobin Variant Found in a Norwegian Patient
Hemoglobin, 42 (2), 78-83
DOI 10.1080/03630269.2018.1468773, PubMed 30032685
Key Residues Affecting Transglycosylation Activity in Family 18 Chitinases: Insights into Donor and Acceptor Subsites
Biochemistry, 57 (29), 4325-4337
DOI 10.1021/acs.biochem.8b00381, PubMed 29939724
Human and mouse albumin bind their respective neonatal Fc receptors differently
Sci Rep, 8 (1), 14648
DOI 10.1038/s41598-018-32817-0, PubMed 30279529
Publications 2017
Structural determinants of bacterial lytic polysaccharide monooxygenase functionality
J Biol Chem, 293 (4), 1397-1412
DOI 10.1074/jbc.M117.817130, PubMed 29222333
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17)
DOI 10.1172/jci.insight.95193, PubMed 28878121
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
DOI 10.1080/19491034.2017.1306161, PubMed 28402725
Publications 2016
Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus
J Biol Chem, 291 (14), 7300-12
DOI 10.1074/jbc.M115.700161, PubMed 26858252
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
DOI 10.1074/jbc.M116.730911, PubMed 27573237
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
DOI 10.1038/srep24979, PubMed 27108838
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Proc Natl Acad Sci U S A, 113 (33), 9339-44
DOI 10.1073/pnas.1604520113, PubMed 27482107
Publications 2015
Structural basis for incision at deaminated adenines in DNA and RNA by endonuclease V
Prog Biophys Mol Biol, 117 (2-3), 134-142
DOI 10.1016/j.pbiomolbio.2015.03.005, PubMed 25824682
Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman
J Biol Chem, 291 (9), 4561-79
DOI 10.1074/jbc.M115.677898, PubMed 26668322
Mutation analysis in Norwegian families with hereditary hemorrhagic telangiectasia: founder mutations in ACVRL1
Clin Genet, 89 (2), 182-6
DOI 10.1111/cge.12612, PubMed 25970827
Synthetic Routes to N-9 Alkylated 8-Oxoguanines; Weak Inhibitors of the Human DNA Glycosylase OGG1
Molecules, 20 (9), 15944-65
DOI 10.3390/molecules200915944, PubMed 26364627
Structural and functional characterization of a small chitin-active lytic polysaccharide monooxygenase domain of a multi-modular chitinase from Jonesia denitrificans
FEBS Lett, 590 (1), 34-42
DOI 10.1002/1873-3468.12025, PubMed 26763108
Structural Features of a Bacteroidetes-Affiliated Cellulase Linked with a Polysaccharide Utilization Locus
Sci Rep, 5, 11666
DOI 10.1038/srep11666, PubMed 26133573
Publications 2014
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716
DOI 10.1016/j.tetlet.2014.05.030
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645
Publications 2013
A new family of proteins related to the HEAT-like repeat DNA glycosylases with affinity for branched DNA structures
J Struct Biol, 183 (1), 66-75
DOI 10.1016/j.jsb.2013.04.007, PubMed 23623903
Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin
DNA Repair (Amst), 12 (12), 1159-64
DOI 10.1016/j.dnarep.2013.04.026, PubMed 23755964
Structural basis of DNA loop recognition by endonuclease V
Structure, 21 (2), 257-65
DOI 10.1016/j.str.2012.12.007, PubMed 23313664
Genotype-phenotype analysis of S326C OGG1 polymorphism: a risk factor for oxidative pathologies
Free Radic Biol Med, 63, 401-9
DOI 10.1016/j.freeradbiomed.2013.05.031, PubMed 23726996
Endonuclease V cleaves at inosines in RNA
Nat Commun, 4, 2271
DOI 10.1038/ncomms3271, PubMed 23912683
Single transmembrane peptide DinQ modulates membrane-dependent activities
PLoS Genet, 9 (2), e1003260
DOI 10.1371/journal.pgen.1003260, PubMed 23408903
Publications 2012
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Nat Commun, 3, 610
DOI 10.1038/ncomms1607, PubMed 22215085
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2
Structure, 21 (1), 154-166
DOI 10.1016/j.str.2012.11.004, PubMed 23245849
The human homolog of Escherichia coli endonuclease V is a nucleolar protein with affinity for branched DNA structures
PLoS One, 7 (11), e47466
DOI 10.1371/journal.pone.0047466, PubMed 23139746
The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control
Mol Cell, 49 (2), 339-45
DOI 10.1016/j.molcel.2012.11.010, PubMed 23246433
Hallmarks of processivity in glycoside hydrolases from crystallographic and computational studies of the Serratia marcescens chitinases
J Biol Chem, 287 (43), 36322-30
DOI 10.1074/jbc.M112.402149, PubMed 22952223
Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities
DNA Repair (Amst), 11 (9), 766-73
DOI 10.1016/j.dnarep.2012.07.002, PubMed 22858590
Publications 2011
The molecular structure of tris-2,2,6,6-tetramethyl-heptane-3,5-dione aluminium: gas-phase electron diffraction, quantum chemical calculations and X-ray crystallography
Struct. Chem., 22 (2), 393-399
DOI 10.1007/s11224-010-9729-0
Separation-of-function mutants unravel the dual-reaction mode of human 8-oxoguanine DNA glycosylase
Structure, 19 (1), 117-27
DOI 10.1016/j.str.2010.09.023, PubMed 21220122
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond
Mech Ageing Dev, 132 (8-9), 424-8
DOI 10.1016/j.mad.2011.02.006, PubMed 21354441
Characterization of the chitinolytic machinery of Enterococcus faecalis V583 and high-resolution structure of its oxidative CBM33 enzyme
J Mol Biol, 416 (2), 239-54
DOI 10.1016/j.jmb.2011.12.033, PubMed 22210154
The ada operon of Mycobacterium tuberculosis encodes two DNA methyltransferases for inducible repair of DNA alkylation damage
DNA Repair (Amst), 10 (6), 595-602
DOI 10.1016/j.dnarep.2011.03.007, PubMed 21570366
Publications 2010
Pseudoracemic amino acid complexes: blind predictions for flexible two-component crystals
Phys Chem Chem Phys, 12 (30), 8466-77
DOI 10.1039/c004055j, PubMed 20461256
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of replication
Mol Microbiol, 79 (2), 433-46
DOI 10.1111/j.1365-2958.2010.07453.x, PubMed 21219462
Publications 2009
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair
Nat Struct Mol Biol, 16 (2), 138-43
DOI 10.1038/nsmb.1538, PubMed 19136958
DNA base repair--recognition and initiation of catalysis
FEMS Microbiol Rev, 33 (6), 1044-78
DOI 10.1111/j.1574-6976.2009.00188.x, PubMed 19659577
Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma
Carcinogenesis, 30 (7), 1147-54
DOI 10.1093/carcin/bgp118, PubMed 19443904
Molecular requirements for sorting of the chemokine interleukin-8/CXCL8 to endothelial Weibel-Palade bodies
J Biol Chem, 284 (35), 23532-9
DOI 10.1074/jbc.M900874200, PubMed 19578117
Publications 2007
Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats
Nucleic Acids Res, 35 (7), 2451-9
DOI 10.1093/nar/gkm039, PubMed 17395642
Publications 2006
Crystal structure and enzymatic properties of a bacterial family 19 chitinase reveal differences from plant enzymes
FEBS J, 273 (21), 4889-900
DOI 10.1111/j.1742-4658.2006.05487.x, PubMed 17010167
Improved one-pot synthesis of mixed methyl-aryl platinum(II) diimine complexes
Organometallics, 25 (4), 1055-1058
DOI 10.1021/om050899z
Publications 2005
Pediocin-like antimicrobial peptides (class IIa bacteriocins) and their immunity proteins: biosynthesis, structure, and mode of action
J Pept Sci, 11 (11), 688-96
DOI 10.1002/psc.699, PubMed 16059970
1.6-Angstroms crystal structure of EntA-im. A bacterial immunity protein conferring immunity to the antimicrobial activity of the pediocin-like bacteriocin enterocin A
J Biol Chem, 280 (19), 19045-50
DOI 10.1074/jbc.M501386200, PubMed 15753083
Publications 2004
Large improvement in the thermal stability of a tetrameric malate dehydrogenase by single point mutations at the dimer-dimer interface
J Mol Biol, 341 (5), 1215-26
DOI 10.1016/j.jmb.2004.06.079, PubMed 15321717
Crystal structures of hydrophobic amino acids: interaction energies of hydrogen-bonded layers revealed by ab initio calculations
Theochem-J. Mol. Struct., 675 (1-3), 47-52
DOI 10.1016/j.theochem.2003.12.032
Synthesis and characterization of half-sandwich N-heterocyclic carbene complexes of cobalt and rhodium
Dalton Trans (22), 3909-17
DOI 10.1039/b408750j, PubMed 15540136
L-Seryl-L-phenylalanine
Acta Crystallogr C, 60 (Pt 10), o771-2
DOI 10.1107/S0108270104021523, PubMed 15467155
A non-planar peptide bond in L-seryl-L-valine
Acta Crystallogr C, 60 (Pt 8), o564-5
DOI 10.1107/S0108270104014325, PubMed 15295188
L-alanyl-L-threonine
Acta Crystallogr. Sect. E.-Crystallogr. Commun., 60, O951-O953
DOI 10.1107/S1600536804010578
Publications 2003
Stabilization of a tetrameric malate dehydrogenase by introduction of a disulfide bridge at the dimer-dimer interface
J Mol Biol, 334 (4), 811-21
DOI 10.1016/j.jmb.2003.10.006, PubMed 14636605
Crystallization and preliminary X-ray data investigation of the bacterial enterocin A immunity protein at 1.65 A resolution
Acta Crystallogr D Biol Crystallogr, 59 (Pt 7), 1291-3
DOI 10.1107/s0907444903009879, PubMed 12832790
DL-valinium perchlorate
Acta Crystallogr. Sect. E.-Crystallogr. Commun., 59, O28-O30
DOI 10.1107/S1600536802022225
Publications 2002
Molecular structure and conformational preferences of trimethylphosphite, P(OCH3)(3), as a free molecule and as a ligand in d-block metal complexes
J. Chem. Soc.-Dalton Trans. (19), 3756-3762
DOI 10.1039/b204777m
Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases
J Mol Biol, 318 (3), 707-21
DOI 10.1016/S0022-2836(02)00050-5, PubMed 12054817
An organometallic RhIII complex with a distorted octahedral structure: (acetonitrile-kappaN)dimethyl(1,4,7-trimethyl-1,4,7-triazacyclononane-kappa3N,N',N")rhodium(III) tetraphenylborate
Acta Crystallogr C, 58 (Pt 12), m567-9
DOI 10.1107/s0108270102019182, PubMed 12466599
Oxidatively induced M-C bond cleavage reactions of Cp*Ir(Me2SO)Me-2 and Cp*Rh(Me2SO)M-2 (Cp* = eta(5)-C5Me5)
J. Chem. Soc.-Dalton Trans. (6), 975-982
DOI 10.1039/b107451m
A triclinic polymorph of L-argininium chloride
Acta Crystallogr. Sect. E.-Crystallogr. Commun., 58, O747-O749
DOI 10.1107/S160053680201022X
L-Methionine L-methioninium perchlorate monohydrate
Acta Crystallogr. Sect. E.-Crystallogr. Commun., 58, O779-O781
DOI 10.1107/S1600536802010656
L-Citrullinium perchlorate
Acta Crystallogr. Sect. E.-Crystallogr. Commun., 58, O1177-O1179
DOI 10.1107/S160053680201766X
Publications 2001
Synthesis of 6-substituted purin-2-ones with potential cytokinin activity
J. Chem. Soc.-Perkin Trans. 1 (14), 1662-1672
DOI 10.1039/b101327k
An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2
J Biol Inorg Chem, 7 (3), 299-304
DOI 10.1007/s007750100296, PubMed 11935353
Publications 2000
Crystal structures of hydrophobic amino acid complexes - a multivariate analysis of hydrogen bond geometries
In Series of dissertations submitted to the Faculty of Mathematics and Natural Sciences, University of Oslo, The Faculty, Oslo, no. 62, 1 b. (flere pag.)
BIBSYS 00107105x
Structural relationships in crystals accommodating different stereoisomers of 2-amino-3-methylpentanoic acid
Acta Crystallogr B, 56 (Pt 4), 720-7
DOI 10.1107/s0108768100002810, PubMed 10944265
Non-centrosymmetric racemates: space-group frequencies and conformational similarities between crystallographically independent molecules
Acta Crystallogr B, 56 (Pt 4), 715-9
DOI 10.1107/s0108768100002172, PubMed 10944264
Synthesis of 1-substituted 7-cyano-2,3-diphenylindolizines and evaluation of antioxidant properties
Eur. J. Org. Chem., 2000 (22), 3763-3770
Publications 1999
Molecular aggregation in selected crystalline 1 : 1 complexes of hydrophobic D- and L-amino acids. II. The D-norleucine series
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 55, 1105-1112
DOI 10.1107/S0108270199003649
Molecular aggregation in selected crystalline 1 : 1 complexes of hydrophohic D- and L-amino acids. III. The L-leucine and L-valine series
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 55, 1547-1555
DOI 10.1107/S0108270199006162
Molecular aggregation in crystalline 1:1 complexes of hydrophobic D- and L-amino acids. I. The L-isoleucine series
Acta Crystallogr B, 55 (Pt 3), 424-431
DOI 10.1107/s0108768198013494, PubMed 10927385
Addition and cycloaddition to 2- and 8-vinylpurines
Acta Chem. Scand., 53 (4), 269-279
DOI 10.3891/acta.chem.scand.53-0269
A 1 : 1 complex between deoxycholate and tris(hydroxymethyl)methylammonium
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 55, 1113-1115
DOI 10.1107/S0108270199004370
Publications 1998
trans-2,3-Diiodo-2-butene-1,4-diol
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 54, 555-557
DOI 10.1107/S0108270197014406
Publications 1996
Crystal structures of hydrophobic amino acids .1. redeterminations of L-methionine and L-valine at 120 K
Acta Chem. Scand., 50 (6), 544-548
DOI 10.3891/acta.chem.scand.50-0544
Triclinic form of DL-valine
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 52, 1759-1761
DOI 10.1107/S0108270196002491
DL-norleucine, beta form at 120 K
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 52, 1761-1764
DOI 10.1107/S0108270196003642
Glycyl-L-leucyl-L-tyrosine dihydrate 2-propanol solvate
Acta Crystallogr C, 52 ( Pt 8), 2087-90
DOI 10.1107/s0108270196002041, PubMed 8819306
L-isoleucine, redetermination at 120 K
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 52, 1464-1466
DOI 10.1107/S0108270195016386
Redetermination of L-leucine at 120 K
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 52, 1754-1756
DOI 10.1107/S0108270196002296
L-cysteine, monoclinic form, redetermination at 120 K
Acta Crystallogr. Sect. C-Cryst. Struct. Commun., 52, 1756-1759
DOI 10.1107/S0108270196003952
Publications 1995
Røntgenkrystallografisk strukturbestemmelse av aminosyrene L-valin og L-metionin og tripeptidet L-glysyl-L-leusyl-L-tyrosin: studier av hydrogenbindingsnettverk i hydrofobe aminosyrestrukturer. Molekyldynamikksimulering av L-glysyl-L-leusyl-L-tyrosin
B. Dalhus, Oslo, 100 s.
BIBSYS 951357018