Kristian Berg
- Professor, Head of department
- +47 22 78 14 79
Room K03 116
Publications 2021
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants, 10 (7), 1149
DOI 10.3390/antiox10071149
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
Nat. Commun., 12 (1), 6427
DOI 10.1038/s41467-021-26018-z
Squamous cell carcinoma of the ear treated by photochemical internalization
Photodiagnosis Photodyn. Ther., 36, 102528
DOI 10.1016/j.pdpdt.2021.102528
An improved in vitro photochemical internalization protocol for 3D spheroid cultures
Lasers Med. Sci., 36 (8), 1567-1571
DOI 10.1007/s10103-021-03332-y
Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
Lasers Med. Sci., 36 (5), 1031-1038
DOI 10.1007/s10103-020-03140-w
Enhanced gene transfection of macrophages by photochemical internalization: Potential for gene-directed enzyme prodrug therapy of gliomas
Photodiagnosis Photodyn. Ther., 33, 102098
DOI 10.1016/j.pdpdt.2020.102098
Publications 2020
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Photochem. Photobiol., 96 (3), 699-707
DOI 10.1111/php.13257
Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study
Photochem. Photobiol., 96 (3), 680-683
DOI 10.1111/php.13210
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J. Clin. Med., 9 (2), 528
DOI 10.3390/jcm9020528
Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
Front. Bioeng. Biotechnol., 8, 1027
DOI 10.3389/fbioe.2020.01027
y Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
J. Clin. Med., 9 (1), 68
DOI 10.3390/jcm9010068
In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
Cancers, 12 (1), 190
DOI 10.3390/cancers12010190
Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model
Photochem. Photobiol., 96 (3), 708-717
DOI 10.1111/php.13267
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers, 12 (2), 417
DOI 10.3390/cancers12020417
Publications 2019
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization
Photodiagnosis Photodyn. Ther., 27, 288-290
DOI 10.1016/j.pdpdt.2019.06.018
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem. Photobiol., 95 (1), 387-396
DOI 10.1111/php.12997
The effects of low irradiance long duration photochemical internalization on glioma spheroids
Photodiagnosis Photodyn. Ther., 26, 442-447
DOI 10.1016/j.pdpdt.2019.05.005
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
npj Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8
Publications 2018
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Lasers Med. Sci., 33 (8), 1747-1755
DOI 10.1007/s10103-018-2534-5
Photochemical internalization enhanced macrophage delivered chemotherapy
Photodiagnosis Photodyn. Ther., 21, 156-162
DOI 10.1016/j.pdpdt.2017.12.002
Light-enhanced VEGF(121)/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J. Control. Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005
Publications 2017
Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy
Photodiagnosis Photodyn. Ther., 18, 140-148
DOI 10.1016/j.pdpdt.2017.02.016
Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
Biomacromolecules, 18 (4), 1108-1126
DOI 10.1021/acs.biomac.6b01670
Photochemical internalization in bladder cancer - development of an orthotopic in vivo model
Photochem. Photobiol. Sci., 16 (11), 1664-1676
DOI 10.1039/c7pp00176b
Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
J. Control. Release, 268, 120-127
DOI 10.1016/j.jconrel.2017.10.015
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn. Ther., 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem. Pharmacol., 144, 63-77
DOI 10.1016/j.bcp.2017.08.002
Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
Photodiagnosis Photodyn. Ther., 20, 95-106
DOI 10.1016/j.pdpdt.2017.08.015
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol., 12, 191-197
DOI 10.1016/j.redox.2017.02.018
Publications 2016
Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery
In Handbook of Porphyrin Science (Kadish KM, Smith KM, Guilard R, eds.), World Scientific Publishing Co, Singapore, 43, 245-300
DOI 10.1142/9789813149632_0004, PublikaID 252, ISBN 978-981-3149-63-2
Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization
Biomed. Opt. Express, 7 (4), 1240-1250
DOI 10.1364/BOE.7.001240
Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization
J. Environ. Pathol. Toxicol. Oncol., 35 (1), 91-98
DOI 10.1615/JEnvironPatholToxicolOncol.2016015463
Biologic Effects of Light: An Enlighting Prospective
Anticancer Res., 36 (3), 1339-1343
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
Lancet Oncol., 17 (9), 1217-1229
DOI 10.1016/S1470-2045(16)30224-8
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem. Biol., 11 (1), 251-262
DOI 10.1021/acschembio.5b00734
Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectives
In Photodynamic Medicine: From Bench to Clinic (Kostron H, Hasan T, eds.), The Royal Society of Chemistry, London, 15, 161-180
DOI 10.1039/9781782626824-00161, PublikaID 251, ISBN 978-1-78262-451-6
Publications 2015
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn. Ther., 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005
Resistance mechanisms in photodynamic therapy
Photochem. Photobiol. Sci., 14 (8), 1376-1377
DOI 10.1039/c5pp90026c
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J. Control. Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-12451
DOI 10.18632/oncotarget.3814
Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
PROC SPIE, 9305
DOI 10.1117/12.2082590
Photochemical internalization of bleomycin and temozolomide - in vitro studies on the glioma cell line F98
Photochem. Photobiol. Sci., 14 (7), 1357-1366
DOI 10.1039/c5pp00144g
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem. Photobiol. Sci., 14 (8), 1433-1450
DOI 10.1039/c5pp00027k
Photochemical Internalization of Tamoxifens Transported by a "Trojan-Horse" Nanoconjugate into Breast-Cancer Cell Lines
Angew. Chem.-Int. Edit., 54 (16), 4885-4889
DOI 10.1002/anie.201500183
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem. Photobiol. Sci., 14 (8), 1465-1475
DOI 10.1039/c5pp00029g
Publications 2014
Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization
Mol. Pharm., 11 (8), 2764-2776
DOI 10.1021/mp500129t
Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
J. Control. Release, 182, 58-66
DOI 10.1016/j.jconrel.2014.03.014
The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells
Photochem. Photobiol. Sci., 13 (1), 8-22
DOI 10.1039/c3pp50181g
Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas.
PROC SPIE, 8928, 89280B
DOI 10.1117/12.2041627
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene
J. Neuro-Oncol., 118 (1), 29-37
DOI 10.1007/s11060-014-1410-9
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
J. Control. Release, 180, 1-9
DOI 10.1016/j.jconrel.2014.02.003
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier
J. Biomed. Opt., 19 (10), 105009
DOI 10.1117/1.JBO.19.10.105009
Publications 2013
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J. Control. Release, 168 (3), 317-326
DOI 10.1016/j.jconrel.2013.03.023
Tetraphenylporphyrin Tethered Chitosan Based Carriers for Photochemical Transfection
J. Med. Chem., 56 (3), 807-819
DOI 10.1021/jm301270r
Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
Free Radic. Biol. Med., 65, 1300-1309
DOI 10.1016/j.freeradbiomed.2013.09.010
The influence of Pluronics (R) on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX
Photochem. Photobiol. Sci., 12 (3), 559-575
DOI 10.1039/c2pp25249j
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim. Biophys. Acta-Gen. Subj., 1830 (8), 4235-4243
DOI 10.1016/j.bbagen.2013.04.033
The photosensitizer disulfonated aluminum phthalocyanine reduces uptake and alters trafficking of fluid phase endocytosed drugs in vascular endothelial cells-Impact on efficacy of photochemical internalization
Biochem. Pharmacol., 86 (6), 748-758
DOI 10.1016/j.bcp.2013.07.011
Vascular endothelial cells as targets for photochemical internalization (PCI)
Photochem. Photobiol., 89 (5), 1185-1192
DOI 10.1111/php.12126
Photophysical and photobiological properties of a sulfonated chlorin photosensitiser TPCS2a for photochemical internalisation (PCI)
Photochem. Photobiol. Sci., 12 (3), 519-526
DOI 10.1039/c2pp25328c
Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
Biochim. Biophys. Acta-Gen. Subj., 1830 (3), 2659-2670
DOI 10.1016/j.bbagen.2012.11.010
Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417
DOI 10.1016/j.bbagen.2013.05.002
Publications 2012
Photochemical internalization (PCI) of HER2-targeted toxins Synergy is dependent on the treatment sequence
Biochim. Biophys. Acta-Gen. Subj., 1820 (12), 1849-1858
DOI 10.1016/j.bbagen.2012.08.027
Cellular uptake of DNA-chitosan nanoparticles: The role of clathrin- and caveolae-mediated pathways
Int. J. Biol. Macromol., 51 (5), 1043-1051
DOI 10.1016/j.ijbiomac.2012.08.016
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
J. Control. Release, 159 (2), 197-203
DOI 10.1016/j.jconrel.2012.02.003
Publications 2011
Photodynamic Therapy of Cancer: An Update
CA-Cancer J. Clin., 61 (4), 250-281
DOI 10.3322/caac.20114
Drug delivery technologies and immunological aspects of photodynamic therapy
Photochem. Photobiol. Sci., 10 (5), 647-648
DOI 10.1039/c1pp90010b
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
Photochem. Photobiol. Sci., 10 (10), 1637-1651
DOI 10.1039/c1pp05128h
The future of medical diagnostics: review paper
Head Neck Oncol., 3, 38
DOI 10.1186/1758-3284-3-38
At the frontiers of surgery: review
Head Neck Oncol., 3, 7
DOI 10.1186/1758-3284-3-7
Photochemical Internalization of Tumor-Targeted Protein Toxins
Lasers Surg. Med., 43 (7), 721-733
DOI 10.1002/lsm.21084
Publications 2010
Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery
Top. Curr. Chem., 296, 251-281
DOI 10.1007/128_2010_63
The Potential of Photochemical Internalixation (PCI) for the Cytosolic Delivery of Nanomedicines
In Organelle-Specific Pharmaceutical Nanotechnology (Weissing V, D'Souza, eds.), John Wiley and Sons Inc, New Jersey, USA, 311-322
PublikaID 72
Assessing autophagy in the context of photodynamic therapy
Autophagy, 6 (1), 7-18
DOI 10.4161/auto.6.1.10220
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
J. Control. Release, 148 (1), 2-12
DOI 10.1016/j.jconrel.2010.06.008
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin - Quantitative studies in normal rat liver
J. Control. Release, 142 (3), 347-353
DOI 10.1016/j.jconrel.2009.11.017
Publications 2009
Photosensitizing properties of chlorins in solution and in membrane-mimicking systems
Photochem. Photobiol. Sci., 8 (6), 778-787
DOI 10.1039/b822269j
PHOTOCHEMICAL INTERNALIZATION OF BLEOMYCIN BEFORE EXTERNAL-BEAM RADIOTHERAPY IMPROVES LOCOREGIONAL CONTROL IN A HUMAN SARCOMA MODEL
Int. J. Radiat. Oncol. Biol. Phys., 75 (3), 878-885
DOI 10.1016/j.ijrobp.2009.04.039
Photochemical Internalization of Bleomycin is Superior to Photodynamic Therapy Due to the Therapeutic Effect in the Tumor Periphery
Photochem. Photobiol., 85 (3), 740-749
DOI 10.1111/j.1751-1097.2008.00477.x
Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model
Photochem. Photobiol. Sci., 8 (6), 758-762
DOI 10.1039/b821129a
Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine
J. Photochem. Photobiol. B-Biol., 96 (2), 83-92
DOI 10.1016/j.jphotobiol.2009.04.012
Multi-Modality Therapeutics with Potent Anti-Tumor Effects: Photochemical Internalization Enhances Delivery of the Fusion Toxin scFvMEL/rGel
PLoS One, 4 (8), e6691
DOI 10.1371/journal.pone.0006691
Photodynamic Therapy Targets the mTOR Signaling Network in Vitro and in Vivo
Mol. Pharm., 6 (1), 255-264
DOI 10.1021/mp800156e
Publications 2008
Photochemical Internalization
In Advances in Photodynamic therapy; basic, translational , and clinical (Hamblin MR, Mroz P, eds.), Norwood: Artech House, Norwood MA, USA, 299-312
PublikaID 71
Photochemical internalization: A technology for effiecient site-directed gene delivery.
In Gene and Cell Therapy. Therapeutic mechanisms and strategies. 3rd edition. (Templeton NS, ed.), CRC Press, 435-442
PublikaID 61
Photochemical enhancement of DNA delivery by EGF reeceptor targeted polyplexes
In Series: Methods in Molecular Biology. Gene therapy protocols Vol 2. Design and characterization of gene transfer vectors. (LeDoux JM, ed.), Humana Press, 434
PublikaID 60
Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization
J. Biomed. Mater. Res. Part A, 87A (1), 147-155
DOI 10.1002/jbm.a.31760
Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival
Mol. Cancer Ther., 7 (6), 1740-1750
DOI 10.1158/1535-7163.MCT-08-0020
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478
Photochem. Photobiol. Sci., 7 (9), 1032-1040
DOI 10.1039/b806209a
Publications 2007
Photochemical internalization: A new tool for drug delivery
Curr. Pharm. Biotechnol., 8 (6), 362-372
DOI 10.2174/138920107783018354
Photochemical internalization for the treatment of malignant gliomas
PROC SPIE, 6424, 64242C
DOI 10.1117/12.705086
Introduction to the special issue on photodynamic therapy and photodetection
Photochem. Photobiol. Sci., 6 (12), 1233
DOI 10.1039/b716101h
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
Biochem. Pharmacol., 74 (2), 226-235
DOI 10.1016/j.bcp.2007.04.018
Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells
Mol. Pharm., 4 (2), 241-251
DOI 10.1021/mp060105u
Publications 2006
Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
Med Laser Appl, 21, 239-251
DOI 10.1016/j.mla.2006.08.004, PublikaID 73
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
J. Gene. Med., 8 (3), 286-297
DOI 10.1002/jgm.853
Photochemical internalization for light directed gene delivery
In Delivery and expression of DNA and RNA, A laboratory manual (Friedmann T, Rossi J, eds.), Cold Spring Harbour Laboratory Press, New York
PublikaID 59
Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
Cancer Biol. Ther., 5 (11), 1511-1520
DOI 10.4161/cbt.5.11.3301
Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
J. Gene. Med., 8 (6), 707-718
DOI 10.1002/jgm.902
DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions
J. Control. Release, 116 (2), 115-122
DOI 10.1016/j.jconrel.2006.07.002
Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization
Mol. Ther., 13 (6), 1156-1162
DOI 10.1016/j.ymthe.2006.02.003
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
FEBS Lett., 580 (24), 5739-5746
DOI 10.1016/j.febslet.2006.09.028
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter
Photochem. Photobiol., 82 (3), 809-816
DOI 10.1562/2005-11-07-RA-731
Photochemical internalization of therapeutic macromolecular agents: A novel strategy to kill multidrug-resistant cancer cells
J. Pharmacol. Exp. Ther., 319 (2), 604-612
DOI 10.1124/jpet.106.109165
Publications 2005
ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies
Photodiagnosis Photodyn. Ther., 2 (4), 299-307
DOI 10.1016/S1572-1000(05)00107-9
Publications 2003
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem. Photobiol. Sci., 2 (4), 407-411
DOI 10.1039/b211880g
Publications 1990
Cellular uptake and photosensitizing effects of porphyrins and phthalocyanines
Department of Biophysics, The Norwegian Radium Hospital, Oslo, Flere pag.
BIBSYS 901007765, ISBN 82-992250-0-0
Publications 1985
Mitokondriell fettsyreoksydasjon i brunt fettvev. Fluksregulerende trinn
K. Berg, Oslo, 174 s.
BIBSYS 961256575