Jan Cato Holter
- MD, PhD
Publications 2024
Deficient SARS-CoV-2 hybrid immunity during inflammatory bowel disease
Clin Immunol, 110404 (in press)
DOI 10.1016/j.clim.2024.110404, PubMed 39645159
Vaccine responses and hybrid immunity in people living with HIV after SARS-CoV-2 breakthrough infections
NPJ Vaccines, 9 (1), 185
DOI 10.1038/s41541-024-00972-3, PubMed 39384763
Escalated complement activation during hospitalization is associated with higher risk of 60-day mortality in SARS-CoV-2-infected patients
J Intern Med, 296 (1), 80-92
DOI 10.1111/joim.13783, PubMed 38539241
Modeling the relative influence of socio-demographic variables on post-acute COVID-19 quality of life
medRxiv
DOI 10.1101/2024.02.21.24303099, PubMed 39040190
Long Covid: a global health issue - a prospective, cohort study set in four continents
BMJ Glob Health, 9 (10)
DOI 10.1136/bmjgh-2024-015245, PubMed 39433402
Publications 2023
Long-term neurological symptoms after acute COVID-19 illness requiring hospitalization in adult patients: insights from the ISARIC-COVID-19 follow-up study
J Neurol, 271 (1), 79-86
DOI 10.1007/s00415-023-12133-y, PubMed 38055020
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19
JAMA Netw Open, 6 (12), e2346502
DOI 10.1001/jamanetworkopen.2023.46502, PubMed 38147336
Neurological manifestations of COVID-19 in adults and children
Brain, 146 (4), 1648-1661
DOI 10.1093/brain/awac332, PubMed 36087305
A second update on mapping the human genetic architecture of COVID-19
Nature, 621 (7977), E7-E26
DOI 10.1038/s41586-023-06355-3, PubMed 37674002
Nausea Predicts Bacteremia in Immunocompetent Patients with Pneumococcal Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
J Clin Med, 12 (12)
DOI 10.3390/jcm12123924, PubMed 37373619
A multi-country analysis of COVID-19 hospitalizations by vaccination status
Med, 4 (11), 797-812.e2
DOI 10.1016/j.medj.2023.08.005, PubMed 37738979
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Res Pract Thromb Haemost, 7 (5), 102142
DOI 10.1016/j.rpth.2023.102142, PubMed 37601011
Characteristics and outcomes of an international cohort of 600 000 hospitalized patients with COVID-19
Int J Epidemiol, 52 (2), 355-376
DOI 10.1093/ije/dyad012, PubMed 36850054
SARS-CoV-2 infection induces long-lived B and T-cell responses up to 15 months post-infection, irrespective of disease severity
J Infect, 87 (4), 346-349
DOI 10.1016/j.jinf.2023.05.023, PubMed 37295510
Circulating markers of extracellular matrix remodelling in severe COVID-19 patients
J Intern Med, 294 (6), 784-797
DOI 10.1111/joim.13725, PubMed 37718572
COVID-19 patients treated with convalescent plasma
Tidsskr Nor Laegeforen, 143 (11)
DOI 10.4045/tidsskr.22.0577, PubMed 37589359
Hepcidin analysis in pneumonia: Comparison of immunoassay and LC-MS/MS
Ann Clin Biochem, 60 (5), 298-305
DOI 10.1177/00045632231159529, PubMed 36759502
Severely ill COVID-19 patients have altered circulating levels of proteins controlling the epitranscriptome
J Infect, 86 (6), 593-595
DOI 10.1016/j.jinf.2023.03.002, PubMed 36889510
Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study
J Crit Care, 77, 154318
DOI 10.1016/j.jcrc.2023.154318, PubMed 37167775
Validation of extracorporeal membrane oxygenation mortality prediction and severity of illness scores in an international COVID-19 cohort
Artif Organs, 47 (9), 1490-1502
DOI 10.1111/aor.14542, PubMed 37032544
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity
FASEB J, 37 (11), e23220
DOI 10.1096/fj.202300077R, PubMed 37801035
Liver injury in hospitalized patients with COVID-19: An International observational cohort study
PLoS One, 18 (9), e0277859
DOI 10.1371/journal.pone.0277859, PubMed 37703268
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280
Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19
Kidney Int Rep, 8 (8), 1514-30 (in press)
DOI 10.1016/j.ekir.2023.05.015, PubMed 37360820
Publications 2022
Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients
Influenza Other Respir Viruses, 16 (6), 1040-1050
DOI 10.1111/irv.13039, PubMed 36825252
Association of body mass index with COVID-19 related in-hospital death
Clin Nutr, 41 (12), 2924-2926
DOI 10.1016/j.clnu.2022.01.017, PubMed 35123821
Novel genes and sex differences in COVID-19 severity
Hum Mol Genet, 31 (22), 3789-3806
DOI 10.1093/hmg/ddac132, PubMed 35708486
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Hum Mol Genet, 31 (23), 3945-3966
DOI 10.1093/hmg/ddac158, PubMed 35848942
SARS-CoV-2 in the Air Surrounding Patients during Nebulizer Therapy
Can J Infect Dis Med Microbiol, 2022, 9297974
DOI 10.1155/2022/9297974, PubMed 36213437
An international observational study to assess the impact of the Omicron variant emergence on the clinical epidemiology of COVID-19 in hospitalised patients
Elife, 11
DOI 10.7554/eLife.80556, PubMed 36197074
Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2
Viruses, 14 (11)
DOI 10.3390/v14112420, PubMed 36366518
CXCL16 associates with adverse outcome and cardiac involvement in hospitalized patients with Covid-19
J Infect, 85 (6), 702-769
DOI 10.1016/j.jinf.2022.09.029, PubMed 36216188
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells
Cell Rep, 38 (10), 110503
DOI 10.1016/j.celrep.2022.110503, PubMed 35235832
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19
Sci Data, 9 (1), 454
DOI 10.1038/s41597-022-01534-9, PubMed 35908040
DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients
J Inflamm Res, 15, 6629-6644
DOI 10.2147/JIR.S379331, PubMed 36514358
Hepcidin predicts 5-year mortality after community-acquired pneumonia
Infect Dis (Lond), 54 (6), 403-409
DOI 10.1080/23744235.2021.2022194, PubMed 35057702
Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study
ERJ Open Res, 8 (1)
DOI 10.1183/23120541.00552-2021, PubMed 35169585
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
Crit Care, 26 (1), 276
DOI 10.1186/s13054-022-04155-1, PubMed 36100904
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Biomark Insights, 17, 11772719221099130
DOI 10.1177/11772719221099130, PubMed 35693251
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
Front Immunol, 13, 964525
DOI 10.3389/fimmu.2022.964525, PubMed 36159859
Corticosteroids and superinfections in COVID-19 patients on invasive mechanical ventilation
J Infect, 85 (1), 57-63
DOI 10.1016/j.jinf.2022.05.015, PubMed 35605805
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405
Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies
J Intern Med, 292 (5), 816-828
DOI 10.1111/joim.13549, PubMed 35982589
High Circulating Levels of the Homeostatic Chemokines CCL19 and CCL21 Predict Mortality and Disease Severity in COVID-19
J Infect Dis, 226 (12), 2150-2160
DOI 10.1093/infdis/jiac313, PubMed 35876699
Use of an extended KDIGO definition to diagnose acute kidney injury in patients with COVID-19: A multinational study using the ISARIC-WHO clinical characterisation protocol
PLoS Med, 19 (4), e1003969
DOI 10.1371/journal.pmed.1003969, PubMed 35442972
Publications 2021
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns
J Intern Med, 290 (3), 677-692
DOI 10.1111/joim.13310, PubMed 34080738
The value of open-source clinical science in pandemic response: lessons from ISARIC
Lancet Infect Dis, 21 (12), 1623-1624
DOI 10.1016/S1473-3099(21)00565-X, PubMed 34619109
Ten months of temporal variation in the clinical journey of hospitalised patients with COVID-19: An observational cohort
Elife, 10
DOI 10.7554/eLife.70970, PubMed 34812731
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
J Clin Invest, 131 (23)
DOI 10.1172/JCI152386, PubMed 34597274
Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
medRxiv
DOI 10.1101/2021.03.07.21252875, PubMed 33758887
Hepcidin and Ferritin Predict Microbial Etiology in Community-Acquired Pneumonia
Open Forum Infect Dis, 8 (4), ofab082
DOI 10.1093/ofid/ofab082, PubMed 33880390
What is the recovery rate and risk of long-term consequences following a diagnosis of COVID-19? A harmonised, global longitudinal observational study protocol
BMJ Open, 11 (3), e043887
DOI 10.1136/bmjopen-2020-043887, PubMed 33692181
Increased inflammatory markers reflecting fibrogenesis are independently associated with cardiac involvement in hospitalized COVID-19 patients
J Infect, 82 (5), 186-230
DOI 10.1016/j.jinf.2021.01.017, PubMed 33516748
Blood neurofilament light concentration at admittance: a potential prognostic marker in COVID-19
J Neurol, 268 (10), 3574-3583
DOI 10.1007/s00415-021-10517-6, PubMed 33743046
Interleukin-6 in Critical Coronavirus Disease 2019, a Driver of Lung Inflammation of Systemic Origin?
Crit Care Explor, 3 (10), e0542
DOI 10.1097/CCE.0000000000000542, PubMed 34604785
Publications 2020
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med, 289 (4), 523-531
DOI 10.1111/joim.13178, PubMed 32976665
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109
Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure
J Infect, 81 (3), e41-e43
DOI 10.1016/j.jinf.2020.06.061, PubMed 32603675
Publications 2019
Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study
ERJ Open Res, 5 (1)
DOI 10.1183/23120541.00014-2019, PubMed 30863773
Publications 2018
Low Levels of Immunoglobulins and Mannose-Binding Lectin Are Not Associated With Etiology, Severity, or Outcome in Community-Acquired Pneumonia
Open Forum Infect Dis, 5 (2), ofy002
DOI 10.1093/ofid/ofy002, PubMed 29410975
Publications 2017
Cytokine responses, microbial aetiology and short-term outcome in community-acquired pneumonia
Eur J Clin Invest, 48 (1)
DOI 10.1111/eci.12865, PubMed 29171871
Publications 2016
Risk Factors for Long-Term Mortality after Hospitalization for Community-Acquired Pneumonia: A 5-Year Prospective Follow-Up Study
PLoS One, 11 (2), e0148741
DOI 10.1371/journal.pone.0148741, PubMed 26849359
Vitamin D Status and Long-Term Mortality in Community-Acquired Pneumonia: Secondary Data Analysis from a Prospective Cohort
PLoS One, 11 (7), e0158536
DOI 10.1371/journal.pone.0158536, PubMed 27367810
Circulating cell-free DNA is elevated in community-acquired bacterial pneumonia and predicts short-term outcome
J Infect, 73 (4), 383-6
DOI 10.1016/j.jinf.2016.07.011, PubMed 27452197
Publications 2015
Etiology of community-acquired pneumonia and diagnostic yields of microbiological methods: a 3-year prospective study in Norway
BMC Infect Dis, 15, 64
DOI 10.1186/s12879-015-0803-5, PubMed 25887603
Publications 2014
Emerging K1 serotype Klebsiella pneumoniae primary liver abscess: three cases presenting to a single university hospital in Norway
Clin Case Rep, 2 (4), 122-7
DOI 10.1002/ccr3.77, PubMed 25356268
Publications 2007
Increased expression of fractalkine (CX3CL1) and its receptor, CX3CR1, in Wegener's granulomatosis--possible role in vascular inflammation
Rheumatology (Oxford), 46 (9), 1422-7
DOI 10.1093/rheumatology/kem168, PubMed 17616549