T-B cell collaboration where T cells recognize immunoglobulin variable region peptides (Id-peptides) on MHC II molecules on B cells. The importance of BCR (B cell receptor ligation) and T cell help in such Id-driven T-B collaboration. The relationship of chronic Id-driven T-B collaboration to development of autoimmunity and B cell lymphomas.
Studies on bystander killing effected by Id-specific CD4+ T cells. The mechanisms by which tumors can escape killing by CD4+ T cells.
Development of DNA vaccines that as proteins target fused antigen to antigen presenting cells for induction of strong immune responses against influenza virus (The Vaccibody principle).
Recent publications
Høydahl LS, Frigstad T, Rasmussen IB, Øynebråten I, Schjetne KW, Andersen JT, Michaelsen TE, Lunde E, Bogen B, Sandlie I(2021) Antibody-mediated delivery of T-cell epitopes to antigen-presenting cells induce strong CD4 and CD8 T-cell responses Vaccine(in press) DOI 10.1016/j.vaccine.2021.02.012, PubMed 33612340
Tveita A, Hestenes S, Sporastøyl ER, Pettersen SA, Neple BL, Myrstad M, Tveit A, Frøen H, Svendsen J, Rønning EJ(2020) Rettelse: Lungeembolisme ved covid-19 Tidsskr Nor Laegeforen, 140(1) DOI 10.4045/tidsskr.20.0987, PubMed 33433107
Rummler M, Ziouti F, Bouchard AL, Brandl A, Duda GN, Bogen B, Beilhack A, Lynch ME, Jundt F, Willie BM(2020) Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model of myeloma bone disease Acta Biomater, 119, 247-258 DOI 10.1016/j.actbio.2020.10.041, PubMed 33130307