Publications 2024

Clarke GJB, Skandsen T, Zetterberg H, Follestad T, Einarsen CE, Vik A, Mollnes TE, Pischke SE, Blennow K, Håberg AK (2024)
Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury After Mild Traumatic Brain Injury
J Neurotrauma, 41 (7-8), 862-878
DOI 10.1089/neu.2023.0419, PubMed 38117157

de Boer E, Sokolova M, Jager NM, Schjalm C, Weiss MG, Liavåg OM, Maassen H, van Goor H, Thorgersen EB, Pettersen K, Christiansen D, Ludviksen JK, Jespersen B, Mollnes TE, Leuvenink HGD, Pischke SE (2024)
Normothermic Machine Perfusion Reconstitutes Porcine Kidney Tissue Metabolism But Induces an Inflammatory Response, Which Is Reduced by Complement C5 Inhibition
Transpl Int, 37, 13348
DOI 10.3389/ti.2024.13348, PubMed 39606689

Weiss MG, de Jong AM, Seegert H, Moeslund N, Maassen H, Schjalm C, de Boer E, Leuvenink H, Mollnes TE, Eijken M, Keller AK, Dijkstra G, Jespersen B, Pischke SE (2024)
Activation of the Innate Immune System in Brain-Dead Donors Can Be Reduced by Luminal Intestinal Preservation During Organ Procurement Surgery - A Porcine Model
Transpl Int, 37, 13569
DOI 10.3389/ti.2024.13569, PubMed 39544322

Publications 2023

Bakkehaug JP, Kåsine T, Romundstad L, Narum J, Laake JH, Svalebjørg M, Fiane AE, Hoel T, Thiara A, Pischke SE, Aasmundstad TA, Barratt-Due A (2023)
[Extracorporeal membrane oxygenation for acute respiratory distress syndrome in patients with COVID-19]
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.22.0545, PubMed 36718886

Chaban V, de Boer E, McAdam KE, Vaage J, Mollnes TE, Nilsson PH, Pischke SE, Islam R (2023)
Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo
Mol Immunol, 157, 70-77
DOI 10.1016/j.molimm.2023.03.006, PubMed 37001293

Heldal TF, Åsberg A, Ueland T, Reisæter AV, Pischke SE, Mollnes TE, Aukrust P, Reinholt F, Hartmann A, Heldal K, Jenssen TG (2023)
Systemic inflammation early after kidney transplantation is associated with long-term graft loss: a cohort study
Front Immunol, 14, 1253991
DOI 10.3389/fimmu.2023.1253991, PubMed 37849758

Laake JH, Aslam TN, Barratt-Due A, Løwhagen B, Pischke SE, Tønnessen TI, Wisløff-Aase K, Aasmundstad TA (2023)
[ARDS or acute respiratory failure syndrome?]
Tidsskr Nor Laegeforen, 143 (10)
DOI 10.4045/tidsskr.23.0402, PubMed 37376931

Maassen H, Venema LH, Weiss MG, Huijink TM, Hofker HS, Keller AK, Mollnes TE, Eijken M, Pischke SE, Jespersen B, van Goor H, Leuvenink HGD (2023)
H₂S-Enriched Flush out Does Not Increase Donor Organ Quality in a Porcine Kidney Perfusion Model
Antioxidants (Basel), 12 (3)
DOI 10.3390/antiox12030749, PubMed 36978997

Rydenfelt K, Kjøsen G, Horneland R, Krey Ludviksen J, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
Local Postoperative Graft Inflammation in Pancreas Transplant Patients With Early Graft Thrombosis
Transplant Direct, 10 (1), e1567
DOI 10.1097/TXD.0000000000001567, PubMed 38094132

Rydenfelt K, Kjøsen G, Horneland R, Ludviksen JK, Jenssen TG, Line PD, Tønnessen TI, Mollnes TE, Haugaa H, Pischke SE (2023)
Thromboinflammatory response is increased in pancreas transplant alone versus simultaneous pancreas-kidney transplantation and early pancreas graft thrombosis is associated with complement activation
Front Immunol, 14, 1044444
DOI 10.3389/fimmu.2023.1044444, PubMed 37063904

Publications 2022

de Boer E, Sokolova M, Quach HQ, McAdam KE, Götz MP, Chaban V, Vaage J, Fageräng B, Woodruff TM, Garred P, Nilsson PH, Mollnes TE, Pischke SE (2022)
Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release
J Immunol, 209 (9), 1760-1767
DOI 10.4049/jimmunol.2101191, PubMed 36104112

Heldal TF, Åsberg A, Ueland T, Reisaeter AV, Pischke SE, Mollnes TE, Aukrust P, Hartmann A, Heldal K, Jenssen T (2022)
Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality
Am J Transplant, 22 (8), 2016-2027
DOI 10.1111/ajt.17047, PubMed 35352462

Hou J, Liavåg OMI, Færden IH, Martinsen ØG, Tønnessen TI, Line PD, Hagness M, Høgetveit JO, Pischke SE, Strand-Amundsen R (2022)
Utilization of dielectric properties for assessment of liver ischemia-reperfusion injury in vivo and during machine perfusion
Sci Rep, 12 (1), 11183
DOI 10.1038/s41598-022-14817-3, PubMed 35778457

Johnson C, Quach HQ, Lau C, Ekholt K, Espevik T, Woodruff TM, Pischke SE, Mollnes TE, Nilsson PH (2022)
Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood
J Immunol, 208 (12), 2771-2778
DOI 10.4049/jimmunol.2101033, PubMed 35675954

Rydenfelt K, Strand-Amundsen R, Horneland R, Hødnebø S, Kjøsen G, Pischke SE, Tønnessen TI, Haugaa H (2022)
Microdialysis and CO2 sensors detect pancreatic ischemia in a porcine model
PLoS One, 17 (2), e0262848
DOI 10.1371/journal.pone.0262848, PubMed 35143517

Torp MK, Ranheim T, Schjalm C, Hjorth M, Heiestad CM, Dalen KT, Nilsson PH, Mollnes TE, Pischke SE, Lien E, Vaage J, Yndestad A, Stensløkken KO (2022)
Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis
Front Immunol, 13, 870811
DOI 10.3389/fimmu.2022.870811, PubMed 35432387

Publications 2021

Chaban V, Nakstad ER, Stær-Jensen H, Schjalm C, Seljeflot I, Vaage J, Lundqvist C, Benth JŠ, Sunde K, Mollnes TE, Andersen GØ, Pischke SE (2021)
Complement activation is associated with poor outcome after out-of-hospital cardiac arrest
Resuscitation, 166, 129-136
DOI 10.1016/j.resuscitation.2021.05.038, PubMed 34126135

Kjøsen G, Rydenfelt K, Horneland R, Aandahl EM, Line PD, Dorenberg E, Berstad AE, Brabrand K, Hagen G, Pischke SE, Bergmann GB, Nordheim E, Jenssen TG, Tønnessen TI, Haugaa H (2021)
Early detection of complications in pancreas transplants by microdialysis catheters, an observational feasibility study
PLoS One, 16 (3), e0247615
DOI 10.1371/journal.pone.0247615, PubMed 33705460

Lindholm E, Bergmann GB, Haugaa H, Labori KJ, Yaqub S, Bjørnbeth BA, Line PD, Grindheim G, Kjøsen G, Pischke SE, Tønnessen TI (2021)
Early detection of anastomotic leakage after pancreatoduodenectomy with microdialysis catheters: an observational Study
HPB (Oxford), 24 (6), 901-909
DOI 10.1016/j.hpb.2021.10.020, PubMed 34836755

Laake JH, Astvad M, Bentsen G, Escher C, Haney M, Hoffmann-Petersen J, Hyllested M, Junttila E, Møller MH, Nellgård P, Nyberg A, Olkkola K, Pedersen SKA, Pischke SE, Reinikainen M, Strand K, Thorarensen G, Thormar K, Tønnessen TI (2021)
A policy for diversity, equity, inclusion and anti-racism in the Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
Acta Anaesthesiol Scand, 66 (1), 141-144
DOI 10.1111/aas.13978, PubMed 34462910

Rognes IN, Pischke SE, Ottestad W, Røislien J, Berg JP, Johnson C, Eken T, Mollnes TE (2021)
Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study
Mol Med, 27 (1), 35
DOI 10.1186/s10020-021-00286-3, PubMed 33832430

Thomas AM, Chaban V, Pischke SE, Orrem HL, Bosnes V, Sunde K, Seljeflot I, Lundqvist C, Nakstad ER, Andersen GØ, Schjalm C, Mollnes TE, Barratt-Due A (2021)
Complement ratios C3bc/C3 and sC5b-9/C5 do not increase the sensitivity of detecting acute complement activation systemically
Mol Immunol, 141, 273-279
DOI 10.1016/j.molimm.2021.11.016, PubMed 34906905

Witczak BJ, Pischke SE, Reisæter AV, Midtvedt K, Ludviksen JK, Heldal K, Jenssen T, Hartmann A, Åsberg A, Mollnes TE (2021)
Elevated Terminal C5b-9 Complement Complex 10 Weeks Post Kidney Transplantation Was Associated With Reduced Long-Term Patient and Kidney Graft Survival
Front Immunol, 12, 738927
DOI 10.3389/fimmu.2021.738927, PubMed 34759922

Publications 2020

Jøntvedt Jørgensen M, Holter JC, Christensen EE, Schjalm C, Tonby K, Pischke SE, Jenum S, Skeie LG, Nur S, Lind A, Opsand H, Enersen TB, Grøndahl R, Hermann A, Dudman S, Muller F, Ueland T, Mollnes TE, Aukrust P, Heggelund L, Holten AR, Dyrhol-Riise AM (2020)
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843

Laake JH, Aasmundstad TA, Kåsine T, Pischke SE, Barratt-Due A (2020)
[COVID-19: evidence, eminence, or experience- based treatment?]
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0649, PubMed 32900165

Nieuwenhuijs-Moeke GJ, Pischke SE, Berger SP, Sanders JSF, Pol RA, Struys MMRF, Ploeg RJ, Leuvenink HGD (2020)
Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair
J Clin Med, 9 (1)
DOI 10.3390/jcm9010253, PubMed 31963521

Ueland T, Heggelund L, Lind A, Holten AR, Tonby K, Michelsen AE, Jenum S, Jørgensen MJ, Barratt-Due A, Skeie LG, Nordøy I, Aanensen Fraz MS, Quist-Paulsen E E, Pischke SE, Johal SK, Hesstvedt L, Bogen M, Fevang B, Halvorsen B, Müller F, Bekken GK, Mollnes TE, Dudman S, Aukrust P, Dyrhol-Riise AM et al. (2020)
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109

Publications 2019

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508, PubMed 30653682

Publications 2018

Orrem HL, Nilsson PH, Pischke SE, Grindheim G, Garred P, Seljeflot I, Husebye T, Aukrust P, Yndestad A, Andersen GØ, Barratt-Due A, Mollnes TE (2018)
Acute heart failure following myocardial infarction: complement activation correlates with the severity of heart failure in patients developing cardiogenic shock
ESC Heart Fail, 5 (3), 292-301
DOI 10.1002/ehf2.12266, PubMed 29424484

Orrem HL, Nilsson PH, Pischke SE, Kleveland O, Yndestad A, Ekholt K, Damås JK, Espevik T, Bendz B, Halvorsen B, Gregersen I, Wiseth R, Andersen GØ, Ueland T, Gullestad L, Aukrust P, Barratt-Due A, Mollnes TE (2018)
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction
Front Immunol, 9, 2035
DOI 10.3389/fimmu.2018.02035, PubMed 30258440

Publications 2017

Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE (2017)
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis
J Intensive Care, 5, 21
DOI 10.1186/s40560-017-0217-0, PubMed 28261486

Pischke SE, Haugaa H, Haney M (2017)
A neglected organ in multiple organ failure - 'skin in the game'?
Acta Anaesthesiol Scand, 61 (1), 5-7
DOI 10.1111/aas.12823, PubMed 27918100

Publications 2016

Barratt-Due A, Pischke SE, Nilsson PH, Espevik T, Mollnes TE (2016)
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
J Leukoc Biol, 101 (1), 193-204
DOI 10.1189/jlb.3VMR0316-132R, PubMed 27581539

Gustavsen A, Nymo S, Landsem A, Christiansen D, Ryan L, Husebye H, Lau C, Pischke SE, Lambris JD, Espevik T, Mollnes TE (2016)
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex
J Infect Dis, 214 (1), 140-50
DOI 10.1093/infdis/jiw100, PubMed 26977050

Publications 2015

Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE (2015)
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
Immunobiology, 220 (8), 999-1005
DOI 10.1016/j.imbio.2015.04.002, PubMed 25956456

Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B (2015)
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial
Medicine (Baltimore), 94 (42), e1786
DOI 10.1097/MD.0000000000001786, PubMed 26496309

Hyler S, Pischke SE, Halvorsen PS, Espinoza A, Bergsland J, Tønnessen TI, Fosse E, Skulstad H (2015)
Continuous monitoring of regional function by a miniaturized ultrasound transducer allows early quantification of low-grade myocardial ischemia
J Am Soc Echocardiogr, 28 (4), 486-94
DOI 10.1016/j.echo.2014.12.014, PubMed 25636368

Khan F, Pharo A, Lindstad JK, Mollnes TE, Tønnessen TI, Pischke SE (2015)
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis
Scand J Immunol, 82 (5), 467-75
DOI 10.1111/sji.12332, PubMed 26099791

Pischke SE (2015)
[Local ischemia can be detected by internal organ CO2 measurement]
Tidsskr Nor Laegeforen, 135 (19), 1774
DOI 10.4045/tidsskr.15.0916, PubMed 26486679

Publications 2014

Huber-Lang M, Barratt-Due A, Pischke SE, Sandanger Ø, Nilsson PH, Nunn MA, Denk S, Gaus W, Espevik T, Mollnes TE (2014)
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice
J Immunol, 192 (11), 5324-31
DOI 10.4049/jimmunol.1400341, PubMed 24790148

Pischke SE, Hyler S, Tronstad C, Bergsland J, Fosse E, Halvorsen PS, Skulstad H, Tønnessen TI (2014)
Myocardial tissue CO2 tension detects coronary blood flow reduction after coronary artery bypass in real-time†
Br J Anaesth, 114 (3), 414-22
DOI 10.1093/bja/aeu381, PubMed 25392231

Publications 2013

Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE (2013)
Combined inhibition of complement C5 and CD14 markedly attenuates inflammation, thrombogenicity, and hemodynamic changes in porcine sepsis
J Immunol, 191 (2), 819-27
DOI 10.4049/jimmunol.1201909, PubMed 23761634

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2013)
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transpl, 19 (3), 305-14
DOI 10.1002/lt.23578, PubMed 23193034

Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE (2013)
Systemic CD14 inhibition attenuates organ inflammation in porcine Escherichia coli sepsis
Infect Immun, 81 (9), 3173-81
DOI 10.1128/IAI.00390-13, PubMed 23774598

Publications 2012

Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Huber-Lang M, Mollnes TE (2012)
Bride and groom in systemic inflammation--the bells ring for complement and Toll in cooperation
Immunobiology, 217 (11), 1047-56
DOI 10.1016/j.imbio.2012.07.019, PubMed 22964230

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE (2012)
Polyvalent immunoglobulin significantly attenuated the formation of IL-1β in Escherichia coli-induced sepsis in pigs
Immunobiology, 218 (5), 683-9
DOI 10.1016/j.imbio.2012.08.268, PubMed 22947599

Håugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tønnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transpl, 18 (7), 839-49
DOI 10.1002/lt.23425, PubMed 22407878

Pischke SE, Tronstad C, Holhjem L, Halvorsen PS, Tønnessen TI (2012)
Perioperative detection of myocardial ischaemia/reperfusion with a novel tissue CO2 monitoring technology
Eur J Cardiothorac Surg, 42 (1), 157-63
DOI 10.1093/ejcts/ezr278, PubMed 22290904

Publications 2005

Pischke SE, Zhou Z, Song R, Ning W, Alam J, Ryter SW, Choi AM (2005)
Phosphatidylinositol 3-kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide
Cell Mol Biol (Noisy-le-grand), 51 (5), 461-70
PubMed 16309568