Publications 2024

Bischof K, Cremaschi A, Eroukhmanoff L, Landskron J, Flage-Larsen LL, Gade A, Bjørge L, Urbanucci A, Taskén K (2024)
Patient-derived acellular ascites fluid affects drug responses in ovarian cancer cell lines through the activation of key signalling pathways
Mol Oncol (in press)
DOI 10.1002/1878-0261.13726, PubMed 39245677

Bjørgo E, Fagereng GL, Russnes HG, Smeland S, Taskén K, Helland Å (2024)
Acta Oncologica Nordic Precision Cancer Medicine Symposium 2023 - merging clinical research and standard healthcare
Acta Oncol, 63, 487-490
DOI 10.2340/1651-226X.2024.24954, PubMed 38910311

Gregersen I, Kong XY, Kooijman S, Foyn H, Grannes H, Olsen MB, Lone AM, Yang K, Quiles-Jiménez A, Tran M, Øgaard J, Segers FM, Rashidi A, Sagen EL, Lauritzen KH, Pronk ACM, de Boer JF, Holven KB, Melum E, Aukrust P, Taskén K, Holm S, Rensen PCN, Dahl TB, Halvorsen B (2024)
T cells with increased responsiveness cause obesity in mice without diet intervention
iScience, 27 (4), 109471
DOI 10.1016/j.isci.2024.109471, PubMed 38551005

Helland Å, Steinskog ESS, Blix ES, Flobak Å, Brabrand S, Puco K, Niehusmann P, Meltzer S, Oppedal IA, Haug Å, Torkildsen CF, Randen U, Gilje B, Lønning PE, Gjertsen BT, Hovland R, Russnes HG, Fagereng GL, Smeland S, Tasken K (2024)
[Raising the quality of cancer treatment]
Tidsskr Nor Laegeforen, 144 (1)
DOI 10.4045/tidsskr.23.0740, PubMed 38258713

Puco K, Fagereng GL, Brabrand S, Niehusmann P, Støre Blix E, Samdal Steinskog ES, Haug Å, Fredvik Torkildsen C, Oppedal IA, Meltzer S, Flobak Å, Johansson KAM, Bjørge L, Hjortland GO, Dalhaug A, Lund JÅ, Gilje B, Grønlie Cameron M, Hovland R, Falk RS, Smeland S, Giercksky Russnes HE, Taskén K, Helland Å, InPreD Consortium et al. (2024)
IMPRESS-Norway: improving public cancer care by implementing precision medicine in Norway; inclusion rates and preliminary results
Acta Oncol, 63, 379-384
DOI 10.2340/1651-226X.2024.28322, PubMed 38779911

Sveen A, Johannessen B, Klokkerud SM, Kraggerud SM, Meza-Zepeda LA, Bjørnslett M, Bischof K, Myklebost O, Taskén K, Skotheim RI, Dørum A, Davidson B, Lothe RA (2024)
Evolutionary mode and timing of dissemination of high-grade serous carcinomas
JCI Insight, 9 (3)
DOI 10.1172/jci.insight.170423, PubMed 38175731

Taskén K, F Haj Mohammad S, Fagereng GL, Sørum Falk R, Helland Å, Barjesteh van Waalwijk van Doorn-Khosrovani S, Steen Carlsson K, Ryll B, Jalkanen K, Edsjö A, Russnes HG, Lassen U, Hallersjö Hult E, Lugowska I, Blay JY, Verlingue L, Abel E, Lowery MA, Krebs MG, Staal Rohrberg K, Ojamaa K, Oliveira J, Verheul HMW, Voest EE, Gelderblom H et al. (2024)
PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe
Acta Oncol, 63, 385-391
DOI 10.2340/1651-226X.2024.34791, PubMed 38779910

Publications 2023

Ayuda-Durán P, Hermansen JU, Giliberto M, Yin Y, Hanes R, Gordon S, Kuusanmäki H, Brodersen AM, Andersen AN, Taskén K, Wennerberg K, Enserink JM, Skånland SS (2023)
Standardized assays to monitor drug sensitivity in hematologic cancers
Cell Death Discov, 9 (1), 435
DOI 10.1038/s41420-023-01722-5, PubMed 38040674

García-Díaz N, Wei Q, Taskén K (2023)
Small molecule inhibitors targeting regulatory T cells for cancer treatment
Eur J Immunol, 54 (2), e2350448
DOI 10.1002/eji.202350448, PubMed 37937687

Hermansen JU, Yin Y, Urban A, Myklebust CV, Karlsen L, Melvold K, Tveita AA, Taskén K, Munthe LA, Tjønnfjord GE, Skånland SS (2023)
A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine
Cell Death Discov, 9 (1), 125
DOI 10.1038/s41420-023-01426-w, PubMed 37055391

Köhn-Luque A, Myklebust EM, Tadele DS, Giliberto M, Schmiester L, Noory J, Harivel E, Arsenteva P, Mumenthaler SM, Schjesvold F, Taskén K, Enserink JM, Leder K, Frigessi A, Foo J (2023)
Phenotypic deconvolution in heterogeneous cancer cell populations using drug-screening data
Cell Rep Methods, 3 (3), 100417
DOI 10.1016/j.crmeth.2023.100417, PubMed 37056380

Le Tourneau C, André F, Helland Å, Mileshkin L, Minnaard W, Schiel A, Taskén K, Thomas DM, Veronese ML, Durán-Pacheco G, Leyens L, Rufibach K, Thomas M, Krämer A (2023)
Modified study designs to expand treatment options in personalised oncology: a multistakeholder view
Eur J Cancer, 194, 113278
DOI 10.1016/j.ejca.2023.113278, PubMed 37820553

Skogestad J, Albert I, Hougen K, Lothe GB, Lunde M, Eken OS, Veras I, Huynh NTT, Børstad M, Marshall S, Shen X, Louch WE, Robinson EL, Cleveland JC, Ambardekar AV, Schwisow JA, Jonas E, Calejo AI, Morth JP, Taskén K, Melleby AO, Lunde PK, Sjaastad I, Carlson CR, Aronsen JM (2023)
Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure
Circulation, 147 (16), 1221-1236
DOI 10.1161/CIRCULATIONAHA.121.054168, PubMed 36876489

Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K et al. (2023)
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745

Publications 2022

Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K (2022)
Correction for Bjørgo et al., "Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/β-Arrestin/cAMP Phosphodiesterase 4 Complex"
Mol Cell Biol, 42 (2), e0055621
DOI 10.1128/mcb.00556-21, PubMed 35175135

Flobak Å, Skånland SS, Hovig E, Taskén K, Russnes HG (2022)
Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
Trends Pharmacol Sci, 43 (11), 973-985
DOI 10.1016/j.tips.2022.08.009, PubMed 36163057

Giliberto M, Santana LM, Holien T, Misund K, Nakken S, Vodak D, Hovig E, Meza-Zepeda LA, Coward E, Waage A, Taskén K, Skånland SS (2022)
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
Front Oncol, 12, 1040730
DOI 10.3389/fonc.2022.1040730, PubMed 36523963

Giliberto M, Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold F, Munthe LA, Taskén K (2022)
Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically
Mol Oncol, 16 (6), 1241-1258
DOI 10.1002/1878-0261.13191, PubMed 35148457

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909

Helland Å, Russnes HG, Fagereng GL, Al-Shibli K, Andersson Y, Berg T, Bjørge L, Blix E, Bjerkehagen B, Brabrand S, Cameron MG, Dalhaug A, Dietzel D, Dønnem T, Enerly E, Flobak Å, Fluge S, Gilje B, Gjertsen BT, Grønberg BH, Grønås K, Guren T, Hamre H, Haug Å, Heinrich D et al. (2022)
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045

Taskén K, Russnes HEG, Aas E, Bjørge L, Blix ES, CONNECT Public–Private Partnership Consortium, Enerly E, Fagereng GL, Flobak Å, Gilje B, Gjertsen BT, Guren TK, Heix J, Hovig E, Hovland R, InPreD-Norway and National Molecular Tumor Board Consortium, IMPRESS-Norway Consortium, Lønning PE, Meza-Zepeda LA, Mæhle PM, Nilsen HL, Thoresen SØ, Widerberg K, Smeland S, Helland Å (2022)
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529

Wei Q, Taskén K (2022)
Immunoregulatory signal networks and tumor immune evasion mechanisms: insights into therapeutic targets and agents in clinical development
Biochem J, 479 (20), 2219-2260
DOI 10.1042/BCJ20210233, PubMed 36305711

Yin Y, Athanasiadis P, Karlsen L, Urban A, Xu H, Murali I, Fernandes SM, Arribas AJ, Hilli AK, Taskén K, Bertoni F, Mato AR, Normant E, Brown JR, Tjønnfjord GE, Aittokallio T, Skånland SS (2022)
Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Clin Cancer Res, 28 (20), 4444-4455
DOI 10.1158/1078-0432.CCR-22-1221, PubMed 35998013

Publications 2021

Chellappa S, Kushekhar K, Hagness M, Horneland R, Taskén K, Aandahl EM (2021)
The Presence of Activated T Cell Subsets prior to Transplantation Is Associated with Increased Rejection Risk in Pancreas Transplant Recipients
J Immunol, 207 (10), 2501-2511
DOI 10.4049/jimmunol.2001103, PubMed 34607938

Jenum S, Tonby K, Rueegg CS, Rühwald M, Kristiansen MP, Bang P, Olsen IC, Sellæg K, Røstad K, Mustafa T, Taskén K, Kvale D, Mortensen R, Dyrhol-Riise AM (2021)
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients
Nat Commun, 12 (1), 6774
DOI 10.1038/s41467-021-27029-6, PubMed 34811370

Jiang X, Bergquist A, Löscher BS, Venkatesh G, Mold JE, Holm K, Laerdahl JK, Skånland SS, Maleki KT, Cornillet M, Taskén K, Franke A, Karlsen TH, Björkström NK, Melum E (2021)
A heterozygous germline CD100 mutation in a family with primary sclerosing cholangitis
Sci Transl Med, 13 (582)
DOI 10.1126/scitranslmed.abb0036, PubMed 33627483

Jøntvedt Jørgensen M, Nore KG, Aass HCD, Layre E, Nigou J, Mortensen R, Tasken K, Kvale D, Jenum S, Tonby K, Dyrhol-Riise AM (2021)
Plasma LOX-Products and Monocyte Signaling Is Reduced by Adjunctive Cyclooxygenase-2 Inhibitor in a Phase I Clinical Trial of Tuberculosis Patients
Front Cell Infect Microbiol, 11, 669623
DOI 10.3389/fcimb.2021.669623, PubMed 34307194

Lone AM, Giansanti P, Jørgensen MJ, Gjerga E, Dugourd A, Scholten A, Saez-Rodriguez J, Heck AJR, Taskén K (2021)
Systems approach reveals distinct and shared signaling networks of the four PGE₂ receptors in T cells
Sci Signal, 14 (703), eabc8579
DOI 10.1126/scisignal.abc8579, PubMed 34609894

Lone AM, Taskén K (2021)
Phosphoproteomics-Based Characterization of Prostaglandin E₂ Signaling in T Cells
Mol Pharmacol, 99 (5), 370-382
DOI 10.1124/molpharm.120.000170, PubMed 33674363

Lorvik KB, Meyer-Myklestad MH, Kushekar K, Handeland C, Medhus AW, Lund-Iversen M, Stiksrud B, Kvale D, Dyrhol-Riise AM, Taskén K, Reikvam DH (2021)
Enhanced Gut-Homing Dynamics and Pronounced Exhaustion of Mucosal and Blood CD4⁺ T Cells in HIV-Infected Immunological Non-Responders
Front Immunol, 12, 744155
DOI 10.3389/fimmu.2021.744155, PubMed 34691047

Melvold K, Giliberto M, Karlsen L, Ayuda-Durán P, Hanes R, Holien T, Enserink J, Brown JR, Tjønnfjord GE, Taskén K, Skånland SS (2021)
Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies
Mol Oncol, 16 (5), 1153-1170
DOI 10.1002/1878-0261.13153, PubMed 34861096

Yaqub S, Bjørnbeth BA, Angelsen JH, Fristrup CW, Grønbech JE, Hemmingsson O, Isaksson B, Juel IS, Larsen PN, Lindell G, Mortensen FV, Mortensen KE, Rizell M, Sandström P, Sandvik OM, Sparrelid E, Taflin H, Taskén K, ASAC study group (2021)
Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial
Trials, 22 (1), 642
DOI 10.1186/s13063-021-05587-w, PubMed 34544470

Publications 2020

Caglayan S, Hashim A, Cieslar-Pobuda A, Jensen V, Behringer S, Talug B, Chu DT, Pecquet C, Rogne M, Brech A, Brorson SH, Nagelhus EA, Hannibal L, Boschi A, Taskén K, Staerk J (2020)
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154, PubMed 32450518

Meås HZ, Haug M, Beckwith MS, Louet C, Ryan L, Hu Z, Landskron J, Nordbø SA, Taskén K, Yin H, Damås JK, Flo TH (2020)
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nat Commun, 11 (1), 147
DOI 10.1038/s41467-019-13837-4, PubMed 31919342

Skånland SS, Karlsen L, Taskén K (2020)
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia
Scand J Immunol, 92 (5), e12931
DOI 10.1111/sji.12931, PubMed 32640099

Publications 2019

Brennecke P, Rasina D, Aubi O, Herzog K, Landskron J, Cautain B, Vicente F, Quintana J, Mestres J, Stechmann B, Ellinger B, Brea J, Kolanowski JL, Pilarski R, Orzaez M, Pineda-Lucena A, Laraia L, Nami F, Zielenkiewicz P, Paruch K, Hansen E, von Kries JP, Neuenschwander M, Specker E, Bartunek P et al. (2019)
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discov, 24 (3), 398-413
DOI 10.1177/2472555218816276, PubMed 30616481

Chellappa S, Kushekhar K, Munthe LA, Tjønnfjord GE, Aandahl EM, Okkenhaug K, Taskén K (2019)
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function
J Immunol, 202 (5), 1397-1405
DOI 10.4049/jimmunol.1701703, PubMed 30692213

Dukic AR, Gerbaud P, Guibourdenche J, Thiede B, Taskén K, Pidoux G (2019)
Correction: Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
Biochem J, 476 (13), 1927
DOI 10.1042/BCJ-2017-0529_COR, PubMed 31266855

Goodridge JP, Jacobs B, Saetersmoen ML, Clement D, Hammer Q, Clancy T, Skarpen E, Brech A, Landskron J, Grimm C, Pfefferle A, Meza-Zepeda L, Lorenz S, Wiiger MT, Louch WE, Ask EH, Liu LL, Oei VYS, Kjällquist U, Linnarsson S, Patel S, Taskén K, Stenmark H, Malmberg KJ (2019)
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Nat Commun, 10 (1), 514
DOI 10.1038/s41467-019-08384-x, PubMed 30705279

Skånland SS, Cremaschi A, Bendiksen H, Hermansen JU, Thimiri Govinda Raj DB, Munthe LA, Tjønnfjord GE, Taskén K (2019)
An in vitro assay for biomarker discovery and dose prediction applied to ibrutinib plus venetoclax treatment of CLL
Leukemia, 34 (2), 478-487
DOI 10.1038/s41375-019-0569-7, PubMed 31471562

Skånland SS, Taskén K (2019)
Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling
J Immunol, 203 (4), 1055-1063
DOI 10.4049/jimmunol.1801660, PubMed 31292214

Sukonina V, Ma H, Zhang W, Bartesaghi S, Subhash S, Heglind M, Foyn H, Betz MJ, Nilsson D, Lidell ME, Naumann J, Haufs-Brusberg S, Palmgren H, Mondal T, Beg M, Jedrychowski MP, Taskén K, Pfeifer A, Peng XR, Kanduri C, Enerbäck S (2019)
FOXK1 and FOXK2 regulate aerobic glycolysis
Nature, 566 (7743), 279-283
DOI 10.1038/s41586-019-0900-5, PubMed 30700909

Publications 2018

Dukic AR, Gerbaud P, Guibourdenche J, Thiede B, Taskén K, Pidoux G (2018)
Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion
Biochem J, 475 (2), 455-476
DOI 10.1042/BCJ20170529, PubMed 29259079

Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Cryopreservation of primary B cells minimally influences their signaling responses
Sci Rep, 8 (1), 17651
DOI 10.1038/s41598-018-36121-9, PubMed 30518828

Myhrvold IK, Cremaschi A, Hermansen JU, Tjønnfjord GE, Munthe LA, Taskén K, Skånland SS (2018)
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia
Oncotarget, 9 (10), 9273-9284
DOI 10.18632/oncotarget.23949, PubMed 29507689

Rogne M, Chu DT, Küntziger TM, Mylonakou MN, Collas P, Tasken K (2018)
OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells
Mol Biol Cell, 29 (12), 1487-1501
DOI 10.1091/mbc.E17-09-0538, PubMed 29688805

Schwab C, Gabrysch A, Olbrich P, Patiño V, Warnatz K, Wolff D, Hoshino A, Kobayashi M, Imai K, Takagi M, Dybedal I, Haddock JA, Sansom DM, Lucena JM, Seidl M, Schmitt-Graeff A, Reiser V, Emmerich F, Frede N, Bulashevska A, Salzer U, Schubert D, Hayakawa S, Okada S, Kanariou M et al. (2018)
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects
J Allergy Clin Immunol, 142 (6), 1932-1946
DOI 10.1016/j.jaci.2018.02.055, PubMed 29729943

Thimiri Govinda Raj DB, Cremaschi A, Skånland SS, Gade A, Schjesvold FH, Tjønnfjord GE, Munthe LA, Tasken K (2018)
In-Vitro Drug Sensitivity Screening in Chronic Lymphocytic Leukemia (CLL) Primary Patient Samples Identifies Drug Candidates for Precision Cancer Therapy
Blood, 132, 4676
DOI 10.1182/blood-2018-99-110357, PublikaID 304

Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold FH, Munthe LA, Tasken K (2018)
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303

Publications 2017

Chellappa S, Hugenschmidt H, Hagness M, Subramani S, Melum E, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2017)
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
J Immunol, 198 (4), 1729-1739
DOI 10.4049/jimmunol.1600061, PubMed 28053236

Chu DT, Tao Y, Taskén K (2017)
OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
Horm Metab Res, 49 (4), 276-285
DOI 10.1055/s-0043-100384, PubMed 28427098

Dukic AR, Haugen LH, Pidoux G, Leithe E, Bakke O, Taskén K (2017)
A protein kinase A-ezrin complex regulates connexin 43 gap junction communication in liver epithelial cells
Cell Signal, 32, 1-11
DOI 10.1016/j.cellsig.2017.01.008, PubMed 28077322

Landskron J, Kraggerud SM, Wik E, Dørum A, Bjørnslett M, Melum E, Helland Ø, Bjørge L, Lothe RA, Salvesen HB, Taskén K (2017)
C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease
PLoS One, 12 (7), e0182030
DOI 10.1371/journal.pone.0182030, PubMed 28759630

Prebensen C, Trøseid M, Ueland T, Dahm A, Sandset PM, Aaberge I, Waalen K, Dyrhol-Riise AM, Taskén K, Kvale D (2017)
Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial
PLoS One, 12 (5), e0176527
DOI 10.1371/journal.pone.0176527, PubMed 28464042

Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239

Wang D, Fløisand Y, Myklebust CV, Bürgler S, Parente-Ribes A, Hofgaard PO, Bogen B, Taskén K, Tjønnfjord GE, Schjesvold F, Dalgaard J, Tveita A, Munthe LA (2017)
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice
Leukemia, 31 (10), 2114-2121
DOI 10.1038/leu.2017.69, PubMed 28232741

Publications 2016

Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
Aspirin As Secondary Prevention in Patients With Colorectal Cancer: An Unselected Population-Based Study
J Clin Oncol, 34 (21), 2501-8
DOI 10.1200/JCO.2015.65.3519, PubMed 27247217

Bains SJ, Mahic M, Myklebust TÅ, Småstuen MC, Yaqub S, Dørum LM, Bjørnbeth BA, Møller B, Brudvik KW, Taskén K (2016)
Reply to M. Løberg et al
J Clin Oncol, 35 (5), 569-571
DOI 10.1200/JCO.2016.70.8263, PubMed 29236616

Bjerregaard-Andersen K, Østensen E, Scott JD, Taskén K, Morth JP (2016)
Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state
Acta Crystallogr F Struct Biol Commun, 72 (Pt 8), 591-7
DOI 10.1107/S2053230X16010189, PubMed 27487922

Dukic AR, McClymont DW, Taskén K (2016)
A Cell-Based High-Throughput Assay for Gap Junction Communication Suitable for Assessing Connexin 43-Ezrin Interaction Disruptors Using IncuCyte ZOOM
SLAS Discov, 22 (1), 77-85
DOI 10.1177/1087057116669120, PubMed 27628689

Landskron J, Taskén K (2016)
Phosphoprotein Detection by High-Throughput Flow Cytometry
Methods Mol Biol, 1355, 275-90
DOI 10.1007/978-1-4939-3049-4_19, PubMed 26584933

Liu LL, Landskron J, Ask EH, Enqvist M, Sohlberg E, Traherne JA, Hammer Q, Goodridge JP, Larsson S, Jayaraman J, Oei VYS, Schaffer M, Taskén K, Ljunggren HG, Romagnani C, Trowsdale J, Malmberg KJ, Béziat V (2016)
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Cell Rep, 15 (5), 1088-1099
DOI 10.1016/j.celrep.2016.04.005, PubMed 27117418

Moltu K, Henjum K, Oberprieler NG, Bjørnbeth BA, Taskén K (2016)
Proximal signaling responses in peripheral T cells from colorectal cancer patients are affected by high concentrations of circulating prostaglandin E₂
Hum Immunol, 78 (2), 129-137
DOI 10.1016/j.humimm.2016.10.007, PubMed 27769746

Stiksrud B, Lorvik KB, Kvale D, Mollnes TE, Ueland PM, Trøseid M, Taskén K, Dyrhol-Riise AM (2016)
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144

Tonby K, Wergeland I, Lieske NV, Kvale D, Tasken K, Dyrhol-Riise AM (2016)
The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection
BMC Infect Dis, 16 (1), 599
DOI 10.1186/s12879-016-1938-8, PubMed 27776487

Wehbi VL, Taskén K (2016)
Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units
Front Immunol, 7, 222
DOI 10.3389/fimmu.2016.00222, PubMed 27375620

Publications 2015

Calejo AI, Taskén K (2015)
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins
Front Pharmacol, 6, 192
DOI 10.3389/fphar.2015.00192, PubMed 26441649

Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2015)
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Oncoimmunology, 5 (4), e1102828
DOI 10.1080/2162402X.2015.1102828, PubMed 27141387

Chellappa S, Lieske NV, Hagness M, Line PD, Taskén K, Aandahl EM (2015)
Human regulatory T cells control TCR signaling and susceptibility to suppression in CD4+ T cells
J Leukoc Biol, 100 (1), 5-16
DOI 10.1189/jlb.2HI0815-334R, PubMed 26715685

Gerbaud P, Taskén K, Pidoux G (2015)
Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion
Front Pharmacol, 6, 202
DOI 10.3389/fphar.2015.00202, PubMed 26441659

Lieske NV, Tonby K, Kvale D, Dyrhol-Riise AM, Tasken K (2015)
Targeting Tuberculosis and HIV Infection-Specific Regulatory T Cells with MEK/ERK Signaling Pathway Inhibitors
PLoS One, 10 (11), e0141903
DOI 10.1371/journal.pone.0141903, PubMed 26544592

Parente-Ribes A, Skånland SS, Bürgler S, Os A, Wang D, Bogen B, Tjønnfjord GE, Taskén K, Munthe LA (2015)
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells
Haematologica, 101 (2), e59-62
DOI 10.3324/haematol.2015.135590, PubMed 26589914

Pidoux G, Taskén K (2015)
Anchored PKA as a gatekeeper for gap junctions
Commun Integr Biol, 8 (4), e1057361
DOI 10.1080/19420889.2015.1057361, PubMed 26478781

Raslan Z, Magwenzi S, Aburima A, Taskén K, Naseem KM (2015)
Targeting of type I protein kinase A to lipid rafts is required for platelet inhibition by the 3',5'-cyclic adenosine monophosphate-signaling pathway
J Thromb Haemost, 13 (9), 1721-34
DOI 10.1111/jth.13042, PubMed 26176741

Santegoets SJ, Dijkgraaf EM, Battaglia A, Beckhove P, Britten CM, Gallimore A, Godkin A, Gouttefangeas C, de Gruijl TD, Koenen HJ, Scheffold A, Shevach EM, Staats J, Taskén K, Whiteside TL, Kroep JR, Welters MJ, van der Burg SH (2015)
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry
Cancer Immunol Immunother, 64 (10), 1271-86
DOI 10.1007/s00262-015-1729-x, PubMed 26122357

Publications 2014

Ellinger B, Silber J, Prashar A, Landskron J, Weber J, Rehermann S, Müller FJ, Smith S, Wrigley S, Taskén K, Gribbon P, Labes A, Imhoff JF (2014)
A phenotypic screening approach to identify anticancer compounds derived from marine fungi
Assay Drug Dev Technol, 12 (3), 162-75
DOI 10.1089/adt.2013.564, PubMed 24735443

Halvorsen B, Smedbakken LM, Michelsen AE, Skjelland M, Bjerkeli V, Sagen EL, Taskén K, Bendz B, Gullestad L, Holm S, Biessen EA, Aukrust P (2014)
Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13
Atherosclerosis, 234 (2), 352-9
DOI 10.1016/j.atherosclerosis.2014.03.021, PubMed 24732574

Landskron J, Helland Ø, Torgersen KM, Aandahl EM, Gjertsen BT, Bjørge L, Taskén K (2014)
Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients
Cancer Immunol Immunother, 64 (3), 337-47
DOI 10.1007/s00262-014-1636-6, PubMed 25416072

Pidoux G, Gerbaud P, Dompierre J, Lygren B, Solstad T, Evain-Brion D, Taskén K (2014)
A PKA-ezrin-Cx43 signaling complex controls gap junction communication and thereby trophoblast cell fusion
J Cell Sci, 127 (Pt 19), 4172-85
DOI 10.1242/jcs.149609, PubMed 25052094

Rogne M, Taskén K (2014)
Compartmentalization of cAMP signaling in adipogenesis, lipogenesis, and lipolysis
Horm Metab Res, 46 (12), 833-40
DOI 10.1055/s-0034-1389955, PubMed 25247872

Skånland SS, Moltu K, Berge T, Aandahl EM, Taskén K (2014)
T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses
Biochem J, 460 (3), 399-410
DOI 10.1042/BJ20140040, PubMed 24665965

Spurgeon BE, Aburima A, Oberprieler NG, Taskén K, Naseem KM (2014)
Multiplexed phosphospecific flow cytometry enables large-scale signaling profiling and drug screening in blood platelets
J Thromb Haemost, 12 (10), 1733-43
DOI 10.1111/jth.12670, PubMed 25056834

Publications 2013

Brudvik KW, Bains SJ, Seeberg LT, Labori KJ, Waage A, Taskén K, Aandahl EM, Bjørnbeth BA (2013)
Aggressive treatment of patients with metastatic colorectal cancer increases survival: a scandinavian single-center experience
HPB Surg, 2013, 727095
DOI 10.1155/2013/727095, PubMed 23840074

Cornez I, Joel M, Taskén K, Langmoen IA, Glover JC, Berge T (2013)
EGF signalling and rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry
J Neurooncol, 112 (1), 49-57
DOI 10.1007/s11060-012-1035-9, PubMed 23299461

Landskron J, Taskén K (2013)
CD147 in regulatory T cells
Cell Immunol, 282 (1), 17-20
DOI 10.1016/j.cellimm.2013.04.008, PubMed 23665204

Lone AM, Taskén K (2013)
Proinflammatory and immunoregulatory roles of eicosanoids in T cells
Front Immunol, 4, 130
DOI 10.3389/fimmu.2013.00130, PubMed 23760108

Rogne M, Taskén K (2013)
Cell signalling analyses in the functional genomics era
N Biotechnol, 30 (3), 333-8
DOI 10.1016/j.nbt.2013.01.003, PubMed 23369868

Singh M, Singh P, Vaira D, Torheim EA, Rahmouni S, Taskén K, Moutschen M (2013)
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice
Eur J Clin Invest, 44 (2), 146-52
DOI 10.1111/eci.12200, PubMed 24283208

Størvold GL, Landskron J, Strozynski M, Arntzen MØ, Koehler CJ, Kalland ME, Taskén K, Thiede B (2013)
Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
J Proteomics, 91, 344-57
DOI 10.1016/j.jprot.2013.07.019, PubMed 23933134

Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA (2013)
The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses
Hum Immunol, 74 (5), 574-85
DOI 10.1016/j.humimm.2012.12.017, PubMed 23333624

Publications 2012

Brudvik KW, Taskén K (2012)
Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states
Br J Pharmacol, 166 (2), 411-9
DOI 10.1111/j.1476-5381.2011.01800.x, PubMed 22141738

Hagness M, Henjum K, Landskron J, Brudvik KW, Bjørnbeth BA, Foss A, Taskén K, Aandahl EM (2012)
Kinetics and activation requirements of contact-dependent immune suppression by human regulatory T cells
J Immunol, 188 (11), 5459-66
DOI 10.4049/jimmunol.1101367, PubMed 22539784

Kalland ME, Solheim SA, Skånland SS, Taskén K, Berge T (2012)
Modulation of proximal signaling in normal and transformed B cells by transmembrane adapter Cbp/PAG
Exp Cell Res, 318 (14), 1611-9
DOI 10.1016/j.yexcr.2012.05.014, PubMed 22659621

Pollheimer J, Bodin J, Sundnes O, Edelmann RJ, Skånland SS, Sponheim J, Brox MJ, Sundlisaeter E, Loos T, Vatn M, Kasprzycka M, Wang J, Küchler AM, Taskén K, Haraldsen G, Hol J (2012)
Interleukin-33 drives a proinflammatory endothelial activation that selectively targets nonquiescent cells
Arterioscler Thromb Vasc Biol, 33 (2), e47-55
DOI 10.1161/ATVBAHA.112.253427, PubMed 23162017

Scott JD, Dessauer CW, Taskén K (2012)
Creating order from chaos: cellular regulation by kinase anchoring
Annu Rev Pharmacol Toxicol, 53, 187-210
DOI 10.1146/annurev-pharmtox-011112-140204, PubMed 23043438

Vang T, Liu WH, Delacroix L, Wu S, Vasile S, Dahl R, Yang L, Musumeci L, Francis D, Landskron J, Tasken K, Tremblay ML, Lie BA, Page R, Mustelin T, Rahmouni S, Rickert RC, Tautz L (2012)
LYP inhibits T-cell activation when dissociated from CSK
Nat Chem Biol, 8 (5), 437-46
DOI 10.1038/nchembio.916, PubMed 22426112

Publications 2011

Andrei M, Bakkebø T, Klaveness J, Taskén K, Undheim K (2011)
Stereoselective synthesis of (RP)-8-substituted-N⁶-acylated and N⁶-alkylated adenosine-3',5'-cyclic phosphorothioic acids as cAMP antagonists
Eur J Med Chem, 46 (12), 5935-40
DOI 10.1016/j.ejmech.2011.10.003, PubMed 22041460

Bjørgo E, Moltu K, Taskén K (2011)
Phosphodiesterases as targets for modulating T-cell responses
Handb Exp Pharmacol (204), 345-63
DOI 10.1007/978-3-642-17969-3_15, PubMed 21695648

Brudvik KW, Henjum K, Aandahl EM, Bjørnbeth BA, Taskén K (2011)
Regulatory T-cell-mediated inhibition of antitumor immune responses is associated with clinical outcome in patients with liver metastasis from colorectal cancer
Cancer Immunol Immunother, 61 (7), 1045-53
DOI 10.1007/s00262-011-1174-4, PubMed 22159472

Brudvik KW, Paulsen JE, Aandahl EM, Roald B, Taskén K (2011)
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice
Mol Cancer, 10, 149
DOI 10.1186/1476-4598-10-149, PubMed 22168384

Kalland ME, Oberprieler NG, Vang T, Taskén K, Torgersen KM (2011)
T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells
J Immunol, 187 (10), 5233-45
DOI 10.4049/jimmunol.1101804, PubMed 22013130

Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD (2011)
An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria
Proc Natl Acad Sci U S A, 108 (48), E1227-35
DOI 10.1073/pnas.1107182108, PubMed 22084075

Mosenden R, Moltu K, Ruppelt A, Berge T, Taskén K (2011)
Effects of type I protein kinase A modulation on the T cell distal pole complex
Scand J Immunol, 74 (6), 568-73
DOI 10.1111/j.1365-3083.2011.02611.x, PubMed 21854406

Mosenden R, Singh P, Cornez I, Heglind M, Ruppelt A, Moutschen M, Enerbäck S, Rahmouni S, Taskén K (2011)
Mice with disrupted type I protein kinase A anchoring in T cells resist retrovirus-induced immunodeficiency
J Immunol, 186 (9), 5119-30
DOI 10.4049/jimmunol.1100003, PubMed 21430226

Pettersen FO, Torheim EA, Dahm AE, Aaberge IS, Lind A, Holm M, Aandahl EM, Sandset PM, Taskén K, Kvale D (2011)
An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T cell-dependent vaccine responses
J Virol, 85 (13), 6557-66
DOI 10.1128/JVI.00073-11, PubMed 21490090

Pidoux G, Witczak O, Jarnæss E, Myrvold L, Urlaub H, Stokka AJ, Küntziger T, Taskén K (2011)
Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
EMBO J, 30 (21), 4371-86
DOI 10.1038/emboj.2011.365, PubMed 21983901

Solstad T, Bains SJ, Landskron J, Aandahl EM, Thiede B, Taskén K, Torgersen KM (2011)
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
Blood, 118 (19), 5141-51
DOI 10.1182/blood-2011-02-339242, PubMed 21937704

Weedon-Fekjær MS, Taskén K (2011)
Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function
Placenta, 33 Suppl, S87-91
DOI 10.1016/j.placenta.2011.11.003, PubMed 22103973

Ånensen N, Hjelle SM, Van Belle W, Haaland I, Silden E, Bourdon JC, Hovland R, Taskén K, Knappskog S, Lønning PE, Bruserud Ø, Gjertsen BT (2011)
Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia
Oncogene, 31 (12), 1533-45
DOI 10.1038/onc.2011.348, PubMed 21860418

Publications 2010

Bjørgo E, Solheim SA, Abrahamsen H, Baillie GS, Brown KM, Berge T, Okkenhaug K, Houslay MD, Taskén K (2010)
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex
Mol Cell Biol, 30 (7), 1660-72
DOI 10.1128/MCB.00696-09, PubMed 20086095

Bjørgo E, Taskén K (2010)
Novel mechanism of signaling by CD28
Immunol Lett, 129 (1), 1-6
DOI 10.1016/j.imlet.2010.01.007, PubMed 20123110

Cornez I, Taskén K (2010)
Spatiotemporal control of cyclic AMP immunomodulation through the PKA-Csk inhibitory pathway is achieved by anchoring to an Ezrin-EBP50-PAG scaffold in effector T cells
FEBS Lett, 584 (12), 2681-8
DOI 10.1016/j.febslet.2010.04.056, PubMed 20420835

Mosenden R, Taskén K (2010)
Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells
Cell Signal, 23 (6), 1009-16
DOI 10.1016/j.cellsig.2010.11.018, PubMed 21130867

Ndhlovu LC, Leal FE, Eccles-James IG, Jha AR, Lanteri M, Norris PJ, Barbour JD, Wachter DJ, Andersson J, Taskén K, Torheim EA, Aandahl EM, Kallas EG, Nixon DF (2010)
A novel human CD4+ T-cell inducer subset with potent immunostimulatory properties
Eur J Immunol, 40 (1), 134-41
DOI 10.1002/eji.200939258, PubMed 19877008

Oberprieler NG, Lemeer S, Kalland ME, Torgersen KM, Heck AJ, Taskén K (2010)
High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells
Blood, 116 (13), 2253-65
DOI 10.1182/blood-2010-01-266650, PubMed 20558615

Oberprieler NG, Taskén K (2010)
Analysing phosphorylation-based signalling networks by phospho flow cytometry
Cell Signal, 23 (1), 14-8
DOI 10.1016/j.cellsig.2010.07.009, PubMed 20643206

Pettersen FO, Taskén K, Kvale D (2010)
Combined Env- and Gag-specific T cell responses in relation to programmed death-1 receptor and CD4 T cell loss rates in human immunodeficiency virus-1 infection
Clin Exp Immunol, 161 (2), 315-23
DOI 10.1111/j.1365-2249.2010.04179.x, PubMed 20491784

Pidoux G, Taskén K (2010)
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins
J Mol Endocrinol, 44 (5), 271-84
DOI 10.1677/JME-10-0010, PubMed 20150326

Solstad T, Bjørgo E, Koehler CJ, Strozynski M, Torgersen KM, Taskén K, Thiede B (2010)
Quantitative proteome analysis of detergent-resistant membranes identifies the differential regulation of protein kinase C isoforms in apoptotic T cells
Proteomics, 10 (15), 2758-68
DOI 10.1002/pmic.201000164, PubMed 20486122

Soond DR, Bjørgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K (2010)
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
Blood, 115 (11), 2203-13
DOI 10.1182/blood-2009-07-232330, PubMed 20081091

Publications 2009

Jarnaess E, Stokka AJ, Kvissel AK, Skålhegg BS, Torgersen KM, Scott JD, Carlson CR, Taskén K (2009)
Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments
J Biol Chem, 284 (50), 35154-64
DOI 10.1074/jbc.M109.056465, PubMed 19840947

Ngai J, Inngjerdingen M, Berge T, Taskén K (2009)
Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation
BMC Immunol, 10, 27
DOI 10.1186/1471-2172-10-27, PubMed 19426503

Stokka AJ, Mosenden R, Ruppelt A, Lygren B, Taskén K (2009)
The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T-cells and the immunomodulating effect of cAMP
Biochem J, 425 (2), 381-8
DOI 10.1042/BJ20091136, PubMed 19857202

Taskén K (2009)
Waking up regulatory T cells
Blood, 114 (6), 1136-7
DOI 10.1182/blood-2009-06-223222, PubMed 19661275

Torheim EA, Jarnaess E, Lygren B, Taskén K (2009)
Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling
Biochem J, 424 (1), 69-78
DOI 10.1042/BJ20090933, PubMed 19715558

Torheim EA, Ndhlovu LC, Pettersen FO, Larsen TL, Jha AR, Torgersen KM, Kvale D, Nixon DF, Taskén K, Aandahl EM (2009)
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population
Eur J Immunol, 39 (5), 1280-7
DOI 10.1002/eji.200839002, PubMed 19384871

Publications 2008

Berg T, Degerman E, Tasken K (2008)
Increased cAMP signaling can ameliorate the hypertensive condition in spontaneously hypertensive rats
J Vasc Res, 46 (1), 25-35
DOI 10.1159/000135662, PubMed 18515972

Bryn T, Mahic M, Aandahl EM, Frøland SS, Aukrust P, Taskén K (2008)
Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients
AIDS Res Hum Retroviruses, 24 (7), 1013-5
DOI 10.1089/aid.2008.0071, PubMed 18593346

Jarnaess E, Ruppelt A, Stokka AJ, Lygren B, Scott JD, Taskén K (2008)
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I
J Biol Chem, 283 (48), 33708-18
DOI 10.1074/jbc.M804807200, PubMed 18824551

Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G (2008)
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A
Cardiovasc Res, 80 (1), 47-54
DOI 10.1093/cvr/cvn180, PubMed 18599478

Lygren B, Taskén K (2008)
The potential use of AKAP18delta as a drug target in heart failure patients
Expert Opin Biol Ther, 8 (8), 1099-108
DOI 10.1517/14712598.8.8.1099, PubMed 18613762

Mahic M, Henjum K, Yaqub S, Bjørnbeth BA, Torgersen KM, Taskén K, Aandahl EM (2008)
Generation of highly suppressive adaptive CD8(+)CD25(+)FOXP3(+) regulatory T cells by continuous antigen stimulation
Eur J Immunol, 38 (3), 640-6
DOI 10.1002/eji.200737529, PubMed 18266270

Mahic M, Kalland ME, Aandahl EM, Torgersen KM, Taskén K (2008)
Human naturally occurring and adaptive regulatory T cells secrete high levels of leukaemia inhibitory factor upon activation
Scand J Immunol, 68 (4), 391-6
DOI 10.1111/j.1365-3083.2008.02148.x, PubMed 18782268

Mahic M, Yaqub S, Bryn T, Henjum K, Eide DM, Torgersen KM, Aandahl EM, Taskén K (2008)
Differentiation of naive CD4+ T cells into CD4+CD25+FOXP3+ regulatory T cells by continuous antigen stimulation
J Leukoc Biol, 83 (5), 1111-7
DOI 10.1189/jlb.0507329, PubMed 18270250

Methi T, Berge T, Torgersen KM, Taskén K (2008)
Reduced Cbl phosphorylation and degradation of the zeta-chain of the T-cell receptor/CD3 complex in T cells with low Lck levels
Eur J Immunol, 38 (9), 2557-63
DOI 10.1002/eji.200737837, PubMed 18792408

Ngai J, Methi T, Andressen KW, Levy FO, Torgersen KM, Vang T, Wettschureck N, Taskén K (2008)
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur J Immunol, 38 (11), 3208-18
DOI 10.1002/eji.200838195, PubMed 18991294

Rogne M, Stokka AJ, Taskén K, Collas P, Küntziger T (2008)
Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network
Hum Mol Genet, 18 (5), 978-87
DOI 10.1093/hmg/ddn425, PubMed 19074462

Solheim SA, Petsalaki E, Stokka AJ, Russell RB, Taskén K, Berge T (2008)
Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity
FEBS J, 275 (19), 4863-74
DOI 10.1111/j.1742-4658.2008.06626.x, PubMed 18721137

Torgersen KM, Aandahl EM, Taskén K (2008)
Molecular architecture of signal complexes regulating immune cell function
Handb Exp Pharmacol (186), 327-63
DOI 10.1007/978-3-540-72843-6_14, PubMed 18491059

Yaqub S, Taskén K (2008)
Role for the cAMP-protein kinase A signaling pathway in suppression of antitumor immune responses by regulatory T cells
Crit Rev Oncog, 14 (1), 57-77
DOI 10.1615/critrevoncog.v14.i1.40, PubMed 19105570

Aandahl EM, Torgersen KM, Taskén K (2008)
CD8+ regulatory T cells-A distinct T-cell lineage or a transient T-cell phenotype?
Hum Immunol, 69 (11), 696-9
DOI 10.1016/j.humimm.2008.08.291, PubMed 18817824

Publications 2007

Andrei M, Bjørnstad V, Langli G, Rømming C, Klaveness J, Taskén K, Undheim K (2007)
Stereoselective preparation of (RP)-8-hetaryladenosine-3',5'-cyclic phosphorothioic acids
Org Biomol Chem, 5 (13), 2070-80
DOI 10.1039/b702403g, PubMed 17581650

Bryn T, Yaqub S, Mahic M, Henjum K, Aandahl EM, Taskén K (2007)
LPS-activated monocytes suppress T-cell immune responses and induce FOXP3+ T cells through a COX-2-PGE2-dependent mechanism
Int Immunol, 20 (2), 235-45
DOI 10.1093/intimm/dxm134, PubMed 18156149

Jarnaess E, Taskén K (2007)
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes
Biochem Soc Trans, 35 (Pt 5), 931-7
DOI 10.1042/BST0350931, PubMed 17956249

Kesti T, Ruppelt A, Wang JH, Liss M, Wagner R, Taskén K, Saksela K (2007)
Reciprocal regulation of SH3 and SH2 domain binding via tyrosine phosphorylation of a common site in CD3epsilon
J Immunol, 179 (2), 878-85
DOI 10.4049/jimmunol.179.2.878, PubMed 17617578

Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E (2007)
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum
EMBO Rep, 8 (11), 1061-7
DOI 10.1038/sj.embor.7401081, PubMed 17901878

Methi T, Ngai J, Vang T, Torgersen KM, Taskén K (2007)
Hypophosphorylated TCR/CD3zeta signals through a Grb2-SOS1-Ras pathway in Lck knockdown cells
Eur J Immunol, 37 (9), 2539-48
DOI 10.1002/eji.200636973, PubMed 17683112

Ruppelt A, Mosenden R, Grönholm M, Aandahl EM, Tobin D, Carlson CR, Abrahamsen H, Herberg FW, Carpén O, Taskén K (2007)
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin
J Immunol, 179 (8), 5159-68
DOI 10.4049/jimmunol.179.8.5159, PubMed 17911601

Solheim SA, Torgersen KM, Taskén K, Berge T (2007)
Regulation of FynT function by dual domain docking on PAG/Cbp
J Biol Chem, 283 (5), 2773-83
DOI 10.1074/jbc.M705215200, PubMed 18056706

Yaqub S, Henjum K, Mahic M, Jahnsen FL, Aandahl EM, Bjørnbeth BA, Taskén K (2007)
Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
Cancer Immunol Immunother, 57 (6), 813-21
DOI 10.1007/s00262-007-0417-x, PubMed 17962941

Publications 2006

Bjørgo E, Taskén K (2006)
Role of cAMP phosphodiesterase 4 in regulation of T-cell function
Crit Rev Immunol, 26 (5), 443-51
DOI 10.1615/critrevimmunol.v26.i5.40, PubMed 17341187

Bryn T, Mahic M, Enserink JM, Schwede F, Aandahl EM, Taskén K (2006)
The cyclic AMP-Epac1-Rap1 pathway is dissociated from regulation of effector functions in monocytes but acquires immunoregulatory function in mature macrophages
J Immunol, 176 (12), 7361-70
DOI 10.4049/jimmunol.176.12.7361, PubMed 16751380

Carlson CR, Lygren B, Berge T, Hoshi N, Wong W, Taskén K, Scott JD (2006)
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor
J Biol Chem, 281 (30), 21535-21545
DOI 10.1074/jbc.M603223200, PubMed 16728392

Damås JK, Smith C, Øie E, Fevang B, Halvorsen B, Waehre T, Boullier A, Breland U, Yndestad A, Ovchinnikova O, Robertson AK, Sandberg WJ, Kjekshus J, Taskén K, Frøland SS, Gullestad L, Hansson GK, Quehenberger O, Aukrust P (2006)
Enhanced expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental atherosclerosis: possible pathogenic role in plaque destabilization
Arterioscler Thromb Vasc Biol, 27 (3), 614-20
DOI 10.1161/01.ATV.0000255581.38523.7c, PubMed 17170367

Gold MG, Lygren B, Dokurno P, Hoshi N, McConnachie G, Taskén K, Carlson CR, Scott JD, Barford D (2006)
Molecular basis of AKAP specificity for PKA regulatory subunits
Mol Cell, 24 (3), 383-95
DOI 10.1016/j.molcel.2006.09.006, PubMed 17081989

Grønning LM, Baillie GS, Cederberg A, Lynch MJ, Houslay MD, Enerbäck S, Taskén K (2006)
Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice
FEBS Lett, 580 (17), 4126-30
DOI 10.1016/j.febslet.2006.06.058, PubMed 16828089

Kvale D, Ormaasen V, Kran AM, Johansson CC, Aukrust P, Aandahl EM, Frøland SS, Taskén K (2006)
Immune modulatory effects of cyclooxygenase type 2 inhibitors in HIV patients on combination antiretroviral treatment
AIDS, 20 (6), 813-20
DOI 10.1097/01.aids.0000218544.54586.f1, PubMed 16549964

Lygren B, Taskén K (2006)
Compartmentalized cAMP signalling is important in the regulation of Ca(2+) cycling in the heart
Biochem Soc Trans, 34 (Pt 4), 489-91
DOI 10.1042/BST0340489, PubMed 16856840

Mahic M, Yaqub S, Johansson CC, Taskén K, Aandahl EM (2006)
FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism
J Immunol, 177 (1), 246-54
DOI 10.4049/jimmunol.177.1.246, PubMed 16785520

Stokka AJ, Gesellchen F, Carlson CR, Scott JD, Herberg FW, Taskén K (2006)
Characterization of A-kinase-anchoring disruptors using a solution-based assay
Biochem J, 400 (3), 493-9
DOI 10.1042/BJ20060962, PubMed 16948636

Tasken K, Ruppelt A (2006)
Negative regulation of T-cell receptor activation by the cAMP-PKA-Csk signalling pathway in T-cell lipid rafts
Front Biosci, 11, 2929-39
DOI 10.2741/2022, PubMed 16720365

Taskén K, Stokka AJ (2006)
The molecular machinery for cAMP-dependent immunomodulation in T-cells
Biochem Soc Trans, 34 (Pt 4), 476-9
DOI 10.1042/BST0340476, PubMed 16856837

Publications 2005

Lygren B, Taskén K, Carlson CR (2005)
A fast and sensitive method for isolation of detergent-resistant membranes from T cells
J Immunol Methods, 305 (2), 199-205
DOI 10.1016/j.jim.2005.06.011, PubMed 16176818

McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD (2005)
In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region
Cell Signal, 17 (9), 1158-73
DOI 10.1016/j.cellsig.2005.04.003, PubMed 15905070

Methi T, Ngai J, Mahic M, Amarzguioui M, Vang T, Tasken K (2005)
Short-interfering RNA-mediated Lck knockdown results in augmented downstream T cell responses
J Immunol, 175 (11), 7398-406
DOI 10.4049/jimmunol.175.11.7398, PubMed 16301647

Vang T, Congia M, Macis MD, Musumeci L, Orrú V, Zavattari P, Nika K, Tautz L, Taskén K, Cucca F, Mustelin T, Bottini N (2005)
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Nat Genet, 37 (12), 1317-9
DOI 10.1038/ng1673, PubMed 16273109

Wong L, Lieser SA, Miyashita O, Miller M, Tasken K, Onuchic JN, Adams JA, Woods VL, Jennings PA (2005)
Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation
J Mol Biol, 351 (1), 131-43
DOI 10.1016/j.jmb.2005.05.042, PubMed 16002086

Zeddou M, Greimers R, de Valensart N, Nayjib B, Tasken K, Boniver J, Moutschen M, Rahmouni S (2005)
Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway
Biochem Pharmacol, 70 (5), 714-24
DOI 10.1016/j.bcp.2005.05.015, PubMed 15978547

Publications 2004

Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, Taskén K (2004)
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling
J Immunol, 173 (8), 4847-58
DOI 10.4049/jimmunol.173.8.4847, PubMed 15470025

Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Taskén K (2004)
The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
J Biol Chem, 279 (43), 44889-96
DOI 10.1074/jbc.M404599200, PubMed 15302884

Johansson CC, Bryn T, Yndestad A, Eiken HG, Bjerkeli V, Frøland SS, Aukrust P, Taskén K (2004)
Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP
AIDS, 18 (2), 171-9
DOI 10.1097/00002030-200401230-00005, PubMed 15075533

Johansson CC, Bryn T, Aandahl EM, Areklett MA, Aukrust P, Taskén K, Frøland SS (2004)
Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy
AIDS, 18 (6), 951-2
DOI 10.1097/00002030-200404090-00015, PubMed 15060445

Johansson CC, Yndestad A, Enserink JM, Ree AH, Aukrust P, Taskén K (2004)
The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types
Endocrinology, 145 (11), 5177-84
DOI 10.1210/en.2004-0232, PubMed 15284208

Nika K, Hyunh H, Williams S, Paul S, Bottini N, Taskén K, Lombroso PJ, Mustelin T (2004)
Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location
Biochem J, 378 (Pt 2), 335-42
DOI 10.1042/BJ20031244, PubMed 14613483

Rahmouni S, Aandahl EM, Nayjib B, Zeddou M, Giannini S, Verlaet M, Greimers R, Boniver J, Tasken K, Moutschen M (2004)
Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice
Biochem J, 384 (Pt 3), 469-76
DOI 10.1042/BJ20031859, PubMed 15344910

Taskén K, Aandahl EM (2004)
Localized effects of cAMP mediated by distinct routes of protein kinase A
Physiol Rev, 84 (1), 137-67
DOI 10.1152/physrev.00021.2003, PubMed 14715913

Vang T, Abrahamsen H, Myklebust S, Enserink J, Prydz H, Mustelin T, Amarzguioui M, Tasken K (2004)
Knockdown of C-terminal Src kinase by siRNA-mediated RNA interference augments T cell receptor signaling in mature T cells
Eur J Immunol, 34 (8), 2191-9
DOI 10.1002/eji.200425036, PubMed 15259016

Waehre T, Damås JK, Yndestad A, Taskén K, Pedersen TM, Smith C, Halvorsen B, Frøland SS, Solum NO, Aukrust P (2004)
Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells - potential role of prostaglandin E2
Thromb Haemost, 92 (6), 1358-67
DOI 10.1160/TH04-03-0146, PubMed 15583745

Publications 2003

Abrahamsen H, Vang T, Taskén K (2003)
Protein kinase A intersects SRC signaling in membrane microdomains
J Biol Chem, 278 (19), 17170-7
DOI 10.1074/jbc.M211426200, PubMed 12606547

Carlson CR, Ruppelt A, Taskén K (2003)
A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system
J Mol Biol, 327 (3), 609-18
DOI 10.1016/s0022-2836(03)00093-7, PubMed 12634056

Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (2003)
Protein kinase A-anchoring protein AKAP95 interacts with MCM2, a regulator of DNA replication
J Biol Chem, 278 (29), 26750-6
DOI 10.1074/jbc.M300765200, PubMed 12740381

Eide T, Taskén KA, Carlson C, Williams G, Jahnsen T, Taskén K, Collas P (2003)
Protein kinase A-anchoring protein AKAP95 interacts with MCM2: a regulator of DNA replication
In Journal of biological chemistry, The Society, Bethesda, Md., 278(2003)29, s.26750-6
BIBSYS 041732448

Grönholm M, Vossebein L, Carlson CR, Kuja-Panula J, Teesalu T, Alfthan K, Vaheri A, Rauvala H, Herberg FW, Taskén K, Carpén O (2003)
Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A
J Biol Chem, 278 (42), 41167-72
DOI 10.1074/jbc.M306149200, PubMed 12896975

Holm AM, Aukrust P, Aandahl EM, Müller F, Taskén K, Frøland SS (2003)
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I
J Immunol, 170 (11), 5772-7
DOI 10.4049/jimmunol.170.11.5772, PubMed 12759461

Johansson CC, Dahle MK, Blomqvist SR, Grønning LM, Aandahl EM, Enerbäck S, Taskén K (2003)
A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T lymphocytes through regulation of cAMP-dependent protein kinase RIalpha
J Biol Chem, 278 (19), 17573-9
DOI 10.1074/jbc.M300311200, PubMed 12621056

Keryer G, Witczak O, Delouvée A, Kemmner WA, Rouillard D, Tasken K, Bornens M (2003)
Dissociating the centrosomal matrix protein AKAP450 from centrioles impairs centriole duplication and cell cycle progression
Mol Biol Cell, 14 (6), 2436-46
DOI 10.1091/mbc.e02-09-0614, PubMed 12808041

Mustelin T, Taskén K (2003)
Positive and negative regulation of T-cell activation through kinases and phosphatases
Biochem J, 371 (Pt 1), 15-27
DOI 10.1042/BJ20021637, PubMed 12485116

Vang T, Abrahamsen H, Myklebust S, Horejsí V, Taskén K (2003)
Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling
J Biol Chem, 278 (20), 17597-600
DOI 10.1074/jbc.C300077200, PubMed 12665526

Yaqub S, Abrahamsen H, Zimmerman B, Kholod N, Torgersen KM, Mustelin T, Herberg FW, Taskén K, Vang T (2003)
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain
Biochem J, 372 (Pt 1), 271-8
DOI 10.1042/BJ20030021, PubMed 12600271

Yaqub S, Solhaug V, Vang T, Solberg R, Aasen A, Taskén K, Wang JE (2003)
A human whole blood model of LPS-mediated suppression of T cell activation
Med Sci Monit, 9 (3), BR120-6
PubMed 12640334

Aandahl EM, Sandberg JK, Beckerman KP, Taskén K, Moretto WJ, Nixon DF (2003)
CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets
J Immunol, 170 (5), 2349-55
DOI 10.4049/jimmunol.170.5.2349, PubMed 12594257

Publications 2002

Birkeli KA, Llorente A, Torgersen ML, Keryer G, Taskén K, Sandvig K (2002)
Endosome-to-Golgi transport is regulated by protein kinase A type II alpha
J Biol Chem, 278 (3), 1991-7
DOI 10.1074/jbc.M209982200, PubMed 12419802

Dahle MK, Grønning LM, Cederberg A, Blomhoff HK, Miura N, Enerback S, Taskén KA, Taskén K (2002)
Mechanisms of FOXC2- and FOXD1-mediated regulation of theRI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by proteinkinase B alpha and cAMP
In Journal of biological chemistry, The Society, Bethesda, Md., 277(2002)nr.25, S. 22902-8
BIBSYS 031080715

Dahle MK, Grønning LM, Cederberg A, Blomhoff HK, Miura N, Enerbäck S, Taskén KA, Taskén K (2002)
Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP
J Biol Chem, 277 (25), 22902-8
DOI 10.1074/jbc.M200131200, PubMed 11943768

Dahle MK, Taskén K, Taskén KA (2002)
USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIbeta subunit of cAMP-dependent protein kinase
BMC Mol Biol, 3, 10
DOI 10.1186/1471-2199-3-10, PubMed 12086590

Eide T, Carlson C, Taskén KA, Hirano T, Taskén K, Collas P (2002)
Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting
EMBO Rep, 3 (5), 426-32
DOI 10.1093/embo-reports/kvf089, PubMed 11964380

Eide T, Carlson C, Taskén KA, Hirano T, Taskén K, Collas P (2002)
Distinct but overlapping domains of AKAP95 are implicatedin chromosome condensation and condensin targeting
In EMBO reports, Nature Publ. Group, London, 3(2002)nr.5, S. 426-32
BIBSYS 031080707

Grønning LM, Cederberg A, Miura N, Enerbäck S, Taskén K (2002)
Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways
Mol Endocrinol, 16 (4), 873-83
DOI 10.1210/mend.16.4.0803, PubMed 11923482

Hoover F, Kalhovde JM, Dahle MK, Skålhegg B, Taskén K, Lømo T (2002)
Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle
Mol Cell Neurosci, 19 (2), 125-37
DOI 10.1006/mcne.2001.1053, PubMed 11860267

Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Taskén K (2002)
Molecular mechanisms for protein kinase A-mediated modulation of immune function
Cell Signal, 14 (1), 1-9
DOI 10.1016/s0898-6568(01)00214-5, PubMed 11747983

Aandahl EM, Moretto WJ, Haslett PA, Vang T, Bryn T, Tasken K, Nixon DF (2002)
Inhibition of antigen-specific T cell proliferation and cytokine production by protein kinase A type I
J Immunol, 169 (2), 802-8
DOI 10.4049/jimmunol.169.2.802, PubMed 12097383

Publications 2001

Carlson CR, Witczak O, Vossebein L, Labbé JC, Skålhegg BS, Keryer G, Herberg FW, Collas P, Taskén K (2001)
CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
J Cell Sci, 114 (Pt 18), 3243-54
DOI 10.1242/jcs.114.18.3243, PubMed 11591813

Cederberg A, Grønning LM, Ahrén B, Taskén K, Carlsson P, Enerbäck S (2001)
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
Cell, 106 (5), 563-73
DOI 10.1016/s0092-8674(01)00474-3, PubMed 11551504

Dahle MK, Knutsen HK, Pilz R, Taskén K, Taskén KA (2001)
Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5' UTR
In European journal of biochemistry, Blackwell, Oxford, 268(2001)22, s. 5920-9
BIBSYS 022074228

Dahle MK, Knutsen HK, Taskén KA, Pilz R, Taskén K (2001)
Cyclic AMP regulates expression of the RI alpha subunit of cAMP-dependent protein kinase through an alternatively spliced 5' UTR
Eur J Biochem, 268 (22), 5920-9
DOI 10.1046/j.0014-2956.2001.02542.x, PubMed 11722580

Dahle MK, Reinton N, Orstavik S, Taskén KA, Taskén K (2001)
Novel alternatively spliced mRNA (1c) of the protein kinase A RIα subunit is implicated in haploid germ cell specific expression
Mol Reprod Dev, 59 (1), 11-6
DOI 10.1002/mrd.1001, PubMed 11335941

Dahle MK, Reinton N, Ørstavik S, Taskén KA, Taskén K (2001)
Novel alternatively spliced mRNA (1c) of the protein kinase A RIα subunit is implicated in haploid germ cell specific expression
In Biology of reproduction, Academic Press, New York, 59(2001)nr. 1, s. 11-16
BIBSYS 022078061

Fax P, Carlson CR, Collas P, Taskén K, Esche H, Brockmann D (2001)
Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity
Virology, 285 (1), 30-41
DOI 10.1006/viro.2001.0926, PubMed 11414803

Hoover F, Mathiesen I, Skålhegg BS, Lømo T, Taskén K (2001)
Differential expression and regulation of the PKA signalling pathway in fast and slow skeletal muscle
Anat Embryol (Berl), 203 (3), 193-201
DOI 10.1007/s004290000155, PubMed 11303905

Landsverk HB, Carlson CR, Steen RL, Vossebein L, Herberg FW, Taskén K, Collas P (2001)
Regulation of anchoring of the RIIalpha regulatory subunit of PKA to AKAP95 by threonine phosphorylation of RIIalpha: implications for chromosome dynamics at mitosis
J Cell Sci, 114 (Pt 18), 3255-64
DOI 10.1242/jcs.114.18.3255, PubMed 11591814

Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2001)
Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein
Mol Endocrinol, 15 (12), 2211-28
DOI 10.1210/mend.15.12.0736, PubMed 11731621

Rahmouni S, Aandahl EM, Trebak M, Boniver J, Taskén K, Moutschen M (2001)
Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing
FASEB J, 15 (8), 1466-8
DOI 10.1096/fj.00-0813fje, PubMed 11387259

Taskén KA, Collas P, Kemmner WA, Witczak O, Conti M, Taskén K (2001)
Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area
J Biol Chem, 276 (25), 21999-2002
DOI 10.1074/jbc.C000911200, PubMed 11285255

Taskén KA, Collas P, Kemmner WA, Witczak O, Conti M, Taskén K (2001)
Phosphodiesterase 4D and protein kinase a type II constitute a signaliling unit in the centrosomal area
In Journal of biological chemistry, The Society, Bethesda, Md., 276(2001)nr. 25, s. 21999-2002
BIBSYS 022078673

Torgersen KM, Vang T, Abrahamsen H, Yaqub S, Horejsí V, Schraven B, Rolstad B, Mustelin T, Taskén K (2001)
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts
J Biol Chem, 276 (31), 29313-8
DOI 10.1074/jbc.C100014200, PubMed 11390365

Torgersen KM, Vaage JT, Rolstad B, Taskén K (2001)
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains
Cell Signal, 13 (3), 213-20
DOI 10.1016/s0898-6568(01)00131-0, PubMed 11282460

Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K (2001)
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
J Exp Med, 193 (4), 497-507
DOI 10.1084/jem.193.4.497, PubMed 11181701

Publications 2000

Grønning LM, Wang JE, Ree AH, Haugen TB, Taskén K, Taskén KA (2000)
Regulation of tissue inhibitor of metalloproteinases-1 in rat Sertoli cells: induction by germ cell residual bodies, interleukin-1alpha, and second messengers
Biol Reprod, 62 (4), 1040-6
DOI 10.1095/biolreprod62.4.1040, PubMed 10727275

Hansson V, Skalhegg BS, Tasken K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 73 (1-2), 81-92
PubMed 10822028

Hansson V, Skalhegg BS, Tasken K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA (vol 69, pg 367, 1999)
J. Steroid Biochem. Mol. Biol., 73 (1-2), 79-+
DOI 10.1016/S0960-0760(00)00057-1

Hansson V, Skålhegg BS, Taskén K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 73 (1-2), 81-92
PubMed 10905822

Herberg FW, Maleszka A, Eide T, Vossebein L, Tasken K (2000)
Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding
J Mol Biol, 298 (2), 329-39
DOI 10.1006/jmbi.2000.3662, PubMed 10764601

Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (2000)
Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
Biol Cell, 92 (1), 27-37
DOI 10.1016/s0248-4900(00)88761-4, PubMed 10761695

Pursiheimo JP, Jalkanen M, Taskén K, Jaakkola P (2000)
Involvement of protein kinase A in fibroblast growth factor-2-activated transcription
Proc Natl Acad Sci U S A, 97 (1), 168-73
DOI 10.1073/pnas.97.1.168, PubMed 10618389

Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000)
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
Dev Biol, 223 (1), 194-204
DOI 10.1006/dbio.2000.9725, PubMed 10864471

Reinton N, Orstavik S, Haugen TB, Jahnsen T, Taskén K, Skålhegg BS (2000)
A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
Biol Reprod, 63 (2), 607-11
DOI 10.1095/biolreprod63.2.607, PubMed 10906071

Skalhegg BS, Tasken K (2000)
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
Front Biosci, 5, D678-93
DOI 10.2741/skalhegg, PubMed 10922298

Steen RL, Martins SB, Taskén K, Collas P (2000)
Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly
J Cell Biol, 150 (6), 1251-62
DOI 10.1083/jcb.150.6.1251, PubMed 10995432

Taskén K, Hansson V, Aukrust P, Frøland S, Skålhegg BS, Müller F, Tobin D, Vang T, Torgersen KM, Aandahl EM (2000)
PKAI as a potential target for therapeutic intervention
Drug News Perspect, 13 (1), 12-8
PubMed 12937648

Publications 1999

Aukrust P, Aandahl EM, Skålhegg BS, Nordøy I, Hansson V, Taskén K, Frøland SS, Müller F (1999)
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
J Immunol, 162 (2), 1178-85
PubMed 9916750

Collas P, Le Guellec K, Taskén K (1999)
The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis
J Cell Biol, 147 (6), 1167-80
DOI 10.1083/jcb.147.6.1167, PubMed 10601332

Gronning LM, Knutsen HK, Eskild W, Hansson V, Taskén K, Taskén KA (1999)
Method of transfection affects the cAMP-mediated induction of the RIIbeta subunit of protein kinase A in Sertoli cells: inhibition of response by increase in intracellullar calcium
Eur J Endocrinol, 141 (1), 75-82
DOI 10.1530/eje.0.1410075, PubMed 10407227

Grønning LM, Dahle MK, Taskén KA, Enerbäck S, Hedin L, Taskén K, Knutsen HK (1999)
Isoform-specific regulation of the CCAAT/enhancer-binding protein family of transcription factors by 3',5'-cyclic adenosine monophosphate in Sertoli cells
Endocrinology, 140 (2), 835-43
DOI 10.1210/endo.140.2.6526, PubMed 9927313

Hansson V, Skålhegg BS, Taskén K (1999)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 69 (1-6), 367-78
DOI 10.1016/s0960-0760(99)00077-1, PubMed 10419014

Keryer G, Skålhegg BS, Landmark BF, Hansson V, Jahnsen T, Taskén K (1999)
Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area
Exp Cell Res, 249 (1), 131-46
DOI 10.1006/excr.1999.4447, PubMed 10328961

Krall J, Taskén K, Staheli J, Jahnsen T, Movsesian MA (1999)
Identification and quantitation of cAMP-dependent protein kinase R subunit isoforms in subcellular fractions of failing human myocardium
J Mol Cell Cardiol, 31 (5), 971-80
DOI 10.1006/jmcc.1999.0926, PubMed 10336837

Laxminarayana D, Khan IU, Mishra N, Olorenshaw I, Taskén K, Kammer GM (1999)
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes
J Immunol, 162 (9), 5639-48
PubMed 10228048

Maronde E, Wicht H, Taskén K, Genieser HG, Dehghani F, Olcese J, Korf HW (1999)
CREB phosphorylation and melatonin biosynthesis in the rat pineal gland: involvement of cyclic AMP dependent protein kinase type II
J Pineal Res, 27 (3), 170-82
DOI 10.1111/j.1600-079x.1999.tb00613.x, PubMed 10535767

Saxena M, Williams S, Taskén K, Mustelin T (1999)
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase
Nat Cell Biol, 1 (5), 305-11
DOI 10.1038/13024, PubMed 10559944

Witczak O, Skålhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999)
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
EMBO J, 18 (7), 1858-68
DOI 10.1093/emboj/18.7.1858, PubMed 10202149

Aandahl EM, Aukrust P, Müller F, Hansson V, Taskén K, Frøland SS (1999)
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART
AIDS, 13 (17), F109-14
DOI 10.1097/00002030-199912030-00001, PubMed 10597771

Publications 1998

Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K (1998)
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
Exp Cell Res, 238 (2), 305-16
DOI 10.1006/excr.1997.3855, PubMed 9473338

Keryer G, Alsat E, Tasken K, Evain-Brion D (1998)
Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro
J Cell Sci, 111 ( Pt 7), 995-1004
DOI 10.1242/jcs.111.7.995, PubMed 9490643

Keryer G, Yassenko M, Labbé JC, Castro A, Lohmann SM, Evain-Brion D, Taskén K (1998)
Mitosis-specific phosphorylation and subcellular redistribution of the RIIalpha regulatory subunit of cAMP-dependent protein kinase
J Biol Chem, 273 (51), 34594-602
DOI 10.1074/jbc.273.51.34594, PubMed 9852131

Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K (1998)
The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
Genomics, 49 (2), 290-7
DOI 10.1006/geno.1998.5240, PubMed 9598317

Singh AK, Taskén K, Walker W, Frizzell RA, Watkins SC, Bridges RJ, Bradbury NA (1998)
Characterization of PKA isoforms and kinase-dependent activation of chloride secretion in T84 cells
Am J Physiol, 275 (2), C562-70
DOI 10.1152/ajpcell.1998.275.2.C562, PubMed 9688611

Skarpen E, Thoresen GH, Taskén K, Samuelsen JT, Jahnsen T, Schwarze PE, Huitfeldt HS (1998)
Localization of cAMP-dependent signal transducers in early rat liver carcinogenesis
Histochem Cell Biol, 109 (3), 203-9
DOI 10.1007/s004180050219, PubMed 9541468

Skålhegg BS, Johansen AK, Levy FO, Andersson KB, Aandahl EM, Blomhoff HK, Hansson V, Taskén K (1998)
Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
J Cell Physiol, 177 (1), 85-93
DOI 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A, PubMed 9731748

Strömstedt M, Waterman MR, Haugen TB, Taskén K, Parvinen M, Rozman D (1998)
Elevated expression of lanosterol 14alpha-demethylase (CYP51) and the synthesis of oocyte meiosis-activating sterols in postmeiotic germ cells of male rats
Endocrinology, 139 (5), 2314-21
DOI 10.1210/endo.139.5.5984, PubMed 9564839

Taskén K, Naylor SL, Solberg R, Jahnsen T (1998)
Mapping of the gene encoding the regulatory subunit RII alpha of cAMP-dependent protein kinase (locus PRKAR2A) to human chromosome region 3p21.3-p21.2
Genomics, 50 (3), 378-81
DOI 10.1006/geno.1998.5326, PubMed 9676433

Taskén K, Schulz T, Elgjo K, Skullerud K, Relman D, Brubakk O (1998)
Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease
Arch Intern Med, 158 (7), 801-3
DOI 10.1001/archinte.158.7.801, PubMed 9554687

Vang T, Taskén K, Skålhegg BS, Hansson V, Levy FO (1998)
Kinetic properties of the C-terminal Src kinase, p50csk
Biochim Biophys Acta, 1384 (2), 285-93
DOI 10.1016/s0167-4838(97)00202-1, PubMed 9659389

Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT (1998)
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
J Exp Med, 187 (7), 1157-61
DOI 10.1084/jem.187.7.1157, PubMed 9529333

Aandahl EM, Aukrust P, Skålhegg BS, Müller F, Frøland SS, Hansson V, Taskén K (1998)
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
FASEB J, 12 (10), 855-62
DOI 10.1096/fasebj.12.10.855, PubMed 9657525

Publications 1997

Foss KB, Solberg R, Simard J, Myklebust F, Hansson V, Jahnsen T, Taskén K (1997)
Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase
Biochim Biophys Acta, 1350 (1), 98-108
DOI 10.1016/s0167-4781(96)00152-2, PubMed 9003463

Knutsen HK, Taskén K, Eskild W, Richards JS, Kurten RC, Torjesen PA, Jahnsen T, Hansson V, Guérin S, Taskén KA (1997)
Characterization of the 5'-flanking region of the gene for the cAMP-inducible protein kinase A subunit, RIIbeta, in Sertoli cells
Mol Cell Endocrinol, 129 (1), 101-14
DOI 10.1016/s0303-7207(97)04045-8, PubMed 9175634

Maronde E, Middendorff R, Telgmann R, Müller D, Hemmings B, Taskén K, Olcese J (1997)
Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase
J Neurochem, 68 (2), 770-7
DOI 10.1046/j.1471-4159.1997.68020770.x, PubMed 9003068

Orstavik S, Natarajan V, Taskén K, Jahnsen T, Sandberg M (1997)
Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1)
Genomics, 42 (2), 311-8
DOI 10.1006/geno.1997.4743, PubMed 9192852

Skålhegg BS, Taskén K (1997)
Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA
Front Biosci, 2, d331-42
DOI 10.2741/a195, PubMed 9236186

Solberg R, Sandberg M, Natarajan V, Torjesen PA, Hansson V, Jahnsen T, Taskén K (1997)
The human gene for the regulatory subunit RI alpha of cyclic adenosine 3', 5'-monophosphate-dependent protein kinase: two distinct promoters provide differential regulation of alternately spliced messenger ribonucleic acids
Endocrinology, 138 (1), 169-81
DOI 10.1210/endo.138.1.4864, PubMed 8977401

Taskén K, Skålhegg BS, Taskén KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Schrader HP, Reinton NT, Torgersen KM, Hansson V, Jahnsen T (1997)
Structure, function, and regulation of human cAMP-dependent protein kinases
Adv Second Messenger Phosphoprotein Res, 31, 191-204
DOI 10.1016/s1040-7952(97)80019-5, PubMed 9344252

Telgmann R, Maronde E, Taskén K, Gellersen B (1997)
Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells
Endocrinology, 138 (3), 929-37
DOI 10.1210/endo.138.3.5004, PubMed 9048592

Torgersen KM, Vaage JT, Levy FO, Hansson V, Rolstad B, Taskén K (1997)
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
J Biol Chem, 272 (9), 5495-500
DOI 10.1074/jbc.272.9.5495, PubMed 9038153

Publications 1996

Hansson V, Skålhegg BS, Taskén K (1996)
Is basic endocrinology disappearing?
Eur J Endocrinol, 134 (1), 7-8
DOI 10.1530/eje.0.1340007, PubMed 8590959

Levy FO, Rasmussen AM, Taskén K, Skålhegg BS, Huitfeldt HS, Funderud S, Smeland EB, Hansson V (1996)
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
DOI 10.1002/eji.1830260617, PubMed 8647207

Levy FO, Taskén K, Hansson V (1996)
Report on the 9th European Workshop on the Molecular and Cellular Endocrinology of the Testis
Mol Cell Endocrinol, 122 (1), 1-13
DOI 10.1016/0303-7207(96)03883-x, PubMed 8898343

Orstavik S, Solberg R, Taskén K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M (1996)
Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase
Biochem Biophys Res Commun, 220 (3), 759-65
DOI 10.1006/bbrc.1996.0477, PubMed 8607838

Taskén K, Solberg R, Zhao Y, Hansson V, Jahnsen T, Siciliano MJ (1996)
The gene encoding the catalytic subunit C alpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1
Genomics, 36 (3), 535-8
DOI 10.1006/geno.1996.0501, PubMed 8884279

Publications 1994

Andersson KB, Taskén K, Blomhoff HK (1994)
Cyclic AMP downregulates c-myc expression by inhibition of transcript initiation in human B-precursor Reh cells
FEBS Lett, 337 (1), 71-6
DOI 10.1016/0014-5793(94)80632-2, PubMed 8276117

Berg JP, Ree AH, Sandvik JA, Taskén K, Landmark BF, Torjesen PA, Haug E (1994)
1,25-dihydroxyvitamin D3 alters the effect of cAMP in thyroid cells by increasing the regulatory subunit type II beta of the cAMP-dependent protein kinase
J Biol Chem, 269 (51), 32233-8
PubMed 7798223

Christoffersen J, Smeland EB, Stokke T, Taskén K, Andersson KB, Blomhoff HK (1994)
Retinoblastoma protein is rapidly dephosphorylated by elevated cyclic adenosine monophosphate levels in human B-lymphoid cells
Cancer Res, 54 (8), 2245-50
PubMed 8174134

Foss KB, Landmark B, Skålhegg BS, Taskén K, Jellum E, Hansson V, Jahnsen T (1994)
Characterization of in-vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases
Eur J Biochem, 220 (1), 217-23
DOI 10.1111/j.1432-1033.1994.tb18617.x, PubMed 8119290

Kristoffersen AK, Taskèn K, Rollag H (1994)
Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection
Arch Virol, 138 (1-2), 85-93
DOI 10.1007/BF01310040, PubMed 7980013

Levy FO, Holtgreve-Grez H, Taskén K, Solberg R, Ried T, Gudermann T (1994)
Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15
Genomics, 22 (3), 637-40
DOI 10.1006/geno.1994.1439, PubMed 8001977

Ree AH, Taskén K, Hansson V (1994)
Regulation of glucocorticoid receptor (GR) mRNA and protein levels by phorbol ester in MCF-7 cells. Mechanism of GR mRNA induction and decay
J Steroid Biochem Mol Biol, 48 (1), 23-9
DOI 10.1016/0960-0760(94)90247-x, PubMed 8136303

Skålhegg BS, Rasmussen AM, Taskén K, Hansson V, Jahnsen T, Lea T (1994)
Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex
Scand J Immunol, 40 (2), 201-8
DOI 10.1111/j.1365-3083.1994.tb03451.x, PubMed 8047842

Skålhegg BS, Taskén K, Hansson V, Huitfeldt HS, Jahnsen T, Lea T (1994)
Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
Science, 263 (5143), 84-7
DOI 10.1126/science.8272870, PubMed 8272870

Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS (1994)
Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells
Exp Cell Res, 214 (2), 595-605
DOI 10.1006/excr.1994.1297, PubMed 7925653

Taskén K, Andersson KB, Erikstein BK, Hansson V, Jahnsen T, Blomhoff HK (1994)
Regulation of growth in a neoplastic B cell line by transfected subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinase
Endocrinology, 135 (5), 2109-19
DOI 10.1210/endo.135.5.7956934, PubMed 7956934

Publications 1993

JAHNSEN T, TASKEN K, LANDMARK B, KNUTSEN H, TASKEN KA, SOLBERG R, FOSS KB, SKALHEGG B, ORSTAVIK S, ESKILD W, HANSSON V (1993)
MULTIPLE GENES FOR REGULATORY AND CATALYTIC SUBUNITS OF CYCLIC-AMP-DEPENDENT PROTEIN-KINASES ARE DIFFERENTIALLY EXPRESSED AND REGULATED IN TESTICULAR CELLS
I C S S, 3, 29-33

Krajci P, Taskén K, Kvale D, Brandtzaeg P (1993)
Interferon-gamma stimulation of messenger RNA for human secretory component (poly-Ig receptor) depends on continuous intermediate protein synthesis
Scand J Immunol, 37 (2), 251-6
DOI 10.1111/j.1365-3083.1993.tb01763.x, PubMed 8434236

Taskén K, Andersson KB, Skålhegg BS, Taskén KA, Hansson V, Jahnsen T, Blomhoff HK (1993)
Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
J Biol Chem, 268 (31), 23483-9
PubMed 8226875

Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993)
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
J Biol Chem, 268 (28), 21276-83
PubMed 8407966

Publications 1992

Krajci P, Kvale D, Taskén K, Brandtzaeg P (1992)
Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor)
Eur J Immunol, 22 (9), 2309-15
DOI 10.1002/eji.1830220920, PubMed 1355431

Taskén KA, Knutsen HK, Eikvar L, Taskén K, Eskild W, Jahnsen T, Hansson V (1992)
Protein kinase C activation by 12-O-tetradecanoylphorbol 13-acetate modulates messenger ribonucleic acid levels for two of the regulatory subunits of 3',5'-cyclic adenosine monophosphate-dependent protein kinases (RII beta and RI alpha) via multiple and distinct mechanisms
Endocrinology, 130 (3), 1271-80
DOI 10.1210/endo.130.3.1311233, PubMed 1311233

Publications 1991

Solberg R, Taskén K, Keiserud A, Jahnsen T (1991)
Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases
Biochem Biophys Res Commun, 176 (1), 166-72
DOI 10.1016/0006-291x(91)90904-l, PubMed 1708242

Taskén KA, Knutsen HK, Attramadal H, Taskén K, Jahnsen T, Hansson V, Eskild W (1991)
Different mechanisms are involved in cAMP-mediated induction of mRNAs for subunits of cAMP-dependent protein kinases
Mol Endocrinol, 5 (1), 21-8
DOI 10.1210/mend-5-1-21, PubMed 1850108

Publications 1990

Dissen E, Vaage JT, Taskén K, Jahnsen T, Rolstad B, Fossum S (1990)
Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors
Int Immunol, 2 (5), 453-60
DOI 10.1093/intimm/2.5.453, PubMed 2150758

Taskén K, Kvale D, Hansson V, Jahnsen T (1990)
Protein kinase C activation selectively increases mRNA levels for one of the regulatory subunits (RI alpha) of cAMP-dependent protein kinases in HT-29 cells
Biochem Biophys Res Commun, 172 (2), 409-14
DOI 10.1016/0006-291x(90)90688-j, PubMed 2241943

Publications 1988

Levy FO, Oyen O, Sandberg M, Taskén K, Eskild W, Hansson V, Jahnsen T (1988)
Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis
Mol Endocrinol, 2 (12), 1364-73
DOI 10.1210/mend-2-12-1364, PubMed 2851102

Oyen O, Sandberg M, Levy FO, Taskén K, Beebe S, Hansson V, Jahnsen T (1988)
Molecular cloning and cell-specific expression of newly discovered subunits of cAMP-dependent protein kinases. Implications for different cellular responses to cAMP
APMIS Suppl, 2, 238-50
PubMed 2846017

OYEN O, SANDBERG M, LEVY FO, TASKEN K, BEEBE S, HANSSON V, JAHNSEN T (1988)
MOLECULAR-CLONING AND CELL-SPECIFIC EXPRESSION OF NEWLY DISCOVERED SUBUNITS OF CAMP-DEPENDENT PROTEIN-KINASES - IMPLICATIONS FOR DIFFERENT CELLULAR-RESPONSES TO CAMP
APMIS, 96 2, 238-250

Publications 1987

Sandberg M, Taskén K, Oyen O, Hansson V, Jahnsen T (1987)
Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis
Biochem Biophys Res Commun, 149 (3), 939-45
DOI 10.1016/0006-291x(87)90499-2, PubMed 3426618