Ebbe Billmann Thorgersen

  • Consultant
 

Publications 2021

Thorgersen EB, Asvall J, Froysnes IS, Schjalm C, Larsen SG, Dueland S, Andersson Y, Fodstad O, Mollnes TE, Flatmark K (2021)
Increased Local Inflammatory Response to MOC31PE Immunotoxin After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Ann. Surg. Oncol., 28 (9), 5252-5262
DOI 10.1245/s10434-021-10022-0

Thorgersen EB, Flatmark K (2021)
ASO Author Reflections: The Peritoneum is an Active Immunological Compartment
Ann. Surg. Oncol., 28 (9), 5263-5264
DOI 10.1245/s10434-021-10036-8

Publications 2019

Thorgersen EB, Barratt-Due A, Haugaa H, Harboe M, Pischke SE, Nilsson PH, Mollnes TE (2019)
The Role of Complement in Liver Injury, Regeneration, and Transplantation
Hepatology, 70 (2), 725-736
DOI 10.1002/hep.30508

Publications 2018

Spasojevic M, Mariathasan AB, Goscinski M, Thorgersen EB, Solbakken AM, Gullestad HP, Ryder T, Flatmark K, Larsen SG (2018)
Vertical Rectus Abdominis Musculocutaneous Flap Repair Improves Perineal Wound Healing after Abdominoperineal Resection for Irradiated Locally Advanced Rectal Cancer
Ann. Surg. Oncol., 25 (5), 1357-1365
DOI 10.1245/s10434-018-6363-3

Thorgersen EB, Melum E, Folseraas T, Larsen SG, Line PD (2018)
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei in a liver-transplanted patient: a case report
World J. Surg. Oncol., 16, 180
DOI 10.1186/s12957-018-1482-7

Publications 2017

Thorgersen EB, Goscinski MA, Spasojevic M, Solbakken AM, Mariathasan AB, Boye K, Larsen SG, Flatmark K (2017)
Deep Pelvic Surgical Site Infection After Radiotherapy and Surgery for Locally Advanced Rectal Cancer
Ann. Surg. Oncol., 24 (3), 721-728
DOI 10.1245/s10434-016-5621-5

Publications 2015

Egge KH, Barratt-Due A, Nymo S, Lindstad JK, Pharo A, Lau C, Espevik T, Thorgersen EB, Mollnes TE (2015)
The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load
Clin. Exp. Immunol., 181 (3), 457-467
DOI 10.1111/cei.12645

Egge KH, Thorgersen EB, Pischke SE, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn MA, Barratt-Due A, Mollnes TE (2015)
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14
Immunobiology, 220 (8), 999-1005
DOI 10.1016/j.imbio.2015.04.002

Hellerud BC, Olstad OK, Nielsen EW, Troseid AMS, Skadberg O, Thorgersen EB, Vege A, Mollnes TE, Brandtzaeg P (2015)
MASSIVE ORGAN INFLAMMATION IN EXPERIMENTAL AND IN CLINICAL MENINGOCOCCAL SEPTIC SHOCK
Shock, 44 (5), 458-469
DOI 10.1097/SHK.0000000000000441

Publications 2014

Egge KH, Thorgersen EB, Lindstad JK, Pharo A, Lambris JD, Barratt-Due A, Mollnes TE (2014)
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood
Innate Immun., 20 (1), 68-77
DOI 10.1177/1753425913482993

Publications 2013

Barratt-Due A, Sokolov A, Gustavsen A, Hellerud BC, Egge K, Pischke SE, Lindstad JK, Pharo A, Castellheim A, Thorgersen EB, Mollnes TE (2013)
Polyvalent immunoglobulin significantly attenuated the formation of IL-1 beta in Escherichia coli-induced sepsis in pigs
Immunobiology, 218 (5), 683-689
DOI 10.1016/j.imbio.2012.08.268

Barratt-Due A, Thorgersen EB, Egge K, Pischke S, Sokolov A, Hellerud BC, Lindstad JK, Pharo A, Bongoni AK, Rieben R, Nunn M, Scott H, Mollnes TE (2013)
Combined Inhibition of Complement (C5) and CD14 Markedly Attenuates Inflammation, Thrombogenicity, and Hemodynamic Changes in Porcine Sepsis
J. Immunol., 191 (2), 819-827
DOI 10.4049/jimmunol.1201909

Haugaa H, Almaas R, Thorgersen EB, Foss A, Line PD, Sanengen T, Bergmann GB, Ohlin P, Waelgaard L, Grindheim G, Pischke SE, Mollnes TE, Tonnessen TI (2013)
Clinical experience with microdialysis catheters in pediatric liver transplants
Liver Transplant., 19 (3), 305-314
DOI 10.1002/lt.23578

Thorgersen EB, Pischke SE, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Hellerud BC, Mollnes TE (2013)
Systemic CD14 Inhibition Attenuates Organ Inflammation in Porcine Escherichia coli Sepsis
Infect. Immun., 81 (9), 3173-3181
DOI 10.1128/IAI.00390-13

Waage S, Poole JC, Thorgersen EB (2013)
Rural hospital mass casualty response to a terrorist shooting spree
Br. J. Surg., 100 (9), 1198-1204
DOI 10.1002/bjs.9203

Publications 2012

Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Huber-Lang M, Mollnes TE (2012)
Bride and groom in systemic inflammation - The bells ring for complement and Toll in cooperation
Immunobiology, 217 (11), 1047-1056
DOI 10.1016/j.imbio.2012.07.019

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Pischke SE, Mollnes TE, Tonnessen TI (2012)
Early bedside detection of ischemia and rejection in liver transplants by microdialysis
Liver Transplant., 18 (7), 839-849
DOI 10.1002/lt.23425

Haugaa H, Thorgersen EB, Pharo A, Boberg KM, Foss A, Line PD, Sanengen T, Almaas R, Grindheim G, Waelgaard L, Pischke SE, Mollnes TE, Tonnessen TI (2012)
Inflammatory markers sampled by microdialysis catheters distinguish rejection from ischemia in liver grafts
Liver Transplant., 18 (12), 1421-1429
DOI 10.1002/lt.23503

Publications 2011

Barratt-Due A, Johansen HT, Sokolov A, Thorgersen EB, Hellerud BC, Reubsaet JL, Seip KF, Tonnessen TI, Lindstad JK, Pharo A, Castellheim A, Mollnes TE, Nielsen EW (2011)
THE ROLE OF BRADYKININ AND THE EFFECT OF THE BRADYKININ RECEPTOR ANTAGONIST ICATIBANT IN PORCINE SEPSIS
Shock, 36 (5), 517-523
DOI 10.1097/SHK.0b013e3182336a34

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Lissina O, Lambris JD, Nunn MA, Mollnes TE (2011)
Ornithodoros moubata Complement Inhibitor Is an Equally Effective C5 Inhibitor in Pigs and Humans
J. Immunol., 187 (9), 4913-4919
DOI 10.4049/jimmunol.1101000

Harboe M, Thorgersen EB, Mollnes TE (2011)
Advances in assay of complement function and activation
Adv. Drug Deliv. Rev., 63 (12), 976-987
DOI 10.1016/j.addr.2011.05.010

Publications 2010

Barratt-Due A, Thorgersen EB, Lindstad JK, Pharo A, Brekke OL, Christiansen D, Lambris JD, Mollnes TE (2010)
Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood
Mol. Immunol., 47 (9), 1774-1782
DOI 10.1016/j.molimm.2010.02.026

Hellerud BC, Nielsen EW, Thorgersen EB, Lindstad JK, Pharo A, Tonnessen TI, Castellheim A, Mollnes TE, Brandtzaeg P (2010)
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis
Crit. Care Med., 38 (6), 1467-1474
DOI 10.1097/CCM.0b013e3181de8c94

Thorgersen EB, Hellerud BC, Nielsen EW, Barratt-Due A, Fure H, Lindstad JK, Pharo A, Fosse E, Tonnessen TI, Johansen HT, Castellheim A, Mollnes TE (2010)
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs
Faseb J., 24 (3), 712-722
DOI 10.1096/fj.09-140798

Thorgersen EB, Ludviksen JK, Lambris JD, Sfyroera G, Nielsen EW, Mollnes TE (2010)
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity
Innate Immun., 16 (4), 254-264
DOI 10.1177/1753425909340420

Publications 2009

Lappegard KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abrahamsen TG, Hoiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE (2009)
Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature
Proc. Natl. Acad. Sci. U. S. A., 106 (37), 15861-15866
DOI 10.1073/pnas.0903613106

Nielsen EW, Hellerud BC, Thorgersen EB, Castellheim A, Pharo A, Lindstad J, Tonnessen TI, Brandtzaeg P, Mollnest TE (2009)
A NEW DYNAMIC PORCINE MODEL OF MENINGOCOCCAL SHOCK
Shock, 32 (3), 302-309
DOI 10.1097/SHK.0b013e31819c37be

Sikkeland LIB, Eduard W, Stangeland AM, Thorgersen EB, Haug T, Aukrust P, Halvorsen B, Mollnes TE, Kongerud J (2009)
Occupational exposure to bacterial single cell protein induces inflammation in lung and blood
Inhal. Toxicol., 21 (8-11), 674-681
DOI 10.1080/08958370802491425

Thorgersen EB (2009)
Complement and CD14: roles in Escherichia coli-induced inflammation in the pig
In Series of dissertations submitted to the Faculty of Medicine, University of Oslo, Unipub, Oslo, no. 858, 1 b. (flere pag.)
BIBSYS 094055637, ISBN 978-82-8072-350-5

Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE (2009)
Inhibition of Complement and CD14 Attenuates the Escherichia coli-Induced Inflammatory Response in Porcine Whole Blood
Infect. Immun., 77 (2), 725-732
DOI 10.1128/IAI.01305-08

Publications 2008

Castellheim A, Thorgersen EB, Hellerud BC, Pharo A, Johansen HT, Brosstad F, Gaustad P, Brun H, Fosse E, Tonnessen TI, Nielsen EW, Mollnes TE (2008)
New biomarkers in an acute model of live Escherichia coli-induced sepsis in pigs
Scand. J. Immunol., 68 (1), 75-84
DOI 10.1111/j.1365-3083.2008.02122.x

Thorgersen EB, Macagno A, Rossetti C, Mollnes TE (2008)
Cyanobacterial LPS antagonist (CyP) - A novel and efficient inhibitor of Escherichia coli LPS-induced cytokine response in the pig
Mol. Immunol., 45 (13), 3553-3557
DOI 10.1016/j.molimm.2008.05.005

Waelgaard L, Thorgersen EB, Line PD, Foss A, Mollnes TE, Tonnessen TI (2008)
Microdialysis Monitoring of Liver Grafts by Metabolic Parameters, Cytokine Production, and Complement Activation
Transplantation, 86 (8), 1096-1103
DOI 10.1097/TP.0b013e31818775ca

Publications 2007

Sikkeland LIB, Thorgersen EB, Haug T, Mollnes TE (2007)
Complement activation and cytokine response by BioProtein, a bacterial single cell protein
Clin. Exp. Immunol., 148 (1), 146-152
DOI 10.1111/j.1365-2249.2007.03339.x

Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE (2007)
Candidate inhibitors of porcine complement
Mol. Immunol., 44 (8), 1827-1834
DOI 10.1016/j.molimm.2006.10.004