T-B cell collaboration where T cells recognize immunoglobulin variable region peptides (Id-peptides) on MHC II molecules on B cells. The importance of BCR (B cell receptor ligation) and T cell help in such Id-driven T-B collaboration. The relationship of chronic Id-driven T-B collaboration to development of autoimmunity and B cell lymphomas.
Studies on bystander killing effected by Id-specific CD4+ T cells. The mechanisms by which tumors can escape killing by CD4+ T cells.
Development of DNA vaccines that as proteins target fused antigen to antigen presenting cells for induction of strong immune responses against influenza virus (The Vaccibody principle).
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Fossum E, Rohringer A, Aune T, Rydland KM, Bragstad K, Hungnes O(2024) Antigenic drift and immunity gap explain reduction in protective responses against influenza A(H1N1)pdm09 and A(H3N2) viruses during the COVID-19 pandemic: a cross-sectional study of human sera collected in 2019, 2021, 2022, and 2023 Virol J, 21(1), 57 DOI 10.1186/s12985-024-02326-w, PubMed 38448981
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