Publications 2021

Christopoulos PF, Grigalavicius M, Corthay A, Berg K, Theodossiou TA (2021)
Reactive Species from Two-Signal Activated Macrophages Interfere with Their Oxygen Consumption Measurements
Antioxidants, 10 (7), 1149
DOI 10.3390/antiox10071149

Engebraaten O, Yau C, Berg K, Borgen E, Garred O, Berstad MEB, Fremstedal ASV, De Michele A, van't Veer L, Esserman L, Weyergang A (2021)
RAB5A expression is a predictive biomarker for trastuzumab emtansine in breast cancer
Nat. Commun., 12 (1), 6427
DOI 10.1038/s41467-021-26018-z

Jerjes W, Hamdoon Z, Berg K, Hogset A, Hopper C (2021)
Squamous cell carcinoma of the ear treated by photochemical internalization
Photodiagnosis Photodyn. Ther., 36, 102528
DOI 10.1016/j.pdpdt.2021.102528

Nguyen L, Madsen SJ, Berg K, Hirschberg H (2021)
An improved in vitro photochemical internalization protocol for 3D spheroid cultures
Lasers Med. Sci., 36 (8), 1567-1571
DOI 10.1007/s10103-021-03332-y

Nguyen L, Potma EO, Le JN, Johnson J, Romena G, Peng Q, Berg K, Hirschberg H (2021)
Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier
Lasers Med. Sci., 36 (5), 1031-1038
DOI 10.1007/s10103-020-03140-w

Romena G, Nguyen L, Berg K, Madsen SJ, Hirschberg H (2021)
Enhanced gene transfection of macrophages by photochemical internalization: Potential for gene-directed enzyme prodrug therapy of gliomas
Photodiagnosis Photodyn. Ther., 33, 102098
DOI 10.1016/j.pdpdt.2020.102098

Publications 2020

Grigalavicius M, Mastrangelopoulou M, Arous D, Juzeniene A, Menard M, Skarpen E, Berg K, Theodossiou TA (2020)
Photodynamic Efficacy of Cercosporin in 3D Tumor Cell Cultures
Photochem. Photobiol., 96 (3), 699-707
DOI 10.1111/php.13257

Jerjes W, Hamdoon Z, Berg K, Hogset A, Hopper C (2020)
Apparent Complete Response of a Treatment Refractory and Recurrent Squamous Cell Carcinoma Lesion to Photochemical Internalization: A Clinical Case Study
Photochem. Photobiol., 96 (3), 680-683
DOI 10.1111/php.13210

Jerjes W, Theodossiou TA, Hirschberg H, Hogset A, Weyergang A, Selbo PK, Hamdoon Z, Hopper C, Berg K (2020)
Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
J. Clin. Med., 9 (2), 528
DOI 10.3390/jcm9020528

Li X, Salzano G, Qiu JW, Menard M, Berg K, Theodossiou T, Ladaviere C, Gref R (2020)
Drug-Loaded Lipid-Coated Hybrid Organic-Inorganic "Stealth" Nanoparticles for Cancer Therapy
Front. Bioeng. Biotechnol., 8, 1027
DOI 10.3389/fbioe.2020.01027

Olsen CE, Cheung LH, Weyergang A, Berg K, Vallera DA, Rosenblum MG, Selbo PK (2020)
y Design, Characterization, and Evaluation of scFvCD133/rGelonin: A CD133-Targeting Recombinant Immunotoxin for Use in Combination with Photochemical Internalization
J. Clin. Med., 9 (1), 68
DOI 10.3390/jcm9010068

Peng W, de Bruijn HS, ten Hagen TLM, Berg K, Roodenburg JLN, van Dam GM, Witjes MJH, Robinson DJ (2020)
In-Vivo Optical Monitoring of the Efficacy of Epidermal Growth Factor Receptor Targeted Photodynamic Therapy: The Effect of Fluence Rate
Cancers, 12 (1), 190
DOI 10.3390/cancers12010190

Peng W, de Bruijn HS, ten Hagen TLM, van Dam GM, Roodenburg JLN, Berg K, Witjes MJH, Robinson DJ (2020)
Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model
Photochem. Photobiol., 96 (3), 708-717
DOI 10.1111/php.13267

Wong JJW, Berstad MB, Fremstedal ASV, Berg K, Patzke S, Sorensen V, Peng Q, Selbo PK, Weyergang A (2020)
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers, 12 (2), 417
DOI 10.3390/cancers12020417

Publications 2019

Jerjes W, Hamdoon Z, Berg K, Hogset A, Hopper C (2019)
Recurrent chondroblastic osteosarcoma of the right mandible subjected to photochemical internalization
Photodiagnosis Photodyn. Ther., 27, 288-290
DOI 10.1016/j.pdpdt.2019.06.018

Mastrangelopoulou M, Grigalavicius M, Berg K, Menard M, Theodossiou TA (2019)
Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Photochem. Photobiol., 95 (1), 387-396
DOI 10.1111/php.12997

Shin D, Nguyen L, Le MT, Ju D, Le JN, Berg K, Hirschberg H (2019)
The effects of low irradiance long duration photochemical internalization on glioma spheroids
Photodiagnosis Photodyn. Ther., 26, 442-447
DOI 10.1016/j.pdpdt.2019.05.005

Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Walchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
npj Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8

Publications 2018

Nair RK, Christie C, Ju D, Shin D, Pomeroy A, Berg K, Peng Q, Hirschberg H (2018)
Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)
Lasers Med. Sci., 33 (8), 1747-1755
DOI 10.1007/s10103-018-2534-5

Shin D, Christie C, Ju D, Nair RK, Molina S, Berg K, Krasieva TB, Madsen SJ, Hirschberg H (2018)
Photochemical internalization enhanced macrophage delivered chemotherapy
Photodiagnosis Photodyn. Ther., 21, 156-162
DOI 10.1016/j.pdpdt.2017.12.002

Weyergang A, Fremstedal AS, Skarpen E, Peng Q, Mohamedali KA, Eng MS, Cheung LH, Rosenblum MG, Waltenberger J, Berg K (2018)
Light-enhanced VEGF(121)/rGel: A tumor targeted modality with vascular and immune-mediated efficacy
J. Control. Release, 288, 161-172
DOI 10.1016/j.jconrel.2018.09.005

Publications 2017

Christie C, Pomeroy A, Nair R, Berg K, Hirschberg H (2017)
Photodynamic therapy enhances the efficacy of gene-directed enzyme prodrug therapy
Photodiagnosis Photodyn. Ther., 18, 140-148
DOI 10.1016/j.pdpdt.2017.02.016

Gaware VS, Hakerud M, Juzeniene A, Hogset A, Berg K, Masson M (2017)
Endosome Targeting meso-Tetraphenylchlorin-Chitosan Nanoconjugates for Photochemical Internalization
Biomacromolecules, 18 (4), 1108-1126
DOI 10.1021/acs.biomac.6b01670

Gederaas OA, Johnsson A, Berg K, Manandhar R, Shrestha C, Skare D, Ekroll IK, Hogset A, Hjelde A (2017)
Photochemical internalization in bladder cancer - development of an orthotopic in vivo model
Photochem. Photobiol. Sci., 16 (11), 1664-1676
DOI 10.1039/c7pp00176b

Norum OJ, Fremstedal ASV, Weyergang A, Golab J, Berg K (2017)
Photochemical delivery of bleomycin induces T-cell activation of importance for curative effect and systemic anti-tumor immunity
J. Control. Release, 268, 120-127
DOI 10.1016/j.jconrel.2017.10.015

Olsen CE, Sellevold S, Theodossiou T, Patzke S, Berg K (2017)
Impact of genotypic and phenotypic differences in sarcoma models on the outcome of photochemical internalization (PCI) of bleomycin
Photodiagnosis Photodyn. Ther., 20, 35-47
DOI 10.1016/j.pdpdt.2017.08.010

Olsen CE, Weyergang A, Edwards VT, Berg K, Brech A, Weisheit S, Hogset A, Selbo PK (2017)
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance
Biochem. Pharmacol., 144, 63-77
DOI 10.1016/j.bcp.2017.08.002

Sellevold S, Peng Q, Fremstedal ASV, Berg K (2017)
Photochemical internalization (PCI) of bleomycin is equally effective in two dissimilar leiomyosarcoma xenografts in athymic mice
Photodiagnosis Photodyn. Ther., 20, 95-106
DOI 10.1016/j.pdpdt.2017.08.015

Theodossiou TA, Olsen CE, Jonsson M, Kubin A, Hothersall JS, Berg K (2017)
The diverse roles of glutathione-associated cell resistance against hypericin photodynamic therapy
Redox Biol., 12, 191-197
DOI 10.1016/j.redox.2017.02.018

Publications 2016

Berg K, Selbo PK (2016)
Photochemical Internalization (PCI) — A Technology for Intracellular Drug Delivery
In Handbook of Porphyrin Science (Kadish KM, Smith KM, Guilard R, eds.), World Scientific Publishing Co, Singapore, 43, 245-300
DOI 10.1142/9789813149632_0004, PublikaID 252, ISBN 978-981-3149-63-2

Christie C, Molina S, Gonzales J, Berg K, Nair RK, Huynh K, Madsen SJ, Hirschberg H (2016)
Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization
Biomed. Opt. Express, 7 (4), 1240-1250
DOI 10.1364/BOE.7.001240

Madsen SJ, Gonzales J, Zamora G, Berg K, Nair RK, Hirschberg H (2016)
Comparing the Effects of Light- or Sonic-Activated Drug Delivery: Photochemical/Sonochemical Internalization
J. Environ. Pathol. Toxicol. Oncol., 35 (1), 91-98
DOI 10.1615/JEnvironPatholToxicolOncol.2016015463

Reichrath J, Berg K, Emmert S, Lademann J, Seckmeyer G, Zastrow L, Vogt T, Holick MF (2016)
Biologic Effects of Light: An Enlighting Prospective
Anticancer Res., 36 (3), 1339-1343

Sultan AA, Jerjes W, Berg K, Hogset A, Mosse CA, Hamoudi R, Hamdoon Z, Simeon C, Carnell D, Forster M, Hopper C (2016)
Disulfonated tetraphenyl chlorin (TPCS2a)-induced photochemical internalisation of bleomycin in patients with solid malignancies: a phase 1, dose-escalation, first-in-man trial
Lancet Oncol., 17 (9), 1217-1229
DOI 10.1016/S1470-2045(16)30224-8

Theodossiou TA, Walchli S, Olsen CE, Skarpen E, Berg K (2016)
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem. Biol., 11 (1), 251-262
DOI 10.1021/acschembio.5b00734

Weyergang A, Selbo PK, Berg K (2016)
Photochemical Internalization-Enhanced Targeting of Vasculature and Cancer Stem Cells—Present and Future Perspectives
In Photodynamic Medicine: From Bench to Clinic (Kostron H, Hasan T, eds.), The Royal Society of Chemistry, London, 15, 161-180
DOI 10.1039/9781782626824-00161, PublikaID 251, ISBN 978-1-78262-451-6

Publications 2015

Baglo Y, Peng Q, Hagen L, Berg K, Hogset A, Drablos F, Gederaas OA (2015)
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn. Ther., 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005

Berg K (2015)
Resistance mechanisms in photodynamic therapy
Photochem. Photobiol. Sci., 14 (8), 1376-1377
DOI 10.1039/c5pp90026c

Bostad M, Olsen CE, Peng Q, Berg K, Hogset A, Selbo PK (2015)
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J. Control. Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008

Bull-Hansen B, Berstad MB, Berg K, Cao Y, Skarpen E, Fremstedal AS, Rosenblum MG, Peng Q, Weyergang A (2015)
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-12451
DOI 10.18632/oncotarget.3814

Christie CE, Zamora G, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2015)
Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
PROC SPIE, 9305
DOI 10.1117/12.2082590

Gederaas OA, Hauge A, Ellingsen PG, Berg K, Altin D, Bardal T, Hogset A, Lindgren M (2015)
Photochemical internalization of bleomycin and temozolomide - in vitro studies on the glioma cell line F98
Photochem. Photobiol. Sci., 14 (7), 1357-1366
DOI 10.1039/c5pp00144g

Selbo PK, Bostad M, Olsen CE, Edwards VT, Hogset A, Weyergang A, Berg K (2015)
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem. Photobiol. Sci., 14 (8), 1433-1450
DOI 10.1039/c5pp00027k

Theodossiou TA, Goncalves AR, Yannakopoulou K, Skarpen E, Berg K (2015)
Photochemical Internalization of Tamoxifens Transported by a "Trojan-Horse" Nanoconjugate into Breast-Cancer Cell Lines
Angew. Chem.-Int. Edit., 54 (16), 4885-4889
DOI 10.1002/anie.201500183

Weyergang A, Berstad MEB, Bull-Hansen B, Olsen CE, Selbo PK, Berg K (2015)
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem. Photobiol. Sci., 14 (8), 1465-1475
DOI 10.1039/c5pp00029g

Publications 2014

Bostad M, Kausberg M, Weyergang A, Olsen CE, Berg K, Hogset A, Selbo PK (2014)
Light-Triggered, Efficient Cytosolic Release of IM7-Saporin Targeting the Putative Cancer Stem Cell Marker CD44 by Photochemical Internalization
Mol. Pharm., 11 (8), 2764-2776
DOI 10.1021/mp500129t

Bull-Hansen B, Cao Y, Berg K, Skarpen E, Rosenblum MG, Weyergang A (2014)
Photochemical activation of the recombinant HER2-targeted fusion toxin MH3-B1/rGel; Impact of HER2 expression on treatment outcome
J. Control. Release, 182, 58-66
DOI 10.1016/j.jconrel.2014.03.014

Sobczynski J, Kristensen S, Berg K (2014)
The influence of Pluronics nanovehicles on dark cytotoxicity, photocytotoxicity and localization of four model photosensitizers in cancer cells
Photochem. Photobiol. Sci., 13 (1), 8-22
DOI 10.1039/c3pp50181g

Wang F, Zamora G, Sun CH, Trinidad A, Berg K, Madsen SJ, Kwon YJ, Hirschberg H (2014)
Photochemical internalization (PCI) enhanced nonviral transfection of tumor suppressor and pro-drug activating genes; a potential treatment modality for gliomas.
PROC SPIE, 8928, 89280B
DOI 10.1117/12.2041627

Wang F, Zamora G, Sun CH, Trinidad A, Chun CH, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2014)
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene
J. Neuro-Oncol., 118 (1), 29-37
DOI 10.1007/s11060-014-1410-9

Weyergang A, Cheung LH, Rosenblum MG, Mohamedali KA, Peng Q, Waltenberger J, Berg K (2014)
Photochemical internalization augments tumor vascular cytotoxicity and specificity of VEGF(121)/rGel fusion toxin
J. Control. Release, 180, 1-9
DOI 10.1016/j.jconrel.2014.02.003

Zamora G, Wang F, Sun CH, Trinidad A, Kwon YJ, Cho SK, Berg K, Madsen SJ, Hirschberg H (2014)
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier
J. Biomed. Opt., 19 (10), 105009
DOI 10.1117/1.JBO.19.10.105009

Publications 2013

Bostad M, Berg K, Hogset A, Skarpen E, Stenmark H, Selbo PK (2013)
Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties
J. Control. Release, 168 (3), 317-326
DOI 10.1016/j.jconrel.2013.03.023

Gaware VS, Hakerud M, Leosson K, Jonsdottir S, Hogset A, Berg K, Masson M (2013)
Tetraphenylporphyrin Tethered Chitosan Based Carriers for Photochemical Transfection
J. Med. Chem., 56 (3), 807-819
DOI 10.1021/jm301270r

Olsen CE, Berg K, Selbo PK, Weyergang A (2013)
Circumvention of resistance to photodynamic therapy in doxorubicin-resistant sarcoma by photochemical internalization of gelonin
Free Radic. Biol. Med., 65, 1300-1309
DOI 10.1016/j.freeradbiomed.2013.09.010

Singh R, Tonnesen HH, Kristensen S, Berg K (2013)
The influence of Pluronics (R) on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX
Photochem. Photobiol. Sci., 12 (3), 559-575
DOI 10.1039/c2pp25249j

Stratford EW, Bostad M, Castro R, Skarpen E, Berg K, Hogset A, Myklebost O, Selbo PK (2013)
Photochemical internalization of CD133-targeting immunotoxins efficiently depletes sarcoma cells with stem-like properties and reduces tumorigenicity
Biochim. Biophys. Acta-Gen. Subj., 1830 (8), 4235-4243
DOI 10.1016/j.bbagen.2013.04.033

Vikdal M, Generalov R, Berg K (2013)
The photosensitizer disulfonated aluminum phthalocyanine reduces uptake and alters trafficking of fluid phase endocytosed drugs in vascular endothelial cells-Impact on efficacy of photochemical internalization
Biochem. Pharmacol., 86 (6), 748-758
DOI 10.1016/j.bcp.2013.07.011

Vikdal M, Weyergang A, Selbo PK, Berg K (2013)
Vascular endothelial cells as targets for photochemical internalization (PCI)
Photochem. Photobiol., 89 (5), 1185-1192
DOI 10.1111/php.12126

Wang JTW, Berg K, Hogset A, Bown SG, MacRobert AJ (2013)
Photophysical and photobiological properties of a sulfonated chlorin photosensitiser TPCS2a for photochemical internalisation (PCI)
Photochem. Photobiol. Sci., 12 (3), 519-526
DOI 10.1039/c2pp25328c

Weyergang A, Selbo PK, Berg K (2013)
Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy
Biochim. Biophys. Acta-Gen. Subj., 1830 (3), 2659-2670
DOI 10.1016/j.bbagen.2012.11.010

Weyergang A, Selbo PK, Berg K (2013)
Sustained ERK inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy (vol 1830, pg 2659, 2013)
Biochim. Biophys. Acta-Gen. Subj., 1830 (10), 4417
DOI 10.1016/j.bbagen.2013.05.002

Publications 2012

Berstad MB, Weyergang A, Berg K (2012)
Photochemical internalization (PCI) of HER2-targeted toxins Synergy is dependent on the treatment sequence
Biochim. Biophys. Acta-Gen. Subj., 1820 (12), 1849-1858
DOI 10.1016/j.bbagen.2012.08.027

Garaiova Z, Strand SP, Reitan NK, Lelu S, Storset SO, Berg K, Malmo J, Folasire O, Bjorkoy A, Davies CD (2012)
Cellular uptake of DNA-chitosan nanoparticles: The role of clathrin- and caveolae-mediated pathways
Int. J. Biol. Macromol., 51 (5), 1043-1051
DOI 10.1016/j.ijbiomac.2012.08.016

Selbo PK, Weyergang A, Eng MS, Bostad M, Maelandsmo GM, Hogset A, Berg K (2012)
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug
J. Control. Release, 159 (2), 197-203
DOI 10.1016/j.jconrel.2012.02.003

Publications 2011

Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J (2011)
Photodynamic Therapy of Cancer: An Update
CA-Cancer J. Clin., 61 (4), 250-281
DOI 10.3322/caac.20114

Berg K, Golab J, Korbelik M, Russell D (2011)
Drug delivery technologies and immunological aspects of photodynamic therapy
Photochem. Photobiol. Sci., 10 (5), 647-648
DOI 10.1039/c1pp90010b

Berg K, Nordstrand S, Selbo PK, Diem TTT, Angell-Petersen E, Hogset A (2011)
Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization
Photochem. Photobiol. Sci., 10 (10), 1637-1651
DOI 10.1039/c1pp05128h

Jerjes WK, Upile T, Wong BJ, Betz CS, Sterenborg HJ, Witjes MJ, Berg K, van Veen R, Biel MA, El-Naggar AK, Mosse CA, Olivo M, Richards-Kortum R, Robinson DJ, Rosen J, Yodh AG, Kendall C, Ilgner JF, Amelink A, Bagnato V, Barr H, Bolotine L, Bigio I, Chen ZP, Choo-Smith LP et al. (2011)
The future of medical diagnostics: review paper
Head Neck Oncol., 3, 38
DOI 10.1186/1758-3284-3-38

Upile T, Jerjes WK, Sterenborg HJ, Wong BJ, El-Naggar AK, Ilgner JF, Sandison A, Witjes MJ, Biel MA, van Veen R, Hamdoon Z, Gillenwater A, Mosse CA, Robinson DJ, Betz CS, Stepp H, Bolotine L, McKenzie G, Barr H, Chen ZP, Berg K, D'Cruz AK, Sudhoff H, Stone N, Kendall C et al. (2011)
At the frontiers of surgery: review
Head Neck Oncol., 3, 7
DOI 10.1186/1758-3284-3-7

Weyergang A, Selbo PK, Berstad MEB, Bostad M, Berg K (2011)
Photochemical Internalization of Tumor-Targeted Protein Toxins
Lasers Surg. Med., 43 (7), 721-733
DOI 10.1002/lsm.21084

Publications 2010

Berg K, Berstad M, Prasmickaite L, Weyergang A, Selbo PK, Hedfors I, Hogset A (2010)
Photochemical Internalization: A New Tool for Gene and Oligonucleotide Delivery
Top. Curr. Chem., 296, 251-281
DOI 10.1007/128_2010_63

Berg K, Weyergang A, Høgset A, Selbo PK (2010)
The Potential of Photochemical Internalixation (PCI) for the Cytosolic Delivery of Nanomedicines
In Organelle-Specific Pharmaceutical Nanotechnology (Weissing V, D'Souza, eds.), John Wiley and Sons Inc, New Jersey, USA, 311-322
PublikaID 72

Reiners JJ, Agostinis P, Berg K, Oleinick NL, Kessel D (2010)
Assessing autophagy in the context of photodynamic therapy
Autophagy, 6 (1), 7-18
DOI 10.4161/auto.6.1.10220

Selbo PK, Weyergang A, Hogset A, Norum OJ, Berstad MB, Vikdal M, Berg K (2010)
Photochemical internalization provides time- and space-controlled endolysosomal escape of therapeutic molecules
J. Control. Release, 148 (1), 2-12
DOI 10.1016/j.jconrel.2010.06.008

Woodhams J, Lou PJ, Selbo PK, Mosse A, Oukrif D, MacRobert A, Novelli M, Peng Q, Berg K, Bown SG (2010)
Intracellular re-localisation by photochemical internalisation enhances the cytotoxic effect of gelonin - Quantitative studies in normal rat liver
J. Control. Release, 142 (3), 347-353
DOI 10.1016/j.jconrel.2009.11.017

Publications 2009

Mojzisova H, Bonneau S, Maillard P, Berg K, Brault D (2009)
Photosensitizing properties of chlorins in solution and in membrane-mimicking systems
Photochem. Photobiol. Sci., 8 (6), 778-787
DOI 10.1039/b822269j

Norum OJ, Bruland OS, Gorunova L, Berg K (2009)
PHOTOCHEMICAL INTERNALIZATION OF BLEOMYCIN BEFORE EXTERNAL-BEAM RADIOTHERAPY IMPROVES LOCOREGIONAL CONTROL IN A HUMAN SARCOMA MODEL
Int. J. Radiat. Oncol. Biol. Phys., 75 (3), 878-885
DOI 10.1016/j.ijrobp.2009.04.039

Norum OJ, Gaustad JV, Angell-Petersen E, Rofstad EK, Peng Q, Giercksky KE, Berg K (2009)
Photochemical Internalization of Bleomycin is Superior to Photodynamic Therapy Due to the Therapeutic Effect in the Tumor Periphery
Photochem. Photobiol., 85 (3), 740-749
DOI 10.1111/j.1751-1097.2008.00477.x

Norum OJ, Giercksky KE, Berg K (2009)
Photochemical internalization as an adjunct to marginal surgery in a human sarcoma model
Photochem. Photobiol. Sci., 8 (6), 758-762
DOI 10.1039/b821129a

Norum OJ, Selbo PK, Weyergang A, Giercksky KE, Berg K (2009)
Photochemical internalization (PCI) in cancer therapy: From bench towards bedside medicine
J. Photochem. Photobiol. B-Biol., 96 (2), 83-92
DOI 10.1016/j.jphotobiol.2009.04.012

Selbo PK, Rosenblum MG, Cheung LH, Zhang W, Berg K (2009)
Multi-Modality Therapeutics with Potent Anti-Tumor Effects: Photochemical Internalization Enhances Delivery of the Fusion Toxin scFvMEL/rGel
PLoS One, 4 (8), e6691
DOI 10.1371/journal.pone.0006691

Weyergang A, Berg K, Kaalhus L, Peng Q, Selbo PK (2009)
Photodynamic Therapy Targets the mTOR Signaling Network in Vitro and in Vivo
Mol. Pharm., 6 (1), 255-264
DOI 10.1021/mp800156e

Publications 2008

Berg K, Bonsted A, Weyergang A, Høgset A, Selbo PK (2008)
Photochemical Internalization
In Advances in Photodynamic therapy; basic, translational , and clinical (Hamblin MR, Mroz P, eds.), Norwood: Artech House, Norwood MA, USA, 299-312
PublikaID 71

Bonsted A, Høgset A, Berg K (2008)
Photochemical internalization: A technology for effiecient site-directed gene delivery.
In Gene and Cell Therapy. Therapeutic mechanisms and strategies. 3rd edition. (Templeton NS, ed.), CRC Press, 435-442
PublikaID 61

Bonsted A, Wagner E, Prasmickaite L, Høgset A, Berg K (2008)
Photochemical enhancement of DNA delivery by EGF reeceptor targeted polyplexes
In Series: Methods in Molecular Biology. Gene therapy protocols Vol 2. Design and characterization of gene transfer vectors. (LeDoux JM, ed.), Humana Press, 434
PublikaID 60

Lai PS, Pai CL, Peng CL, Shieh MJ, Berg K, Lou PJ (2008)
Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization
J. Biomed. Mater. Res. Part A, 87A (1), 147-155
DOI 10.1002/jbm.a.31760

Weyergang A, Kaalhus O, Berg K (2008)
Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun NH2 terminal kinase with opposing effects on cell survival
Mol. Cancer Ther., 7 (6), 1740-1750
DOI 10.1158/1535-7163.MCT-08-0020

Weyergang A, Kaalhus O, Berg K (2008)
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478
Photochem. Photobiol. Sci., 7 (9), 1032-1040
DOI 10.1039/b806209a

Publications 2007

Berg K, Folini M, Prasmickaite L, Selbo PK, Bonsted A, Engesaeter BO, Zaffaroni N, Weyergang A, Dietze A, Maelandsmo GM, Wagner E, Norum OJ, Hogset A (2007)
Photochemical internalization: A new tool for drug delivery
Curr. Pharm. Biotechnol., 8 (6), 362-372
DOI 10.2174/138920107783018354

Madsen SJ, Kharkhuu K, Berg K, Hirschberg H (2007)
Photochemical internalization for the treatment of malignant gliomas
PROC SPIE, 6424, 64242C
DOI 10.1117/12.705086

Peng Q, Berg K (2007)
Introduction to the special issue on photodynamic therapy and photodetection
Photochem. Photobiol. Sci., 6 (12), 1233
DOI 10.1039/b716101h

Weyeyang A, Selbo PK, Berg K (2007)
Y1068 phosphorylation is the most sensitive target of disulfonated tetraphenylporphyrin-based photodynamic therapy on epidermal growth factor receptor
Biochem. Pharmacol., 74 (2), 226-235
DOI 10.1016/j.bcp.2007.04.018

Yip WL, Weyergang A, Berg K, Tonnesen HH, Selbo PK (2007)
Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells
Mol. Pharm., 4 (2), 241-251
DOI 10.1021/mp060105u

Publications 2006

Berg K, Høgset A, Prasmickaite L, Weyergang A, Bonsted A, Dietze A, Lou PJ, Bown S, Norum OJ, Møllergard HM, Selbo PK (2006)
Photochemical internalization (PCI): A novel technology for activation of endocytosed therapeutic agents.
Med Laser Appl, 21, 239-251
DOI 10.1016/j.mla.2006.08.004, PublikaID 73

Bonsted A, Engesaeter BO, Hogset A, Maelandsmo GM, Prasmickaite L, D'Oliveira C, Hennink WE, Steenis JH, Berg K (2006)
Photochemically enhanced transduction of polymer-complexed adenovirus targeted to the epidermal growth factor receptor
J. Gene. Med., 8 (3), 286-297
DOI 10.1002/jgm.853

Bonsted A, Høgset A, Wagner E, Berg K (2006)
Photochemical internalization for light directed gene delivery
In Delivery and expression of DNA and RNA, A laboratory manual (Friedmann T, Rossi J, eds.), Cold Spring Harbour Laboratory Press, New York
PublikaID 59

Engesaeter BO, Bonsted A, Lillehammer T, Engebraaten O, Berg K, Maelandsmo GM (2006)
Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines
Cancer Biol. Ther., 5 (11), 1511-1520
DOI 10.4161/cbt.5.11.3301

Engesaeter BO, Tveito S, Bonsted A, Engebraaten O, Berg K, Maelandsmo GM (2006)
Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus
J. Gene. Med., 8 (6), 707-718
DOI 10.1002/jgm.902

Kloeckner J, Boeckle S, Persson D, Roedl W, Ogris M, Berg K, Wagner E (2006)
DNA polyplexes based on degradable oligoethylenimine-derivatives: Combination with EGF receptor targeting and endosomal release functions
J. Control. Release, 116 (2), 115-122
DOI 10.1016/j.jconrel.2006.07.002

Ndoye A, Dolivet G, Hogset A, Leroux A, Fifre A, Erbacher P, Berg K, Behr JP, Guillemin F, Merlin JL (2006)
Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization
Mol. Ther., 13 (6), 1156-1162
DOI 10.1016/j.ymthe.2006.02.003

Prasmickaite L, Cekaite L, Hellum M, Hovig E, Hogset A, Berg K (2006)
Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI)
FEBS Lett., 580 (24), 5739-5746
DOI 10.1016/j.febslet.2006.09.028

Prasmickaite L, Hellum M, Kaalhus O, Hogset A, Wagner E, Berg K (2006)
Photochemical internalization of transgenes controlled by the heat-shock protein 70 promoter
Photochem. Photobiol., 82 (3), 809-816
DOI 10.1562/2005-11-07-RA-731

Selbo PK, Weyergang A, Bonsted A, Bown SG, Berg K (2006)
Photochemical internalization of therapeutic macromolecular agents: A novel strategy to kill multidrug-resistant cancer cells
J. Pharmacol. Exp. Ther., 319 (2), 604-612
DOI 10.1124/jpet.106.109165

Publications 2005

Dietze A, Berg K (2005)
ALA-induced porphyrin formation and fluorescence in synovitis tissue In-vitro and in vivo studies
Photodiagnosis Photodyn. Ther., 2 (4), 299-307
DOI 10.1016/S1572-1000(05)00107-9

Publications 2003

Hellum M, Hogset A, Engesaeter BO, Prasmickaite L, Stokke T, Wheeler C, Berg K (2003)
Photochemically enhanced gene delivery with cationic lipid formulations
Photochem. Photobiol. Sci., 2 (4), 407-411
DOI 10.1039/b211880g

Publications 1990

Berg K (1990)
Cellular uptake and photosensitizing effects of porphyrins and phthalocyanines
Department of Biophysics, The Norwegian Radium Hospital, Oslo, Flere pag.
BIBSYS 901007765, ISBN 82-992250-0-0

Publications 1985

Berg K (1985)
Mitokondriell fettsyreoksydasjon i brunt fettvev. Fluksregulerende trinn
K. Berg, Oslo, 174 s.
BIBSYS 961256575