T-B cell collaboration where T cells recognize immunoglobulin variable region peptides (Id-peptides) on MHC II molecules on B cells. The importance of BCR (B cell receptor ligation) and T cell help in such Id-driven T-B collaboration. The relationship of chronic Id-driven T-B collaboration to development of autoimmunity and B cell lymphomas.
Studies on bystander killing effected by Id-specific CD4+ T cells. The mechanisms by which tumors can escape killing by CD4+ T cells.
Development of DNA vaccines that as proteins target fused antigen to antigen presenting cells for induction of strong immune responses against influenza virus (The Vaccibody principle).
Recent publications
Kwon M, Kim CG, Lee H, Cho H, Kim Y, Lee EC, Choi SJ, Park J, Seo IH, Bogen B, Song IC, Jo DY, Kim JS, Park SH, Choi I, Choi YS, Shin EC(2020) PD-1 blockade reinvigorates bone marrow CD8+ T cells from patients with multiple myeloma in the presence of TGF-b inhibitors Clin Cancer Res(in press) DOI 10.1158/1078-0432.CCR-19-0267, PubMed 31941832
Brandwein M, Horev A, Bogen B, Fuks G, Israel A, Shalom G, Pinsk V, Steinberg D, Bentwich Z, Shental N, Meshner S(2019) The role of sweat in the composition of skin microbiome: lessons learned from patients with congenital insensitivity to pain with anhidrosis J Eur Acad Dermatol Venereol(in press) DOI 10.1111/jdv.16170, PubMed 31875978
Grodeland G, Fossum E, Bogen B(2019) Targeting of HA to chemokine receptors induces strong and cross-reactive T cell responses after DNA vaccination in pigs Vaccine(in press) DOI 10.1016/j.vaccine.2019.11.084, PubMed 31836256