Christen Peder Dahl
- Postdoctoral research fellow; MD, PhD
- +47 230 70638
Christen Peder Dahl successfully defended his thesis "Inflammatory cytokines in heart failure – Potential role as mediators and biomarkers." in December 2010.
Immune activation and inflammation may be involved in the development of chronic heart failure.
The goal of the studies in this thesis was to uncover new mediators that may contribute to the development of heart failure, with a particular focus on participants in inflammatory reactions.
We have shown that several substances that promote inflammation are up-regulated in both clinical and experimental heart failure. In laboratory experiments, we have shown that these substances can promote further inflammation of blood cells as well as cause breakdown of connective tissue in the heart. We have also shown that measurement of osteoprotegerin in the blood, a marker of inflammation and calcification, was able to provide independent prognostic information in a large population of heart failure patients.
Finally, we showed that mediators from the lungs can also contribute to increased inflammation in heart failure patients. We have already identified new prognostic markers in this condition, and in the long run our results may lead to completely new forms of treatment in patients with heart failure.
Publications 2021
Etiology-Dependent Impairment of Diastolic Cardiomyocyte Calcium Homeostasis in Heart Failure With Preserved Ejection Fraction
J. Am. Coll. Cardiol., 77 (4), 405-419
DOI 10.1016/j.jacc.2020.11.044
The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGF beta signalling in cardiac fibroblasts
Sci Rep, 11 (1), 19757
DOI 10.1038/s41598-021-99032-2
Publications 2020
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC-Basic Transl. Sci., 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013
Publications 2019
Low Molecular Mass Myocardial Hyaluronan in Human Hypertrophic Cardiomyopathy
Cells, 8 (2), 97
DOI 10.3390/cells8020097
Publications 2018
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422
Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole
Am. J. Physiol.-Heart Circul. Physiol., 315 (5), H1137-H1147
DOI 10.1152/ajpheart.00208.2018
Increased Levels of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Ischemic Stroke and Transient Ischemic Attack
J. Am. Heart Assoc., 7 (2), e006479
DOI 10.1161/JAHA.117.006479
Publications 2017
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7, 3490
DOI 10.1038/s41598-017-03625-9
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J. Mol. Med., 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1
Increased Secondary/Primary Bile Acid Ratio in Chronic Heart Failure
J. Card. Fail., 23 (9), 666-671
DOI 10.1016/j.cardfail.2017.06.007
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J. Cardiovasc. Transl. Res., 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y
Limited Added Value of Circulating Inflammatory Biomarkers in Chronic Heart Failure
JACC-Heart Fail., 5 (4), 256-264
DOI 10.1016/j.jchf.2017.01.008
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ.Res., 121 (12), 1323-+
DOI 10.1161/CIRCRESAHA.117.311920
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans
Scand. J. Clin. Lab. Invest., 77 (5), 321-331
DOI 10.1080/00365513.2017.1318447
The alternative complement pathway is dysregulated in patients with chronic heart failure
Sci Rep, 7, 42532
DOI 10.1038/srep42532
Publications 2016
Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure
J. Card. Fail., 22 (10), 823-828
DOI 10.1016/j.cardfail.2016.06.013
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am. J. Gastroenterol., 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol., 9 (6), 1455-1465
DOI 10.1038/mi.2016.18
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079
Circulating nucleosomes in chronic heart failure
Int. J. Cardiol., 203, 742-743
DOI 10.1016/j.ijcard.2015.10.219
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic. Biol. Med., 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001
Publications 2015
Interleukin 23 Levels Are Increased in Carotid Atherosclerosis Possible Role for the Interleukin 23/Interleukin 17 Axis
Stroke, 46 (3), 793-+
DOI 10.1161/STROKEAHA.114.006516
The Notch ligand Delta-like 1 is elevated and associated with mortality in patients with symptomatic aortic stenosis
Int. J. Cardiol., 180, 18-20
DOI 10.1016/j.ijcard.2014.11.111
The p66ShcA adaptor protein regulates healing after myocardial infarction
Basic Res. Cardiol., 110 (2), 13
DOI 10.1007/s00395-015-0470-0
Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure
J. Card. Fail., 21 (11), 916-923
DOI 10.1016/j.cardfail.2015.07.014
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure
J. Intern. Med., 277 (6), 717-726
DOI 10.1111/joim.12328
Publications 2014
Noninvasive assessment of myocardial fibrosis in patients with obstructive hypertrophic cardiomyopathy
Heart, 100 (8), 631-638
DOI 10.1136/heartjnl-2013-304923
Familial globotriaosylceramide-associated cardiomyopathy mimicking Fabry disease
Heart, 100 (22), 1793-1798
DOI 10.1136/heartjnl-2014-305616
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J. Intern. Med., 275 (6), 621-630
DOI 10.1111/joim.12175
Expression of retinoic acid target genes in coronary artery disease
Int. J. Mol. Med., 33 (3), 677-686
DOI 10.3892/ijmm.2014.1623
The Homeostatic Chemokine CCL21 Predicts Mortality in Aortic Stenosis Patients and Modulates Left Ventricular Remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
Br. J. Pharmacol., 171 (23), 5169-5181
DOI 10.1111/bph.12647
Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
Life Sci., 97 (2), 145-154
DOI 10.1016/j.lfs.2013.12.030
Publications 2013
Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy
Europace, 15 (9), 1319-1327
DOI 10.1093/europace/eut028
Prognostic value of CXCL16 in patients with left ventricular systolic dysfunction and heart failure
Int. J. Cardiol., 168 (4), 4427-4429
DOI 10.1016/j.ijcard.2013.05.008
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli
FEBS J., 280 (10), 2382-2398
DOI 10.1111/febs.12235
Increased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosis
PLoS One, 8 (8), e72769
DOI 10.1371/journal.pone.0072769
Tetradecylthioacetic Acid Increases Fat Metabolism and Improves Cardiac Function in Experimental Heart Failure
Lipids, 48 (2), 139-154
DOI 10.1007/s11745-012-3749-z
Association of Ficolin-3 with Severity and Outcome of Chronic Heart Failure
PLoS One, 8 (4), e60976
DOI 10.1371/journal.pone.0060976
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemiareperfusion injury
Cardiovasc. Res., 99 (1), 164-174
DOI 10.1093/cvr/cvt091
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart
FEBS J., 280 (10), 2228-2247
DOI 10.1111/febs.12161
Disturbed carnitine regulation in chronic heart failure - Increased plasma levels of palmitoyl-carnitine are associated with poor prognosis
Int. J. Cardiol., 167 (5), 1892-1899
DOI 10.1016/j.ijcard.2012.04.150
Publications 2012
Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium
Eur. J. Pharmacol., 686 (1-3), 66-73
DOI 10.1016/j.ejphar.2012.04.022
Prostaglandin E-1 facilitates inotropic effects of 5-HT4 serotonin receptors and beta-adrenoceptors in failing human heart
Basic Res. Cardiol., 107 (5), 295
DOI 10.1007/s00395-012-0295-z
Systemic biomarkers of inflammation and haemostasis in patients with chronic necrotizing pulmonary aspergillosis
BMC Infect. Dis., 12, 144
DOI 10.1186/1471-2334-12-144
Aquaporin-4 in the heart: expression, regulation and functional role in ischemia
Basic Res. Cardiol., 107 (5), 280
DOI 10.1007/s00395-012-0280-6
Increased Levels of Inflammatory Cytokines and Endothelin-1 in Alveolar Macrophages from Patients with Chronic Heart Failure
PLoS One, 7 (5), e36815
DOI 10.1371/journal.pone.0036815
High-sensitive troponin T and N-terminal-brain-natriuretic-peptide predict outcome in symptomatic aortic stenosis
Scand. Cardiovasc. J., 46 (5), 278-285
DOI 10.3109/14017431.2012.687836
The Homeostatic Chemokine CCL21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038
Publications 2011
Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality
J. Intern. Med., 270 (3), 263-272
DOI 10.1111/j.1365-2796.2011.02384.x
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis
J. Intern. Med., 270 (5), 452-460
DOI 10.1111/j.1365-2796.2011.02393.x
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure
Clin. Sci., 121 (3-4), 119-127
DOI 10.1042/CS20100589
Osteoprotegerin Predicts Progression of Chronic Heart Failure: Results From CORONA
Circ.-Heart Fail., 4 (2), 145-152
DOI 10.1161/CIRCHEARTFAILURE.110.957332
Lack of Chemokine Signaling through CXCR5 Causes Increased Mortality, Ventricular Dilatation and Deranged Matrix during Cardiac Pressure Overload
PLoS One, 6 (4), e18668
DOI 10.1371/journal.pone.0018668
Publications 2010
Inflammatory cytokines in heart failure: potential role as mediators and biomakers
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 1042, 1 b. (flere pag.)
BIBSYS 102590028, ISBN 978-82-8264-107-4
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure
Basic Res. Cardiol., 105 (1), 89-98
DOI 10.1007/s00395-009-0070-y
Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis
J. Intern. Med., 268 (5), 483-492
DOI 10.1111/j.1365-2796.2010.02264.x
Publications 2009
Increased Production of CXCL16 in Experimental and Clinical Heart Failure A Possible Role in Extracellular Matrix Remodeling
Circ.-Heart Fail., 2 (6), 624-632
DOI 10.1161/CIRCHEARTFAILURE.108.821074
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure
Eur. Heart J., 30 (10), 1229-1236
DOI 10.1093/eurheartj/ehp088
Publications 2008
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br. J. Pharmacol., 155 (7), 1005-1014
DOI 10.1038/bjp.2008.339
Increased expression of LIGHT/TNFSF 14 and its receptors in experimental and clinical heart failure
Eur. J. Heart Fail., 10 (4), 352-359
DOI 10.1016/j.ejheart.2008.02.010
Raised LIGHT levels in pulmonary arterial hypertension potential role in thrombus formation
Am. J. Respir. Crit. Care Med., 177 (2), 202-207
DOI 10.1164/rccm.200703-506OC