T-B cell collaboration where T cells recognize immunoglobulin variable region peptides (Id-peptides) on MHC II molecules on B cells. The importance of BCR (B cell receptor ligation) and T cell help in such Id-driven T-B collaboration. The relationship of chronic Id-driven T-B collaboration to development of autoimmunity and B cell lymphomas.
Studies on bystander killing effected by Id-specific CD4+ T cells. The mechanisms by which tumors can escape killing by CD4+ T cells.
Development of DNA vaccines that as proteins target fused antigen to antigen presenting cells for induction of strong immune responses against influenza virus (The Vaccibody principle).
Recent publications
Rummler M, Ziouti F, Bouchard AL, Brandl A, Duda GN, Bogen B, Beilhack A, Lynch ME, Jundt F, Willie BM(2020) Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model of myeloma bone disease Acta Biomater(in press) DOI 10.1016/j.actbio.2020.10.041, PubMed 33130307
Wilk AJ, Weidenbacher NL, Vergara R, Haabeth OAW, Levy R, Waymouth RM, Wender PA, Blish CA(2020) Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy Blood Adv, 4(17), 4244-4255 DOI 10.1182/bloodadvances.2020002355, PubMed 32898247
Ihle-Hansen H, Berge T, Ernø PE, Rønning EJ, Svendsen J, Wien TN, Tveita A, Andersen EL, Thallinger M, Tveit A, Myrstad M(2020) Komplikasjoner og dødelighet blant pasienter innlagt med covid-19 Tidsskr Nor Laegeforen, 140(11) DOI 10.4045/tidsskr.20.0432, PubMed 32815354