Publications 2024

Alonso-Rodríguez N, Vianello E, van Veen S, Jenum S, Tonby K, van Riessen R, Lai X, Mortensen R, Ottenhoff THM, Dyrhol-Riise AM (2024)
Whole blood RNA signatures in tuberculosis patients receiving H56:IC31 vaccine as adjunctive therapy
Front Immunol, 15, 1350593
DOI 10.3389/fimmu.2024.1350593, PubMed 38433842

Markussen DL, Wathne JS, Ritz C, van Werkhoven CH, Serigstad S, Bjørneklett RO, Ulvestad E, Knoop ST, Jenum S, Grewal HMS (2024)
Determinants of non-adherence to antibiotic treatment guidelines in hospitalized adults with suspected community-acquired pneumonia: a prospective study
Antimicrob Resist Infect Control, 13 (1), 140
DOI 10.1186/s13756-024-01494-2, PubMed 39580437

Mortensen R, Clemmensen HS, Woodworth JS, Therkelsen ML, Mustafa T, Tonby K, Jenum S, Agger EM, Dyrhol-Riise AM, Andersen P (2024)
Author Correction: Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Commun Biol, 7 (1), 662
DOI 10.1038/s42003-024-06260-z, PubMed 38811662

Nore KG, Louet C, Bugge M, Gidon A, Jørgensen MJ, Jenum S, Dyrhol-Riise AM, Tonby K, Flo TH (2024)
The Cyclooxygenase 2 Inhibitor Etoricoxib as Adjunctive Therapy in Tuberculosis Impairs Macrophage Control of Mycobacterial Growth
J Infect Dis, 229 (3), 888-897
DOI 10.1093/infdis/jiad390, PubMed 37721470

Sivakumaran D, Jenum S, Markussen DL, Serigstad S, Srivastava A, Saghaug CS, Ulvestad E, Knoop ST, Grewal HMS (2024)
Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial-viral differentiation
Microbiol Spectr, 12 (10), e0283123
DOI 10.1128/spectrum.02831-23, PubMed 39269158

Publications 2023

Markussen DL, Ebbesen M, Serigstad S, Knoop ST, Ritz C, Bjørneklett R, Kommedal Ø, Jenum S, Ulvestad E, Grewal HMS (2023)
The diagnostic utility of microscopic quality assessment of sputum samples in the era of rapid syndromic PCR testing
Microbiol Spectr, 11 (5), e0300223 (in press)
DOI 10.1128/spectrum.03002-23, PubMed 37772853

Sivakumaran D, Jenum S, Srivastava A, Steen VM, Vaz M, Doherty TM, Ritz C, Grewal HMS (2023)
Host blood-based biosignatures for subclinical TB and incipient TB: A prospective study of adult TB household contacts in Southern India
Front Immunol, 13, 1051963
DOI 10.3389/fimmu.2022.1051963, PubMed 36713386

Trøseid M, Holter JC, Holm K, Vestad B, Sazonova T, Granerud BK, Dyrhol-Riise AM, Holten AR, Tonby K, Kildal AB, Heggelund L, Tveita A, Bøe S, Müller KE, Jenum S, Hov JR, Ueland T, Norwegian SARS-CoV-2 study group (2023)
Gut microbiota composition during hospitalization is associated with 60-day mortality after severe COVID-19
Crit Care, 27 (1), 69
DOI 10.1186/s13054-023-04356-2, PubMed 36814280

Publications 2022

Siljan WW, Sivakumaran D, Ritz C, Jenum S, Ottenhoff TH, Ulvestad E, Holter JC, Heggelund L, Grewal HM (2022)
Host Transcriptional Signatures Predict Etiology in Community-Acquired Pneumonia: Potential Antibiotic Stewardship Tools
Biomark Insights, 17, 11772719221099130
DOI 10.1177/11772719221099130, PubMed 35693251

Sivakumaran D, Jenum S, Ritz C, Vaz M, Doherty TM, Grewal HMS (2022)
Improving Assignments for Therapeutic and Prophylactic Treatment Within TB Households. A Potential for Immuno-Diagnosis?
Front Immunol, 13, 801616
DOI 10.3389/fimmu.2022.801616, PubMed 35401549

Publications 2021

Chendi BH, Snyders CI, Tonby K, Jenum S, Kidd M, Walzl G, Chegou NN, Dyrhol-Riise AM (2021)
A Plasma 5-Marker Host Biosignature Identifies Tuberculosis in High and Low Endemic Countries
Front Immunol, 12, 608846
DOI 10.3389/fimmu.2021.608846, PubMed 33732236

Chendi BH, Tveiten H, Snyders CI, Tonby K, Jenum S, Nielsen SD, Hove-Skovsgaard M, Walzl G, Chegou NN, Dyrhol-Riise AM (2021)
CCL1 and IL-2Ra differentiate Tuberculosis disease from latent infection Irrespective of HIV infection in low TB burden countries
J Infect, 83 (4), 433-443
DOI 10.1016/j.jinf.2021.07.036, PubMed 34333033

Christensen EE, Jørgensen MJ, Nore KG, Dahl TB, Yang K, Ranheim T, Huse C, Lind A, Nur S, Stiksrud B, Jenum S, Tonby K, Holter JC, Holten AR, Halvorsen B, Dyrhol-Riise AM (2021)
Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns
J Intern Med, 290 (3), 677-692
DOI 10.1111/joim.13310, PubMed 34080738

Jenum S, Tonby K, Rueegg CS, Rühwald M, Kristiansen MP, Bang P, Olsen IC, Sellæg K, Røstad K, Mustafa T, Taskén K, Kvale D, Mortensen R, Dyrhol-Riise AM (2021)
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat Commun, 12 (1), 6774
DOI 10.1038/s41467-021-27029-6, PubMed 34811370

Jøntvedt Jørgensen M, Nore KG, Aass HCD, Layre E, Nigou J, Mortensen R, Tasken K, Kvale D, Jenum S, Tonby K, Dyrhol-Riise AM (2021)
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front Cell Infect Microbiol, 11, 669623
DOI 10.3389/fcimb.2021.669623, PubMed 34307194

Pedersen HB, Kaviyani RS, Quist-Paulsen E, Dedi L, Reikvam DH, Jenum S, Fosshaug L, Biernat D, Schwartz T (2021)
A man in his seventies with pleural effusion, knee pain and dysarthria following open heart surgery
Tidsskr Nor Laegeforen, 141 (18)
DOI 10.4045/tidsskr.21.0163, PubMed 34911264

Sivakumaran D, Blatner G, Bakken R, Hokey D, Ritz C, Jenum S, Grewal HMS (2021)
A 2-Dose AERAS-402 Regimen Boosts CD8⁺ Polyfunctionality in HIV-Negative, BCG-Vaccinated Recipients
Front Immunol, 12, 673532
DOI 10.3389/fimmu.2021.673532, PubMed 34177914

Sivakumaran D, Ritz C, Gjøen JE, Vaz M, Selvam S, Ottenhoff THM, Doherty TM, Jenum S, Grewal HMS (2021)
Host Blood RNA Transcript and Protein Signatures for Sputum-Independent Diagnostics of Tuberculosis in Adults
Front Immunol, 11, 626049
DOI 10.3389/fimmu.2020.626049, PubMed 33613569

Publications 2020

Bekken GK, Ritz C, Selvam S, Jesuraj N, Hesseling AC, Doherty TM, Grewal HMS, Vaz M, Jenum S (2020)
Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations
BMC Infect Dis, 20 (1), 96
DOI 10.1186/s12879-020-4800-y, PubMed 32005136

Holter JC, Pischke SE, de Boer E, Lind A, Jenum S, Holten AR, Tonby K, Barratt-Due A, Sokolova M, Schjalm C, Chaban V, Kolderup A, Tran T, Tollefsrud Gjølberg T, Skeie LG, Hesstvedt L, Ormåsen V, Fevang B, Austad C, Müller KE, Fladeby C, Holberg-Petersen M, Halvorsen B, Müller F, Aukrust P et al. (2020)
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Jøntvedt Jørgensen M, Jenum S, Tonby K, Mortensen R, Walzl G, Du Plessis N, Dyrhol-Riise AM (2020)
Monocytic myeloid-derived suppressor cells reflect tuberculosis severity and are influenced by cyclooxygenase-2 inhibitors
J Leukoc Biol, 110 (1), 177-186
DOI 10.1002/JLB.4A0720-409RR, PubMed 33155730

Nore KG, Jørgensen MJ, Dyrhol-Riise AM, Jenum S, Tonby K (2020)
Elevated Levels of Anti-Inflammatory Eicosanoids and Monocyte Heterogeneity in Mycobacterium tuberculosis Infection and Disease
Front Immunol, 11, 579849
DOI 10.3389/fimmu.2020.579849, PubMed 33304347

Sivakumaran D, Jenum S, Vaz M, Selvam S, Ottenhoff THM, Haks MC, Malherbe ST, Doherty TM, Ritz C, Grewal HMS (2020)
Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes
Commun Biol, 3 (1), 359
DOI 10.1038/s42003-020-1087-x, PubMed 32647325

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

Publications 2019

Mortensen R, Clemmensen HS, Woodworth JS, Therkelsen ML, Mustafa T, Tonby K, Jenum S, Agger EM, Dyrhol-Riise AM, Andersen P (2019)
Cyclooxygenase inhibitors impair CD4 T cell immunity and exacerbate Mycobacterium tuberculosis infection in aerosol-challenged mice
Commun Biol, 2, 288
DOI 10.1038/s42003-019-0530-3, PubMed 31396568

Tonby K, Mortensen R, Ruhwald M, Dyrhol-Riise AM, Jenum S (2019)
KLRG1-Expressing CD4 T Cells Are Reduced in Tuberculosis Patients Compared to Healthy Mycobacterium tuberculosis-Infected Subjects, but Increase With Treatment
J Infect Dis, 220 (1), 174-176
DOI 10.1093/infdis/jiz056, PubMed 30888024

Publications 2018

Bollestad M, Grude N, Solhaug S, Raffelsberger N, Handal N, Nilsen HS, Romstad MR, Emmert A, Tveten Y, Søraas A, Jenum PA, Jenum S, Møller-Stray J, Weme ET, Lindbaek M, Simonsen GS, (the Norwegian ESBL UTI study group) (2018)
Clinical and bacteriological efficacy of pivmecillinam treatment for uncomplicated urinary tract infections caused by ESBL-producing Escherichia coli: a prospective, multicentre, observational cohort study
J Antimicrob Chemother, 73 (9), 2503-2509
DOI 10.1093/jac/dky230, PubMed 29982514

Jenum S, Selvam S, Jesuraj N, Ritz C, Hesseling AC, Cardenas V, Lau E, Doherty TM, Grewal HMS, Vaz M (2018)
Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: a cluster randomised trial in Indian neonates vaccinated with BCG
BMJ Open Respir Res, 5 (1), e000304
DOI 10.1136/bmjresp-2018-000304, PubMed 30397482

Publications 2017

Gjøen JE, Jenum S, Sivakumaran D, Mukherjee A, Macaden R, Kabra SK, Lodha R, Ottenhoff THM, Haks MC, Doherty TM, Ritz C, Grewal HMS (2017)
Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children
Sci Rep, 7 (1), 5839
DOI 10.1038/s41598-017-05057-x, PubMed 28724962

Publications 2016

Jenum S, Bakken R, Dhanasekaran S, Mukherjee A, Lodha R, Singh S, Singh V, Haks MC, Ottenhoff TH, Kabra SK, Doherty TM, Ritz C, Grewal HM (2016)
BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome
Sci Rep, 6, 38841
DOI 10.1038/srep38841, PubMed 27941850

Jenum S, Dhanasekaran S, Lodha R, Mukherjee A, Kumar Saini D, Singh S, Singh V, Medigeshi G, Haks MC, Ottenhoff TH, Doherty TM, Kabra SK, Ritz C, Grewal HM (2016)
Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum
Sci Rep, 6, 18520
DOI 10.1038/srep18520, PubMed 26725873

Jenum S, Dhanasekaran S, Ritz C, Macaden R, Doherty TM, Grewal HM, TB Trials Study Group (2016)
Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
Pediatr Infect Dis J, 35 (12), 1336-1338
DOI 10.1097/INF.0000000000001328, PubMed 27642776

Publications 2014

Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Kenneth J, Vaz M, Doherty TM, Grewal HM, TB Trials Study Group (2014)
Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles
Genes Immun, 15 (5), 265-74
DOI 10.1038/gene.2014.13, PubMed 24739497

Dhanasekaran S, Jenum S, Stavrum R, Wiker HG, Kenneth J, Vaz M, Doherty TM, Grewal HM, TB Trials Study Group (2014)
Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management
PLoS Negl Trop Dis, 8 (10), e3243
DOI 10.1371/journal.pntd.0003243, PubMed 25329719

Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL, TB Trials Study Group (2014)
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents
PLoS One, 9 (7), e101224
DOI 10.1371/journal.pone.0101224, PubMed 24992314

Jenum S, Selvam S, Mahelai D, Jesuraj N, Cárdenas V, Kenneth J, Hesseling AC, Doherty TM, Vaz M, Grewal HM (2014)
Influence of age and nutritional status on the performance of the tuberculin skin test and QuantiFERON-TB gold in-tube in young children evaluated for tuberculosis in Southern India
Pediatr Infect Dis J, 33 (10), e260-9
DOI 10.1097/INF.0000000000000399, PubMed 24797993

Publications 2013

Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Faurholt-Jepsen D, Kenneth J, Vaz M, Grewal HM, Doherty TM, TB Trials Study Group (2013)
Identification of biomarkers for Mycobacterium tuberculosis infection and disease in BCG-vaccinated young children in Southern India
Genes Immun, 14 (6), 356-64
DOI 10.1038/gene.2013.26, PubMed 23676757