Publications 2024

Karlsen H, Strand-Amundsen RJ, Skåre C, Eriksen M, Skulberg VM, Sunde K, Tønnessen TI, Olasveengen TM (2024)
Cerebral perfusion and metabolism with mild hypercapnia vs. normocapnia in a porcine post cardiac arrest model with and without targeted temperature management
Resusc Plus, 18, 100604
DOI 10.1016/j.resplu.2024.100604, PubMed 38510376

Sjøen GH, Falk RS, Hauge TH, Tønnessen TI, Langesæter E (2024)
Haemodynamic effects of remifentanil during induction of general anaesthesia with propofol. A randomised trial
Acta Anaesthesiol Scand, 68 (5), 601-609
DOI 10.1111/aas.14394, PubMed 38400761

Publications 2023

Laake JH, Aslam TN, Barratt-Due A, Løwhagen B, Pischke SE, Tønnessen TI, Wisløff-Aase K, Aasmundstad TA (2023)
[ARDS or acute respiratory failure syndrome?]
Tidsskr Nor Laegeforen, 143 (10)
DOI 10.4045/tidsskr.23.0402, PubMed 37376931

Rydenfelt K, Kjøsen G, Horneland R, Krey Ludviksen J, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
Transplant Direct, 10 (1), e1567
DOI 10.1097/TXD.0000000000001567, PubMed 38094132

Rydenfelt K, Kjøsen G, Horneland R, Ludviksen JK, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
Front Immunol, 14, 1044444
DOI 10.3389/fimmu.2023.1044444, PubMed 37063904

Sjøen GH, Falk RS, Hauge TH, Tønnessen TI, Langesaeter E (2023)
Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia. A randomized trial
Acta Anaesthesiol Scand, 67 (9), 1178-1186
DOI 10.1111/aas.14293, PubMed 37291731

Publications 2022

Hou J, Liavåg OMI, Færden IH, Martinsen ØG, Tønnessen TI, Line PD, Hagness M, Høgetveit JO, Pischke SE, Strand-Amundsen R (2022)
Utilization of dielectric properties for assessment of liver ischemia-reperfusion injury in vivo and during machine perfusion
Sci Rep, 12 (1), 11183
DOI 10.1038/s41598-022-14817-3, PubMed 35778457

Hou J, Ness SS, Tschudi J, O'Farrell M, Veddegjerde R, Martinsen ØG, Tønnessen TI, Strand-Amundsen R (2022)
Assessment of Intestinal Ischemia-Reperfusion Injury Using Diffuse Reflectance VIS-NIR Spectroscopy and Histology
Sensors (Basel), 22 (23)
DOI 10.3390/s22239111, PubMed 36501812

Hou J, Strand-Amundsen R, Tronstad C, Tønnessen TI, Høgetveit JO, Martinsen ØG (2022)
Small intestinal viability assessment using dielectric relaxation spectroscopy and deep learning
Sci Rep, 12 (1), 3279
DOI 10.1038/s41598-022-07140-4, PubMed 35228559

Kjøsen G, Horneland R, Nordheim E, Aandahl EM, Line PD, Rydenfelt K, Jenssen TG, Tønnessen TI, Haugaa H (2022)
Validating the US pancreas donor risk index in a Norwegian population, a retrospective observational study
Scand J Gastroenterol, 57 (3), 345-351
DOI 10.1080/00365521.2021.2012590, PubMed 35130456

Rydenfelt K, Strand-Amundsen R, Horneland R, Hødnebø S, Kjøsen G, Pischke SE, Tønnessen TI, Haugaa H (2022)
Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model
PLoS One, 17 (2), e0262848
DOI 10.1371/journal.pone.0262848, PubMed 35143517

Publications 2021

Hausken J, Haugaa H, Hagness M, Line PD, Melum E, Tønnessen TI (2021)
Thoracic Epidural Analgesia for Postoperative Pain Management in Liver Transplantation: A 10-year Study on 685 Liver Transplant Recipients
Transplant Direct, 7 (2), e648
DOI 10.1097/TXD.0000000000001101, PubMed 33437863

Hou J, Strand-Amundsen R, Hødnebø S, Tønnessen TI, Høgetveit JO (2021)
Assessing Ischemic Injury in Human Intestine Ex Vivo with Electrical Impedance Spectroscopy
J Electr Bioimpedance, 12 (1), 82-88
DOI 10.2478/joeb-2021-0011, PubMed 34966469

Hou J, Strand-Amundsen R, Tronstad C, Høgetveit JO, Martinsen ØG, Tønnessen TI (2021)
Automatic Prediction of Ischemia-Reperfusion Injury of Small Intestine Using Convolutional Neural Networks: A Pilot Study
Sensors (Basel), 21 (19)
DOI 10.3390/s21196691, PubMed 34641009

Kjøsen G, Rydenfelt K, Horneland R, Aandahl EM, Line PD, Dorenberg E, Berstad AE, Brabrand K, Hagen G, Pischke SE, Bergmann GB, Nordheim E, Jenssen TG, Tønnessen TI, Haugaa H (2021)
Early detection of complications in pancreas transplants by microdialysis catheters, an observational feasibility study
PLoS One, 16 (3), e0247615
DOI 10.1371/journal.pone.0247615, PubMed 33705460

Lindholm E, Bergmann GB, Haugaa H, Labori KJ, Yaqub S, Bjørnbeth BA, Line PD, Grindheim G, Kjøsen G, Pischke SE, Tønnessen TI (2021)
Early detection of anastomotic leakage after pancreatoduodenectomy with microdialysis catheters: an observational Study
HPB (Oxford), 24 (6), 901-909
DOI 10.1016/j.hpb.2021.10.020, PubMed 34836755

Lindholm E, Ekiz N, Tønnessen TI (2021)
Monitoring of patients with microdialysis following pancreaticoduodenectomy-the MINIMUM study: study protocol for a randomized controlled trial
Trials, 22 (1), 329
DOI 10.1186/s13063-021-05221-9, PubMed 33962656

Laake JH, Astvad M, Bentsen G, Escher C, Haney M, Hoffmann-Petersen J, Hyllested M, Junttila E, Møller MH, Nellgård P, Nyberg A, Olkkola K, Pedersen SKA, Pischke SE, Reinikainen M, Strand K, Thorarensen G, Thormar K, Tønnessen TI (2021)
A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
Acta Anaesthesiol Scand, 66 (1), 141-144
DOI 10.1111/aas.13978, PubMed 34462910

Skåre C, Karlsen H, Strand-Amundsen RJ, Eriksen M, Skulberg VM, Sunde K, Tønnessen TI, Olasveengen TM (2021)
Cerebral perfusion and metabolism with mean arterial pressure 90 vs. 60 mmHg in a porcine post cardiac arrest model with and without targeted temperature management
Resuscitation, 167, 251-260
DOI 10.1016/j.resuscitation.2021.06.011, PubMed 34166747

Strand-Amundsen R, Tronstad C, Elvebakk O, Martinsen T, Dybwad M, Lingaas E, Tønnessen TI (2021)
Quantification of aerosol dispersal from suspected aerosol-generating procedures
ERJ Open Res, 7 (4)
DOI 10.1183/23120541.00206-2021, PubMed 34877350

Sun X, Zhu S, Dong X, Strand-Amundsen RJ, Tonnessen TI, Yang R (2021)
Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis
Biomed Pharmacother, 137, 111392
DOI 10.1016/j.biopha.2021.111392, PubMed 33761609

Publications 2020

Haugaa H, Line PD, Tønnessen TI (2020)
An Increased Lactate-to-pyruvate Ratio Is Not a Stand-alone Marker of Ischemia
Transplant Direct, 6 (5), e551
DOI 10.1097/TXD.0000000000000991, PubMed 32548245

Hausken J, Fretland ÅA, Edwin B, Kvarstein G, Tønnessen TI (2020)
Response to the Comment on "Epidural Analgesia (TEA) vs. IV-PCA After Open Liver Surgery"
Ann Surg, 271 (5), e126-e127
DOI 10.1097/SLA.0000000000003684, PubMed 31800498

Lindholm E, Tonnessen TI (2020)
Prolonged illness after covid-19
Tidsskr. Nor. Laegeforen., 140 (14), 1433-1435

Lindholm E, Tønnessen TI (2020)
Prolonged illness after COVID-19
Tidsskr Nor Laegeforen, 140 (14)
DOI 10.4045/tidsskr.20.0753, PubMed 33070586

Lindholm E, Tønnessen TI (2020)
[Correction: Prolonged illness after COVID-19]
Tidsskr Nor Laegeforen, 140 (16)
DOI 10.4045/tidsskr.20.0831, PubMed 33172247

Lipcsey M, Tenhunen J, Pischke SE, Kuitunen A, Flaatten H, De Geer L, Sjölin J, Frithiof R, Chew MS, Bendel S, Kawati R, Larsson A, Mollnes TE, Tønnessen TI, Rubertsson S (2020)
Endotoxin Removal in Septic Shock with the Alteco LPS Adsorber Was Safe But Showed no Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial-the Asset Study
Shock, 54 (2), 224-231
DOI 10.1097/SHK.0000000000001503, PubMed 31880758

Pischke SE, Hødnebø S, Wester T, Haugaa H, Kvernebo K, Barratt-Due A, Tønnessen TI (2020)
Intraperitoneal microdialysis detects intestinal leakage earlier than hemodynamic surveillance and systemic inflammation in a pig model
Scand J Gastroenterol, 56 (2), 219-227
DOI 10.1080/00365521.2020.1863459, PubMed 33356757

Sun X, Zhu S, Tonnessen TI, Yang R (2020)
Bile is a promising gut nutrient that inhibits intestinal bacterial translocation and promotes gut motility via an interleukin-6-related pathway in an animal model of endotoxemia
Nutrition, 84, 111064
DOI 10.1016/j.nut.2020.111064, PubMed 33418232

Publications 2019

Hausken J, Fretland ÅA, Edwin B, Andersen MH, Dagenborg VJ, Bjørnelv GMW, Kristiansen R, Røysland K, Kvarstein G, Tønnessen TI (2019)
Intravenous Patient-controlled Analgesia Versus Thoracic Epidural Analgesia After Open Liver Surgery: A Prospective, Randomized, Controlled, Noninferiority Trial
Ann Surg, 270 (2), 193-199
DOI 10.1097/SLA.0000000000003209, PubMed 30676382

Hausken J, Rydenfelt K, Horneland R, Ullensvang K, Kjøsen G, Tønnessen TI, Haugaa H (2019)
First Experience With Rectus Sheath Block for Postoperative Analgesia After Pancreas Transplant: A Retrospective Observational Study
Transplant Proc, 51 (2), 479-484
DOI 10.1016/j.transproceed.2019.01.065, PubMed 30879572

Publications 2018

Fretland ÅA, Dagenborg VJ, Bjørnelv GMW, Kazaryan AM, Kristiansen R, Fagerland MW, Hausken J, Tønnessen TI, Abildgaard A, Barkhatov L, Yaqub S, Røsok BI, Bjørnbeth BA, Andersen MH, Flatmark K, Aas E, Edwin B (2018)
Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial
Ann Surg, 267 (2), 199-207
DOI 10.1097/SLA.0000000000002353, PubMed 28657937

Holhjem L, Strand-Amundsen R, Aasmundtveit KE, Tonnessen TI (2018)
Stability of Laser-Patterned Electrode Compositions
IEEE Trans. Compon. Pack. Manuf. Technol., 8 (9), 1517-1523
DOI 10.1109/TCPMT.2018.2863221

Laake JH, Tønnessen TI, Chew MS, Lipcsey M, Hjelmqvist H, Wilkman E, Pettilä V, Hoffmann-Petersen J, Møller MH, Board of the Scandinavian Society of Anaesthesiology Intensive Care Medicine (SSAI) (2018)
The SSAI fully supports the suspension of hydroxyethyl-starch solutions commissioned by the European Medicines Agency
Acta Anaesthesiol Scand, 62 (6), 874-875
DOI 10.1111/aas.13120, PubMed 29658984

Stafseth SK, Tønnessen TI, Fagerström L (2018)
Association between patient classification systems and nurse staffing costs in intensive care units: An exploratory study
Intensive Crit Care Nurs, 45, 78-84
DOI 10.1016/j.iccn.2018.01.007, PubMed 29402682

Stafseth SK, Tønnessen TI, My Diep L, Fagerstrøm L (2018)
Testing the Reliability and Validity of the Nursing Activities Score in Critical Care Nursing
J Nurs Meas, 26 (1), 142-162
DOI 10.1891/1061-3749.26.1.142, PubMed 29724285

Strand-Amundsen RJ, Reims HM, Reinholt FP, Ruud TE, Yang R, Høgetveit JO, Tønnessen TI (2018)
Ischemia/reperfusion injury in porcine intestine - Viability assessment
World J Gastroenterol, 24 (18), 2009-2023
DOI 10.3748/wjg.v24.i18.2009, PubMed 29760544

Strand-Amundsen RJ, Tronstad C, Kalvøy H, Ruud TE, Høgetveit JO, Martinsen ØG, Tønnessen TI (2018)
Small intestinal ischemia and reperfusion-bioimpedance measurements
Physiol Meas, 39 (2), 025001
DOI 10.1088/1361-6579/aaa576, PubMed 29303488

Strand-Amundsen RJ, Tronstad C, Reims HM, Reinholt FP, Høgetveit JO, Tønnessen TI (2018)
Machine learning for intraoperative prediction of viability in ischemic small intestine
Physiol Meas, 39 (10), 105011
DOI 10.1088/1361-6579/aae0ea, PubMed 30207981

Yang R, Zhu S, Pischke SE, Haugaa H, Zou X, Tonnessen TI (2018)
Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice
J Surg Res, 228, 14-19
DOI 10.1016/j.jss.2018.02.049, PubMed 29907203

Publications 2017

Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE (2017)
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Basic Res Cardiol, 112 (3), 20
DOI 10.1007/s00395-017-0610-9, PubMed 28258298

Strand-Amundsen RJ, Reims HM, Tronstad C, Kalvøy H, Martinsen ØG, Høgetveit JO, Ruud TE, Tønnessen TI (2017)
Ischemic small intestine-in vivo versus ex vivo bioimpedance measurements
Physiol Meas, 38 (5), 715-728
DOI 10.1088/1361-6579/aa67b7, PubMed 28319030

Yang R, Tenhunen J, Tonnessen TI (2017)
HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis
Int J Inflam, 2017, 1817564
DOI 10.1155/2017/1817564, PubMed 28316860

Yang R, Zou X, Tenhunen J, Tønnessen TI (2017)
HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure
Mediators Inflamm, 2017, 5928078
DOI 10.1155/2017/5928078, PubMed 28694564

Publications 2016

Lipcsey M, Tenhunen J, Sjölin J, Frithiof R, Bendel S, Flaatten H, Kawati R, Kuitunen A, Tønnessen TI, Rubertsson S (2016)
Abdominal Septic Shock - Endotoxin Adsorption Treatment (ASSET) - endotoxin removal in abdominal and urogenital septic shock with the Alteco® LPS Adsorber: study protocol for a double-blinded, randomized placebo-controlled trial
Trials, 17 (1), 587
DOI 10.1186/s13063-016-1723-4, PubMed 27931259

Strand-Amundsen RJ, Tronstad C, Kalvøy H, Gundersen Y, Krohn CD, Aasen AO, Holhjem L, Reims HM, Martinsen ØG, Høgetveit JO, Ruud TE, Tønnessen TI (2016)
In vivo characterization of ischemic small intestine using bioimpedance measurements
Physiol Meas, 37 (2), 257-75
DOI 10.1088/0967-3334/37/2/257, PubMed 26805916

Tønnessen TI (2016)
[Not Available]
Tidsskr Nor Laegeforen, 136 (5), 380-1
DOI 10.4045/tidsskr.16.0171, PubMed 26983125

Yang R, Zhu S, Tonnessen TI (2016)
Ethyl pyruvate is a novel anti-inflammatory agent to treat multiple inflammatory organ injuries
J Inflamm (Lond), 13, 37
DOI 10.1186/s12950-016-0144-1, PubMed 27980458

Publications 2015

Fretland ÅA, Kazaryan AM, Bjørnbeth BA, Flatmark K, Andersen MH, Tønnessen TI, Bjørnelv GM, Fagerland MW, Kristiansen R, Øyri K, Edwin B (2015)
Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet Study): study protocol for a randomized controlled trial
Trials, 16, 73
DOI 10.1186/s13063-015-0577-5, PubMed 25872027

Haugaa H, Gómez H, Maberry DR, Holder A, Ogundele O, Quintero AM, Escobar D, Tønnessen TI, Airgood H, Dezfulian C, Kenny E, Shiva S, Zuckerbraun B, Pinsky MR (2015)
Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine
Crit Care, 19 (1), 184
DOI 10.1186/s13054-015-0903-z, PubMed 25899004

Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tønnessen TI, Fosse E, Skulstad H (2015)
Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia
J Am Soc Echocardiogr, 28 (4), 486-94
DOI 10.1016/j.echo.2014.12.014, PubMed 25636368

Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE (2015)
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
Scand J Immunol, 82 (5), 467-75
DOI 10.1111/sji.12332, PubMed 26099791

Publications 2014

Haugaa H, Taraldsrud E, Nyrerød HC, Tønnessen TI, Foss A, Solheim BG (2014)
Low incidence of hyperfibrinolysis and thromboembolism in 195 primary liver transplantations transfused with solvent/detergent-treated plasma
Clin Med Res, 12 (1-2), 27-32
DOI 10.3121/cmr.2013.1168, PubMed 24415744

Pischke SE, Hyler S, Tronstad C, Bergsland J, Fosse E, Halvorsen PS, Skulstad H, Tønnessen TI (2014)
Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time†
Br J Anaesth, 114 (3), 414-22
DOI 10.1093/bja/aeu381, PubMed 25392231

Yang R, Zou X, Tenhunen J, Zhu S, Kajander H, Koskinen ML, Tonnessen TI (2014)
HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
BMC Gastroenterol, 14, 66
DOI 10.1186/1471-230X-14-66, PubMed 24708589

Publications 2013

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2013)
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transpl, 19 (3), 305-14
DOI 10.1002/lt.23578, PubMed 23193034

Holhjem L, Strand-Amundsen R, Aasmundtveit KE, Tonnessen TI (2013)
Development of a Conductometric Biocompatible Sensor For Detecting Ischemia
EUR MICROELECTRON PA

Publications 2012

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878

Pischke SE, Tronstad C, Holhjem L, Halvorsen PS, Tønnessen TI (2012)
Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology
Eur J Cardiothorac Surg, 42 (1), 157-63
DOI 10.1093/ejcts/ezr278, PubMed 22290904

Pischke SE, Tronstad C, Holhjem L, Line PD, Haugaa H, Tønnessen TI (2012)
Hepatic and abdominal carbon dioxide measurements detect and distinguish hepatic artery occlusion and portal vein occlusion in pigs
Liver Transpl, 18 (12), 1485-94
DOI 10.1002/lt.23544, PubMed 22961940

Sokolov A, Hellerud BC, Tønnessen TI, Johannessen EA, Mollnes TE (2012)
Activation of coagulation and platelets by candidate membranes of implantable devices in a whole blood model without soluble anticoagulant
J Biomed Mater Res A, 101 (2), 575-81
DOI 10.1002/jbm.a.34348, PubMed 22949225

Publications 2011

Barratt-Due A, Johansen HT, Sokolov A, Thorgersen EB, Hellerud BC, Reubsaet JL, Seip KF, Tønnessen TI, Lindstad JK, Pharo A, Castellheim A, Mollnes TE, Nielsen EW (2011)
The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis
Shock, 36 (5), 517-23
DOI 10.1097/SHK.0b013e3182336a34, PubMed 21921836

Krushinitskaya O, Tonnessen TI, Jakobsen H, Johannessen EA (2011)
Characterization of nanoporous membranes for implementation in an osmotic glucose sensor based on the concanavalin A-dextran affinity assay
J. Membr. Sci., 376 (1-2), 153-161
DOI 10.1016/j.memsci.2011.04.009

Krushinitskaya O, Tønnessen TI, Jakobsen H, Johannessen E (2011)
The assessment of potentially interfering metabolites and dietary components in blood using an osmotic glucose sensor based on the concanavalin A-dextran affinity assay
Biosens Bioelectron, 28 (1), 195-203
DOI 10.1016/j.bios.2011.07.019, PubMed 21816599

Waelgaard L, Dahl BM, Kvarstein G, Tønnessen TI (2011)
Tissue gas tensions and tissue metabolites for detection of organ hypoperfusion and ischemia
Acta Anaesthesiol Scand, 56 (2), 200-9
DOI 10.1111/j.1399-6576.2011.02572.x, PubMed 22103593

Publications 2010

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tønnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit Care Med, 38 (6), 1467-74
DOI 10.1097/CCM.0b013e3181de8c94, PubMed 20400898

Johannessen E, Krushinitskaya O, Sokolov A, Philipp H, Hoogerwerf A, Hinderling C, Kautio K, Lenkkeri J, Strömmer E, Kondratyev V, Tønnessen TI, Mollnes TE, Jakobsen H, Zimmer E, Akselsen B (2010)
Toward an injectable continuous osmotic glucose sensor
J Diabetes Sci Technol, 4 (4), 882-92
DOI 10.1177/193229681000400417, PubMed 20663452

Tronstad C, Pischke SE, Holhjem L, Tønnessen TI, Martinsen OG, Grimnes S (2010)
Early detection of cardiac ischemia using a conductometric pCO(2) sensor: real-time drift correction and parameterization
Physiol Meas, 31 (9), 1241-55
DOI 10.1088/0967-3334/31/9/013, PubMed 20702916

Publications 2009

Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, Stubhaug A, Tønnessen TI, Beivik H (2009)
A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy--a 12-month follow-up
Pain, 145 (3), 279-286
DOI 10.1016/j.pain.2009.05.001, PubMed 19647940

Kvarstein G, Måwe L, Indahl A, Hol PK, Tennøe B, Digernes R, Tønnessen TI, Beivik H, Stubhaug A (2009)
Placebo control--still the most ethical study design
Pain, 148 (1), 174-175
DOI 10.1016/j.pain.2009.11.013, PubMed 19962241

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tønnessen TI, Brandtzaeg P, Mollnes TE (2009)
A new dynamic porcine model of meningococcal shock
Shock, 32 (3), 302-9
DOI 10.1097/SHK.0b013e31819c37be, PubMed 19174740

Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tønnessen TI, Johansen HT, Castellheim A, Mollnes TE (2009)
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
FASEB J, 24 (3), 712-22
DOI 10.1096/fj.09-140798, PubMed 19841036

Publications 2008

Castellheim A, Thorgersen EB, Hellerud BC, Pharo A, Johansen HT, Brosstad F, Gaustad P, Brun H, Fosse E, Tønnessen TI, Nielsen EW, Mollnes TE (2008)
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand J Immunol, 68 (1), 75-84
DOI 10.1111/j.1365-3083.2008.02122.x, PubMed 18466195

Waelgaard L, Thorgersen EB, Line PD, Foss A, Mollnes TE, Tønnessen TI (2008)
Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation
Transplantation, 86 (8), 1096-103
DOI 10.1097/TP.0b013e31818775ca, PubMed 18946348

Publications 2007

Andersen MH, Mathisen L, Veenstra M, Oyen O, Edwin B, Digernes R, Kvarstein G, Tønnessen TI, Wahl AK, Hanestad BR, Fosse E (2007)
Quality of life after randomization to laparoscopic versus open living donor nephrectomy: long-term follow-up
Transplantation, 84 (1), 64-9
DOI 10.1097/01.tp.0000268071.63977.42, PubMed 17627239

Halvorsen PS, Sokolov A, Cvancarova M, Hol PK, Lundblad R, Tønnessen TI (2007)
Continuous cardiac output during off-pump coronary artery bypass surgery: pulse-contour analyses vs pulmonary artery thermodilution
Br J Anaesth, 99 (4), 484-92
DOI 10.1093/bja/aem199, PubMed 17650518

Publications 2006

Andersen MH, Mathisen L, Oyen O, Edwin B, Digernes R, Kvarstein G, Tønnessen TI, Wahl AK, Hanestad BR, Fosse E (2006)
Postoperative pain and convalescence in living kidney donors-laparoscopic versus open donor nephrectomy: a randomized study
Am J Transplant, 6 (6), 1438-43
DOI 10.1111/j.1600-6143.2006.01301.x, PubMed 16686768

Halvorsen PS, Espinoza A, Lundblad R, Cvancarova M, Hol PK, Fosse E, Tønnessen TI (2006)
Agreement between PiCCO pulse-contour analysis, pulmonal artery thermodilution and transthoracic thermodilution during off-pump coronary artery by-pass surgery
Acta Anaesthesiol Scand, 50 (9), 1050-7
DOI 10.1111/j.1399-6576.2006.01118.x, PubMed 16987335

Waelgaard L, Pharo A, Tønnessen TI, Mollnes TE (2006)
Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions
Scand J Immunol, 64 (3), 345-52
DOI 10.1111/j.1365-3083.2006.01826.x, PubMed 16918704

Publications 2005

Mathisen L, Andersen MH, Hol PK, Lingaas PS, Lundblad R, Rein KA, Tønnessen TI, Mørk BE, Svennevig JL, Wahl AK, Hanestad BR, Fosse E (2005)
Patient-reported outcome after randomization to on-pump versus off-pump coronary artery surgery
Ann Thorac Surg, 79 (5), 1584-9
DOI 10.1016/j.athoracsur.2004.10.019, PubMed 15854937

Publications 2004

Kvarstein G, Mirtaheri P, Tønnessen TI (2004)
Detection of ischemia by PCO2 before adenosine triphosphate declines in skeletal muscle
Crit Care Med, 32 (1), 232-7
DOI 10.1097/01.CCM.0000104948.41544.FC, PubMed 14707584

Mirtaheri P, Grimnes S, Martinsen OG, Tønnessen TI (2004)
A new biomedical sensor for measuring PCO2
Physiol Meas, 25 (2), 421-36
DOI 10.1088/0967-3334/25/2/002, PubMed 15132308

Mirtaheri P, Omtveit T, Klotzbuecher T, Grimnes S, Martinsen OG, Tønnessen TI (2004)
Miniaturization of a biomedical gas sensor
Physiol Meas, 25 (6), 1511-22
DOI 10.1088/0967-3334/25/6/015, PubMed 15712728

Skulstad H, Andersen K, Edvardsen T, Rein KA, Tønnessen TI, Hol PK, Fosse E, Ihlen H (2004)
Detection of ischemia and new insight into left ventricular physiology by strain Doppler and tissue velocity imaging: assessment during coronary bypass operation of the beating heart
J Am Soc Echocardiogr, 17 (12), 1225-33
DOI 10.1016/j.echo.2004.07.014, PubMed 15562259

Publications 2003

Bjørnstad PG, Smevik B, Holmstrøm H, Thaulow E, Hagemo PS, Ihlen H, Bjørnerheim R, Lindberg HL, Seem E, Tønnessen TI, Hustveit O, Fosse E (2003)
[Transcatheter closure of atrial septal defects in the oval fossa]
Tidsskr Nor Laegeforen, 123 (15), 2052-4
PubMed 12934130

Kvarstein G, Barstad M, Mirtaheri P, Tønnessen TI (2003)
Tissue carbon dioxide tension: a putative specific indicator of ischemia in porcine latissimus dorsi flaps
Plast Reconstr Surg, 112 (7), 1825-31
DOI 10.1097/01.PRS.0000091166.83956.39, PubMed 14663226

Kvarstein G, Mirtaheri P, Tønnessen TI (2003)
Detection of organ ischemia during hemorrhagic shock
Acta Anaesthesiol Scand, 47 (6), 675-86
DOI 10.1034/j.1399-6576.2003.00134.x, PubMed 12803584

Tønnessen TI (2003)
Detection of hypoperfusion: read your patient's hand
Crit Care Med, 31 (9), 2407-8
DOI 10.1097/01.CCM.0000084862.72867.87, PubMed 14501978

Tønnessen TI (2003)
Postoperativ smertebehandling
Pensumtjeneste, Oslo, 154 s.
BIBSYS 040221962, ISBN 82-13-02156-8

Publications 2002

Bjørnstad PG, Holmstrøm H, Smevik B, Tønnessen TI, Fosse E (2002)
Transcatheter closure of atrial septal defects in the oval fossa: is the method applicable in small children?
Cardiol Young, 12 (4), 352-6
DOI 10.1017/s1047951100012956, PubMed 12206558

Rasmussen H, Mirtaheri P, Dirven H, Johnsen H, Kvarstein G, Tønnessen TI, Midtvedt T (2002)
PCO(2) in the large intestine of mice, rats, guinea pigs, and dogs and effects of the dietary substrate
J Appl Physiol (1985), 92 (1), 219-24
DOI 10.1152/japplphysiol.00190.2001, PubMed 11744663

Publications 2001

Edwin B, Kazaryan AM, Mala T, Pfeffer PF, Tønnessen TI, Fosse E (2001)
Laparoscopic and open surgery for pheochromocytoma
BMC Surg, 1, 2
DOI 10.1186/1471-2482-1-2, PubMed 11580870

Hol PK, Fosse E, Mork BE, Lundblad R, Rein KA, Lingaas PS, Geiran O, Svennevig JL, Tonnessen TI, Nitter-Hauge S, Due-Tonnessen P, Vatne K, Smith HJ (2001)
Graft control by transit time flow measurement and intraoperative angiography in coronary artery bypass surgery
Heart Surg Forum, 4 (3), 254-7; discussion 257-8
PubMed 11673148

Kvarstein G, Tønnessen TI (2001)
[Pain--difficult for both laymen and professionals]
Tidsskr Nor Laegeforen, 121 (22), 2577
PubMed 11668750

Lund C, Lundblad R, Fosse E, Tønnessen TI, Sundet K, Brucher R, Russell D (2001)
Ventricular fibrillation during off-pump coronary artery bypass grafting: transcranial Doppler and clinical findings
Cerebrovasc Dis, 12 (2), 139-41
DOI 10.1159/000047693, PubMed 11490108

Publications 2000

Fosse E, Elle OJ, Samset E, Johansen M, Røtnes JS, Tønnessen TI, Edwin B (2000)
[Image guided and robotic treatment--the advance of cybernetics in clinical medicine]
Tidsskr Nor Laegeforen, 120 (1), 65-9
PubMed 10815485

Hol PK, Kvarstein G, Viken O, Smedby O, Tønnessen TI (2000)
MRI-guided celiac plexus block
J Magn Reson Imaging, 12 (4), 562-4
DOI 10.1002/1522-2586(200010)12:4<562::aid-jmri7>3.0.co;2-a, PubMed 11042637

Tønnessen TI (2000)
Smerter og smertebehandling
Ad Notam Gyldendal, Oslo
BIBSYS 980976871, ISBN 82-417-0897-1

Publications 1999

Rasmussen H, Kvarstein G, Johnsen H, Dirven H, Midtvedt T, Mirtaheri P, Tønnessen TI (1999)
Gas supersaturation in the cecal wall of mice due to bacterial CO2 production
J Appl Physiol (1985), 86 (4), 1311-8
DOI 10.1152/jappl.1999.86.4.1311, PubMed 10194217

Publications 1998

Barstad RM, Fosse E, Geiran OR, Simonsen S, Vatne K, Andersen K, Tønnessen TI (1998)
Minimally invasive direct coronary artery bypass grafting without cardiopulmonary bypass in combination with intraoperative percutaneous transluminal coronary angioplasty for palliative coronary revascularization in a heart transplant recipient
J Heart Lung Transplant, 17 (6), 629-34
PubMed 9662100

Dishart MK, Schlichtig R, Tonnessen TI, Rozenfeld RA, Simplaceanu E, Williams D, Gayowski TJ (1998)
Mitochondrial redox state as a potential detector of liver dysoxia in vivo
J Appl Physiol (1985), 84 (3), 791-7
DOI 10.1152/jappl.1998.84.3.791, PubMed 9480934

Publications 1997

Barstad RM, Fosse E, Vatne K, Andersen K, Tønnessen TI, Svennevig JL, Geiran OR (1997)
Intraoperative angiography in minimally invasive direct coronary artery bypass grafting
Ann Thorac Surg, 64 (6), 1835-9
DOI 10.1016/s0003-4975(97)01072-2, PubMed 9436590

Bjørnstad PG, Thaulow E, Smevik B, Michelsen SS, Tønnessen TI, Fosse E (1997)
[Catheter treatment of congenital heart defects. Arterial septal defects and open ductus arteriosus]
Tidsskr Nor Laegeforen, 117 (20), 2961-4
PubMed 9340856

Fosse E, Lilleås F, Røtnes JS, Edwin B, Tønnessen TI, Hafsahl G, Laerum F (1997)
[The intervention center at the Rikshospital. Experiences from the first year of activity]
Tidsskr Nor Laegeforen, 117 (19), 2779-83
PubMed 9312869

Kvarstein G, Tønnessen TI (1997)
[CO2 pressure used in the diagnosis of ischemia]
Tidsskr Nor Laegeforen, 117 (29), 4251-5
PubMed 9441471

Tønnessen TI (1997)
Biological basis for PCO2 as a detector of ischemia
Acta Anaesthesiol Scand, 41 (6), 659-69
DOI 10.1111/j.1399-6576.1997.tb04764.x, PubMed 9241323

Publications 1996

Rozenfeld RA, Dishart MK, Tønnessen TI, Schlichtig R (1996)
Methods for detecting local intestinal ischemic anaerobic metabolic acidosis by PCO2
J Appl Physiol (1985), 81 (4), 1834-42
DOI 10.1152/jappl.1996.81.4.1834, PubMed 8904606

Tønnessen TI (1996)
Postoperativ smertebehandling
Ad notam Gyldendal, Oslo, 154 s.
BIBSYS 961214163, ISBN 82-417-0736-3

Tønnessen TI, Kvarstein G (1996)
PCO2 electrodes at the surface of the kidney detect ischaemia
Acta Anaesthesiol Scand, 40 (5), 510-9
DOI 10.1111/j.1399-6576.1996.tb04481.x, PubMed 8792878

Publications 1995

Tønnessen TI (1995)
Smertebehandling av eldre pasienter
Pharmacia & Upjohn, Oslo, 29 s.
BIBSYS 000186619

Tønnessen TI, Værøy H (1995)
Akutte ryggsmerter: diagnose og behandling
Dumex, Hvalstad, 40 s.
BIBSYS 951001175, ISBN 82-993196-0-9

Aas AT, Tønnessen TI, Brun A, Salford LG (1995)
Growth inhibition of rat glioma cells in vitro and in vivo by aspirin
J Neurooncol, 24 (2), 171-80
DOI 10.1007/BF01078487, PubMed 7562004

Publications 1994

Tønnessen TI (1994)
Smerter og andre symptomer hos cancerpatienter
Foreningen af Danske Lægestuderendes Forl., København, 228 s.
BIBSYS 950507237, ISBN 87-7749-079-7

Publications 1991

Ludt J, Tønnessen TI, Sandvig K, Olsnes S (1991)
Evidence for involvement of protein kinase C in regulation of intracellular pH by Cl-/HCO-3 antiport
J Membr Biol, 119 (2), 179-86
DOI 10.1007/BF01871417, PubMed 2046087

Tønnessen TI, Tveter KJ (1991)
Drug treatment of pain in patients with urological cancers
Scand J Urol Nephrol Suppl, 138, 253-64
PubMed 1785017

Publications 1990

Tønnessen TI, Sandvig K, Olsnes S (1990)
Role of Na(+)-H+ and Cl(-)-HCO3- antiports in the regulation of cytosolic pH near neutrality
Am J Physiol, 258 (6 Pt 1), C1117-26
DOI 10.1152/ajpcell.1990.258.6.C1117, PubMed 2163200

Tønnessen TI, Aas AT, Ludt J, Blomhoff HK, Olsnes S (1990)
Regulation of Na+/H+ and Cl-/HCO3- antiports in Vero cells
J Cell Physiol, 143 (1), 178-87
DOI 10.1002/jcp.1041430125, PubMed 2156872

Publications 1989

Tønnessen TI, Aas AT, Sandvig K, Olsnes S (1989)
Effect of anti-inflammatory analgesic drugs on the regulation of cytosolic pH by anion antiport
J Pharmacol Exp Ther, 248 (3), 1197-206
PubMed 2703970

Tønnessen TI, Aas AT, Sandvig K, Olsnes S (1989)
Inhibition of chloride/bicarbonate antiports in monkey kidney cells (Vero) by non-steroidal anti-inflammatory drugs
Biochem Pharmacol, 38 (20), 3583-91
DOI 10.1016/0006-2952(89)90131-7, PubMed 2818647

Publications 1988

Reinertsen KV, Tønnessen TI, Jacobsen J, Sandvig K, Olsnes S (1988)
Role of chloride/bicarbonate antiport in the control of cytosolic pH. Cell-line differences in activity and regulation of antiport
J Biol Chem, 263 (23), 11117-25
PubMed 3403517

Publications 1987

Madshus IH, Tønnessen TI, Olsnes S, Sandvig K (1987)
Effect of potassium depletion of Hep 2 cells on intracellular pH and on chloride uptake by anion antiport
J Cell Physiol, 131 (1), 6-13
DOI 10.1002/jcp.1041310103, PubMed 3571337

Olsnes S, Ludt J, Tønnessen TI, Sandvig K (1987)
Bicarbonate/chloride antiport in Vero cells: II. Mechanisms for bicarbonate-dependent regulation of intracellular pH
J Cell Physiol, 132 (2), 192-202
DOI 10.1002/jcp.1041320203, PubMed 3624315

Olsnes S, Tønnessen TI, Ludt J, Sandvig K (1987)
Effect of intracellular pH on the rate of chloride uptake and efflux in different mammalian cell lines
Biochemistry, 26 (10), 2778-85
DOI 10.1021/bi00384a019, PubMed 3606992

Tønnessen TI, Ludt J, Sandvig K, Olsnes S (1987)
Bicarbonate/chloride antiport in Vero cells: I. Evidence for both sodium-linked and sodium-independent exchange
J Cell Physiol, 132 (2), 183-91
DOI 10.1002/jcp.1041320202, PubMed 3624314

Publications 1986

Olsnes S, Tønnessen TI, Sandvig K (1986)
pH-regulated anion antiport in nucleated mammalian cells
J Cell Biol, 102 (3), 967-71
DOI 10.1083/jcb.102.3.967, PubMed 3949885

Sandvig K, Tønnessen TI, Olsnes S (1986)
Ability of inhibitors of glycosylation and protein synthesis to sensitize cells to abrin, ricin, Shigella toxin, and Pseudomonas toxin
Cancer Res, 46 (12 Pt 1), 6418-22
PubMed 3096563

Sandvig K, Tønnessen TI, Sand O, Olsnes S (1986)
Requirement of a transmembrane pH gradient for the entry of diphtheria toxin into cells at low pH
J Biol Chem, 261 (25), 11639-44
PubMed 3745160

van Deurs B, Tønnessen TI, Petersen OW, Sandvig K, Olsnes S (1986)
Routing of internalized ricin and ricin conjugates to the Golgi complex
J Cell Biol, 102 (1), 37-47
DOI 10.1083/jcb.102.1.37, PubMed 3001103

Publications 1982

Tönnessen TI, Nyland H, Aarli JA (1982)
Complement factors and acute phase reactants in the Guillain-Barré syndrome
Eur Neurol, 21 (2), 124-8
DOI 10.1159/000115467, PubMed 6920298