![](https://ous-research.no/files/braathen/bilder/Even-Fossum.jpg)
Even Fossum
- Researcher; PhD
- +47 23 07 30 45
Publications 2024
Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
Virol J, 21 (1), 57
DOI 10.1186/s12985-024-02326-w, PubMed 38448981
Correction: antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023
Virol J, 21 (1), 66
DOI 10.1186/s12985-024-02341-x, PubMed 38500208
Characterization of the SARS-CoV-2 antibody landscape in Norway in the late summer of 2022: high seroprevalence in all age groups with patterns of primary Omicron infection in children and hybrid immunity in adults
BMC Infect Dis, 24 (1), 841
DOI 10.1186/s12879-024-09670-w, PubMed 39164637
Publications 2023
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
PNAS Nexus, 2 (12), pgad403
DOI 10.1093/pnasnexus/pgad403, PubMed 38077689
XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
Cell Rep, 42 (2), 112123
DOI 10.1016/j.celrep.2023.112123, PubMed 36795562
Poor neutralizing antibody responses against SARS-CoV-2 Omicron BQ.1.1 and XBB in Norway in October 2022
Influenza Other Respir Viruses, 17 (6), e13144
DOI 10.1111/irv.13144, PubMed 37273461
Neuraminidase delivered as an APC-targeted DNA vaccine induces protective antibodies against influenza
Mol Ther, 31 (7), 2188-2205
DOI 10.1016/j.ymthe.2023.03.012, PubMed 36926694
Id-neoantigen vaccine induces therapeutic CD8+ T cells against multiple myeloma: H chain-loss escapees cause FLC MM
J Immunother Cancer, 11 (8)
DOI 10.1136/jitc-2023-006944, PubMed 37607769
Publications 2022
Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses
Cell Rep, 39 (9), 110901
DOI 10.1016/j.celrep.2022.110901, PubMed 35649357
Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection
Front Immunol, 13, 752714
DOI 10.3389/fimmu.2022.752714, PubMed 35296089
Publications 2021
ARHGAP45 controls naïve T- and B-cell entry into lymph nodes and T-cell progenitor thymus seeding
EMBO Rep, 22 (4), e52196
DOI 10.15252/embr.202052196, PubMed 33719206
Intranasal delivery of a cDC1 targeted influenza vaccine with poly(I:C) enhances T cell responses and protects against influenza infection
Scand J Immunol, 95 (3), e13128
DOI 10.1111/sji.13128, PubMed 34923667
Publications 2020
A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza
Mol Ther Methods Clin Dev, 17, 378-392
DOI 10.1016/j.omtm.2020.01.007, PubMed 32128342
Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response
J Immunol, 205 (3), 661-673
DOI 10.4049/jimmunol.1901119, PubMed 32591401
Author Correction: Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site
Sci Rep, 10 (1), 5944
DOI 10.1038/s41598-020-62688-3, PubMed 32231213
Publications 2019
Targeting of HA to chemokine receptors induces strong and cross-reactive T cell responses after DNA vaccination in pigs
Vaccine, 38 (6), 1280-1285
DOI 10.1016/j.vaccine.2019.11.084, PubMed 31836256
Endocytosis Deficient Murine Xcl1-Fusion Vaccine Enhances Protective Antibody Responses in Mice
Front Immunol, 10, 1086
DOI 10.3389/fimmu.2019.01086, PubMed 31156636
Dendritic cell targeted Ccl3- and Xcl1-fusion DNA vaccines differ in induced immune responses and optimal delivery site
Sci Rep, 9 (1), 1820
DOI 10.1038/s41598-018-38080-7, PubMed 30755656
Targeting Conventional Dendritic Cells to Fine-Tune Antibody Responses
Front Immunol, 10, 1529
DOI 10.3389/fimmu.2019.01529, PubMed 31333661
Publications 2018
The Magnitude and IgG Subclass of Antibodies Elicited by Targeted DNA Vaccines Are Influenced by Specificity for APC Surface Molecules
Immunohorizons, 2 (1), 38-53
DOI 10.4049/immunohorizons.1700038, PubMed 31022690
Publications 2017
The anti-influenza M2e antibody response is promoted by XCR1 targeting in pig skin
Sci Rep, 7 (1), 7639
DOI 10.1038/s41598-017-07372-9, PubMed 28794452
Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
J Immunol, 198 (7), 2785-2795
DOI 10.4049/jimmunol.1601881, PubMed 28228559
Publications 2016
Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery
Immunity, 45 (2), 305-18
DOI 10.1016/j.immuni.2016.07.019, PubMed 27533013
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1
Dev Comp Immunol, 65, 31-40
DOI 10.1016/j.dci.2016.06.015, PubMed 27345169
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
Immunity, 45 (3), 669-684
DOI 10.1016/j.immuni.2016.08.015, PubMed 27637149
Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
Sci Rep, 6, 38597
DOI 10.1038/srep38597, PubMed 27934903
Publications 2015
Polarizing T and B Cell Responses by APC-Targeted Subunit Vaccines
Front Immunol, 6, 367
DOI 10.3389/fimmu.2015.00367, PubMed 26257735
Selected Aspects in the Pathogenesis of Autoimmune Diseases
Mediators Inflamm, 2015, 351732
DOI 10.1155/2015/351732, PubMed 26300591
Inflammatory Mediators in Autoimmunity and Systemic Autoimmune Diseases
Mediators Inflamm, 2015, 878712
DOI 10.1155/2015/878712, PubMed 26346773
Laser-assisted intradermal delivery of adjuvant-free vaccines targeting XCR1+ dendritic cells induces potent antitumoral responses
J Immunol, 194 (12), 5895-902
DOI 10.4049/jimmunol.1500564, PubMed 25941327
Publications 2014
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells
J Immunol, 193 (4), 1622-35
DOI 10.4049/jimmunol.1401243, PubMed 25009205
TLR3-responsive, XCR1+, CD141(BDCA-3)+/CD8α+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques
J Immunol, 192 (10), 4697-708
DOI 10.4049/jimmunol.1302448, PubMed 24740505
Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8+ T-cell responses against influenza virus
Eur J Immunol, 45 (2), 624-35
DOI 10.1002/eji.201445080, PubMed 25410055
Publications 2013
A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication
PLoS Pathog, 9 (8), e1003514
DOI 10.1371/journal.ppat.1003514, PubMed 23950709
Publications 2011
Genomic and surface proteomic analysis of the canine pathogen Staphylococcus pseudintermedius reveals proteins that mediate adherence to the extracellular matrix
Infect Immun, 79 (8), 3074-86
DOI 10.1128/IAI.00137-11, PubMed 21576333
Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8α+ type
J Immunol, 187 (9), 4411-5
DOI 10.4049/jimmunol.1101717, PubMed 21948982
Publications 2010
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling
J Virol, 84 (23), 12255-64
DOI 10.1128/JVI.01484-10, PubMed 20861242
Publications 2009
Evolutionarily conserved herpesviral protein interaction networks
PLoS Pathog, 5 (9), e1000570
DOI 10.1371/journal.ppat.1000570, PubMed 19730696
Publications 2008
Epstein-Barr virus LF2: an antagonist to type I interferon
J Virol, 83 (2), 1140-6
DOI 10.1128/JVI.00602-08, PubMed 18987133
Publications 2005
Herpesviral protein networks and their interaction with the human proteome
Science, 311 (5758), 239-42
DOI 10.1126/science.1116804, PubMed 16339411