Jan Otto Beitnes

  • Consultant Cardiologist; MD, PhD

Jan Otto Beitnes successfully defended his thesis "Cell therapy in acute myocardial infarctio" in February 2012.
He investigated the effect of different types of stem cell treatment after acute myocardial infarction.

The ASTAMI study was conducted in 2003-05. 100 patients treated with acute PCI (percutanious coronary intervention) for left frontal vein due to acute myocardial infarction were randomized to a group receiving cell therapy and a control group. Both groups received regular medical treatment. In the cell group, bone marrow cells were harvested and were injected into the coronary artery of the heart 5-8 days after the infarction.

The follow-up study showed low incidence of reinfarction, stroke, death, arrhythmias and other clinical events three years after cell treatment, with no signs of difference between the groups. Working capacity and quality of life were similar in both groups. Treatment with bone marrow cells had no significant effect on the heart's structure or function assessed by MRI and extensive ultrasound analyzes of the heart.

Mesenchymal stem cells (MSC) can be harvested from adipose tissue and muscle tissue, and when these cells are grown and then injected into the heart after a heart attack, a reduction in infarct size and improvement of cardiac function can be seen four weeks after the treatment. The injected cells do not appear to form heart muscle or vascular structures themselves, but affect the healing process after the infarction in another way. MSC are relevant cells for testing in further studies.

 

Publications 2024

Tavazzi G, Price S, Beitnes JO, Bleakley C, Balik M, Lochy S, Moller JE, Guarracino F, Donal E, Donker DW, Belohlavek J, Hassager C (2024)
Imaging in acute percutaneous mechanical circulatory support in adults. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Cardiovascular Imaging (EACVI) of the ESC and the European branch of the Extracorporeal Life Support Organization (EuroELSO)
Eur Heart J Cardiovasc Imaging (in press)
DOI 10.1093/ehjci/jeae219, PubMed 39180134

Publications 2023

Dodgson CS, Beitnes JO, Kløve SF, Herstad J, Opdahl A, Undseth R, Eek CH, Broch K, Gullestad L, Aaberge L, Lunde K, Bendz B, Lie ØH (2023)
An investigator-sponsored pragmatic randomized controlled trial of AntiCoagulation vs AcetylSalicylic Acid after Transcatheter Aortic Valve Implantation: Rationale and design of ACASA-TAVI
Am Heart J, 265, 225-232
DOI 10.1016/j.ahj.2023.08.010, PubMed 37634655

Rootwelt-Norberg C, Skjølsvik ET, Chivulescu M, Bogsrud MP, Ribe MP, Aabel EW, Beitnes JO, Brekke PH, Håland TF, Hasselberg NE, Lie ØH, Haugaa KH (2023)
Disease progression rate is a strong predictor of ventricular arrhythmias in patients with cardiac laminopathies: a primary prevention cohort study
Europace, 25 (2), 634-642
DOI 10.1093/europace/euac192, PubMed 36352512

Publications 2022

Massey RJ, Myrdal OH, Diep PP, Burman MM, Brinch L, Gullestad LL, Ruud E, Aakhus S, Beitnes JO (2022)
Reduced exercise capacity is associated with left ventricular systolic dysfunction in long-term survivors of allogeneic hematopoietic stem-cell transplantation
J Clin Ultrasound, 51 (1), 5-15
DOI 10.1002/jcu.23264, PubMed 35788941

Wisløff-Aase K, Skulstad H, Beitnes JO, Lundblad R, Halvorsen PS, Fiane A, Espinoza A (2022)
Left Ventricular Function Changes Induced by Moderate Hypothermia Are Rapidly Reversed After Rewarming-A Clinical Study
Crit Care Med, 50 (1), e52-e60
DOI 10.1097/CCM.0000000000005170, PubMed 34259452

Wisløff-Aase K, Skulstad H, Haugaa K, Lingaas PS, Beitnes JO, Halvorsen PS, Espinoza A (2022)
Myocardial electrophysiological and mechanical changes caused by moderate hypothermia-A clinical study
Physiol Rep, 10 (8), e15259
DOI 10.14814/phy2.15259, PubMed 35439365

Publications 2021

Kvitting JP, Beitnes JO, Lundblad R (2021)
Early results after aortic annuloplasty with a complete external Dacron band
Gen Thorac Cardiovasc Surg, 70 (4), 329-336
DOI 10.1007/s11748-021-01695-1, PubMed 34542798

Lie ØH, Chivulescu M, Rootwelt-Norberg C, Ribe M, Bogsrud MP, Lyseggen E, Beitnes JO, Almaas V, Haugaa KH (2021)
Left Ventricular Dysfunction in Arrhythmogenic Cardiomyopathy: Association With Exercise Exposure, Genetic Basis, and Prognosis
J Am Heart Assoc, 10 (8), e018680
DOI 10.1161/JAHA.120.018680, PubMed 33821670

Massey RJ, Diep PP, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad L, Ruud E, Beitnes JO (2021)
Impaired right ventricular function in long-term survivors of allogeneic haematopoietic stem-cell transplantation
Open Heart, 8 (2)
DOI 10.1136/openhrt-2021-001768, PubMed 34933961

Publications 2020

Massey RJ, Diep PP, Ruud E, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad LL, Beitnes JO (2020)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
JACC CardioOncol, 2 (3), 460-471
DOI 10.1016/j.jaccao.2020.06.011, PubMed 34396253

Massey RJ, Diep PP, Ruud E, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad LL, Beitnes JO (2020)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
JACC CardioOncol, 2 (3), 460-471
DOI 10.1016/j.jaccao.2020.06.011, PublikaID 352

Muthiah A, Beitnes JO, Skulstad H (2020)
Patients with infective endocarditis referred to Division of Cardiovascular and Pulmonary Diseases at Oslo University Hospital between 2014 and 2017
Scand Cardiovasc J, 54 (4), 258-264
DOI 10.1080/14017431.2020.1734232, PubMed 32157906

Saevik M, Beitnes JO, Aaberge L, Halvorsen PS (2020)
Safety and feasibility of dobutamine stress echocardiography in symptomatic high gradient aortic stenosis patients scheduled for transcatheter aortic valve implantation
J Clin Ultrasound, 49 (1), 38-48
DOI 10.1002/jcu.22915, PubMed 32914454

Publications 2019

Dahle G, Helle-Valle T, Beitnes JO, Espinoza A, Halvorsen PS, Rein KA (2019)
Single-centre first experience with transapical transcatheter mitral valve replacement with an apical tether: factors influencing screening outcomes
Interact Cardiovasc Thorac Surg, 28 (5), 695-703
DOI 10.1093/icvts/ivy343, PubMed 30602024

Solberg OG, Stavem K, Ragnarsson A, Beitnes JO, Skårdal R, Seljeflot I, Ueland T, Aukrust P, Gullestad L, Aaberge L (2019)
Index of microvascular resistance to assess the effect of rosuvastatin on microvascular function in women with chest pain and no obstructive coronary artery disease: A double-blind randomized study
Catheter Cardiovasc Interv, 94 (5), 660-668
DOI 10.1002/ccd.28157, PubMed 30790446

Publications 2018

Hussain AI, Auensen A, Brunborg C, Beitnes JO, Gullestad L, Pettersen KI (2018)
Age-dependent morbidity and mortality outcomes after surgical aortic valve replacement
Interact Cardiovasc Thorac Surg, 27 (5), 650-656
DOI 10.1093/icvts/ivy154, PubMed 29746650

Lunde K, Al-Ani A, Bjørnerheim R, Hervold A, Opdahl A, Beitnes JO (2018)
Catheter-based left atrial appendage closure
Tidsskr Nor Laegeforen, 138 (7)
DOI 10.4045/tidsskr.17.0601, PubMed 29663763

Publications 2017

Auensen A, Hussain AI, Bendz B, Aaberge L, Falk RS, Walle-Hansen MM, Bye J, Andreassen J, Beitnes JO, Rein KA, Pettersen KI, Gullestad L (2017)
Morbidity outcomes after surgical aortic valve replacement
Open Heart, 4 (1), e000588
DOI 10.1136/openhrt-2017-000588, PubMed 28674629

Grymyr OH, Beitnes JO, Eidet J, Tølløfsrud S, Fiane A, Skulstad H, Fosse E, Halvorsen PS (2017)
Detection of intraoperative myocardial dysfunction by accelerometer during aortic valve replacement
Interact Cardiovasc Thorac Surg, 24 (2), 188-195
DOI 10.1093/icvts/ivw326, PubMed 28364479

Publications 2016

Jortveit J, Dahlslett T, Kvien EH, Lundblad R, Trøseid M, Beitnes JO (2016)
[A man in his 20s with abdominal pain and heart murmurs]
Tidsskr Nor Laegeforen, 136 (3), 238-40
DOI 10.4045/tidsskr.15.0790, PubMed 26860384

Saberniak J, Leren IS, Haland TF, Beitnes JO, Hopp E, Borgquist R, Edvardsen T, Haugaa KH (2016)
Comparison of patients with early-phase arrhythmogenic right ventricular cardiomyopathy and right ventricular outflow tract ventricular tachycardia
Eur Heart J Cardiovasc Imaging, 18 (1), 62-69
DOI 10.1093/ehjci/jew014, PubMed 26903598

Publications 2015

Hussain AI, Garratt AM, Beitnes JO, Gullestad L, Pettersen KI (2015)
Validity of standard gamble utilities in patients referred for aortic valve replacement
Qual Life Res, 25 (7), 1703-12
DOI 10.1007/s11136-015-1186-1, PubMed 26603737

Publications 2014

Beitnes JO, Klæboe LG, Karlsen JS, Urheim S (2014)
Mitral valve analysis using a novel 3D holographic display: a feasibility study of 3D ultrasound data converted to a holographic screen
Int J Cardiovasc Imaging, 31 (2), 323-8
DOI 10.1007/s10554-014-0564-z, PubMed 25392054

Bersvendsen J, Beitnes JO, Urheim S, Aakhus S, Samset E (2014)
Automatic measurement of aortic annulus diameter in 3-dimensional transoesophageal echocardiography
BMC Med Imaging, 14, 31
DOI 10.1186/1471-2342-14-31, PubMed 25200865

Christiansen JR, Hamre H, Massey R, Dalen H, Beitnes JO, Fosså SD, Kiserud CE, Aakhus S (2014)
Left ventricular function in long-term survivors of childhood lymphoma
Am J Cardiol, 114 (3), 483-90
DOI 10.1016/j.amjcard.2014.04.055, PubMed 24948492

Publications 2013

Estensen ME, Beitnes JO, Grindheim G, Aaberge L, Smiseth OA, Henriksen T, Aakhus S (2013)
Altered maternal left ventricular contractility and function during normal pregnancy
Ultrasound Obstet Gynecol, 41 (6), 659-66
DOI 10.1002/uog.12296, PubMed 23001841

Gjesdal O, Almeida AL, Hopp E, Beitnes JO, Lunde K, Smith HJ, Lima JA, Edvardsen T (2013)
Long axis strain by MRI and echocardiography in a postmyocardial infarct population
J Magn Reson Imaging, 40 (5), 1247-51
DOI 10.1002/jmri.24485, PubMed 24214923

Publications 2012

Øie E, Berge RK, Ueland T, Dahl CP, Edvardsen T, Beitnes JO, Bohov P, Aukrust P, Yndestad A (2012)
Tetradecylthioacetic acid increases fat metabolism and improves cardiac function in experimental heart failure
Lipids, 48 (2), 139-54
DOI 10.1007/s11745-012-3749-z, PubMed 23266898

Publications 2011

Beitnes JO, Lunde K, Brinchmann JE, Aakhus S (2011)
Stem cells for cardiac repair in acute myocardial infarction
Expert Rev Cardiovasc Ther, 9 (8), 1015-25
DOI 10.1586/erc.11.108, PubMed 21878046

Fosshaug LE, Berge RK, Beitnes JO, Berge K, Vik H, Aukrust P, Gullestad L, Vinge LE, Øie E (2011)
Krill oil attenuates left ventricular dilatation after myocardial infarction in rats
Lipids Health Dis, 10, 245
DOI 10.1186/1476-511X-10-245, PubMed 22206454

Mistry N, Beitnes JO, Halvorsen S, Abdelnoor M, Hoffmann P, Kjeldsen SE, Smith G, Aakhus S, Bjørnerheim R (2011)
Assessment of left ventricular function in ST-elevation myocardial infarction by global longitudinal strain: a comparison with ejection fraction, infarct size, and wall motion score index measured by non-invasive imaging modalities
Eur J Echocardiogr, 12 (9), 678-83
DOI 10.1093/ejechocard/jer113, PubMed 21810829

Publications 2010

Beitnes JO, Gjesdal O, Lunde K, Solheim S, Edvardsen T, Arnesen H, Forfang K, Aakhus S (2010)
Left ventricular systolic and diastolic function improve after acute myocardial infarction treated with acute percutaneous coronary intervention, but are not influenced by intracoronary injection of autologous mononuclear bone marrow cells: a 3 year serial echocardiographic sub-study of the randomized-controlled ASTAMI study
Eur J Echocardiogr, 12 (2), 98-106
DOI 10.1093/ejechocard/jeq116, PubMed 20851818

Publications 2009

Beitnes JO, Hopp E, Lunde K, Solheim S, Arnesen H, Brinchmann JE, Forfang K, Aakhus S (2009)
Long-term results after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: the ASTAMI randomised, controlled study
Heart, 95 (24), 1983-9
DOI 10.1136/hrt.2009.178913, PubMed 19833610

Publications 2001

Aaseth JO, Tangen MK, Beitnes JO (2001)
[Hyponatremic crisis--a serious side effect of diuretics in the elderly]
Tidsskr Nor Laegeforen, 121 (8), 921-3
PubMed 11332379

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