Kristian Berg
- Professor, Head of department
- +47 22 78 14 79
Room K03 116
Publications 2024
Enhancing the Efficacy of Radiation Therapy by Photochemical Internalization of Fibrin-Hydrogel-Delivered Bleomycin
Cancers (Basel), 16 (23)
DOI 10.3390/cancers16234029, PubMed 39682215
Corrigendum: Light-enhanced VEGF121/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment
Front Immunol, 14, 1359973
DOI 10.3389/fimmu.2023.1359973, PubMed 38264651
Publications 2023
Light-enhanced VEGF121/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment
Front Immunol, 14, 1278000
DOI 10.3389/fimmu.2023.1278000, PubMed 38173721
Small anticancer drug release by light: Photochemical internalization of porphyrin-β-cyclodextrin nanoparticles
Carbohydr Polym, 306, 120579
DOI 10.1016/j.carbpol.2023.120579, PubMed 36746578
Phonetic characteristics of German unstressed vowels: The case of opa vs Oper
JASA Express Lett, 3 (9)
DOI 10.1121/10.0020813, PubMed 37656143
Publications 2022
Inhibition of glioma development by doxorubicin-photochemical internalization generated macrophage vaccine: A survival study in rats
Photodiagnosis Photodyn Ther, 38, 102879
DOI 10.1016/j.pdpdt.2022.102879, PubMed 35489691
Sonochemical Internalization of Bleomycin Inhibits Adenocarcinoma Breast Tumor Development in an Orthotopic Rat Model
J Environ Pathol Toxicol Oncol, 41 (2), 25-35
DOI 10.1615/JEnvironPatholToxicolOncol.2021040536, PubMed 35695649
Publications 2021
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants (Basel), 10 (7)
DOI 10.3390/antiox10071149, PubMed 34356382
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
Nat Commun, 12 (1), 6427
DOI 10.1038/s41467-021-26018-z, PubMed 34741021
Squamous cell carcinoma of the ear treated by photochemical internalization
Photodiagnosis Photodyn Ther, 36, 102528
DOI 10.1016/j.pdpdt.2021.102528, PubMed 34509683
An improved in vitro photochemical internalization protocol for 3D spheroid cultures
Lasers Med Sci, 36 (8), 1567-1571
DOI 10.1007/s10103-021-03332-y, PubMed 34185168
Publications 2020
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Photochem Photobiol, 96 (3), 699-707
DOI 10.1111/php.13257, PubMed 32125700
Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study
Photochem Photobiol, 96 (3), 680-683
DOI 10.1111/php.13210, PubMed 31901218
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J Clin Med, 9 (2)
DOI 10.3390/jcm9020528, PubMed 32075165
Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
Front Bioeng Biotechnol, 8, 1027
DOI 10.3389/fbioe.2020.01027, PubMed 33042960
Predictive biomarkers for 5-ALA-PDT can lead to personalized treatments and overcome tumor-specific resistances
Cancer Rep (Hoboken), 5 (12), e1278
DOI 10.1002/cnr2.1278, PubMed 32737955
Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
Lasers Med Sci, 36 (5), 1031-1038
DOI 10.1007/s10103-020-03140-w, PubMed 33123852
In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
Cancers (Basel), 12 (1)
DOI 10.3390/cancers12010190, PubMed 31940973
Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model
Photochem Photobiol, 96 (3), 708-717
DOI 10.1111/php.13267, PubMed 32222965
Enhanced gene transfection of macrophages by photochemical internalization: Potential for gene-directed enzyme prodrug therapy of gliomas
Photodiagnosis Photodyn Ther, 33, 102098
DOI 10.1016/j.pdpdt.2020.102098, PubMed 33188941
Word class and spelling in English
J Exp Psychol Learn Mem Cogn, 47 (6), 1027-1035
DOI 10.1037/xlm0000969, PubMed 33151716
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965
Publications 2019
Proton-dynamic therapy following photosensitiser activation by accelerated protons demonstrated through fluorescence and singlet oxygen production
Nat Commun, 10 (1), 3986
DOI 10.1038/s41467-019-12042-7, PubMed 31484929
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization
Photodiagnosis Photodyn Ther, 27, 288-290
DOI 10.1016/j.pdpdt.2019.06.018, PubMed 31252139
Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
J Clin Med, 9 (1)
DOI 10.3390/jcm9010068, PubMed 31888091
The effects of low irradiance long duration photochemical internalization on glioma spheroids
Photodiagnosis Photodyn Ther, 26, 442-447
DOI 10.1016/j.pdpdt.2019.05.005, PubMed 31075319
Photochemical Internalization Enhanced Nonviral Suicide Gene Therapy
Methods Mol Biol, 1895, 165-176
DOI 10.1007/978-1-4939-8922-5_13, PubMed 30539537
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194
Publications 2018
Photodynamic therapy mediated immune therapy of brain tumors
Neuroimmunol Neuroinflamm, 5
DOI 10.20517/2347-8659.2018.31, PubMed 30221185
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem Photobiol, 95 (1), 387-396
DOI 10.1111/php.12997, PubMed 30107033
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Lasers Med Sci, 33 (8), 1747-1755
DOI 10.1007/s10103-018-2534-5, PubMed 29802587
Light-enhanced VEGF121/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J Control Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005, PubMed 30217739
Publications 2017
Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy
Photodiagnosis Photodyn Ther, 18, 140-148
DOI 10.1016/j.pdpdt.2017.02.016, PubMed 28257943
Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
Biomacromolecules, 18 (4), 1108-1126
DOI 10.1021/acs.biomac.6b01670, PubMed 28245649
Photochemical internalization in bladder cancer - development of an orthotopic in vivo model
Photochem Photobiol Sci, 16 (11), 1664-1676
DOI 10.1039/c7pp00176b, PubMed 28972608
Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
J Control Release, 268, 120-127
DOI 10.1016/j.jconrel.2017.10.015, PubMed 29042319
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn Ther, 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010, PubMed 28838761
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem Pharmacol, 144, 63-77
DOI 10.1016/j.bcp.2017.08.002, PubMed 28784290
Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
Photodiagnosis Photodyn Ther, 20, 95-106
DOI 10.1016/j.pdpdt.2017.08.015, PubMed 28865875
Photochemical internalization enhanced macrophage delivered chemotherapy
Photodiagnosis Photodyn Ther, 21, 156-162
DOI 10.1016/j.pdpdt.2017.12.002, PubMed 29221858
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol, 12, 191-197
DOI 10.1016/j.redox.2017.02.018, PubMed 28254657
Publications 2016
Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery
In Handbook of Porphyrin Science (Kadish KM, Smith KM, Guilard R, eds.), World Scientific Publishing Co, Singapore, 43, 245-300
DOI 10.1142/9789813149632_0004, PublikaID 252, ISBN 978-981-3149-63-2
Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization
Biomed Opt Express, 7 (4), 1240-50
DOI 10.1364/BOE.7.001240, PubMed 27446650
Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization
J Environ Pathol Toxicol Oncol, 35 (1), 91-8
DOI 10.1615/JEnvironPatholToxicolOncol.2016015463, PubMed 27279586
Biologic Effects of Light: An Enlighting Prospective
Anticancer Res, 36 (3), 1339-43
PubMed 26977035
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
Lancet Oncol, 17 (9), 1217-29
DOI 10.1016/S1470-2045(16)30224-8, PubMed 27475428
Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectives
In Photodynamic Medicine: From Bench to Clinic (Kostron H, Hasan T, eds.), The Royal Society of Chemistry, London, 15, 161-180
DOI 10.1039/9781782626824-00161, PublikaID 251, ISBN 978-1-78262-451-6
Publications 2015
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn Ther, 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005, PubMed 25575731
Resistance mechanisms in photodynamic therapy
Photochem Photobiol Sci, 14 (8), 1376-7
DOI 10.1039/c5pp90026c, PubMed 26212047
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-51
DOI 10.18632/oncotarget.3814, PubMed 26002552
Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
PROC SPIE, 9305
DOI 10.1117/12.2082590
Photochemical internalization of bleomycin and temozolomide--in vitro studies on the glioma cell line F98
Photochem Photobiol Sci, 14 (7), 1357-66
DOI 10.1039/c5pp00144g, PubMed 26088711
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem Photobiol Sci, 14 (8), 1433-50
DOI 10.1039/c5pp00027k, PubMed 25805311
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem Photobiol Sci, 14 (8), 1465-75
DOI 10.1039/c5pp00029g, PubMed 25849953
Publications 2014
Light-triggered, efficient cytosolic release of IM7-saporin targeting the putative cancer stem cell marker CD44 by photochemical internalization
Mol Pharm, 11 (8), 2764-76
DOI 10.1021/mp500129t, PubMed 24960585
Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
J Control Release, 182, 58-66
DOI 10.1016/j.jconrel.2014.03.014, PubMed 24637464
Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas.
PROC SPIE, 8928, 89280B
DOI 10.1117/12.2041627
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene
J Neurooncol, 118 (1), 29-37
DOI 10.1007/s11060-014-1410-9, PubMed 24610460
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
J Control Release, 180, 1-9
DOI 10.1016/j.jconrel.2014.02.003, PubMed 24531010
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier
J Biomed Opt, 19 (10), 105009
DOI 10.1117/1.JBO.19.10.105009, PubMed 25341069
Publications 2013
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J Control Release, 168 (3), 317-26
DOI 10.1016/j.jconrel.2013.03.023, PubMed 23567040
Tetraphenylporphyrin tethered chitosan based carriers for photochemical transfection
J Med Chem, 56 (3), 807-19
DOI 10.1021/jm301270r, PubMed 23281854
Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
Free Radic Biol Med, 65, 1300-1309
DOI 10.1016/j.freeradbiomed.2013.09.010, PubMed 24076428
The influence of Pluronics® on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX
Photochem Photobiol Sci, 12 (3), 559-75
DOI 10.1039/c2pp25249j, PubMed 23108412
The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells
Photochem Photobiol Sci, 13 (1), 8-22
DOI 10.1039/c3pp50181g, PubMed 24158176
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim Biophys Acta, 1830 (8), 4235-43
DOI 10.1016/j.bbagen.2013.04.033, PubMed 23643966
The photosensitizer disulfonated aluminum phthalocyanine reduces uptake and alters trafficking of fluid phase endocytosed drugs in vascular endothelial cells--impact on efficacy of photochemical internalization
Biochem Pharmacol, 86 (6), 748-58
DOI 10.1016/j.bcp.2013.07.011, PubMed 23876343
Vascular endothelial cells as targets for photochemical internalization (PCI)
Photochem Photobiol, 89 (5), 1185-92
DOI 10.1111/php.12126, PubMed 23819771
Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
Biochim Biophys Acta, 1830 (3), 2659-70
DOI 10.1016/j.bbagen.2012.11.010, PubMed 23671927
Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417
DOI 10.1016/j.bbagen.2013.05.002
Publications 2012
Photochemical internalization (PCI) of HER2-targeted toxins: synergy is dependent on the treatment sequence
Biochim Biophys Acta, 1820 (12), 1849-58
DOI 10.1016/j.bbagen.2012.08.027, PubMed 22981913
Cellular uptake of DNA-chitosan nanoparticles: the role of clathrin- and caveolae-mediated pathways
Int J Biol Macromol, 51 (5), 1043-51
DOI 10.1016/j.ijbiomac.2012.08.016, PubMed 22947453
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
J Control Release, 159 (2), 197-203
DOI 10.1016/j.jconrel.2012.02.003, PubMed 22349185
Photophysical and photobiological properties of a sulfonated chlorin photosensitiser TPCS(2a) for photochemical internalisation (PCI)
Photochem Photobiol Sci, 12 (3), 519-26
DOI 10.1039/c2pp25328c, PubMed 23232550
Publications 2011
Photodynamic therapy of cancer: an update
CA Cancer J Clin, 61 (4), 250-81
DOI 10.3322/caac.20114, PubMed 21617154
Drug delivery technologies and immunological aspects of photodynamic therapy
Photochem Photobiol Sci, 10 (5), 647-8
DOI 10.1039/c1pp90010b, PubMed 21487635
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
Photochem Photobiol Sci, 10 (10), 1637-51
DOI 10.1039/c1pp05128h, PubMed 21773635
The future of medical diagnostics: review paper
Head Neck Oncol, 3, 38
DOI 10.1186/1758-3284-3-38, PubMed 21861912
At the frontiers of surgery: review
Head Neck Oncol, 3 (1), 7
DOI 10.1186/1758-3284-3-7, PubMed 21306627
Photochemical internalization of tumor-targeted protein toxins
Lasers Surg Med, 43 (7), 721-33
DOI 10.1002/lsm.21084, PubMed 22057500
Publications 2010
Photochemical internalization: a new tool for gene and oligonucleotide delivery
Top Curr Chem, 296, 251-81
DOI 10.1007/128_2010_63, PubMed 21504105
The Potential of Photochemical Internalixation (PCI) for the Cytosolic Delivery of Nanomedicines
In Organelle-Specific Pharmaceutical Nanotechnology (Weissing V, D'Souza, eds.), John Wiley and Sons Inc, New Jersey, USA, 311-322
PublikaID 72
Photochemical internalization (PCI): a technology for drug delivery
Methods Mol Biol, 635, 133-45
DOI 10.1007/978-1-60761-697-9_10, PubMed 20552345
[Photochemical internalisation (PCI): a further development of photodynamic therapy for the treatment of skin cancer]
Praxis (Bern 1994), 99 (23), 1423-8
DOI 10.1024/1661-8157/a000310, PubMed 21082595
Assessing autophagy in the context of photodynamic therapy
Autophagy, 6 (1), 7-18
DOI 10.4161/auto.6.1.10220, PubMed 19855190
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
J Control Release, 148 (1), 2-12
DOI 10.1016/j.jconrel.2010.06.008, PubMed 20600406
Publications 2009
Photosensitizing properties of chlorins in solution and in membrane-mimicking systems
Photochem Photobiol Sci, 8 (6), 778-87
DOI 10.1039/b822269j, PubMed 19492105
Photochemical internalization of bleomycin before external-beam radiotherapy improves locoregional control in a human sarcoma model
Int J Radiat Oncol Biol Phys, 75 (3), 878-85
DOI 10.1016/j.ijrobp.2009.04.039, PubMed 19665318
Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model
Photochem Photobiol Sci, 8 (6), 758-62
DOI 10.1039/b821129a, PubMed 19492102
Photochemical internalization (PCI) in cancer therapy: from bench towards bedside medicine
J Photochem Photobiol B, 96 (2), 83-92
DOI 10.1016/j.jphotobiol.2009.04.012, PubMed 19467605
Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel
PLoS One, 4 (8), e6691
DOI 10.1371/journal.pone.0006691, PubMed 19690617
Head & neck optical diagnostics: vision of the future of surgery
Head Neck Oncol, 1, 25
DOI 10.1186/1758-3284-1-25, PubMed 19594907
Photodynamic therapy targets the mTOR signaling network in vitro and in vivo
Mol Pharm, 6 (1), 255-64
DOI 10.1021/mp800156e, PubMed 19125612
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin--quantitative studies in normal rat liver
J Control Release, 142 (3), 347-53
DOI 10.1016/j.jconrel.2009.11.017, PubMed 19932724
Publications 2008
Photochemical Internalization
In Advances in Photodynamic therapy; basic, translational , and clinical (Hamblin MR, Mroz P, eds.), Norwood: Artech House, Norwood MA, USA, 299-312
PublikaID 71
Photochemical internalization: A technology for effiecient site-directed gene delivery.
In Gene and Cell Therapy. Therapeutic mechanisms and strategies. 3rd edition. (Templeton NS, ed.), CRC Press, 435-442
PublikaID 61
Photochemical enhancement of DNA delivery by EGF receptor targeted polyplexes
Methods Mol Biol, 434, 171-81
DOI 10.1007/978-1-60327-248-3_11, PubMed 18470645
Photochemical enhancement of DNA delivery by EGF reeceptor targeted polyplexes
In Series: Methods in Molecular Biology. Gene therapy protocols Vol 2. Design and characterization of gene transfer vectors. (LeDoux JM, ed.), Humana Press, 434
PublikaID 60
Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization
J Biomed Mater Res A, 87 (1), 147-55
DOI 10.1002/jbm.a.31760, PubMed 18085655
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
Photochem Photobiol, 85 (3), 740-9
DOI 10.1111/j.1751-1097.2008.00477.x, PubMed 19076314
Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival
Mol Cancer Ther, 7 (6), 1740-50
DOI 10.1158/1535-7163.MCT-08-0020, PubMed 18566245
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478
Photochem Photobiol Sci, 7 (9), 1032-40
DOI 10.1039/b806209a, PubMed 18754049
Publications 2007
Photochemical internalization: a new tool for drug delivery
Curr Pharm Biotechnol, 8 (6), 362-72
DOI 10.2174/138920107783018354, PubMed 18289045
Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting human telomerase reverse transcriptase: effects on telomere status and proliferative potential of human prostate cancer cells
Cell Prolif, 40 (6), 905-20
DOI 10.1111/j.1365-2184.2007.00470.x, PubMed 18021178
Photochemical internalization for the treatment of malignant gliomas
PROC SPIE, 6424, 64242C
DOI 10.1117/12.705086
Introduction to the special issue on photodynamic therapy and photodetection
Photochem. Photobiol. Sci., 6 (12), 1233
DOI 10.1039/b716101h
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
Biochem Pharmacol, 74 (2), 226-35
DOI 10.1016/j.bcp.2007.04.018, PubMed 17531956
Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells
Mol Pharm, 4 (2), 241-51
DOI 10.1021/mp060105u, PubMed 17263556
Publications 2006
Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
Med Laser Appl, 21, 239-251
DOI 10.1016/j.mla.2006.08.004, PublikaID 73
Photochemically enhanced adenoviral transduction in a multicellular environment
Photochem Photobiol Sci, 5 (4), 411-21
DOI 10.1039/b515066c, PubMed 16583022
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
J Gene Med, 8 (3), 286-97
DOI 10.1002/jgm.853, PubMed 16342300
Photochemical internalization for light directed gene delivery
In Delivery and expression of DNA and RNA, A laboratory manual (Friedmann T, Rossi J, eds.), Cold Spring Harbour Laboratory Press, New York
PublikaID 59
Photochemical internalization (PCI): a new modality for light activation of endocytosed therapeuticals
J Environ Pathol Toxicol Oncol, 25 (1-2), 521-36
DOI 10.1615/jenvironpatholtoxicoloncol.v25.i1-2.330, PubMed 16566739
Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
Cancer Biol Ther, 5 (11), 1511-20
DOI 10.4161/cbt.5.11.3301, PubMed 17012835
Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
J Gene Med, 8 (6), 707-18
DOI 10.1002/jgm.902, PubMed 16518880
DNA polyplexes based on degradable oligoethylenimine-derivatives: combination with EGF receptor targeting and endosomal release functions
J Control Release, 116 (2), 115-22
DOI 10.1016/j.jconrel.2006.07.002, PubMed 16959361
Reversal of doxorubicin resistance in breast cancer cells by photochemical internalization
Int J Cancer, 119 (11), 2692-8
DOI 10.1002/ijc.22098, PubMed 16991130
Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization
Mol Ther, 13 (6), 1156-62
DOI 10.1016/j.ymthe.2006.02.003, PubMed 16564229
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
FEBS Lett, 580 (24), 5739-46
DOI 10.1016/j.febslet.2006.09.028, PubMed 17007842
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter
Photochem Photobiol, 82 (3), 809-16
DOI 10.1562/2005-11-07-RA-731, PubMed 16420102
Photochemical internalization of therapeutic macromolecular agents: a novel strategy to kill multidrug-resistant cancer cells
J Pharmacol Exp Ther, 319 (2), 604-12
DOI 10.1124/jpet.106.109165, PubMed 16902053
Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin
J Control Release, 111 (1-2), 165-73
DOI 10.1016/j.jconrel.2005.12.002, PubMed 16466823
Publications 2005
Site-specific drug delivery by photochemical internalization enhances the antitumor effect of bleomycin
Clin Cancer Res, 11 (23), 8476-85
DOI 10.1158/1078-0432.CCR-05-1245, PubMed 16322311
Photochemical enhancement of gene delivery to glioblastoma cells is dependent on the vector applied
Anticancer Res, 25 (1A), 291-7
PubMed 15816550
ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies
Photodiagnosis Photodyn Ther, 2 (4), 299-307
DOI 10.1016/S1572-1000(05)00107-9, PubMed 25048871
PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles
Cancer Gene Ther, 12 (5), 439-48
DOI 10.1038/sj.cgt.7700808, PubMed 15678152
Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization
Photochem Photobiol Sci, 4 (4), 383-9
DOI 10.1039/b502000j, PubMed 15803209
Publications 2004
Photochemical drug and gene delivery
Curr Opin Mol Ther, 6 (3), 279-87
PubMed 15264430
Photochemical internalisation in drug and gene delivery
Adv Drug Deliv Rev, 56 (1), 95-115
DOI 10.1016/j.addr.2003.08.016, PubMed 14706447
Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes
J Drug Target, 12 (4), 205-13
DOI 10.1080/10611860410001723090, PubMed 15506169
Sustained gene transfer and enhanced cell death following glucosylated-PEI-mediated p53 gene transfer with photochemical internalisation in p53-mutated head and neck carcinoma cells
Int J Oncol, 25 (6), 1575-81
PubMed 15547693
Enhanced gene transfer and cell death following p53 gene transfer using photochemical internalisation of glucosylated PEI-DNA complexes
J Gene Med, 6 (8), 884-94
DOI 10.1002/jgm.573, PubMed 15293347
Light-directed gene delivery by photochemical internalisation
Expert Opin Biol Ther, 4 (9), 1403-12
DOI 10.1517/14712598.4.9.1403, PubMed 15335308
Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir
Cancer Gene Ther, 11 (7), 514-23
DOI 10.1038/sj.cgt.7700720, PubMed 15118758
Publications 2003
Photochemical internalization (PCI)--a novel technology for release of macromolecules from endocytic vesicles
Oftalmologia, 56 (1), 67-71
PubMed 12886687
Photochemical internalization of a peptide nucleic acid targeting the catalytic subunit of human telomerase
Cancer Res, 63 (13), 3490-4
PubMed 12839932
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem. Photobiol. Sci., 2 (4), 407-411
DOI 10.1039/b211880g
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem Photobiol Sci, 2 (4), 407-11
DOI 10.1039/b211880g, PubMed 12760539
Light directed gene transfer by photochemical internalisation
Curr Gene Ther, 3 (2), 89-112
DOI 10.2174/1566523034578438, PubMed 12653404
Publications 2002
Light-induced adenovirus gene transfer, an efficient and specific gene delivery technology for cancer gene therapy
Cancer Gene Ther, 9 (4), 365-71
DOI 10.1038/sj.cgt.7700447, PubMed 11960287
Photochemical transfection: a technology for efficient light-directed gene delivery
Somat Cell Mol Genet, 27 (1-6), 97-113
DOI 10.1023/a:1022979806314, PubMed 12774944
Photochemical transfection. Light-induced, site-directed gene delivery
Methods Mol Med, 69, 123-35
DOI 10.1385/1-59259-141-8:123, PubMed 11987772
The role of the cell cycle on the efficiency of photochemical gene transfection
Biochim Biophys Acta, 1570 (3), 210-8
DOI 10.1016/s0304-4165(02)00202-7, PubMed 12020812
Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy
Br J Cancer, 86 (4), 652-7
DOI 10.1038/sj.bjc.6600138, PubMed 11870551
Photochemical internalisation: a novel drug delivery system
Tumour Biol, 23 (2), 103-12
DOI 10.1159/000059713, PubMed 12065848
Publications 2001
Evaluation of different photosensitizers for use in photochemical gene transfection
Photochem Photobiol, 73 (4), 388-95
DOI 10.1562/0031-8655(2001)073<0388:eodpfu>2.0.co;2, PubMed 11332034
5-Aminolevulinic acid-based photochemical internalization of the immunotoxin MOC31-gelonin generates synergistic cytotoxic effects in vitro
Photochem Photobiol, 74 (2), 303-10
DOI 10.1562/0031-8655(2001)074<0303:aabpio>2.0.co;2, PubMed 11547569
In vivo documentation of photochemical internalization, a novel approach to site specific cancer therapy
Int J Cancer, 92 (5), 761-6
DOI 10.1002/1097-0215(20010601)92:5<761::aid-ijc1238>3.0.co;2-4, PubMed 11340584
Publications 2000
Role of endosomes in gene transfection mediated by photochemical internalisation (PCI)
J Gene Med, 2 (6), 477-88
DOI 10.1002/1521-2254(200011/12)2:6<477::AID-JGM137>3.0.CO;2-B, PubMed 11199268
Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization
Biochim Biophys Acta, 1475 (3), 307-13
DOI 10.1016/s0304-4165(00)00082-9, PubMed 10913830
Photochemical internalisation increases the cytotoxic effect of the immunotoxin MOC31-gelonin
Int J Cancer, 87 (6), 853-9
DOI 10.1002/1097-0215(20000915)87:6<853::aid-ijc15>3.0.co;2-0, PubMed 10956397
Publications 1999
Photochemical internalization: a novel technology for delivery of macromolecules into cytosol
Cancer Res, 59 (6), 1180-3
PubMed 10096543
Publications 1998
Verapamil enhances the uptake and the photocytotoxic effect of PII, but not that of tetra(4-sulfonatophenyl)porphine
Biochim Biophys Acta, 1370 (2), 317-24
DOI 10.1016/s0005-2736(97)00282-4, PubMed 9545591
Publications 1992
The unpolymerized form of tubulin is the target for microtubule inhibition by photoactivated tetra(4-sulfonatophenyl)porphine
Biochim Biophys Acta, 1135 (2), 147-53
DOI 10.1016/0167-4889(92)90130-4, PubMed 1616935
Publications 1990
Cellular uptake and photosensitizing effects of porphyrins and phthalocyanines
Department of Biophysics, The Norwegian Radium Hospital, Oslo, Flere pag.
BIBSYS 901007765, ISBN 82-992250-0-0
Publications 1985
Mitokondriell fettsyreoksydasjon i brunt fettvev. Fluksregulerende trinn
K. Berg, Oslo, 174 s.
BIBSYS 961256575