Publications
Publications published since 2000 from OUS - Department of Cancer Genetics
1078 publications found (only first 1000 shown)
Publications 2024
-
Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia
Cell Rep Med, 5 (5), 101521
DOI 10.1016/j.xcrm.2024.101521, PubMed 38653245 -
Editorial overview-Artificial intelligence methodologies in structural biology: Bridging the gap to medical applications
Curr Opin Struct Biol, 87, 102862
DOI 10.1016/j.sbi.2024.102862, PubMed 38870638 -
Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors - a biomarker analysis of the ALICE and ICON trials
Mol Oncol (in press)
DOI 10.1002/1878-0261.13675, PubMed 38978352 -
Ipilimumab and nivolumab combined with anthracycline-based chemotherapy in metastatic hormone receptor-positive breast cancer: a randomized phase 2b trial
J Immunother Cancer, 12 (1)
DOI 10.1136/jitc-2023-007990, PubMed 38242720 -
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762 -
Acta Oncologica Nordic Precision Cancer Medicine Symposium 2023 - merging clinical research and standard healthcare
Acta Oncol, 63, 487-490
DOI 10.2340/1651-226X.2024.24954, PubMed 38910311 -
Multi-omics analysis reveals epigenetically regulated processes and patient classification in lung adenocarcinoma
Int J Cancer, 155 (2), 282-297
DOI 10.1002/ijc.34915, PubMed 38489486 -
A synthetic lethal dependency on casein kinase 2 in response to replication-perturbing therapeutics in RB1-deficient cancer cells
Sci Adv, 10 (21), eadj1564
DOI 10.1126/sciadv.adj1564, PubMed 38781347 -
Comprehensive molecular characterization of early stage grade 3 endometrioid endometrial adenocarcinoma
Gynecol Oncol, 189, 138-145 (in press)
DOI 10.1016/j.ygyno.2024.07.677, PubMed 39126895 -
Evaluation of NTRK expression and fusions in a large cohort of early-stage lung cancer
Clin Exp Med, 24 (1), 10
DOI 10.1007/s10238-023-01273-0, PubMed 38240952 -
High-throughput molecular assays for inclusion in personalised oncology trials - State-of-the-art and beyond
J Intern Med, 295 (6), 785-803
DOI 10.1111/joim.13785, PubMed 38698538 -
Protocol to identify defined reprogramming factor expression using a factor-indexing single-nuclei multiome sequencing approach
STAR Protoc, 5 (3), 103148 (in press)
DOI 10.1016/j.xpro.2024.103148, PubMed 38909361 -
Real-world outcomes with durvalumab after chemoradiotherapy in patients with unresectable stage III NSCLC: interim analysis of overall survival from PACIFIC-R
ESMO Open, 9 (6), 103464
DOI 10.1016/j.esmoop.2024.103464, PubMed 38833971 -
An integrated omics approach highlights how epigenetic events can explain and predict response to neoadjuvant chemotherapy and bevacizumab in breast cancer
Mol Oncol, 18 (8), 2042-2059
DOI 10.1002/1878-0261.13656, PubMed 38671580 -
Lung cancer reirradiation: Exploring modifications to utilization, treatment modalities and factors associated with outcomes
J Med Imaging Radiat Sci, 55 (2), 221-231
DOI 10.1016/j.jmir.2024.02.004, PubMed 38429174 -
[Raising the quality of cancer treatment]
Tidsskr Nor Laegeforen, 144 (1)
DOI 10.4045/tidsskr.23.0740, PubMed 38258713 -
UV1 telomerase vaccine with ipilimumab and nivolumab as second line treatment for pleural mesothelioma - A phase II randomised trial
Eur J Cancer, 202, 113973
DOI 10.1016/j.ejca.2024.113973, PubMed 38447379 -
RepurposeDrugs: an interactive web-portal and predictive platform for repurposing mono- and combination therapies
Brief Bioinform, 25 (4)
DOI 10.1093/bib/bbae328, PubMed 38980370 -
Transposable elements as drivers of dedifferentiation: Connections between enhancers in embryonic stem cells, placenta, and cancer
Bioessays, e2400059 (in press)
DOI 10.1002/bies.202400059, PubMed 39073128 -
A federated learning system for precision oncology in Europe: DigiONE
Nat Med, 30 (2), 334-337
DOI 10.1038/s41591-023-02715-8, PubMed 38195748 -
Gender Difference in sidE eFfects of ImmuNotherapy: a possible clue to optimize cancEr tReatment (G-DEFINER): study protocol of an observational prospective multicenter study
Acta Oncol, 63, 213-219
DOI 10.2340/1651-226X.2024.24179, PubMed 38647024 -
The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma
Breast Cancer Res, 26 (1), 122
DOI 10.1186/s13058-024-01871-0, PubMed 39138514 -
ScType enables fast and accurate cell type identification from spatial transcriptomics data
Bioinformatics, 40 (7)
DOI 10.1093/bioinformatics/btae426, PubMed 38936341 -
Desmoplastic non-infantile ganglioglioma mimicking diffuse leptomeningeal glioneuronal tumor: precision diagnostics and therapeutic implications
Acta Oncol, 63, 392-394
DOI 10.2340/1651-226X.2024.31720, PubMed 38779936 -
Thoracic radiation in combination with erlotinib-results from a phase 2 randomized trial
Front Oncol, 14, 1412716
DOI 10.3389/fonc.2024.1412716, PubMed 39148905 -
Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer-a prospective national multicentre study (EMIT-1)
ESMO Open, 9 (6), 103475
DOI 10.1016/j.esmoop.2024.103475, PubMed 38838499 -
The Tumor Immune Microenvironment in Breast Cancer Progression
Acta Oncol, 63, 359-367
DOI 10.2340/1651-226X.2024.33008, PubMed 38779867 -
IMPRESS-Norway: improving public cancer care by implementing precision medicine in Norway; inclusion rates and preliminary results
Acta Oncol, 63, 379-384
DOI 10.2340/1651-226X.2024.28322, PubMed 38779911 -
Strategies to decrease inequalities in cancer therapeutics, care and prevention: Proceedings on a conference organized by the Pontifical Academy of Sciences and the European Academy of Cancer Sciences, Vatican City, February 23-24, 2023
Mol Oncol, 18 (2), 245-279
DOI 10.1002/1878-0261.13575, PubMed 38135904 -
Attention-based approach to predict drug-target interactions across seven target superfamilies
Bioinformatics, 40 (8)
DOI 10.1093/bioinformatics/btae496, PubMed 39115379 -
Copy number alterations: a catastrophic orchestration of the breast cancer genome
Trends Mol Med, 30 (8), 750-764
DOI 10.1016/j.molmed.2024.04.017, PubMed 38772764 -
Preoperative profiles of plasma amino acids and derivatives distinguish periampullary cancer and benign disease
BMC Cancer, 24 (1), 555
DOI 10.1186/s12885-024-12320-8, PubMed 38702616 -
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia
J Clin Invest, 134 (8)
DOI 10.1172/JCI168536, PubMed 38618957 -
PCM4EU and PRIME-ROSE: Collaboration for implementation of precision cancer medicine in Europe
Acta Oncol, 63, 385-391
DOI 10.2340/1651-226X.2024.34791, PubMed 38779910 -
Outcome prediction based on [18F]FDG PET/CT in patients with pleural mesothelioma treated with ipilimumab and nivolumab +/- UV1 telomerase vaccine
Eur J Nucl Med Mol Imaging (in press)
DOI 10.1007/s00259-024-06853-0, PubMed 39133306 -
Telomere length as a predictor of therapy response and survival in patients diagnosed with ovarian carcinoma
Heliyon, 10 (13), e33525
DOI 10.1016/j.heliyon.2024.e33525, PubMed 39050459 -
ESMO Recommendations on clinical reporting of genomic test results for solid cancers
Ann Oncol (in press)
DOI 10.1016/j.annonc.2024.06.018, PubMed 39112111 -
Optimizing Drug Combinations for T-PLL: Restoring DNA Damage and P53-Mediated Apoptotic Responses
Blood (in press)
DOI 10.1182/blood.2023022884, PubMed 38941598 -
Tutorial on survival modeling with applications to omics data
Bioinformatics, 40 (3)
DOI 10.1093/bioinformatics/btae132, PubMed 38445722
Publications 2023
-
Chemogenomic library design strategies for precision oncology, applied to phenotypic profiling of glioblastoma patient cells
iScience, 26 (7), 107209
DOI 10.1016/j.isci.2023.107209, PubMed 37485377 -
Initial investigation of using Norwegian health data for the purpose of external comparator arms - an example for non-small cell lung cancer
Acta Oncol, 62 (12), 1642-1648
DOI 10.1080/0284186X.2023.2264484, PubMed 37801361 -
Robust scoring of selective drug responses for patient-tailored therapy selection
Nat Protoc, 19 (1), 60-82
DOI 10.1038/s41596-023-00903-x, PubMed 37996540 -
ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines
Genes (Basel), 14 (2)
DOI 10.3390/genes14020296, PubMed 36833223 -
PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells
Mol Oncol, 17 (9), 1803-1820
DOI 10.1002/1878-0261.13488, PubMed 37458534 -
"Evaluation of ROS1 expression and rearrangements in a large cohort of early-stage lung cancer"
Diagn Pathol, 18 (1), 70
DOI 10.1186/s13000-023-01357-1, PubMed 37237384 -
Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases
Cancers (Basel), 15 (13)
DOI 10.3390/cancers15133313, PubMed 37444426 -
Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature
Curr Oncol, 30 (11), 10007-10018
DOI 10.3390/curroncol30110727, PubMed 37999147 -
OSCAR: Optimal subset cardinality regression using the L0-pseudonorm with applications to prognostic modelling of prostate cancer
PLoS Comput Biol, 19 (3), e1010333
DOI 10.1371/journal.pcbi.1010333, PubMed 36897911 -
Liver X receptors induce antiproliferative effects in basal-like breast cancer
Mol Oncol, 17 (10), 2041-2055
DOI 10.1002/1878-0261.13476, PubMed 37341140 -
The Geriatric Prognostic Index: a clinical prediction model for survival of older diffuse large B-cell lymphoma patients treated with standard immunochemotherapy
Haematologica, 108 (9), 2454-2466
DOI 10.3324/haematol.2022.282289, PubMed 36861406 -
Glioblastoma and the search for non-hypothesis driven combination therapeutics in academia
Front Oncol, 12, 1075559
DOI 10.3389/fonc.2022.1075559, PubMed 36733367 -
Factors associated with failure to start consolidation durvalumab after definitive chemoradiation for locally advanced NSCLC
Front Oncol, 13, 1217424
DOI 10.3389/fonc.2023.1217424, PubMed 37476372 -
Modified study designs to expand treatment options in personalised oncology: a multistakeholder view
Eur J Cancer, 194, 113278
DOI 10.1016/j.ejca.2023.113278, PubMed 37820553 -
Analysis of Spatial Molecular Data
Methods Mol Biol, 2614, 349-356
DOI 10.1007/978-1-0716-2914-7_20, PubMed 36587134 -
Systematic Literature Review of Economic Evaluations of Treatment Alternatives in Chronic Lymphocytic Leukemia
BioDrugs, 37 (2), 219-233
DOI 10.1007/s40259-023-00583-9, PubMed 36795353 -
MRI Assessment of Changes in Tumor Vascularization during Neoadjuvant Anti-Angiogenic Treatment in Locally Advanced Breast Cancer Patients
Cancers (Basel), 15 (18)
DOI 10.3390/cancers15184662, PubMed 37760629 -
Obesity-associated changes in molecular biology of primary breast cancer
Nat Commun, 14 (1), 4418
DOI 10.1038/s41467-023-39996-z, PubMed 37479706 -
A PRRX1 Signature Identifies TIM-3 and VISTA as Potential Immune Checkpoint Targets in a Subgroup of Microsatellite Stable Colorectal Cancer Liver Metastases
Cancer Res Commun, 3 (2), 235-244
DOI 10.1158/2767-9764.CRC-22-0295, PubMed 36968142 -
The miR-141/200c-STAT4 Axis Contributes to Leukemogenesis by Enhancing Cell Proliferation in T-PLL
Cancers (Basel), 15 (9)
DOI 10.3390/cancers15092527, PubMed 37173993 -
Rapid assessment of 3-dimensional intra-tumor heterogeneity through cycling temperature capillary electrophoresis
BMC Res Notes, 16 (1), 167
DOI 10.1186/s13104-023-06437-5, PubMed 37568187 -
Breeze 2.0: an interactive web-tool for visual analysis and comparison of drug response data
Nucleic Acids Res, 51 (W1), W57-W61
DOI 10.1093/nar/gkad390, PubMed 37178002 -
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
Ann Oncol, 34 (7), 578-588
DOI 10.1016/j.annonc.2023.04.005, PubMed 37100205 -
Applying recommended definition of aggressive prostate cancer: a validation study using high-quality data from the Cancer Registry of Norway
Acta Oncol, 62 (1), 8-14
DOI 10.1080/0284186X.2023.2175331, PubMed 36762472 -
New centres to carry out more clinical trials in Norway
Tidsskr Nor Laegeforen, 143 (2)
DOI 10.4045/tidsskr.22.0722, PubMed 36718905 -
A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer
Nat Commun, 14 (1), 3561
DOI 10.1038/s41467-023-39085-1, PubMed 37322009 -
Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
J Mammary Gland Biol Neoplasia, 28 (1), 17
DOI 10.1007/s10911-023-09544-y, PubMed 37450065 -
Transcriptomic pan-cancer analysis using rank-based Bayesian inference
Mol Oncol, 17 (4), 548-563
DOI 10.1002/1878-0261.13354, PubMed 36562628 -
Resistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities
Br J Cancer, 129 (8), 1212-1224
DOI 10.1038/s41416-023-02361-4, PubMed 37454231 -
Bile acid metabolites in early pregnancy and risk of gestational diabetes mellitus: Results from a prospective cohort study
Diabetes Obes Metab, 25 (8), 2255-2267
DOI 10.1111/dom.15104, PubMed 37161712
Publications 2022
-
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Breast Cancer Res, 24 (1), 2
DOI 10.1186/s13058-021-01484-x, PubMed 34983606 -
What are the current challenges for machine learning in drug discovery and repurposing?
Expert Opin Drug Discov, 17 (5), 423-425
DOI 10.1080/17460441.2022.2050694, PubMed 35255749 -
Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients
Transl Lung Cancer Res, 11 (10), 2064-2078
DOI 10.21037/tlcr-22-236, PubMed 36386450 -
Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway
Cancer Rep (Hoboken), 6 (2), e1736
DOI 10.1002/cnr2.1736, PubMed 36251678 -
ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series
JCO Precis Oncol, 6 (1), e2200015
DOI 10.1200/PO.22.00015, PubMed 35476549 -
Epigenetic alterations at distal enhancers are linked to proliferation in human breast cancer
NAR Cancer, 4 (1), zcac008
DOI 10.1093/narcan/zcac008, PubMed 35350772 -
Computational Pipeline for Rational Drug Combination Screening in Patient-Derived Cells
Methods Mol Biol, 2449, 327-348
DOI 10.1007/978-1-0716-2095-3_14, PubMed 35507270 -
Artificial intelligence for drug response prediction in disease models
Brief Bioinform, 23 (1)
DOI 10.1093/bib/bbab450, PubMed 34655289 -
Circulating T Cell Activation and Exhaustion Markers Are Associated With Radiation Pneumonitis and Poor Survival in Non-Small-Cell Lung Cancer
Front Immunol, 13, 875152
DOI 10.3389/fimmu.2022.875152, PubMed 35911763 -
Corrigendum: Circulating T cell activation and exhaustion markers are associated with radiation pneumonitis and poor survival in non-small-cell lung cancer
Front Immunol, 13, 1051156
DOI 10.3389/fimmu.2022.1051156, PubMed 36263024 -
Comparative analysis of the molecular subtype landscape in canine and human mammary gland tumors
J Mammary Gland Biol Neoplasia, 27 (2), 171-183
DOI 10.1007/s10911-022-09523-9, PubMed 35932380 -
Subtype and cell type specific expression of lncRNAs provide insight into breast cancer
Commun Biol, 5 (1), 834
DOI 10.1038/s42003-022-03559-7, PubMed 35982125 -
Improvements in survival for patients with stage IV adenocarcinoma in the lung, diagnosed between 2010 - 2020 - A population-based registry study from Norway
Front Oncol, 12, 1017902
DOI 10.3389/fonc.2022.1017902, PubMed 36523970 -
Circulating tumour DNA and its clinical utility in predicting treatment response or survival in patients with metastatic colorectal cancer: a systematic review and meta-analysis
Br J Cancer, 127 (3), 500-513
DOI 10.1038/s41416-022-01816-4, PubMed 35440666 -
Circulating DNA in patients undergoing loco-regional treatment of colorectal cancer metastases: a systematic review and meta-analysis
Ther Adv Med Oncol, 14, 17588359221133171
DOI 10.1177/17588359221133171, PubMed 36339929 -
Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers
Nucleic Acids Res, 50 (21), 12131-12148
DOI 10.1093/nar/gkac1143, PubMed 36477895 -
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
Mol Oncol, 17 (1), 173-187
DOI 10.1002/1878-0261.13345, PubMed 36408734 -
Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells
Sci Rep, 12 (1), 13796
DOI 10.1038/s41598-022-18118-7, PubMed 35963891 -
Development of a High-Affinity Antibody against the Tumor-Specific and Hyperactive 611-p95HER2 Isoform
Cancers (Basel), 14 (19)
DOI 10.3390/cancers14194859, PubMed 36230782 -
Osimertinib in non-small cell lung cancer with uncommon EGFR-mutations: a post-hoc subgroup analysis with pooled data from two phase II clinical trials
Transl Lung Cancer Res, 11 (6), 953-963
DOI 10.21037/tlcr-21-995, PubMed 35832438 -
Rank-based Bayesian variable selection for genome-wide transcriptomic analyses
Stat Med, 41 (23), 4532-4553
DOI 10.1002/sim.9524, PubMed 35844145 -
Functional precision cancer medicine: drug sensitivity screening enabled by cell culture models
Trends Pharmacol Sci, 43 (11), 973-985
DOI 10.1016/j.tips.2022.08.009, PubMed 36163057 -
Treatment Characteristics and Real-World Progression-Free Survival in Patients With Unresectable Stage III NSCLC Who Received Durvalumab After Chemoradiotherapy: Findings From the PACIFIC-R Study
J Thorac Oncol, 18 (2), 181-193
DOI 10.1016/j.jtho.2022.10.003, PubMed 36307040 -
[Checkpoint inhibitor-induced myocarditis]
Tidsskr Nor Laegeforen, 142 (18)
DOI 10.4045/tidsskr.21.0817, PubMed 36511752 -
Tumor microenvironment as a metapopulation model: The effects of angiogenesis, emigration and treatment modalities
J Theor Biol, 545, 111147
DOI 10.1016/j.jtbi.2022.111147, PubMed 35489642 -
EGFR-mutation testing and TKI treatment patterns in locally advanced and metastatic NSCLC in Norway - A nationwide retrospective cohort study
Cancer Treat Res Commun, 33, 100636
DOI 10.1016/j.ctarc.2022.100636, PubMed 36155129 -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 225
DOI 10.1186/s12967-022-03432-5, PubMed 35568909 -
Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
J Transl Med, 20 (1), 317
DOI 10.1186/s12967-022-03518-0, PubMed 35841045 -
Incidence of breast cancer subtypes in immigrant and non-immigrant women in Norway
Breast Cancer Res, 24 (1), 4
DOI 10.1186/s13058-021-01498-5, PubMed 35012613 -
Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses-the ComIT-1 trial
Mol Oncol, 17 (3), 487-498
DOI 10.1002/1878-0261.13330, PubMed 36330681 -
Fully-automated and ultra-fast cell-type identification using specific marker combinations from single-cell transcriptomic data
Nat Commun, 13 (1), 1246
DOI 10.1038/s41467-022-28803-w, PubMed 35273156 -
SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples
Nucleic Acids Res, 50 (W1), W739-W743
DOI 10.1093/nar/gkac382, PubMed 35580060 -
Epigenome-wide three-way interaction study identifies a complex pattern between TRIM27, KIAA0226, and smoking associated with overall survival of early-stage NSCLC
Mol Oncol, 16 (3), 717-731
DOI 10.1002/1878-0261.13167, PubMed 34932879 -
Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma
Front Oncol, 12, 873532
DOI 10.3389/fonc.2022.873532, PubMed 35574381 -
An immunity and pyroptosis gene-pair signature predicts overall survival in acute myeloid leukemia
Leukemia, 36 (10), 2384-2395
DOI 10.1038/s41375-022-01662-6, PubMed 35945345 -
Systematic review of computational methods for drug combination prediction
Comput Struct Biotechnol J, 20, 2807-2814
DOI 10.1016/j.csbj.2022.05.055, PubMed 35685365 -
Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer
Cancers (Basel), 14 (14)
DOI 10.3390/cancers14143430, PubMed 35884490 -
Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Cancer Discov, 12 (12), 2930-2953
DOI 10.1158/2159-8290.CD-21-0865, PubMed 36108220 -
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers
Epigenetics Chromatin, 15 (1), 13
DOI 10.1186/s13072-022-00444-9, PubMed 35440061 -
PHLPP1 regulates CFTR activity and lumen expansion through AMPK
Development, 149 (20)
DOI 10.1242/dev.200955, PubMed 35997536 -
A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
Front Oncol, 12, 1031232
DOI 10.3389/fonc.2022.1031232, PubMed 36439452 -
Quantification of Tumor Hypoxia through Unsupervised Modelling of Consumption and Supply Hypoxia MR Imaging in Breast Cancer
Cancers (Basel), 14 (5)
DOI 10.3390/cancers14051326, PubMed 35267636 -
Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma
Br J Cancer, 128 (4), 678-690
DOI 10.1038/s41416-022-02067-z, PubMed 36476658 -
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
Breast Cancer Res, 24 (1), 43
DOI 10.1186/s13058-022-01537-9, PubMed 35751095 -
Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2-host protein-protein interaction network
Brief Bioinform, 23 (6)
DOI 10.1093/bib/bbac456, PubMed 36305426 -
Cost-effectiveness of molecularly matched off-label therapies for end-stage cancer - the MetAction precision medicine study
Acta Oncol, 61 (8), 955-962
DOI 10.1080/0284186X.2022.2098053, PubMed 35943168 -
Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy
Front Oncol, 12, 1016958
DOI 10.3389/fonc.2022.1016958, PubMed 36531044 -
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Cancer Res Commun, 2 (6), 434-446
DOI 10.1158/2767-9764.CRC-21-0100, PublikaID 411 -
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Cancer Res Commun, 2 (6), 434-446
DOI 10.1158/2767-9764.CRC-21-0100, PubMed 36923555 -
Evaluation of statistical approaches for association testing in noisy drug screening data
BMC Bioinformatics, 23 (1), 188
DOI 10.1186/s12859-022-04693-z, PubMed 35585485 -
RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
NPJ Breast Cancer, 8 (1), 94
DOI 10.1038/s41523-022-00465-3, PubMed 35974007 -
A national precision cancer medicine implementation initiative for Norway
Nat Med, 28 (5), 885-887
DOI 10.1038/s41591-022-01777-4, PubMed 35513529 -
Serum RNAs can predict lung cancer up to 10 years prior to diagnosis
Elife, 11
DOI 10.7554/eLife.71035, PubMed 35147498 -
Target-specific compound selectivity for multi-target drug discovery and repurposing
Front Pharmacol, 13, 1003480
DOI 10.3389/fphar.2022.1003480, PubMed 36225560 -
Final efficacy and safety data, and exploratory molecular profiling from the phase III ALUR study of alectinib versus chemotherapy in crizotinib-pretreated ALK-positive non-small-cell lung cancer
ESMO Open, 7 (1), 100333
DOI 10.1016/j.esmoop.2021.100333, PubMed 35042152 -
NRF2 drives an oxidative stress response predictive of breast cancer
Free Radic Biol Med, 184, 170-184
DOI 10.1016/j.freeradbiomed.2022.03.029, PubMed 35381325 -
Functional Testing to Characterize and Stratify PI3K Inhibitor Responses in Chronic Lymphocytic Leukemia
Clin Cancer Res, 28 (20), 4444-4455
DOI 10.1158/1078-0432.CCR-22-1221, PubMed 35998013 -
Tissue-specific identification of multi-omics features for pan-cancer drug response prediction
iScience, 25 (8), 104767
DOI 10.1016/j.isci.2022.104767, PubMed 35992090 -
EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets
Bioinform Adv, 2 (1), vbac073
DOI 10.1093/bioadv/vbac073, PubMed 36699400
Publications 2021
-
Re-defining synthetic lethality by phenotypic profiling for precision oncology
Cell Chem Biol, 28 (3), 246-256
DOI 10.1016/j.chembiol.2021.01.026, PubMed 33631125 -
Crosstalk between microRNA expression and DNA methylation drives the hormone-dependent phenotype of breast cancer
Genome Med, 13 (1), 72
DOI 10.1186/s13073-021-00880-4, PubMed 33926515 -
Lack of cross-resistance between non-steroidal and steroidal aromatase inhibitors in breast cancer patients: the potential role of the adipokine leptin
Breast Cancer Res Treat, 190 (3), 435-449
DOI 10.1007/s10549-021-06399-x, PubMed 34554372 -
Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
Am J Hum Genet, 108 (7), 1190-1203
DOI 10.1016/j.ajhg.2021.05.013, PubMed 34146516 -
miRNA normalization enables joint analysis of several datasets to increase sensitivity and to reveal novel miRNAs differentially expressed in breast cancer
PLoS Comput Biol, 17 (2), e1008608
DOI 10.1371/journal.pcbi.1008608, PubMed 33566819 -
Lung Function After Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer, Changes and Predictive Markers
Front Oncol, 11, 674731
DOI 10.3389/fonc.2021.674731, PubMed 34109123 -
Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174456, PubMed 34503266 -
Whole genome copy number analyses reveal a highly aberrant genome in TP53 mutant lung adenocarcinoma tumors
BMC Cancer, 21 (1), 1089
DOI 10.1186/s12885-021-08811-7, PubMed 34625038 -
Improved adaptive radiotherapy to adjust for anatomical alterations during curative treatment for locally advanced lung cancer
Phys Imaging Radiat Oncol, 18, 51-54
DOI 10.1016/j.phro.2021.04.003, PubMed 34258408 -
Breast Cancer Risk Genes - Association Analysis in More than 113,000 Women
N Engl J Med, 384 (5), 428-439
DOI 10.1056/NEJMoa1913948, PubMed 33471991 -
Machine Learning of Bone Marrow Histopathology Identifies Genetic and Clinical Determinants in Patients with MDS
Blood Cancer Discov, 2 (3), 238-249
DOI 10.1158/2643-3230.BCD-20-0162, PubMed 34661156 -
Crowdsourced mapping of unexplored target space of kinase inhibitors
Nat Commun, 12 (1), 3307
DOI 10.1038/s41467-021-23165-1, PubMed 34083538 -
Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study
Acta Oncol, 60 (12), 1565-1571
DOI 10.1080/0284186X.2021.1973092, PubMed 34486915 -
Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation
Proc Natl Acad Sci U S A, 118 (45)
DOI 10.1073/pnas.2100050118, PubMed 34737229 -
[Immunotherapy for malignant pleural mesothelioma]
Tidsskr Nor Laegeforen, 141
DOI 10.4045/tidsskr.21.0503, PubMed 34505475 -
Immunotherapy in malignant pleural mesothelioma
Tidsskr. Nor. Laegeforen., 141 (12), 1167-1169 -
Circadian PERformance in breast cancer: a germline and somatic genetic study of PER3VNTR polymorphisms and gene co-expression
NPJ Breast Cancer, 7 (1), 118
DOI 10.1038/s41523-021-00329-2, PubMed 34508103 -
The Immune Landscape of Human Primary Lung Tumors Is Th2 Skewed
Front Immunol, 12, 764596
DOI 10.3389/fimmu.2021.764596, PubMed 34868011 -
Efficient gene expression signature for a breast cancer immuno-subtype
PLoS One, 16 (1), e0245215
DOI 10.1371/journal.pone.0245215, PubMed 33434192 -
Clinicopathological factors associated with tumour-specific mutation detection in plasma of patients with RAS-mutated or BRAF-mutated metastatic colorectal cancer
Int J Cancer, 149 (6), 1385-1397
DOI 10.1002/ijc.33672, PubMed 33961700 -
Survival Trends of Right- and Left-Sided Colon Cancer across Four Decades: A Norwegian Population-Based Study
Cancer Epidemiol Biomarkers Prev, 31 (2), 342-351
DOI 10.1158/1055-9965.EPI-21-0555, PubMed 34853022 -
Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers
JCO Precis Oncol, 5
DOI 10.1200/PO.20.00086, PubMed 34036235 -
Characterizing the Quality of Insight by Interactions: A Case Study
IEEE Trans Vis Comput Graph, 27 (8), 3410-3424
DOI 10.1109/TVCG.2020.2977634, PubMed 32142444 -
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs
Antimicrob Agents Chemother, 65 (4)
DOI 10.1128/AAC.01146-20, PubMed 33468464 -
Erratum for Herring et al., "Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs"
Antimicrob Agents Chemother, 65 (6)
DOI 10.1128/AAC.00653-21, PubMed 34006613 -
NIPU: a randomised, open-label, phase II study evaluating nivolumab and ipilimumab combined with UV1 vaccination as second line treatment in patients with malignant mesothelioma
J Transl Med, 19 (1), 232
DOI 10.1186/s12967-021-02905-3, PubMed 34059094 -
Patient-tailored design for selective co-inhibition of leukemic cell subpopulations
Sci Adv, 7 (8)
DOI 10.1126/sciadv.abe4038, PubMed 33608276 -
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Mol Syst Biol, 17 (3), e9526
DOI 10.15252/msb.20209526, PubMed 33750001 -
The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2+ breast cancer
JCI Insight, 6 (11)
DOI 10.1172/jci.insight.147617, PubMed 33886505 -
COVID-19 in Cancer Patients, Risk Factors for Disease and Adverse Outcome, a Population-Based Study From Norway
Front Oncol, 11, 652535
DOI 10.3389/fonc.2021.652535, PubMed 33842366 -
In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study
Breast Cancer Res, 23 (1), 17
DOI 10.1186/s13058-021-01393-z, PubMed 33526044 -
Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer
Sci Rep, 11 (1), 3388
DOI 10.1038/s41598-021-81914-0, PubMed 33564016 -
A scalable solver for a stochastic, hybrid cellular automaton model of personalized breast cancer therapy
Int J Numer Method Biomed Eng, 38 (1), e3542
DOI 10.1002/cnm.3542, PubMed 34716985 -
Proteogenomics of non-small cell lung cancer reveals molecular subtypes associated with specific therapeutic targets and immune evasion mechanisms
Nat Cancer, 2 (11), 1224-1242
DOI 10.1038/s43018-021-00259-9, PubMed 34870237 -
Assessing heterogeneity in spatial data using the HTA index with applications to spatial transcriptomics and imaging
Bioinformatics, 37 (21), 3796-3804
DOI 10.1093/bioinformatics/btab569, PubMed 34358288 -
Sample Preparation Approach Influences PAM50 Risk of Recurrence Score in Early Breast Cancer
Cancers (Basel), 13 (23)
DOI 10.3390/cancers13236118, PubMed 34885228 -
Can breast cancer be stopped? Modifiable risk factors of breast cancer among women with a prior benign or premalignant lesion
Int J Cancer, 149 (6), 1247-1256
DOI 10.1002/ijc.33680, PubMed 33990967 -
Tailored graphical lasso for data integration in gene network reconstruction
BMC Bioinformatics, 22 (1), 498
DOI 10.1186/s12859-021-04413-z, PubMed 34654363 -
Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia
Cancer Discov, 12 (2), 388-401
DOI 10.1158/2159-8290.CD-21-0410, PubMed 34789538 -
Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment
Breast Cancer Res, 23 (1), 86
DOI 10.1186/s13058-021-01450-7, PubMed 34407845 -
Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis
Crit Rev Oncol Hematol, 161, 103312
DOI 10.1016/j.critrevonc.2021.103312, PubMed 33794308 -
Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma
Sci Rep, 11 (1), 6317
DOI 10.1038/s41598-021-85613-8, PubMed 33737576 -
Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?
Cancers (Basel), 13 (10)
DOI 10.3390/cancers13102370, PubMed 34069208 -
Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression
Mol Oncol, 16 (1), 88-103
DOI 10.1002/1878-0261.13047, PubMed 34165864 -
Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling
Cancers (Basel), 13 (4)
DOI 10.3390/cancers13040927, PubMed 33672199 -
Artificial intelligence, machine learning, and drug repurposing in cancer
Expert Opin Drug Discov, 16 (9), 977-989
DOI 10.1080/17460441.2021.1883585, PubMed 33543671 -
High-throughput proteomics of breast cancer interstitial fluid: identification of tumor subtype-specific serologically relevant biomarkers
Mol Oncol, 15 (2), 429-461
DOI 10.1002/1878-0261.12850, PubMed 33176066 -
Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia
J Med Chem, 64 (12), 8486-8509
DOI 10.1021/acs.jmedchem.1c00420, PubMed 34101461 -
The Prognostic Effect of KRAS Mutations in Non-Small Cell Lung Carcinoma Revisited: A Norwegian Multicentre Study
Cancers (Basel), 13 (17)
DOI 10.3390/cancers13174294, PubMed 34503114 -
Modeling drug combination effects via latent tensor reconstruction
Bioinformatics, 37 (Suppl_1), i93-i101
DOI 10.1093/bioinformatics/btab308, PubMed 34252952 -
Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia
NPJ Precis Oncol, 5 (1), 71
DOI 10.1038/s41698-021-00209-9, PubMed 34302041 -
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses
mBio, 12 (6), e0334721
DOI 10.1128/mbio.03347-21, PubMed 34933447 -
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses
mBio, 12 (6), e03347-21 -
Multi-Omics Marker Analysis Enables Early Prediction of Breast Tumor Progression
Front Genet, 12, 670749
DOI 10.3389/fgene.2021.670749, PubMed 34149812 -
Dynamic changes in the T cell receptor repertoire during treatment with radiotherapy combined with an immune checkpoint inhibitor
Mol Oncol, 15 (11), 2958-2968
DOI 10.1002/1878-0261.13082, PubMed 34402187 -
Ipilimumab in a real-world population: A prospective Phase IV trial with long-term follow-up
Int J Cancer, 150 (1), 100-111
DOI 10.1002/ijc.33768, PubMed 34449877
Publications 2020
-
Radiotherapy-related lymphopenia in patients with advanced non-small cell lung cancer receiving palliative radiotherapy
Clin Transl Radiat Oncol, 22, 15-21
DOI 10.1016/j.ctro.2020.02.005, PubMed 32181373 -
Improved detection of differentially represented DNA barcodes for high-throughput clonal phenomics
Mol Syst Biol, 16 (3), e9195
DOI 10.15252/msb.20199195, PubMed 32187448 -
A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Med, 2 (2), 180-195.e5
DOI 10.1016/j.medj.2020.10.006, PubMed 35590201 -
Comparable cancer-relevant mutation profiles in synchronous ductal carcinoma in situ and invasive breast cancer
Cancer Rep (Hoboken), 3 (3), e1248
DOI 10.1002/cnr2.1248, PubMed 32671987 -
Contrasting DCIS and invasive breast cancer by subtype suggests basal-like DCIS as distinct lesions
NPJ Breast Cancer, 6, 26
DOI 10.1038/s41523-020-0167-x, PubMed 32577501 -
Lung cancer: Improved prognosis presents capacity challenges
Tidsskr. Nor. Laegeforen., 140 (5), 432-434 -
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
Aging (Albany NY), 12 (11), 10642-10662
DOI 10.18632/aging.103284, PubMed 32511103 -
MiR-18a and miR-18b are expressed in the stroma of oestrogen receptor alpha negative breast cancers
BMC Cancer, 20 (1), 377
DOI 10.1186/s12885-020-06857-7, PubMed 32370743 -
Osimertinib in T790M-positive and -negative patients with EGFR-mutated advanced non-small cell lung cancer (the TREM-study)
Lung Cancer, 143, 27-35
DOI 10.1016/j.lungcan.2020.03.009, PubMed 32200138 -
AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer
iScience, 23 (11), 101649
DOI 10.1016/j.isci.2020.101649, PubMed 33103086 -
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis
Nat Commun, 11 (1), 312
DOI 10.1038/s41467-019-14100-6, PubMed 31949161 -
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes
Nat Genet, 52 (1), 56-73
DOI 10.1038/s41588-019-0537-1, PubMed 31911677 -
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status
Genet Epidemiol, 44 (5), 442-468
DOI 10.1002/gepi.22288, PubMed 32115800 -
JASPAR 2020: update of the open-access database of transcription factor binding profiles
Nucleic Acids Res, 48 (D1), D87-D92
DOI 10.1093/nar/gkz1001, PubMed 31701148 -
Re-definition of claudin-low as a breast cancer phenotype
Nat Commun, 11 (1), 1787
DOI 10.1038/s41467-020-15574-5, PubMed 32286297 -
Antibody combinations for optimized staining of macrophages in human lung tumours
Scand J Immunol, 92 (1), e12889
DOI 10.1111/sji.12889, PubMed 32299134 -
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D132-D141
DOI 10.1093/nar/gkz885, PubMed 31598695 -
MirGeneDB 2.0: the metazoan microRNA complement
Nucleic Acids Res, 48 (D1), D1172
DOI 10.1093/nar/gkz1016, PubMed 31642479 -
Distribution of allele frequencies for genes associated with physical activity and/or physical capacity in a homogenous Norwegian cohort- a cross-sectional study
BMC Genet, 21 (1), 8
DOI 10.1186/s12863-020-0813-1, PubMed 31973699 -
Modeling molecular development of breast cancer in canine mammary tumors
Genome Res, 31 (2), 337-347
DOI 10.1101/gr.256388.119, PubMed 33361113 -
Protein Kinase C Isozymes Associated With Relapse Free Survival in Non-Small Cell Lung Cancer Patients
Front Oncol, 10, 590755
DOI 10.3389/fonc.2020.590755, PubMed 33324562 -
Radiological review of prior screening mammograms of screen-detected breast cancer
Eur Radiol, 31 (4), 2568-2579
DOI 10.1007/s00330-020-07130-y, PubMed 33001307 -
Molecular characterisation of TP53 mutated squamous cell carcinomas of the lung to identify putative targets for therapy
Int J Cancer, 147 (10), 2957-2966
DOI 10.1002/ijc.33121, PubMed 32468587 -
SynergyFinder 2.0: visual analytics of multi-drug combination synergies
Nucleic Acids Res, 48 (W1), W488-W493
DOI 10.1093/nar/gkaa216, PubMed 32246720 -
Pan-cancer analysis of whole genomes
Nature, 578 (7793), 82-93
DOI 10.1038/s41586-020-1969-6, PubMed 32025007 -
Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
Mol Oncol, 14 (11), 2759-2774
DOI 10.1002/1878-0261.12785, PubMed 33448640 -
Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects
Nat Commun, 11 (1), 6136
DOI 10.1038/s41467-020-19950-z, PubMed 33262326 -
The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
Sci Rep, 10 (1), 1277
DOI 10.1038/s41598-020-57759-4, PubMed 31992741 -
Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk
Am J Hum Genet, 107 (5), 837-848
DOI 10.1016/j.ajhg.2020.09.001, PubMed 33022221 -
ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer
J Transl Med, 18 (1), 269
DOI 10.1186/s12967-020-02421-w, PubMed 32620163 -
Multicenter Evaluation of Circulating Cell-Free DNA Extraction and Downstream Analyses for the Development of Standardized (Pre)analytical Work Flows
Clin Chem, 66 (1), 149-160
DOI 10.1373/clinchem.2019.306837, PubMed 31628139 -
Spatial transcriptomics inferred from pathology whole-slide images links tumor heterogeneity to survival in breast and lung cancer
Sci Rep, 10 (1), 18802
DOI 10.1038/s41598-020-75708-z, PubMed 33139755 -
KIT pathway upregulation predicts dasatinib efficacy in acute myeloid leukemia
Leukemia, 34 (10), 2780-2784
DOI 10.1038/s41375-020-0978-7, PubMed 32678289 -
DNA copy number motifs are strong and independent predictors of survival in breast cancer
Commun Biol, 3 (1), 153
DOI 10.1038/s42003-020-0884-6, PubMed 32242091 -
Multiobjective optimization identifies cancer-selective combination therapies
PLoS Comput Biol, 16 (12), e1008538
DOI 10.1371/journal.pcbi.1008538, PubMed 33370253 -
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
Acta Oncol, 59 (7), 733-740
DOI 10.1080/0284186X.2020.1742377, PubMed 32208873 -
Modern surgical treatment of breast cancer
Ann Med Surg (Lond), 56, 95-107
DOI 10.1016/j.amsu.2020.06.016, PubMed 32637082 -
Future perspectives of surgical treatment of breast cancer
Ann Med Surg (Lond), 59, 93-95
DOI 10.1016/j.amsu.2020.09.021, PubMed 33005399 -
Clinical trials in the era of precision cancer medicine - for the few or for the many?
Acta Oncol, 59 (7), 731-732
DOI 10.1080/0284186X.2020.1777582, PubMed 32579040 -
The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases
Scand J Immunol, 92 (2), e12893
DOI 10.1111/sji.12893, PubMed 32433774 -
Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration
Breast Cancer Res, 22 (1), 73
DOI 10.1186/s13058-020-01295-6, PubMed 32605588 -
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
Oncoimmunology, 9 (1), 1824644
DOI 10.1080/2162402X.2020.1824644, PubMed 33457104 -
A 10-year prediagnostic follow-up study shows that serum RNA signals are highly dynamic in lung carcinogenesis
Mol Oncol, 14 (2), 235-247
DOI 10.1002/1878-0261.12620, PubMed 31851411 -
Immune phenotype of tumor microenvironment predicts response to bevacizumab in neoadjuvant treatment of ER-positive breast cancer
Int J Cancer, 147 (9), 2515-2525
DOI 10.1002/ijc.33108, PubMed 32488909 -
Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer
Comput Struct Biotechnol J, 18, 3819-3832
DOI 10.1016/j.csbj.2020.11.001, PubMed 33335681 -
Technical Evaluation of Commercial Mutation Analysis Platforms and Reference Materials for Liquid Biopsy Profiling
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061588, PubMed 32560092 -
Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer
Clin Lung Cancer, 22 (4), e555-e562
DOI 10.1016/j.cllc.2020.09.018, PubMed 33214079 -
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses
Nat Genet, 52 (6), 572-581
DOI 10.1038/s41588-020-0609-2, PubMed 32424353 -
Independent Validation of Early-Stage Non-Small Cell Lung Cancer Prognostic Scores Incorporating Epigenetic and Transcriptional Biomarkers With Gene-Gene Interactions and Main Effects
Chest, 158 (2), 808-819
DOI 10.1016/j.chest.2020.01.048, PubMed 32113923 -
Subtype-specific transcriptional regulators in breast tumors subjected to genetic and epigenetic alterations
Bioinformatics, 36 (4), 994-999
DOI 10.1093/bioinformatics/btz709, PubMed 31529022 -
Immune checkpoint blockade in the treatment of advanced non-small cell lung cancer - predictors of response and impact of previous radiotherapy
Acta Oncol, 60 (2), 149-156
DOI 10.1080/0284186X.2020.1854851, PubMed 33356733
Publications 2019
-
Mapping Bone Marrow Response in the Vertebral Column by Positron Emission Tomography Following Radiotherapy and Erlotinib Therapy of Lung Cancer
Mol Imaging Biol, 21 (2), 391-398
DOI 10.1007/s11307-018-1226-7, PubMed 29916117 -
A Longitudinal Study of the Association between Mammographic Density and Gene Expression in Normal Breast Tissue
J Mammary Gland Biol Neoplasia, 24 (2), 163-175
DOI 10.1007/s10911-018-09423-x, PubMed 30613869 -
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128 -
Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation
Nat Commun, 10 (1), 1749
DOI 10.1038/s41467-019-09828-0, PubMed 30988298 -
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 10 (1), 525
DOI 10.1038/s41467-019-08512-7, PubMed 30692535 -
Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma
Aging (Albany NY), 11 (16), 6312-6335
DOI 10.18632/aging.102189, PubMed 31434796 -
Two truncating variants in FANCC and breast cancer risk
Sci Rep, 9 (1), 12524
DOI 10.1038/s41598-019-48804-y, PubMed 31467304 -
Genome-wide association study of germline variants and breast cancer-specific mortality
Br J Cancer, 120 (6), 647-657
DOI 10.1038/s41416-019-0393-x, PubMed 30787463 -
Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer
Nat Commun, 10 (1), 1741
DOI 10.1038/s41467-018-08053-5, PubMed 30988301 -
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111 -
Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers
Breast Cancer Res, 21 (1), 85
DOI 10.1186/s13058-019-1170-8, PubMed 31366361 -
A map of direct TF-DNA interactions in the human genome
Nucleic Acids Res, 47 (4), e21
DOI 10.1093/nar/gky1210, PubMed 30517703 -
A map of direct TF-DNA interactions in the human genome
Nucleic Acids Res, 47 (14), 7715
DOI 10.1093/nar/gkz582, PubMed 31251803 -
Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis
BMC Genomics, 20 (1), 718
DOI 10.1186/s12864-019-6063-9, PubMed 31533632 -
Identification of microRNAs involved in pathways which characterize the expression subtypes of NSCLC
Mol Oncol, 13 (12), 2604-2615
DOI 10.1002/1878-0261.12571, PubMed 31505091 -
Total circulating cell-free DNA as a prognostic biomarker in metastatic colorectal cancer before first-line oxaliplatin-based chemotherapy
Ann Oncol, 30 (7), 1088-1095
DOI 10.1093/annonc/mdz139, PubMed 31046124 -
High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
Theranostics, 9 (8), 2183-2197
DOI 10.7150/thno.30834, PubMed 31149037 -
Shared heritability and functional enrichment across six solid cancers
Nat Commun, 10 (1), 431
DOI 10.1038/s41467-018-08054-4, PubMed 30683880 -
Publisher Correction: Shared heritability and functional enrichment across six solid cancers
Nat Commun, 10 (1), 4386
DOI 10.1038/s41467-019-12095-8, PubMed 31548585 -
Breast cancer quantitative proteome and proteogenomic landscape
Nat Commun, 10 (1), 1600
DOI 10.1038/s41467-019-09018-y, PubMed 30962452 -
Microvessel density in breast cancer: the impact of field area on prognostic informativeness
J Clin Pathol, 72 (4), 304-310
DOI 10.1136/jclinpath-2018-205536, PubMed 30630872 -
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Cancer Res, 79 (16), 4293-4304
DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201 -
A Computational Framework for Genome-wide Characterization of the Human Disease Landscape
Cell Syst, 8 (2), 152-162.e6
DOI 10.1016/j.cels.2018.12.010, PubMed 30685436 -
miR-342-5p as a Potential Regulator of HER2 Breast Cancer Cell Growth
Microrna, 8 (2), 155-165
DOI 10.2174/2211536608666181206124922, PubMed 30520388 -
miRNA expression changes during the course of neoadjuvant bevacizumab and chemotherapy treatment in breast cancer
Mol Oncol, 13 (10), 2278-2296
DOI 10.1002/1878-0261.12561, PubMed 31402562 -
Historical Biobanks in Breast Cancer Metabolomics- Challenges and Opportunities
Metabolites, 9 (11)
DOI 10.3390/metabo9110278, PubMed 31766128 -
TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer
J Natl Cancer Inst, 111 (11), 1202-1215
DOI 10.1093/jnci/djz051, PubMed 30990221 -
Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Int J Cancer, 146 (1), 223-235
DOI 10.1002/ijc.32638, PubMed 31444972 -
GLI1-induced mammary gland tumours are transplantable and maintain major molecular features
Int J Cancer, 146 (4), 1125-1138
DOI 10.1002/ijc.32522, PubMed 31219615 -
PathTracer: High-sensitivity detection of differential pathway activity in tumours
Sci Rep, 9 (1), 16332
DOI 10.1038/s41598-019-52529-3, PubMed 31704995 -
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
Cell Rep, 29 (13), 4389-4406.e10
DOI 10.1016/j.celrep.2019.11.085, PubMed 31875548 -
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006 -
Meta-Analysis of 1,200 Transcriptomic Profiles Identifies a Prognostic Model for Pancreatic Ductal Adenocarcinoma
JCO Clin Cancer Inform, 3, 1-16
DOI 10.1200/CCI.18.00102, PubMed 31070984 -
EMT network-based feature selection improves prognosis prediction in lung adenocarcinoma
PLoS One, 14 (1), e0204186
DOI 10.1371/journal.pone.0204186, PubMed 30703089 -
Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis
Int J Epidemiol, 48 (3), 795-806
DOI 10.1093/ije/dyy201, PubMed 30277539 -
The circular RNome of primary breast cancer
Genome Res, 29 (3), 356-366
DOI 10.1101/gr.238121.118, PubMed 30692147 -
Immune Cell Composition in Human Non-small Cell Lung Cancer
Front Immunol, 9, 3101
DOI 10.3389/fimmu.2018.03101, PubMed 30774636 -
A clinico-molecular predictor identifies follicular lymphoma patients at risk of early transformation after first-line immunotherapy
Haematologica, 104 (10), e460-e464
DOI 10.3324/haematol.2018.209080, PubMed 30846496 -
A Bayesian two-way latent structure model for genomic data integration reveals few pan-genomic cluster subtypes in a breast cancer cohort
Bioinformatics, 35 (23), 4886-4897
DOI 10.1093/bioinformatics/btz381, PubMed 31077301 -
Simulated ablation for detection of cells impacting paracrine signalling in histology analysis
Math Med Biol, 36 (1), 93-112
DOI 10.1093/imammb/dqx022, PubMed 29452382 -
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750 -
Development of high‑resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma
Oncol Rep, 42 (2), 763-774
DOI 10.3892/or.2019.7186, PubMed 31173253 -
SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis
Mol Oncol, 13 (5), 1235-1248
DOI 10.1002/1878-0261.12482, PubMed 30924596 -
EGLN2 DNA methylation and expression interact with HIF1A to affect survival of early-stage NSCLC
Epigenetics, 14 (2), 118-129
DOI 10.1080/15592294.2019.1573066, PubMed 30665327 -
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery
Mol Oncol, 13 (5), 1166-1179
DOI 10.1002/1878-0261.12475, PubMed 30854794
Publications 2018
-
Levels and prognostic impact of circulating markers of inflammation, endothelial activation and extracellular matrix remodelling in patients with lung cancer and chronic obstructive pulmonary disease
BMC Cancer, 18 (1), 739
DOI 10.1186/s12885-018-4659-0, PubMed 30005623 -
ReMap 2018: an updated atlas of regulatory regions from an integrative analysis of DNA-binding ChIP-seq experiments
Nucleic Acids Res, 46 (D1), D267-D275
DOI 10.1093/nar/gkx1092, PubMed 29126285 -
Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 9 (1), 5397
DOI 10.1038/s41467-018-07842-2, PubMed 30559362 -
Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy
Adv Radiat Oncol, 3 (2), 130-138
DOI 10.1016/j.adro.2017.12.007, PubMed 29904737 -
Number of Risky Lifestyle Behaviors and Breast Cancer Risk
JNCI Cancer Spectr, 2 (3), pky030
DOI 10.1093/jncics/pky030, PubMed 31360858 -
MANTA2, update of the Mongo database for the analysis of transcription factor binding site alterations
Sci Data, 5, 180141
DOI 10.1038/sdata.2018.141, PubMed 30040077 -
Atezolizumab Treatment Beyond Progression in Advanced NSCLC: Results From the Randomized, Phase III OAK Study
J Thorac Oncol, 13 (12), 1906-1918
DOI 10.1016/j.jtho.2018.08.2027, PubMed 30217492 -
Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers
Ann Oncol, 29 (11), 2223-2231
DOI 10.1093/annonc/mdy404, PubMed 30252041 -
DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients
Cancer Epidemiol Biomarkers Prev, 27 (12), 1527-1535
DOI 10.1158/1055-9965.EPI-18-0454, PubMed 30185536 -
Circulating microRNAs associated with prolonged overall survival in lung cancer patients treated with nivolumab
Acta Oncol, 57 (9), 1225-1231
DOI 10.1080/0284186X.2018.1465585, PubMed 29683761 -
Groundbreaking basic research
Tidsskr. Nor. Laegeforen., 138 (20), 1905 -
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
Genome Med, 10 (1), 92
DOI 10.1186/s13073-018-0601-y, PubMed 30497530 -
Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics
Oncoimmunology, 8 (2), e1537691
DOI 10.1080/2162402X.2018.1537691, PubMed 30713794 -
Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab
Oncoimmunology, 7 (11), e1457598
DOI 10.1080/2162402X.2018.1457598, PubMed 30377556 -
Correction to: A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 18 (1), 80
DOI 10.1186/s12885-017-3766-7, PubMed 29338700 -
JASPAR 2018: update of the open-access database of transcription factor binding profiles and its web framework
Nucleic Acids Res, 46 (D1), D1284
DOI 10.1093/nar/gkx1188, PubMed 29161433 -
Super-enhancers are transcriptionally more active and cell type-specific than stretch enhancers
Epigenetics, 13 (9), 910-922
DOI 10.1080/15592294.2018.1514231, PubMed 30169995 -
Put science first and formatting later
EMBO Rep, 19 (5)
DOI 10.15252/embr.201845731, PubMed 29650529 -
Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response
Genetics, 209 (4), 1055-1071
DOI 10.1534/genetics.118.301116, PubMed 29871881 -
Enrichment of methylated molecules using enhanced-ice-co-amplification at lower denaturation temperature-PCR (E-ice-COLD-PCR) for the sensitive detection of disease-related hypermethylation
Epigenomics, 10 (5), 525-537
DOI 10.2217/epi-2017-0166, PubMed 29697281 -
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes
Am J Hum Genet, 104 (1), 21-34
DOI 10.1016/j.ajhg.2018.11.002, PubMed 30554720 -
Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome
Brain Behav Immun, 76, 82-96
DOI 10.1016/j.bbi.2018.11.008, PubMed 30419269 -
The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology
Biol Res, 51 (1), 3
DOI 10.1186/s40659-017-0151-6, PubMed 29316982 -
Alectinib versus chemotherapy in crizotinib-pretreated anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer: results from the phase III ALUR study
Ann Oncol, 29 (6), 1409-1416
DOI 10.1093/annonc/mdy121, PubMed 29668860 -
Identification of nine new susceptibility loci for endometrial cancer
Nat Commun, 9 (1), 3166
DOI 10.1038/s41467-018-05427-7, PubMed 30093612 -
Genetic overlap between endometriosis and endometrial cancer: evidence from cross-disease genetic correlation and GWAS meta-analyses
Cancer Med, 7 (5), 1978-1987
DOI 10.1002/cam4.1445, PubMed 29608257 -
Basal-like breast cancer engages tumor-supportive macrophages via secreted factors induced by extracellular S100A4
Mol Oncol, 12 (9), 1540-1558
DOI 10.1002/1878-0261.12319, PubMed 29741811 -
Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients
J Mol Diagn, 20 (6), 883-892
DOI 10.1016/j.jmoldx.2018.07.005, PubMed 30165204 -
Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors
Mol Oncol, 12 (11), 1838-1855
DOI 10.1002/1878-0261.12375, PubMed 30133130 -
A multi-omic study reveals BTG2 as a reliable prognostic marker for early-stage non-small cell lung cancer
Mol Oncol, 12 (6), 913-924
DOI 10.1002/1878-0261.12204, PubMed 29656435 -
Characterization of the human RFX transcription factor family by regulatory and target gene analysis
BMC Genomics, 19 (1), 181
DOI 10.1186/s12864-018-4564-6, PubMed 29510665 -
MicroRNA Networks in Breast Cancer Cells
Methods Mol Biol, 1711, 55-81
DOI 10.1007/978-1-4939-7493-1_4, PubMed 29344885 -
N-glycan signatures identified in tumor interstitial fluid and serum of breast cancer patients: association with tumor biology and clinical outcome
Mol Oncol, 12 (6), 972-990
DOI 10.1002/1878-0261.12312, PubMed 29698574 -
Prognostic role of carcinoembryonic antigen and carbohydrate antigen 19-9 in metastatic colorectal cancer: a BRAF-mutant subset with high CA 19-9 level and poor outcome
Br J Cancer, 118 (12), 1609-1616
DOI 10.1038/s41416-018-0115-9, PubMed 29872151 -
Subtype-specific clinical and prognostic relevance of tumor-expressed F5 and regulatory F5 variants in breast cancer: the CoCaV study
J Thromb Haemost, 16 (7), 1347-1356
DOI 10.1111/jth.14151, PubMed 29766637 -
Sample-Index Misassignment Impacts Tumour Exome Sequencing
Sci Rep, 8 (1), 5307
DOI 10.1038/s41598-018-23563-4, PubMed 29593270 -
Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC
Clin Epigenetics, 10, 41
DOI 10.1186/s13148-018-0474-3, PubMed 29619118 -
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Nat Genet, 50 (7), 968-978
DOI 10.1038/s41588-018-0132-x, PubMed 29915430
Publications 2017
-
Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib
Clin Transl Radiat Oncol, 4, 57-63
DOI 10.1016/j.ctro.2017.04.002, PubMed 29594209 -
A new method to assess pulmonary changes using 18F-fluoro-2-deoxyglucose positron emission tomography for lung cancer patients following radiotherapy
Acta Oncol, 56 (11), 1597-1603
DOI 10.1080/0284186X.2017.1349336, PubMed 28849707 -
AKT1low Quiescent Cancer Cells Promote Solid Tumor Growth
Mol Cancer Ther, 17 (1), 254-263
DOI 10.1158/1535-7163.MCT-16-0868, PubMed 29054988 -
Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome
Breast Cancer Res, 19 (1), 44
DOI 10.1186/s13058-017-0812-y, PubMed 28356166 -
Widespread alternative exon usage in clinically distinct subtypes of Invasive Ductal Carcinoma
Sci Rep, 7 (1), 5568
DOI 10.1038/s41598-017-05537-0, PubMed 28717182 -
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Nat Rev Cancer, 17 (4), 254-268
DOI 10.1038/nrc.2016.140, PubMed 28104906 -
Interrogating open issues in cancer medicine with patient-derived xenografts
Nat Rev Cancer, 17 (10), 632 (in press)
DOI 10.1038/nrc.2017.85, PubMed 28912576 -
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Nat Commun, 8 (1), 1221
DOI 10.1038/s41467-017-01355-0, PubMed 29089486 -
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery
Curr Pharm Des, 23 (32), 4716-4725
DOI 10.2174/1381612823666170710154936, PubMed 28699527 -
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7
Thromb Res, 157, 111-116
DOI 10.1016/j.thromres.2017.07.013, PubMed 28734156 -
Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity
Oncotarget, 8 (34), 57121-57133
DOI 10.18632/oncotarget.19078, PubMed 28915659 -
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
Nat Med, 23 (4), 517-525
DOI 10.1038/nm.4292, PubMed 28288110 -
Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency
Cancer Res, 77 (18), 4755-4762
DOI 10.1158/0008-5472.CAN-17-1083, PubMed 28904067 -
Interactions between the tumor and the blood systemic response of breast cancer patients
PLoS Comput Biol, 13 (9), e1005680
DOI 10.1371/journal.pcbi.1005680, PubMed 28957325 -
Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case-Control Study from the Norwegian Breast Cancer Screening Program
Cancer Epidemiol Biomarkers Prev, 26 (12), 1736-1744
DOI 10.1158/1055-9965.EPI-17-0611, PubMed 28877889 -
Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy
Metabolomics, 13 (4), 37
DOI 10.1007/s11306-017-1168-0 -
DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival
Oncotarget, 8 (1), 1074-1082
DOI 10.18632/oncotarget.13718, PubMed 27911866 -
DNA methylation at enhancers identifies distinct breast cancer lineages
Nat Commun, 8 (1), 1379
DOI 10.1038/s41467-017-00510-x, PubMed 29123100 -
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Biochim Biophys Acta Mol Cell Res, 1864 (12), 2241-2252
DOI 10.1016/j.bbamcr.2017.08.011, PubMed 28867611 -
Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition
Cancer Discov, 7 (10), 1098-1115
DOI 10.1158/2159-8290.CD-17-0222, PubMed 28652380 -
A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nat Genet, 49 (3), 341-348
DOI 10.1038/ng.3771, PubMed 28112740 -
Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
Nat Genet, 49 (11), 1661
DOI 10.1038/ng1117-1661a, PubMed 29074948 -
Body mass index and breast cancer survival: a Mendelian randomization analysis
Int J Epidemiol, 46 (6), 1814-1822
DOI 10.1093/ije/dyx131, PubMed 29232439 -
Cetuximab in treatment of metastatic colorectal cancer: final survival analyses and extended RAS data from the NORDIC-VII study
Br J Cancer, 116 (10), 1271-1278
DOI 10.1038/bjc.2017.93, PubMed 28399112 -
HER2 expression patterns in paired primary and metastatic endometrial cancer lesions
Br J Cancer, 118 (3), 378-387
DOI 10.1038/bjc.2017.422, PubMed 29169184 -
Evaluation of Prognostic and Predictive Significance of Circulating MicroRNAs in Ovarian Cancer Patients
Dis Markers, 2017, 3098542
DOI 10.1155/2017/3098542, PubMed 28293063 -
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
Breast Cancer Res, 19 (1), 125
DOI 10.1186/s13058-017-0916-4, PubMed 29183390 -
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924 -
Drug-screening and genomic analyses of HER2-positive breast cancer cell lines reveal predictors for treatment response
Breast Cancer (Dove Med Press), 9, 185-198
DOI 10.2147/BCTT.S115600, PubMed 28356768 -
PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1
Oncotarget, 8 (61), 102769-102782
DOI 10.18632/oncotarget.21800, PubMed 29262523 -
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo
Nature, 543 (7647), 714-718
DOI 10.1038/nature21703, PubMed 28329761 -
Intervene: a tool for intersection and visualization of multiple gene or genomic region sets
BMC Bioinformatics, 18 (1), 287
DOI 10.1186/s12859-017-1708-7, PubMed 28569135 -
The Antigenicity of the Tumor Cell - Context Matters
N Engl J Med, 376 (5), 491-493
DOI 10.1056/NEJMcibr1613793, PubMed 28146670 -
Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy - results from two independent randomized trials
Acta Oncol, 57 (1), 38-43
DOI 10.1080/0284186X.2017.1401735, PubMed 29172851 -
Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice
Cancer Res, 77 (6), 1250-1260
DOI 10.1158/0008-5472.CAN-16-2179, PubMed 28254861 -
NSCLC depend upon YAP expression and nuclear localization after acquiring resistance to EGFR inhibitors
Genes Cancer, 8 (3-4), 497-504
DOI 10.18632/genesandcancer.136, PubMed 28680534 -
Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer
Virchows Arch, 472 (3), 395-405
DOI 10.1007/s00428-017-2263-3, PubMed 29134439 -
Association analysis identifies 65 new breast cancer risk loci
Nature, 551 (7678), 92-94
DOI 10.1038/nature24284, PubMed 29059683 -
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Nat Genet, 49 (12), 1767-1778
DOI 10.1038/ng.3785, PubMed 29058716 -
Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up
Breast Cancer Res, 19 (1), 120
DOI 10.1186/s13058-017-0911-9, PubMed 29137653 -
Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue
Oncoimmunology, 6 (11), e1356142
DOI 10.1080/2162402X.2017.1356142, PubMed 29147603 -
Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate
ESMO Open, 2 (2), e000158
DOI 10.1136/esmoopen-2017-000158, PubMed 28761742 -
Breast Cancer Molecular Stratification: From Intrinsic Subtypes to Integrative Clusters
Am J Pathol, 187 (10), 2152-2162
DOI 10.1016/j.ajpath.2017.04.022, PubMed 28733194 -
Serum N-glycome alterations in breast cancer during multimodal treatment and follow-up
Mol Oncol, 11 (10), 1361-1379
DOI 10.1002/1878-0261.12105, PubMed 28657165 -
Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk
Hum Mutat, 38 (3), 265-268
DOI 10.1002/humu.23154, PubMed 27957778 -
BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Cancer Res, 77 (11), 2789-2799
DOI 10.1158/0008-5472.CAN-16-2568, PubMed 28283652 -
TP53 Mutations in Breast and Ovarian Cancer
Cold Spring Harb Perspect Med, 7 (1)
DOI 10.1101/cshperspect.a026252, PubMed 27815305 -
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer
Clin Cancer Res, 23 (16), 4662-4670
DOI 10.1158/1078-0432.CCR-17-0160, PubMed 28487444 -
Health-related quality of life in patients with metastatic colorectal cancer, association with systemic inflammatory response and RAS and BRAF mutation status
Eur J Cancer, 81, 26-35
DOI 10.1016/j.ejca.2017.04.026, PubMed 28595137 -
Molecular signatures reflecting microenvironmental metabolism and chemotherapy-induced immunogenic cell death in colorectal liver metastases
Oncotarget, 8 (44), 76290-76304
DOI 10.18632/oncotarget.19350, PubMed 29100312
Publications 2016
-
Real-world data on nivolumab treatment of non-small cell lung cancer
Acta Oncol, 56 (3), 438-440
DOI 10.1080/0284186X.2016.1253865, PubMed 27892773 -
Galaxy Portal: interacting with the galaxy platform through mobile devices
Bioinformatics, 32 (11), 1743-5
DOI 10.1093/bioinformatics/btw042, PubMed 26819474 -
Five endometrial cancer risk loci identified through genome-wide association analysis
Nat Genet, 48 (6), 667-674
DOI 10.1038/ng.3562, PubMed 27135401 -
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Nat Commun, 7, 11375
DOI 10.1038/ncomms11375, PubMed 27117709 -
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377 -
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)
Sci Rep, 6, 32512
DOI 10.1038/srep32512, PubMed 27600471 -
Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing
Genome Biol, 17 (1), 250
DOI 10.1186/s13059-016-1109-7, PubMed 27931250 -
Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients
Cancer Res, 76 (18), 5326-36
DOI 10.1158/0008-5472.CAN-16-1162, PubMed 27406829 -
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170
Nat Genet, 48 (4), 374-86
DOI 10.1038/ng.3521, PubMed 26928228 -
No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing
J Med Genet, 53 (5), 298-309
DOI 10.1136/jmedgenet-2015-103529, PubMed 26921362 -
GFRA3 promoter methylation may be associated with decreased postoperative survival in gastric cancer
BMC Cancer, 16, 225
DOI 10.1186/s12885-016-2247-8, PubMed 26984265 -
The MYCN-HMGA2-CDKN2A pathway in non-small cell lung carcinoma--differences in histological subtypes
BMC Cancer, 16, 71
DOI 10.1186/s12885-016-2104-9, PubMed 26858029 -
Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease
Clin Transl Immunology, 5 (11), e109
DOI 10.1038/cti.2016.65, PubMed 27990285 -
Cytokine profiling of tumor interstitial fluid of the breast and its relationship with lymphocyte infiltration and clinicopathological characteristics
Oncoimmunology, 5 (12), e1248015
DOI 10.1080/2162402X.2016.1248015, PubMed 28123884 -
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Nucleic Acids Res, 44 (22), 10588-10602
DOI 10.1093/nar/gkw785, PubMed 27638884 -
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation
Am J Hum Genet, 99 (4), 903-911
DOI 10.1016/j.ajhg.2016.07.017, PubMed 27640304 -
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent
PLoS Med, 13 (8), e1002105
DOI 10.1371/journal.pmed.1002105, PubMed 27551723 -
A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer
Oncotarget, 7 (24), 37250-37259
DOI 10.18632/oncotarget.9363, PubMed 27191990 -
Profiling of microRNAs in tumor interstitial fluid of breast tumors - a novel resource to identify biomarkers for prognostic classification and detection of cancer
Mol Oncol, 11 (2), 220-234
DOI 10.1002/1878-0261.12025, PubMed 28145100 -
TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer Patients
Front Genet, 7, 85
DOI 10.3389/fgene.2016.00085, PubMed 27242894 -
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21
Oncotarget, 7 (49), 80140-80163
DOI 10.18632/oncotarget.12818, PubMed 27792995 -
Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3
Breast Cancer Res Treat, 161 (1), 117-134
DOI 10.1007/s10549-016-4018-2, PubMed 27796716 -
Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes
Cancer Metab, 4, 12
DOI 10.1186/s40170-016-0152-x, PubMed 27350877 -
MicroRNA-profiles in lung adenocarcinomas
Expert Rev. Precis. Med. Drug Dev., 1 (5), 469-474
DOI 10.1080/23808993.2016.1240011 -
Fine-Mapping of the 1p11.2 Breast Cancer Susceptibility Locus
PLoS One, 11 (8), e0160316
DOI 10.1371/journal.pone.0160316, PubMed 27556229 -
Subtype-specific micro-RNA expression signatures in breast cancer progression
Int J Cancer, 139 (5), 1117-28
DOI 10.1002/ijc.30142, PubMed 27082076 -
Rituximab efficiently depletes B cells in lung tumors and normal lung tissue
F1000Res, 5, 38
DOI 10.12688/f1000research.7599.1, PubMed 27081474 -
Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Cancer Discov, 6 (9), 1052-67
DOI 10.1158/2159-8290.CD-15-1227, PubMed 27432226 -
A systematic comparison of copy number alterations in four types of female cancer
BMC Cancer, 16 (1), 913
DOI 10.1186/s12885-016-2899-4, PubMed 27876019 -
Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management
Breast, 28, 136-44
DOI 10.1016/j.breast.2016.05.006, PubMed 27318168 -
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
Nat Commun, 7, 12675
DOI 10.1038/ncomms12675, PubMed 27601076 -
Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
Cell Rep, 16 (4), 1166-1179
DOI 10.1016/j.celrep.2016.06.051, PubMed 27396337 -
STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo
Oncotarget, 8 (54), 91817-91827
DOI 10.18632/oncotarget.11131, PubMed 29190878 -
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
Sci Rep, 6, 36874
DOI 10.1038/srep36874, PubMed 27845421 -
Update of the FANTOM web resource: high resolution transcriptome of diverse cell types in mammals
Nucleic Acids Res, 45 (D1), D737-D743
DOI 10.1093/nar/gkw995, PubMed 27794045 -
DNA Shape Features Improve Transcription Factor Binding Site Predictions In Vivo
Cell Syst, 3 (3), 278-286.e4
DOI 10.1016/j.cels.2016.07.001, PubMed 27546793 -
PIK3CA mutations as prognostic factor in squamous cell lung carcinoma
Lung Cancer, 103, 52-57
DOI 10.1016/j.lungcan.2016.11.018, PubMed 28024696 -
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer
Oncotarget, 7 (27), 41948-41958
DOI 10.18632/oncotarget.9632, PubMed 27248825 -
The topography of mutational processes in breast cancer genomes
Nat Commun, 7, 11383
DOI 10.1038/ncomms11383, PubMed 27136393 -
Genetic modifiers of CHEK2*1100delC-associated breast cancer risk
Genet Med, 19 (5), 599-603
DOI 10.1038/gim.2016.147, PubMed 27711073 -
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Nature, 534 (7605), 47-54
DOI 10.1038/nature17676, PubMed 27135926 -
Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors
Oncotarget, 7 (6), 6891-901
DOI 10.18632/oncotarget.6902, PubMed 26771843 -
Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer
Cancer Epidemiol Biomarkers Prev, 25 (11), 1503-1510
DOI 10.1158/1055-9965.EPI-16-0147, PubMed 27550749 -
Contribution of APC and MUTYH mutations to familial adenomatous polyposis susceptibility in Hungary
Fam Cancer, 15 (1), 85-97
DOI 10.1007/s10689-015-9845-5, PubMed 26446593 -
RAD51B in Familial Breast Cancer
PLoS One, 11 (5), e0153788
DOI 10.1371/journal.pone.0153788, PubMed 27149063 -
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
Nat Commun, 7, 11479
DOI 10.1038/ncomms11479, PubMed 27161491 -
Genetic predisposition to ductal carcinoma in situ of the breast
Breast Cancer Res, 18 (1), 22
DOI 10.1186/s13058-016-0675-7, PubMed 26884359 -
Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer
Cell Rep, 16 (4), 1153-1165
DOI 10.1016/j.celrep.2016.06.061, PubMed 27425619 -
Fatigue During and After Breast Cancer Therapy-A Prospective Study
J Pain Symptom Manage, 53 (3), 551-560
DOI 10.1016/j.jpainsymman.2016.09.011, PubMed 28042070 -
Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
J Transl Med, 14 (1), 295
DOI 10.1186/s12967-016-1059-6, PubMed 27756323 -
Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney Int Rep, 2 (3), 461-469
DOI 10.1016/j.ekir.2016.11.005, PubMed 29142973 -
Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
Diagn Pathol, 11 (1), 50
DOI 10.1186/s13000-016-0504-4, PubMed 27316334 -
The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma
Cancer Res, 76 (17), 5092-102
DOI 10.1158/0008-5472.CAN-16-0658, PubMed 27488532 -
LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer
EMBO Mol Med, 8 (9), 1052-64
DOI 10.15252/emmm.201606198, PubMed 27485121 -
Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers
J Clin Oncol, 34 (23), 2750-60
DOI 10.1200/JCO.2016.66.5844, PubMed 27269948 -
Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer
Int J Cancer, 139 (6), 1303-1317
DOI 10.1002/ijc.30150, PubMed 27087578 -
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Rep, 16 (7), 2032-46
DOI 10.1016/j.celrep.2016.07.028, PubMed 27498871 -
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration
Nat Commun, 7, 12910
DOI 10.1038/ncomms12910, PubMed 27666519 -
Gene expression analysis supports tumor threshold over 2.0 cm for T-category breast cancer
EURASIP J Bioinform Syst Biol, 2016 (1), 6
DOI 10.1186/s13637-015-0034-5, PubMed 26900390 -
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS
J Med Genet, 53 (12), 800-811
DOI 10.1136/jmedgenet-2016-103839, PubMed 27595995 -
The Impact of Gene Expression Patterns in Breast Cancer
Clin Chem, 62 (8), 1150-1
DOI 10.1373/clinchem.2015.253229, PubMed 27022070 -
TIMP-1 is under regulation of the EGF signaling axis and promotes an aggressive phenotype in KRAS-mutated colorectal cancer cells: a potential novel approach to the treatment of metastatic colorectal cancer
Oncotarget, 7 (37), 59441-59457
DOI 10.18632/oncotarget.11118, PubMed 27509063 -
Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report
Cell Oncol (Dordr), 39 (6), 583-589
DOI 10.1007/s13402-016-0295-3, PubMed 27572263 -
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783 -
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
Nature, 537 (7618), 63-68
DOI 10.1038/nature19081, PubMed 27533040 -
Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer
Oncotarget, 7 (46), 75013-75022
DOI 10.18632/oncotarget.12601, PubMed 27738330 -
Determinants of acquired activated protein C resistance and D-dimer in breast cancer
Thromb Res, 145, 78-83
DOI 10.1016/j.thromres.2016.08.003, PubMed 27505249 -
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Nat Genet, 49 (1), 65-74
DOI 10.1038/ng.3722, PubMed 27869826 -
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression
Hum Mol Genet, 25 (17), 3863-3876
DOI 10.1093/hmg/ddw223, PubMed 27402876 -
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus
Breast Cancer Res, 18 (1), 64
DOI 10.1186/s13058-016-0718-0, PubMed 27459855 -
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry
Cancer Causes Control, 27 (5), 679-93
DOI 10.1007/s10552-016-0741-6, PubMed 27053251 -
Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy
Biomed Hub, 1 (3), 1-9
DOI 10.1159/000453253, PubMed 31988890
Publications 2015
-
Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer
Genes (Basel), 6 (3), 878-900
DOI 10.3390/genes6030878, PubMed 26393654 -
High ABCC2 and low ABCG2 gene expression are early events in the colorectal adenoma-carcinoma sequence
PLoS One, 10 (3), e0119255
DOI 10.1371/journal.pone.0119255, PubMed 25793771 -
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer
Genome Med, 7 (1), 21
DOI 10.1186/s13073-015-0135-5, PubMed 25873999 -
Preoperative cognitive function predicts survival in patients with resectable pancreatic ductal adenocarcinoma
HPB (Oxford), 18 (3), 247-54
DOI 10.1016/j.hpb.2015.09.004, PubMed 27017164 -
EGFR mutation testing of lung cancer patients - Experiences from Vestfold Hospital Trust
Acta Oncol, 55 (2), 149-55
DOI 10.3109/0284186X.2015.1062537, PubMed 26313507 -
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas
BMC Cancer, 15, 524
DOI 10.1186/s12885-015-1510-8, PubMed 26183823 -
Genome-wide DNA methylation analyses in lung adenocarcinomas: Association with EGFR, KRAS and TP53 mutation status, gene expression and prognosis
Mol Oncol, 10 (2), 330-43
DOI 10.1016/j.molonc.2015.10.021, PubMed 26601720 -
Canine Mammary Tumours Are Affected by Frequent Copy Number Aberrations, including Amplification of MYC and Loss of PTEN
PLoS One, 10 (5), e0126371
DOI 10.1371/journal.pone.0126371, PubMed 25955013 -
The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study
BMC Cancer, 15, 468
DOI 10.1186/s12885-015-1479-3, PubMed 26062614 -
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1
Sci Rep, 5, 17369
DOI 10.1038/srep17369, PubMed 26621817 -
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Nat Cell Biol, 17 (6), 816-26
DOI 10.1038/ncb3169, PubMed 25985394 -
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression
Am J Hum Genet, 97 (1), 22-34
DOI 10.1016/j.ajhg.2015.05.002, PubMed 26073781 -
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Nat Genet, 47 (11), 1294-1303
DOI 10.1038/ng.3412, PubMed 26414677 -
Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT
Obstet. Gynecol. Surv., 70 (12), 758-762
DOI 10.1097/01.ogx.0000473766.71624.99 -
Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer
Ann Oncol, 27 (2), 225-32
DOI 10.1093/annonc/mdv560, PubMed 26578726 -
Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer
Cancer Res, 75 (4), 698-708
DOI 10.1158/0008-5472.CAN-14-2637, PubMed 25649770 -
Identification of novel genetic markers of breast cancer survival
J Natl Cancer Inst, 107 (5)
DOI 10.1093/jnci/djv081, PubMed 25890600 -
Fine-scale mapping of the 4q24 locus identifies two independent loci associated with breast cancer risk
Cancer Epidemiol Biomarkers Prev, 24 (11), 1680-91
DOI 10.1158/1055-9965.EPI-15-0363, PubMed 26354892 -
Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes
Int J Cancer, 138 (1), 87-97
DOI 10.1002/ijc.29684, PubMed 26174627 -
Serum N-Glycome Characterization in Patients with Resectable Periampullary Adenocarcinoma
J Proteome Res, 14 (12), 5144-56
DOI 10.1021/acs.jproteome.5b00395, PubMed 26515733 -
Gene jockeys Life science and the rise of biotech enterprise.
Tidsskr. Nor. Laegeforen., 135 (4), 356
DOI 10.4045/tidsskr.14.1367 -
Cancer stem cells
Tidsskr. Nor. Laegeforen., 135 (8), 783
DOI 10.4045/tidsskr.15.0031 -
Viruses and human cancer
Tidsskr. Nor. Laegeforen., 135 (9), 874
DOI 10.4045/tidsskr.15.0167 -
Tumour exosome integrins determine organotropic metastasis
Nature, 527 (7578), 329-35
DOI 10.1038/nature15756, PubMed 26524530 -
Serum N-glycan analysis in breast cancer patients--Relation to tumour biology and clinical outcome
Mol Oncol, 10 (1), 59-72
DOI 10.1016/j.molonc.2015.08.002, PubMed 26321095 -
Impact of genetic variants of RFC1, DHFR and MTHFR in osteosarcoma patients treated with high-dose methotrexate
Pharmacogenomics J, 15 (5), 385-90
DOI 10.1038/tpj.2015.11, PubMed 25778468 -
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer
Clin Epigenetics, 7 (1), 75
DOI 10.1186/s13148-015-0094-0, PubMed 26213588 -
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Genome Res, 25 (6), 814-24
DOI 10.1101/gr.190470.115, PubMed 25963125 -
Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer
Carcinogenesis, 36 (2), 256-71
DOI 10.1093/carcin/bgu326, PubMed 25586992 -
AGXT and ERCC2 polymorphisms are associated with clinical outcome in metastatic colorectal cancer patients treated with 5-FU/oxaliplatin
Pharmacogenomics J, 16 (3), 272-9
DOI 10.1038/tpj.2015.54, PubMed 26261061 -
Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study
Acta Oncol, 55 (3), 265-77
DOI 10.3109/0284186X.2015.1068445, PubMed 26213211 -
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray
PLoS One, 10 (2), e0117261
DOI 10.1371/journal.pone.0117261, PubMed 25706641 -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
Genom Data, 5, 176-83
DOI 10.1016/j.gdata.2015.05.019, PubMed 26484252 -
Genetic variation in the immunosuppression pathway genes and breast cancer susceptibility: a pooled analysis of 42,510 cases and 40,577 controls from the Breast Cancer Association Consortium
Hum Genet, 135 (1), 137-54
DOI 10.1007/s00439-015-1616-8, PubMed 26621531 -
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy
Breast Cancer Res, 17 (1), 18
DOI 10.1186/s13058-015-0522-2, PubMed 25849327 -
Prediction of breast cancer risk based on profiling with common genetic variants
J Natl Cancer Inst, 107 (5)
DOI 10.1093/jnci/djv036, PubMed 25855707 -
BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers
J Natl Cancer Inst, 108 (2)
DOI 10.1093/jnci/djv315, PubMed 26586665 -
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
Nat Genet, 47 (4), 373-80
DOI 10.1038/ng.3242, PubMed 25751625 -
MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase
Mol Oncol, 9 (6), 1056-70
DOI 10.1016/j.molonc.2015.01.005, PubMed 25682900 -
Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors
Endocr Relat Cancer, 22 (6), 953-67
DOI 10.1530/ERC-15-0086, PubMed 26400872 -
A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5
Dev Biol, 404 (2), 35-48
DOI 10.1016/j.ydbio.2015.05.002, PubMed 26003047 -
Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer
Endocr Relat Cancer, 22 (5), 851-61
DOI 10.1530/ERC-15-0319, PubMed 26330482 -
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2
Hum Mol Genet, 24 (10), 2966-84
DOI 10.1093/hmg/ddv035, PubMed 25652398 -
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer
Gynecol Oncol, 141 (2), 386-401
DOI 10.1016/j.ygyno.2015.04.034, PubMed 25940428 -
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
Genes Dev, 29 (12), 1298-315
DOI 10.1101/gad.263202.115, PubMed 26080815 -
Common germline polymorphisms associated with breast cancer-specific survival
Breast Cancer Res, 17 (1), 58
DOI 10.1186/s13058-015-0570-7, PubMed 25897948 -
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival
Mol Oncol, 9 (4), 861-76
DOI 10.1016/j.molonc.2014.12.013, PubMed 25655580 -
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells
Mol Oncol, 9 (10), 2054-62
DOI 10.1016/j.molonc.2015.10.003, PubMed 26607741 -
Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma
Mol Oncol, 10 (2), 303-16
DOI 10.1016/j.molonc.2015.10.011, PubMed 26590090 -
A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients
BMC Cancer, 15, 978
DOI 10.1186/s12885-015-1957-7, PubMed 26674097 -
The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer
PLoS One, 10 (10), e0139965
DOI 10.1371/journal.pone.0139965, PubMed 26460974 -
From autonomy to community; new perspectives on tumorigenicity and therapy resistance
Cancer Treat Rev, 41 (10), 809-13
DOI 10.1016/j.ctrv.2015.10.004, PubMed 26519005 -
Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures
Cancer Res, 75 (12), 2457-67
DOI 10.1158/0008-5472.CAN-14-2012, PubMed 25862352 -
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
DOI 10.3389/fgene.2015.00070, PubMed 25774168 -
CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer
Endocr Relat Cancer, 23 (2), 77-91
DOI 10.1530/ERC-15-0386, PubMed 26574572 -
Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF
Breast Cancer Res, 17 (1), 44
DOI 10.1186/s13058-015-0548-5, PubMed 25882602 -
Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization
J Natl Cancer Inst, 107 (11)
DOI 10.1093/jnci/djv219, PubMed 26296642 -
MicroRNA-135b regulates ERα, AR and HIF1AN and affects breast and prostate cancer cell growth
Mol Oncol, 9 (7), 1287-300
DOI 10.1016/j.molonc.2015.03.001, PubMed 25907805
Publications 2014
-
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity
Cell Rep, 6 (3), 514-27
DOI 10.1016/j.celrep.2013.12.041, PubMed 24462293 -
Global gene expression analysis reveals a link between NDRG1 and vesicle transport
PLoS One, 9 (1), e87268
DOI 10.1371/journal.pone.0087268, PubMed 24498060 -
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas
Int J Cancer, 135 (8), 1812-21
DOI 10.1002/ijc.28828, PubMed 24599520 -
Candidate locus analysis of the TERT-CLPTM1L cancer risk region on chromosome 5p15 identifies multiple independent variants associated with endometrial cancer risk
Hum Genet, 134 (2), 231-45
DOI 10.1007/s00439-014-1515-4, PubMed 25487306 -
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers
Cancer Cell, 26 (6), 863-879
DOI 10.1016/j.ccell.2014.10.010, PubMed 25490449 -
Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients
Int J Cancer, 134 (11), 2615-25
DOI 10.1002/ijc.28606, PubMed 24395279 -
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis
Genome Biol, 15 (8), 435
DOI 10.1186/PREACCEPT-2333349012841587, PubMed 25146004 -
Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation
Nat Commun, 4, 4999
DOI 10.1038/ncomms5999, PubMed 25248036 -
Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1
Am J Hum Genet, 96 (1), 5-20
DOI 10.1016/j.ajhg.2014.11.009, PubMed 25529635 -
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts
Breast Cancer Res, 16 (1), R5
DOI 10.1186/bcr3597, PubMed 24447408 -
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy
Int J Cancer, 135 (9), 2085-95
DOI 10.1002/ijc.28862, PubMed 24658971 -
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells - A data description
Genom Data, 2, 249-53
DOI 10.1016/j.gdata.2014.06.025, PubMed 26484103 -
Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study
Breast Cancer Res, 16 (3), R51
DOI 10.1186/bcr3662, PubMed 24887515 -
MicroRNA related polymorphisms and breast cancer risk
PLoS One, 9 (11), e109973
DOI 10.1371/journal.pone.0109973, PubMed 25390939 -
FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab
BMC Cancer, 14, 340
DOI 10.1186/1471-2407-14-340, PubMed 24884501 -
DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors
Clin Cancer Res, 20 (24), 6357-66
DOI 10.1158/1078-0432.CCR-14-0297, PubMed 25294903 -
A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients
Clin Cancer Res, 21 (5), 1207-14
DOI 10.1158/1078-0432.CCR-14-2011, PubMed 25547678 -
Principles and methods of integrative genomic analyses in cancer
Nat Rev Cancer, 14 (5), 299-313
DOI 10.1038/nrc3721, PubMed 24759209 -
2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Nat Commun, 5, 4051
DOI 10.1038/ncomms5051, PubMed 24937182 -
Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk
Hum Mol Genet, 24 (1), 285-98
DOI 10.1093/hmg/ddu431, PubMed 25168388 -
Lessons learned from the intrinsic subtypes of breast cancer in the quest for precision therapy
Br J Surg, 101 (8), 925-38
DOI 10.1002/bjs.9562, PubMed 24849143 -
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c
Br J Cancer, 110 (8), 2072-80
DOI 10.1038/bjc.2014.113, PubMed 24577056 -
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk
Hum Mol Genet, 24 (5), 1478-92
DOI 10.1093/hmg/ddu552, PubMed 25378557 -
Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade
Hum Mol Genet, 23 (22), 6034-46
DOI 10.1093/hmg/ddu300, PubMed 24927736 -
RNA-seq permits a closer look at normal skin and psoriasis gene networks
J Invest Dermatol, 134 (7), 1789-1791
DOI 10.1038/jid.2014.66, PubMed 24924757 -
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
Mol Cancer Res, 13 (3), 493-501
DOI 10.1158/1541-7786.MCR-14-0387, PubMed 25351767 -
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes
PLoS One, 9 (9), e106076
DOI 10.1371/journal.pone.0106076, PubMed 25264628 -
eEF2K--a new target in breast cancers with combined inactivation of p53 and PTEN
EMBO Mol Med, 6 (12), 1512-4
DOI 10.15252/emmm.201404683, PubMed 25471453 -
The multitude of molecular analyses in cancer: the opening of Pandora’s box
Genome Biol, 15 (9), 447
DOI 10.1186/s13059-014-0447-6, PubMed 25316146 -
Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors
Genes Chromosomes Cancer, 54 (4), 235-48
DOI 10.1002/gcc.22237, PubMed 25546585 -
Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC
J Proteome Res, 13 (5), 2314-27
DOI 10.1021/pr401092y, PubMed 24669823 -
Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas
Mol Oncol, 9 (4), 758-71
DOI 10.1016/j.molonc.2014.12.002, PubMed 25579086 -
Genetic predisposition to in situ and invasive lobular carcinoma of the breast
PLoS Genet, 10 (4), e1004285
DOI 10.1371/journal.pgen.1004285, PubMed 24743323 -
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance
Clin Cancer Res, 20 (13), 3569-80
DOI 10.1158/1078-0432.CCR-13-2943, PubMed 24803582 -
Differential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer xenograft
PLoS One, 9 (11), e113278
DOI 10.1371/journal.pone.0113278, PubMed 25419568 -
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer
Br J Cancer, 111 (2), 326-38
DOI 10.1038/bjc.2014.297, PubMed 24901235 -
Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE)
Methods Mol Biol, 1105, 315-24
DOI 10.1007/978-1-62703-739-6_25, PubMed 24623239 -
Plasma YKL-40 in patients with metastatic colorectal cancer treated with first line oxaliplatin-based regimen with or without cetuximab: RESULTS from the NORDIC VII Study
PLoS One, 9 (2), e87746
DOI 10.1371/journal.pone.0087746, PubMed 24498368 -
Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study
BMC Cancer, 14, 845
DOI 10.1186/1471-2407-14-845, PubMed 25407022 -
Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer
Acta Oncol, 53 (10), 1337-46
DOI 10.3109/0284186X.2014.925580, PubMed 24957550 -
Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort
Clin Cancer Res, 20 (20), 5272-80
DOI 10.1158/1078-0432.CCR-14-0458, PubMed 25149560 -
GoIFISH: a system for the quantification of single cell heterogeneity from IFISH images
Genome Biol, 15 (8), 442
DOI 10.1186/s13059-014-0442-y, PubMed 25168174 -
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Science, 345 (6196), 1251343
DOI 10.1126/science.1251343, PubMed 25082706 -
Intestinal PTGS2 mRNA levels, PTGS2 gene polymorphisms, and colorectal carcinogenesis
PLoS One, 9 (8), e105254
DOI 10.1371/journal.pone.0105254, PubMed 25166592 -
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer
Mol Oncol, 9 (1), 115-27
DOI 10.1016/j.molonc.2014.07.019, PubMed 25169931 -
Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines
PLoS One, 9 (8), e103873
DOI 10.1371/journal.pone.0103873, PubMed 25148029 -
Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo
Br J Cancer, 111 (11), 2142-51
DOI 10.1038/bjc.2014.524, PubMed 25268374 -
JARID1B is a luminal lineage-driving oncogene in breast cancer
Cancer Cell, 25 (6), 762-77
DOI 10.1016/j.ccr.2014.04.024, PubMed 24937458 -
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status
BMC Cancer, 14, 211
DOI 10.1186/1471-2407-14-211, PubMed 24645668
Publications 2013
-
Signatures of mutational processes in human cancer
Nature, 500 (7463), 415-21
DOI 10.1038/nature12477, PubMed 23945592 -
Low ABCB1 gene expression is an early event in colorectal carcinogenesis
PLoS One, 8 (8), e72119
DOI 10.1371/journal.pone.0072119, PubMed 23977225 -
Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors
Genome Biol, 14 (11), R126
DOI 10.1186/gb-2013-14-11-r126, PubMed 24257477 -
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data
PLoS One, 8 (1), e53014
DOI 10.1371/journal.pone.0053014, PubMed 23382830 -
High levels of genomic aberrations in serous ovarian cancers are associated with better survival
PLoS One, 8 (1), e54356
DOI 10.1371/journal.pone.0054356, PubMed 23372714 -
Improving breast cancer survival analysis through competition-based multidimensional modeling
PLoS Comput Biol, 9 (5), e1003047
DOI 10.1371/journal.pcbi.1003047, PubMed 23671412 -
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
Nat Genet, 45 (4), 371-84, 384e1-2
DOI 10.1038/ng.2566, PubMed 23535731 -
Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics
Cell Stem Cell, 13 (1), 117-30
DOI 10.1016/j.stem.2013.05.004, PubMed 23770079 -
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling
Int J Radiat Oncol Biol Phys, 86 (4), 791-9
DOI 10.1016/j.ijrobp.2013.02.025, PubMed 23597419 -
Triple-negative breast cancer and the need for new therapeutic targets
Am J Pathol, 183 (4), 1064-1074
DOI 10.1016/j.ajpath.2013.05.033, PubMed 23920327 -
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
Am J Hum Genet, 92 (4), 489-503
DOI 10.1016/j.ajhg.2013.01.002, PubMed 23540573 -
Genome-wide association studies identify four ER negative-specific breast cancer risk loci
Nat Genet, 45 (4), 392-8, 398e1-2
DOI 10.1038/ng.2561, PubMed 23535733 -
Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer
Cancer Res, 73 (21), 6424-34
DOI 10.1158/0008-5472.CAN-12-4573, PubMed 24030979 -
Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype
PLoS One, 8 (11), e78241
DOI 10.1371/journal.pone.0078241, PubMed 24244297 -
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells
PLoS One, 8 (10), e77232
DOI 10.1371/journal.pone.0077232, PubMed 24194875 -
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53
Breast Cancer Res Treat, 141 (3), 397-408
DOI 10.1007/s10549-013-2702-z, PubMed 24091768 -
A functional link between FOXA1 and breast cancer SNPs
Breast Cancer Res, 15 (1), 303
DOI 10.1186/bcr3360, PubMed 23427833 -
Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first-line oxaliplatin-based treatment
Mol Oncol, 8 (1), 59-67
DOI 10.1016/j.molonc.2013.09.001, PubMed 24119443 -
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
BMC Cancer, 13, 456
DOI 10.1186/1471-2407-13-456, PubMed 24093668 -
Clinical significance of disseminated tumour cells in non-small cell lung cancer
Br J Cancer, 109 (5), 1264-70
DOI 10.1038/bjc.2013.450, PubMed 23942067 -
Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II
Genomics, 102 (4), 278-87
DOI 10.1016/j.ygeno.2013.07.006, PubMed 23880221 -
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
Mol Oncol, 8 (1), 93-104
DOI 10.1016/j.molonc.2013.10.001, PubMed 24148764 -
Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size
J Med Genet, 50 (10), 666-73
DOI 10.1136/jmedgenet-2013-101708, PubMed 23825393 -
Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations
Clin Cancer Res, 20 (2), 404-12
DOI 10.1158/1078-0432.CCR-13-1865, PubMed 24192926 -
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
Breast Cancer Res Treat, 143 (1), 189-201
DOI 10.1007/s10549-013-2796-3, PubMed 24305980 -
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer
Sci Transl Med, 5 (181), 181re1
DOI 10.1126/scitranslmed.3006112, PubMed 23596205 -
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1
Am J Hum Genet, 93 (6), 1046-60
DOI 10.1016/j.ajhg.2013.10.026, PubMed 24290378 -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
Nat Genet, 45 (4), 353-61, 361e1-2
DOI 10.1038/ng.2563, PubMed 23535729 -
A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium
Hum Mol Genet, 23 (7), 1934-46
DOI 10.1093/hmg/ddt581, PubMed 24242184 -
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins
Mol Oncol, 7 (3), 704-18
DOI 10.1016/j.molonc.2013.02.018, PubMed 23562353 -
Next-generation sequencing of disseminated tumor cells
Front Oncol, 3, 320
DOI 10.3389/fonc.2013.00320, PubMed 24427740 -
Identifying clusters in genomics data by recursive partitioning
Stat Appl Genet Mol Biol, 12 (5), 637-52
DOI 10.1515/sagmb-2013-0016, PubMed 23942354 -
Improved survival and quality of life in patients undergoing R1 pancreatic resection compared to patients with locally advanced unresectable pancreatic adenocarcinoma
Pancreatology, 13 (2), 180-5
DOI 10.1016/j.pan.2013.01.003, PubMed 23561977 -
Novel molecular tumor cell markers in regional lymph nodes and blood samples from patients undergoing surgery for non-small cell lung cancer
PLoS One, 8 (5), e62153
DOI 10.1371/journal.pone.0062153, PubMed 23671585 -
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer
Carcinogenesis, 35 (5), 1012-9
DOI 10.1093/carcin/bgt404, PubMed 24325915 -
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors
Mol Oncol, 8 (2), 273-84
DOI 10.1016/j.molonc.2013.11.008, PubMed 24388359 -
Two Distinct Categories of Focal Deletions in Cancer Genomes
PLoS One, 8 (6), e66264
DOI 10.1371/journal.pone.0066264, PubMed 23805207 -
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways
ISRN Oncol, 2013, 924971
DOI 10.1155/2013/924971, PubMed 23533813 -
Osteopontin is a prognostic biomarker in non-small cell lung cancer
BMC Cancer, 13, 540
DOI 10.1186/1471-2407-13-540, PubMed 24215488 -
Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors
Carcinogenesis, 35 (1), 76-85
DOI 10.1093/carcin/bgt333, PubMed 24104550 -
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection
Virchows Arch, 463 (6), 775-86
DOI 10.1007/s00428-013-1486-1, PubMed 24100522 -
Integrative bioinformatics analysis of genomic and proteomic approaches to understand the transcriptional regulatory program in coronary artery disease pathways
PLoS One, 8 (2), e57193
DOI 10.1371/journal.pone.0057193, PubMed 23468932 -
Novel network biomarkers profile based coronary artery disease risk stratification in Asian Indians
Adv Biomed Res, 2, 59
DOI 10.4103/2277-9175.115805, PubMed 24223374 -
Molecular subtypes in ductal carcinoma in situ of the breast and their relation to prognosis: a population-based cohort study
BMC Cancer, 13, 512
DOI 10.1186/1471-2407-13-512, PubMed 24171825 -
Personalized cancer care conference
J Pers Med, 3 (2), 70-81
DOI 10.3390/jpm3020070, PubMed 25562519
Publications 2012
-
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers
PLoS One, 7 (6), e38575
DOI 10.1371/journal.pone.0038575, PubMed 22719901 -
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts
Mol Oncol, 7 (1), 130-42
DOI 10.1016/j.molonc.2012.10.005, PubMed 23142657 -
[Mutation testing for non-small-cell lung cancer]
Tidsskr Nor Laegeforen, 132 (8), 952-5
DOI 10.4045/tidsskr.11.1017, PubMed 22562326 -
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
Nature, 486 (7403), 346-52
DOI 10.1038/nature10983, PubMed 22522925 -
Gefitinib in Combination with Weekly Docetaxel in Patients with Metastatic Breast Cancer Caused Unexpected Toxicity: Results from a Randomized Phase II Clinical Trial
ISRN Oncol, 2012, 176789
DOI 10.5402/2012/176789, PubMed 22666610 -
Cooperating transcription factors mediate the function of estrogen receptor
Chromosoma, 122 (1-2), 1-12
DOI 10.1007/s00412-012-0392-7, PubMed 23192763 -
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
Cell, 148 (1-2), 244-58
DOI 10.1016/j.cell.2011.12.017, PubMed 22265415 -
Genome-wide association analysis identifies three new breast cancer susceptibility loci
Nat Genet, 44 (3), 312-8
DOI 10.1038/ng.1049, PubMed 22267197 -
Functional genomic methods to study estrogen receptor activity
J Mammary Gland Biol Neoplasia, 17 (2), 147-53
DOI 10.1007/s10911-012-9254-4, PubMed 22588661 -
Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement
Ann Oncol, 23 (12), 2997-3006
DOI 10.1093/annonc/mds586, PubMed 23166150 -
Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput sequencing
PLoS One, 7 (4), e34150
DOI 10.1371/journal.pone.0034150, PubMed 22529906 -
Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)
PLoS One, 7 (8), e42380
DOI 10.1371/journal.pone.0042380, PubMed 22879957 -
Relationship between p53 overexpression, human papillomavirus infection, and lifestyle in Indian patients with head and neck cancers
Tumour Biol, 33 (2), 543-50
DOI 10.1007/s13277-011-0295-x, PubMed 22231431 -
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway
Br J Cancer, 107 (10), 1722-8
DOI 10.1038/bjc.2012.461, PubMed 23079576 -
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes
BMC Genomics, 13, 199
DOI 10.1186/1471-2164-13-199, PubMed 22616941 -
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity
Proc Natl Acad Sci U S A, 109 (16), 6124-9
DOI 10.1073/pnas.1203203109, PubMed 22454501 -
Let-7 miRNA-binding site polymorphism in the KRAS 3'UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/- cetuximab
BMC Cancer, 12, 534
DOI 10.1186/1471-2407-12-534, PubMed 23167843 -
KRAS mutational test for metastatic colorectal cancer patients: not just a technical problem
Expert Rev Mol Diagn, 12 (4), 327-8
DOI 10.1586/erm.12.29, PubMed 22616697 -
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Hum Mutat, 33 (7), 1123-32
DOI 10.1002/humu.22089, PubMed 22461340 -
Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival
Breast Cancer Res, 14 (4), R117
DOI 10.1186/bcr3242, PubMed 22889108 -
Functional characterization of the 19q12 amplicon in grade III breast cancers
Breast Cancer Res, 14 (2), R53
DOI 10.1186/bcr3154, PubMed 22433433 -
Mutational processes molding the genomes of 21 breast cancers
Cell, 149 (5), 979-93
DOI 10.1016/j.cell.2012.04.024, PubMed 22608084 -
The life history of 21 breast cancers
Cell, 149 (5), 994-1007
DOI 10.1016/j.cell.2012.04.023, PubMed 22608083 -
Copynumber: Efficient algorithms for single- and multi-track copy number segmentation
BMC Genomics, 13, 591
DOI 10.1186/1471-2164-13-591, PubMed 23442169 -
Low-grade and high-grade mammary carcinomas in WAP-T transgenic mice are independent entities distinguished by Met expression
Int J Cancer, 132 (6), 1300-10
DOI 10.1002/ijc.27783, PubMed 22907219 -
Tumor phosphatidylinositol-3-kinase signaling and development of metastatic disease in locally advanced rectal cancer
PLoS One, 7 (11), e50806
DOI 10.1371/journal.pone.0050806, PubMed 23226389 -
Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes
ISRN Oncol, 2012, 450267
DOI 10.5402/2012/450267, PubMed 23227362 -
Increasing age and carcinoma not otherwise specified: a 20-year population study of 40,118 lung cancer patients
J Thorac Oncol, 7 (1), 57-63
DOI 10.1097/JTO.0b013e3182307f7e, PubMed 21900838 -
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells
Mol Oncol, 7 (3), 392-401
DOI 10.1016/j.molonc.2012.10.012, PubMed 23253899 -
Relationship of adiponectin and leptin to coronary artery disease, classical cardiovascular risk factors and atherothrombotic biomarkers in the IARS cohort
Thromb Haemost, 108 (4), 769-80
DOI 10.1160/TH12-04-0263, PubMed 22955445 -
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma
Virchows Arch, 462 (2), 163-73
DOI 10.1007/s00428-012-1347-3, PubMed 23242172 -
The landscape of cancer genes and mutational processes in breast cancer
Nature, 486 (7403), 400-4
DOI 10.1038/nature11017, PubMed 22722201 -
19p13.1 is a triple-negative-specific breast cancer susceptibility locus
Cancer Res, 72 (7), 1795-803
DOI 10.1158/0008-5472.CAN-11-3364, PubMed 22331459 -
Combined analysis of vascular invasion, grade, HER2 and Ki67 expression identifies early breast cancer patients with questionable benefit of systemic adjuvant therapy
Acta Oncol, 52 (1), 91-101
DOI 10.3109/0284186X.2012.713508, PubMed 22934555 -
Phase III trial of cetuximab with continuous or intermittent fluorouracil, leucovorin, and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer: the NORDIC-VII study
J Clin Oncol, 30 (15), 1755-62
DOI 10.1200/JCO.2011.38.0915, PubMed 22473155 -
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk
Cancer Epidemiol Biomarkers Prev, 21 (7), 1156-66
DOI 10.1158/1055-9965.EPI-12-0066, PubMed 22454379 -
Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis
Clin Chem Lab Med, 50 (11), 1999-2007
DOI 10.1515/cclm-2012-0103, PubMed 23093106 -
Analyzing cancer samples with SNP arrays
Methods Mol Biol, 802, 57-72
DOI 10.1007/978-1-61779-400-1_4, PubMed 22130873 -
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer
J Clin Oncol, 30 (35), 4308-16
DOI 10.1200/JCO.2012.42.7336, PubMed 23109706
Publications 2011
-
Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue
Mol Oncol, 5 (6), 564-76
DOI 10.1016/j.molonc.2011.08.004, PubMed 21917534 -
Identification of genetic variation in 11 candidate genes of canine mammary tumour
Vet Comp Oncol, 9 (4), 241-50
DOI 10.1111/j.1476-5829.2010.00250.x, PubMed 22077404 -
The level of claudin-7 is reduced as an early event in colorectal carcinogenesis
BMC Cancer, 11, 65
DOI 10.1186/1471-2407-11-65, PubMed 21310043 -
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium
Hum Mol Genet, 20 (16), 3289-303
DOI 10.1093/hmg/ddr228, PubMed 21596841 -
Identification of fusion genes in breast cancer by paired-end RNA-sequencing
Genome Biol, 12 (1), R6
DOI 10.1186/gb-2011-12-1-r6, PubMed 21247443 -
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
PLoS One, 6 (2), e16915
DOI 10.1371/journal.pone.0016915, PubMed 21364938 -
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
Clin Proteomics, 8 (1), 11
DOI 10.1186/1559-0275-8-11, PubMed 21906370 -
13C high-resolution-magic angle spinning MRS reveals differences in glucose metabolism between two breast cancer xenograft models with different gene expression patterns
NMR Biomed, 24 (10), 1243-52
DOI 10.1002/nbm.1683, PubMed 21462378 -
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
Cancer Discov, 1 (1), 78-89
DOI 10.1158/2159-8274.CD-11-0005, PubMed 22328973 -
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers
PLoS One, 6 (4), e18064
DOI 10.1371/journal.pone.0018064, PubMed 21533284 -
EGFR gene alterations in a Norwegian cohort of lung cancer patients selected for surgery
J Thorac Oncol, 6 (5), 947-50
DOI 10.1097/JTO.0b013e31820db209, PubMed 21623266 -
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters
Nat Genet, 43 (7), 621-9
DOI 10.1038/ng.848, PubMed 21642992 -
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas
BMC Cancer, 11, 332
DOI 10.1186/1471-2407-11-332, PubMed 21812955 -
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features
BMC Med Genomics, 4, 77
DOI 10.1186/1755-8794-4-77, PubMed 22044755 -
Allele-specific disparity in breast cancer
BMC Med Genomics, 4, 85
DOI 10.1186/1755-8794-4-85, PubMed 22188678 -
The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians
Cancer Cell, 19 (2), 273-82
DOI 10.1016/j.ccr.2010.12.019, PubMed 21316605 -
Divide and conquer: the genetic basis of molecular subclassification of breast cancer
EMBO Mol Med, 3 (4), 183-5
DOI 10.1002/emmm.201100128, PubMed 21394915 -
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling
Proc Natl Acad Sci U S A, 109 (8), 2802-7
DOI 10.1073/pnas.1108781108, PubMed 21908711 -
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues
Front Biosci (Elite Ed), 3 (4), 1443-55
DOI 10.2741/e345, PubMed 21622148 -
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer
Int J Cancer, 131 (4), E405-15
DOI 10.1002/ijc.26444, PubMed 21935921 -
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer
Cancer Epidemiol Biomarkers Prev, 20 (10), 2222-31
DOI 10.1158/1055-9965.EPI-11-0569, PubMed 21795498 -
The prognostic significance of tumour cell detection in the peripheral blood versus the bone marrow in 733 early-stage breast cancer patients
Breast Cancer Res, 13 (3), R61
DOI 10.1186/bcr2898, PubMed 21672237 -
A SImplified method for Segregation Analysis (SISA) to determine penetrance and expression of a genetic variant in a family
Hum Mutat, 32 (5), 568-71
DOI 10.1002/humu.21441, PubMed 21309035 -
Systems biology and genomics of breast cancer
Cold Spring Harb Perspect Biol, 3 (2)
DOI 10.1101/cshperspect.a003293, PubMed 21047916 -
Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway
Brain Behav Immun, 25 (7), 1376-83
DOI 10.1016/j.bbi.2011.04.001, PubMed 21496483 -
Paired distribution of molecular subtypes in bilateral breast carcinomas
Cancer Genet, 204 (2), 96-102
DOI 10.1016/j.cancergencyto.2010.09.012, PubMed 21504707 -
Insight into the heterogeneity of breast cancer through next-generation sequencing
J Clin Invest, 121 (10), 3810-8
DOI 10.1172/JCI57088, PubMed 21965338 -
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer
BMC Bioinformatics, 12, 197
DOI 10.1186/1471-2105-12-197, PubMed 21609452 -
How to personalise treatment in early breast cancer
Eur J Cancer, 47 Suppl 3, S310-1
DOI 10.1016/S0959-8049(11)70182-4, PubMed 21943994 -
Stereotactic body radiation therapy is effective and safe in patients with early-stage non-small cell lung cancer with low performance status and severe comorbidity
Case Rep Oncol, 4 (1), 25-34
DOI 10.1159/000324113, PubMed 21526003 -
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups
Breast Cancer Res Treat, 130 (2), 599-608
DOI 10.1007/s10549-011-1615-y, PubMed 21667122 -
The breast cancer genome--a key for better oncology
BMC Cancer, 11, 501
DOI 10.1186/1471-2407-11-501, PubMed 22128823 -
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
Breast Cancer Res Treat, 133 (3), 865-80
DOI 10.1007/s10549-011-1846-y, PubMed 22048815 -
Gene expression profiling of human dermal fibroblasts exposed to bleomycin sulphate does not differentiate between radiation sensitive and control patients
Radiat Oncol, 6, 42
DOI 10.1186/1748-717X-6-42, PubMed 21521514 -
Combining gene signatures improves prediction of breast cancer survival
PLoS One, 6 (3), e17845
DOI 10.1371/journal.pone.0017845, PubMed 21423775
Publications 2010
-
p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines
Cancer Lett, 300 (2), 215-24
DOI 10.1016/j.canlet.2010.10.008, PubMed 21071137 -
EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors
Sci Signal, 3 (124), ra43
DOI 10.1126/scisignal.2000876, PubMed 20516477 -
Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers
Mol Cancer, 9, 173
DOI 10.1186/1476-4598-9-173, PubMed 20594292 -
Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study
J Natl Cancer Inst, 102 (7), 475-83
DOI 10.1093/jnci/djq055, PubMed 20305132 -
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density
BMC Med Genomics, 3, 9
DOI 10.1186/1755-8794-3-9, PubMed 20302654 -
Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study
Hum Mutat, 31 (3), E1200-40
DOI 10.1002/humu.21202, PubMed 20104584 -
Merging transcriptomics and metabolomics--advances in breast cancer profiling
BMC Cancer, 10, 628
DOI 10.1186/1471-2407-10-628, PubMed 21080935 -
Europe's largest Member Association for Cancer Research
Period. Biol., 112 (4), 483-485 -
On the molecular biology of breast cancer
Mol Oncol, 4 (3), 171-3
DOI 10.1016/j.molonc.2010.04.007, PubMed 20483673 -
Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment
Am J Pathol, 176 (3), 1229-40
DOI 10.2353/ajpath.2010.090648, PubMed 20133812 -
DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response
Mol Cancer, 9, 68
DOI 10.1186/1476-4598-9-68, PubMed 20338046 -
Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition
Int J Cancer, 127 (2), 442-51
DOI 10.1002/ijc.25050, PubMed 19924816 -
Deciphering normal blood gene expression variation--The NOWAC postgenome study
PLoS Genet, 6 (3), e1000873
DOI 10.1371/journal.pgen.1000873, PubMed 20300640 -
SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance
Pharmacogenomics J, 10 (6), 513-23
DOI 10.1038/tpj.2010.6, PubMed 20157331 -
NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
Mol Cancer, 9, 113
DOI 10.1186/1476-4598-9-113, PubMed 20482849 -
A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers
Clin Proteomics, 6 (4), 129-51
DOI 10.1007/s12014-010-9055-y, PubMed 21691416 -
G127R: A novel SOD1 mutation associated with rapidly evolving ALS and severe pain syndrome
Amyotroph Lateral Scler, 11 (5), 478-80
DOI 10.3109/17482960903580315, PubMed 20192886 -
BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations
BMC Cancer, 10, 654
DOI 10.1186/1471-2407-10-654, PubMed 21118481 -
Expression levels of uridine 5'-diphospho-glucuronosyltransferase genes in breast tissue from healthy women are associated with mammographic density
Breast Cancer Res, 12 (4), R65
DOI 10.1186/bcr2632, PubMed 20799965 -
International network of cancer genome projects
Nature, 464 (7291), 993-8
DOI 10.1038/nature08987, PubMed 20393554 -
The epigenetics of breast cancer
Mol Oncol, 4 (3), 242-54
DOI 10.1016/j.molonc.2010.04.002, PubMed 20627830 -
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables
Mol Oncol, 5 (1), 77-92
DOI 10.1016/j.molonc.2010.11.002, PubMed 21169070 -
Mutations for the people
EMBO Mol Med, 2 (5), 143-5
DOI 10.1002/emmm.201000071, PubMed 20461736 -
Blood gene expression profiling of breast cancer survivors experiencing fibrosis
Int J Radiat Oncol Biol Phys, 79 (3), 875-83
DOI 10.1016/j.ijrobp.2010.09.052, PubMed 21129856 -
The genetics and epigenetics of fatigue
PM R, 2 (5), 456-65
DOI 10.1016/j.pmrj.2010.04.003, PubMed 20656628 -
[How do Norwegian oncologists perceive their working conditions?]
Tidsskr Nor Laegeforen, 130 (5), 487-9
DOI 10.4045/tidsskr.08.0305, PubMed 20224615 -
Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models
BMC Cancer, 10, 433
DOI 10.1186/1471-2407-10-433, PubMed 20716336 -
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
Mol Oncol, 4 (4), 357-68
DOI 10.1016/j.molonc.2010.06.007, PubMed 20663721 -
Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer
Breast Cancer Res, 12 (1), R3
DOI 10.1186/bcr2466, PubMed 20056007 -
In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome
PLoS One, 5 (11), e14002
DOI 10.1371/journal.pone.0014002, PubMed 21124964 -
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer (vol 1, pg 160, 2007)
Mol. Oncol., 4 (2), 169
DOI 10.1016/j.molonc.2010.01.003 -
High prevalence of germline STK11 mutations in Hungarian Peutz-Jeghers Syndrome patients
BMC Med Genet, 11, 169
DOI 10.1186/1471-2350-11-169, PubMed 21118512 -
Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations
Eur J Clin Pharmacol, 66 (12), 1199-205
DOI 10.1007/s00228-010-0864-8, PubMed 20665013 -
Regularized Multivariate Regression for Identifying Master Predictors with Application to Integrative Genomics Study of Breast Cancer
Ann Appl Stat, 4 (1), 53-77
DOI 10.1214/09-AOAS271SUPP, PubMed 24489618 -
Triple-negative breast cancer: present challenges and new perspectives
Mol Oncol, 4 (3), 209-29
DOI 10.1016/j.molonc.2010.04.006, PubMed 20537966 -
Integrative functional genomics analysis of sustained polyploidy phenotypes in breast cancer cells identifies an oncogenic profile for GINS2
Neoplasia, 12 (11), 877-88
DOI 10.1593/neo.10548, PubMed 21082043 -
Cisplatin-induced apoptosis involves a Fas-ROCK-ezrin-dependent actin remodelling in human colon cancer cells
Eur J Cancer, 46 (8), 1445-55
DOI 10.1016/j.ejca.2010.01.034, PubMed 20202822 -
Predictors and course of chronic fatigue in long-term breast cancer survivors
J Cancer Surviv, 4 (4), 405-14
DOI 10.1007/s11764-010-0145-7, PubMed 20862614 -
Genomic architecture characterizes tumor progression paths and fate in breast cancer patients
Sci Transl Med, 2 (38), 38ra47
DOI 10.1126/scitranslmed.3000611, PubMed 20592421 -
Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer
Mol Oncol, 5 (1), 61-76
DOI 10.1016/j.molonc.2010.11.004, PubMed 21212030 -
The importance of gene-centring microarray data
Lancet Oncol, 11 (8), 719-20; author reply 720-1
DOI 10.1016/S1470-2045(10)70174-1, PubMed 20688275 -
Excessive Soft Tissue Reaction after Stereotactic Body Radiation Therapy in a Woman with Four Different Cancer Diagnoses
Case Rep Oncol, 3 (2), 195-201
DOI 10.1159/000317104, PubMed 20740196 -
Allele-specific copy number analysis of tumors
Proc Natl Acad Sci U S A, 107 (39), 16910-5
DOI 10.1073/pnas.1009843107, PubMed 20837533 -
Gene expression profiling of peripheral blood cells for early detection of breast cancer
Breast Cancer Res, 12 (1), R7
DOI 10.1186/bcr2472, PubMed 20078854
Publications 2009
-
Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer
Clin Cancer Res, 15 (11), 3654-62
DOI 10.1158/1078-0432.CCR-08-3293, PubMed 19470724 -
The multidrug resistance 1 (MDR1) gene polymorphism G-rs3789243-A is not associated with disease susceptibility in Norwegian patients with colorectal adenoma and colorectal cancer; a case control study
BMC Med Genet, 10, 18
DOI 10.1186/1471-2350-10-18, PubMed 19250544 -
N-Myristoylation targets dihydroceramide Delta4-desaturase 1 to mitochondria: partial involvement in the apoptotic effect of myristic acid
Biochimie, 91 (11-12), 1411-9
DOI 10.1016/j.biochi.2009.07.014, PubMed 19647031 -
Molecular profiling and characterization of luminal-like and basal-like in vivo breast cancer xenograft models
Mol Oncol, 3 (5-6), 469-82
DOI 10.1016/j.molonc.2009.07.003, PubMed 19713161 -
Focal amplification and oncogene dependency of GAB2 in breast cancer
Oncogene, 29 (5), 774-9
DOI 10.1038/onc.2009.364, PubMed 19881546 -
Association of ESR1 gene tagging SNPs with breast cancer risk
Hum Mol Genet, 18 (6), 1131-9
DOI 10.1093/hmg/ddn429, PubMed 19126777 -
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
Breast Cancer Res Treat, 120 (1), 175-83
DOI 10.1007/s10549-009-0455-5, PubMed 19597986 -
Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium
Cancer Epidemiol Biomarkers Prev, 18 (5), 1610-6
DOI 10.1158/1055-9965.EPI-08-0745, PubMed 19423537 -
Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone
Cytogenet Genome Res, 124 (2), 121-7
DOI 10.1159/000207516, PubMed 19420923 -
Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays
Nucleic Acids Res, 37 (15), e105
DOI 10.1093/nar/gkp526, PubMed 19541849 -
A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide
Clin Cancer Res, 15 (12), 4165-73
DOI 10.1158/1078-0432.CCR-09-0119, PubMed 19509150 -
Cytogenetic effects of 18.0 and 16.5 GHz microwave radiation on human lymphocytes in vitro
Anticancer Res, 29 (8), 2885-92
PubMed 19661291 -
Methylation detection oligonucleotide microarray analysis: a high-resolution method for detection of CpG island methylation
Nucleic Acids Res, 37 (12), e89
DOI 10.1093/nar/gkp413, PubMed 19474344 -
TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies
Lancet Oncol, 10 (8), 772-84
DOI 10.1016/S1470-2045(09)70187-1, PubMed 19625214 -
Functional glutathione S-transferase genotypes among testicular germ cell tumor survivors: associations with primary and post-chemotherapy tumor histology
Pharmacogenet Genomics, 19 (10), 751-9
DOI 10.1097/FPC.0b013e3283304253, PubMed 19741569 -
Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors
Pharmacogenomics J, 9 (5), 333-40
DOI 10.1038/tpj.2009.27, PubMed 19546881 -
Protein lysate microarray analysis to identify microRNAs regulating estrogen receptor signaling in breast cancer cell lines
Oncogene, 28 (44), 3926-36
DOI 10.1038/onc.2009.241, PubMed 19684618 -
Found in transcription: gene expression and other novel blood biomarkers for the early detection of breast cancer
Expert Rev Anticancer Ther, 9 (8), 1115-23
DOI 10.1586/era.09.31, PubMed 19671031 -
Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line
BMC Med Genomics, 2, 26
DOI 10.1186/1755-8794-2-26, PubMed 19432969 -
Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis
PLoS One, 4 (5), e5583
DOI 10.1371/journal.pone.0005583, PubMed 19440550 -
Somatic mutation databases as tools for molecular epidemiology and molecular pathology of cancer: proposed guidelines for improving data collection, distribution, and integration
Hum Mutat, 30 (3), 275-82
DOI 10.1002/humu.20832, PubMed 19006239 -
Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression
Mol Oncol, 4 (2), 98-118
DOI 10.1016/j.molonc.2009.12.001, PubMed 20060370 -
Two brothers with a microduplication including the MECP2 gene: rapid head growth in infancy and resolution of susceptibility to infection
Clin Dysmorphol, 18 (2), 78-82
DOI 10.1097/MCD.0b013e32831e19cd, PubMed 19057379 -
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesis
BMC Cancer, 9, 201
DOI 10.1186/1471-2407-9-201, PubMed 19555470 -
X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene
J Clin Endocrinol Metab, 94 (10), 4086-93
DOI 10.1210/jc.2009-0923, PubMed 19773398 -
A universal assay for detection of oncogenic fusion transcripts by oligo microarray analysis
Mol Cancer, 8, 5
DOI 10.1186/1476-4598-8-5, PubMed 19152679 -
Collagen mRNA levels changes during colorectal cancer carcinogenesis
BMC Cancer, 9, 136
DOI 10.1186/1471-2407-9-136, PubMed 19422682 -
Frequency-Domain Pearson Distribution Approach for Independent Component Analysis (FD-Pearson-ICA) in Blind Source Separation
IEEE Trans. Audio Speech Lang. Process., 17 (4), 639-649
DOI 10.1109/TASL.2008.2011527 -
Complex landscapes of somatic rearrangement in human breast cancer genomes
Nature, 462 (7276), 1005-10
DOI 10.1038/nature08645, PubMed 20033038 -
Integrated study of copy number states and genotype calls using high-density SNP arrays
Nucleic Acids Res, 37 (16), 5365-77
DOI 10.1093/nar/gkp493, PubMed 19581427 -
Introducing molecular subtyping of breast cancer into the clinic?
J Clin Oncol, 27 (8), 1153-4
DOI 10.1200/JCO.2008.20.6276, PubMed 19204193 -
Recommendations to improve identification of hereditary and familial colorectal cancer in Europe
Fam Cancer, 9 (2), 109-15
DOI 10.1007/s10689-009-9291-3, PubMed 19763885 -
Full sequencing of TP53 identifies identical mutations within in situ and invasive components in breast cancer suggesting clonal evolution
Mol Oncol, 3 (3), 214-9
DOI 10.1016/j.molonc.2009.03.001, PubMed 19403344
Publications 2008
-
A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients
Acta Oncol, 47 (4), 600-7
DOI 10.1080/02841860802047411, PubMed 18465328 -
Comparison of the Agilent, ROMA/NimbleGen and Illumina platforms for classification of copy number alterations in human breast tumors
BMC Genomics, 9, 379
DOI 10.1186/1471-2164-9-379, PubMed 18691401 -
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
Mol Oncol, 2 (4), 327-39
DOI 10.1016/j.molonc.2008.09.004, PubMed 19383354 -
Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome
J Pathol, 214 (3), 357-67
DOI 10.1002/path.2278, PubMed 18044827 -
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation
Mol Syst Biol, 4, 229
DOI 10.1038/msb.2008.65, PubMed 19034270 -
Variants in the ATM gene associated with a reduced risk of contralateral breast cancer
Cancer Res, 68 (16), 6486-91
DOI 10.1158/0008-5472.CAN-08-0134, PubMed 18701470 -
Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study
Breast Cancer Res, 10 (1), R13
DOI 10.1186/bcr1859, PubMed 18271962 -
Comparison of globin RNA processing methods for genome-wide transcriptome analysis from whole blood
Biomark Med, 2 (1), 11-21
DOI 10.2217/17520363.2.1.11, PubMed 20477359 -
Human papillomavirus DNA and e6/e7 mRNA status in relation to survival of patients treated for cervical squamous cell carcinoma
Open Virol J, 2, 74-81
DOI 10.2174/1874357900802010074, PubMed 19440467 -
ESR1 gene amplification in breast cancer: a common phenomenon?
Nat Genet, 40 (7), 807-8; author reply 810-2
DOI 10.1038/ng0708-807, PubMed 18583965 -
SNPs associated with molecular subtypes of breast cancer: on the usefulness of stratified Genome-wide Association Studies (GWAS) in the identification of novel susceptibility loci
Mol Oncol, 2 (1), 12-5
DOI 10.1016/j.molonc.2008.02.003, PubMed 19383324 -
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation
Genet Epidemiol, 32 (2), 168-78
DOI 10.1002/gepi.20273, PubMed 17968987 -
Accounting for haplotype phase uncertainty in linkage disequilibrium estimation (vol 32, pg 168, 2008)
Genet. Epidemiol., 32 (6), 586-587
DOI 10.1002/gepi.20332 -
Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks
Biochemistry, 47 (51), 13674-85
DOI 10.1021/bi801368n, PubMed 19035652 -
Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study
Br J Cancer, 98 (4), 728-33
DOI 10.1038/sj.bjc.6604228, PubMed 18253122 -
Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival
Int J Cancer, 123 (3), 577-85
DOI 10.1002/ijc.23541, PubMed 18498133 -
Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients
Genes Chromosomes Cancer, 47 (8), 680-96
DOI 10.1002/gcc.20569, PubMed 18398821 -
Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering
Hepatology, 47 (1), 59-70
DOI 10.1002/hep.21958, PubMed 18038449 -
EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer
Breast Cancer Res, 10 (6), R109
DOI 10.1186/bcr2214, PubMed 19099573 -
GSTP1 promoter haplotypes affect DNA methylation levels and promoter activity in breast carcinomas
Cancer Res, 68 (14), 5562-71
DOI 10.1158/0008-5472.CAN-07-5828, PubMed 18632608 -
ST-PLS: a multi-directional nearest shrunken centroid type classi er via PLS
J. Chemometr., 22 (1-2), 54-62
DOI 10.1002/cem.1101 -
CYP1A2 164 A-->C polymorphism, cigarette smoking, consumption of well-done red meat and risk of developing colorectal adenomas and carcinomas
Anticancer Res, 28 (4C), 2289-95
PubMed 18751408 -
Voice activity detection based on adjustable linear prediction and GARCH models
Speech Commun., 50 (6), 476-486
DOI 10.1016/j.specom.2008.02.003 -
TP53 mutations in synchronous and metachronous bilateral breast carcinomas
Cancer Genet Cytogenet, 184 (2), 119-21
DOI 10.1016/j.cancergencyto.2008.03.005, PubMed 18617062 -
Transcriptional networks inferred from molecular signatures of breast cancer
Am J Pathol, 172 (2), 495-509
DOI 10.2353/ajpath.2008.061079, PubMed 18187569 -
Single nucleotide polymorphisms in the multidrug resistance gene 1 (ABCB1): effects on its expression and clinicopathological characteristics in breast cancer patients
Pharmacogenet Genomics, 18 (3), 263-73
DOI 10.1097/FPC.0b013e3282f60a91, PubMed 18300948 -
Hormone replacement therapy use and plasma levels of sex hormones in the Norwegian Women and Cancer postgenome cohort - a cross-sectional analysis
BMC Womens Health, 8, 1
DOI 10.1186/1472-6874-8-1, PubMed 18194511 -
[The selected contagions]
Tidsskr Nor Laegeforen, 128 (20), 2304
PubMed 19096483
Publications 2007
-
Differential gene expression before and after ionizing radiation of subcutaneous fibroblasts identifies breast cancer patients resistant to radiation-induced fibrosis
Radiother Oncol, 83 (3), 261-6
DOI 10.1016/j.radonc.2007.05.001, PubMed 17512072 -
Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy
BMC Cancer, 7, 197
DOI 10.1186/1471-2407-7-197, PubMed 17956601 -
Predicting survival from microarray data--a comparative study
Bioinformatics, 23 (16), 2080-7
DOI 10.1093/bioinformatics/btm305, PubMed 17553857 -
Relationship between p53 and p27 expression following HER2 signaling
Breast, 16 (6), 597-605
DOI 10.1016/j.breast.2007.05.007, PubMed 17604627 -
Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
Breast Cancer Res, 9 (1), R5
DOI 10.1186/bcr1637, PubMed 17224074 -
Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma
Cancer, 110 (6), 1264-71
DOI 10.1002/cncr.22918, PubMed 17647260 -
Germline glutathione S-transferase variants in breast cancer: relation to diagnosis and cutaneous long-term adverse effects after two fractionation patterns of radiotherapy
Int J Radiat Oncol Biol Phys, 67 (4), 1163-71
DOI 10.1016/j.ijrobp.2006.11.009, PubMed 17336217 -
Linkage disequilibrium pattern of the ATM gene in breast cancer patients and controls; association of SNPs and haplotypes to radio-sensitivity and post-lumpectomy local recurrence
Radiat Oncol, 2, 25
DOI 10.1186/1748-717X-2-25, PubMed 17623063 -
Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer
Int J Cancer, 121 (11), 2532-8
DOI 10.1002/ijc.22985, PubMed 17683073 -
Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status
Cancer Epidemiol Biomarkers Prev, 16 (11), 2269-75
DOI 10.1158/1055-9965.EPI-07-0449, PubMed 18006915 -
Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells
Chem Biol Interact, 167 (1), 41-55
DOI 10.1016/j.cbi.2007.01.008, PubMed 17289009 -
c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis
Cancer Res, 67 (4), 1696-705
DOI 10.1158/0008-5472.CAN-06-2327, PubMed 17308111 -
Discovery and validation of breast cancer subtypes (vol 8, pg 101, 2007)
BMC Genomics, 8, 101
DOI 10.1186/1471-2164-8-101 -
Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review
Am J Epidemiol, 165 (11), 1221-30
DOI 10.1093/aje/kwm003, PubMed 17404387 -
Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses
Mol Cancer, 6, 2
DOI 10.1186/1476-4598-6-2, PubMed 17201907 -
Mutations and polymorphisms of the p21B transcript in breast cancer
Int J Cancer, 121 (4), 908-10
DOI 10.1002/ijc.22777, PubMed 17443496 -
Transcriptional response to ionizing radiation in human radiation sensitive cell lines
Radiother Oncol, 83 (3), 256-60
DOI 10.1016/j.radonc.2007.04.017, PubMed 17512073 -
TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer
Breast Cancer Res, 9 (3), R30
DOI 10.1186/bcr1675, PubMed 17504517 -
Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma
BMC Cancer, 7, 192
DOI 10.1186/1471-2407-7-192, PubMed 17935612 -
Hormone replacement therapy and breast cancer in former users of oral contraceptives--The Norwegian Women and Cancer study
Int J Cancer, 121 (3), 645-8
DOI 10.1002/ijc.22699, PubMed 17372914 -
Cohort profile: The Norwegian Women and Cancer Study--NOWAC--Kvinner og kreft
Int J Epidemiol, 37 (1), 36-41
DOI 10.1093/ije/dym137, PubMed 17644530 -
Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
Lancet Oncol, 8 (1), 26-34
DOI 10.1016/S1470-2045(06)70983-4, PubMed 17196508 -
Presence of bone marrow micrometastasis is associated with different recurrence risk within molecular subtypes of breast cancer
Mol Oncol, 1 (2), 160-71
DOI 10.1016/j.molonc.2007.03.004, PubMed 19383292 -
Disease-specific genomic analysis: identifying the signature of pathologic biology
Bioinformatics, 23 (8), 957-65
DOI 10.1093/bioinformatics/btm033, PubMed 17277331 -
Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes
Breast Cancer Res, 9 (6), 113
DOI 10.1186/bcr1784, PubMed 18036273 -
ABCB1 and GST polymorphisms associated with TP53 status in breast cancer
Pharmacogenet Genomics, 17 (2), 127-36
DOI 10.1097/FPC.0b013e328011abaa, PubMed 17301692 -
TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
Oncogene, 26 (15), 2157-65
DOI 10.1038/sj.onc.1210302, PubMed 17401424 -
Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells
Cancer Res, 67 (16), 7865-74
DOI 10.1158/0008-5472.CAN-07-0353, PubMed 17699793 -
Ocular findings in Norwegian patients with ataxia-telangiectasia: a 5 year prospective cohort study
Acta Ophthalmol Scand, 85 (5), 557-62
DOI 10.1111/j.1600-0420.2007.00890.x, PubMed 17376192 -
Features of 5'-splice-site efficiency derived from disease-causing mutations and comparative genomics
Genome Res, 18 (1), 77-87
DOI 10.1101/gr.6859308, PubMed 18032726 -
Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis
Radiother Oncol, 86 (3), 314-20
DOI 10.1016/j.radonc.2007.09.013, PubMed 17963910 -
Airway inflammation in paper mill workers
J Occup Environ Med, 49 (10), 1135-42
DOI 10.1097/JOM.0b013e31814b2e87, PubMed 18000418 -
Macrophage enrichment from induced sputum
Thorax, 62 (6), 558-9
DOI 10.1136/thx.2006.073544, PubMed 17536036 -
Meat, vegetables and genetic polymorphisms and the risk of colorectal carcinomas and adenomas
BMC Cancer, 7, 228
DOI 10.1186/1471-2407-7-228, PubMed 18093316 -
Prevention of colorectal cancer by colonoscopic surveillance in families with hereditary colorectal cancer
Scand J Gastroenterol, 42 (5), 611-7
DOI 10.1080/00365520601010230, PubMed 17454882 -
Alpha fetoprotein is increasing with age in ataxia-telangiectasia
Eur J Paediatr Neurol, 11 (6), 375-80
DOI 10.1016/j.ejpn.2007.04.001, PubMed 17540590 -
A retroviral vector for siRNA expression in mammalian cells
Mol Biotechnol, 35 (3), 275-82
DOI 10.1007/BF02686013, PubMed 17652791 -
Nonrandom distribution of oncogene amplifications in bilateral breast carcinomas: Possible role of host factors and survival bias
Int J Cancer, 120 (2), 297-302
DOI 10.1002/ijc.22265, PubMed 17066426 -
Molecular classification of breast tumors: toward improved diagnostics and treatments
Methods Mol Biol, 360, 91-114
DOI 10.1385/1-59745-165-7:91, PubMed 17172726 -
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer)
J Med Genet, 44 (6), 353-62
DOI 10.1136/jmg.2007.048991, PubMed 17327285 -
TP53 mutations and codon 72 genotype--impact on survival among ovarian cancer patients
Ann Oncol, 18 (5), 964-6
DOI 10.1093/annonc/mdm134, PubMed 17488735 -
A supervised approach for identifying discriminating genotype patterns and its application to breast cancer data
Bioinformatics, 23 (2), e91-8
DOI 10.1093/bioinformatics/btl298, PubMed 17237111
Publications 2006
-
Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report
Leukemia, 20 (4), 734-6
DOI 10.1038/sj.leu.2404117, PubMed 16437140 -
Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters
Mol Cancer, 5, 47
DOI 10.1186/1476-4598-5-47, PubMed 17054774 -
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
Genes Chromosomes Cancer, 45 (11), 1033-40
DOI 10.1002/gcc.20366, PubMed 16897746 -
Rearrangement of chromosomal region 8q11-13 in lipomatous tumours: correlation with lipoblastoma morphology
J Pathol, 208 (3), 388-94
DOI 10.1002/path.1879, PubMed 16308870 -
Genomic aberrations in mucinous tubular and spindle cell renal cell carcinomas
Mod Pathol, 19 (2), 186-94
DOI 10.1038/modpathol.3800499, PubMed 16258504 -
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers
PLoS Med, 3 (3), e47
DOI 10.1371/journal.pmed.0030047, PubMed 16417408 -
Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization
J Invest Dermatol, 126 (10), 2308-15
DOI 10.1038/sj.jid.5700375, PubMed 16728973 -
Genome-wide linkage screen for testicular germ cell tumour susceptibility loci
Hum Mol Genet, 15 (3), 443-51
DOI 10.1093/hmg/ddi459, PubMed 16407372 -
Diagnostic and prognostic value of molecular cytogenetic analyses of sextant biopsies from prostate cancer suspects
Crit Rev Oncog, 12 (3-4), 303-4; discussion 304
DOI 10.1615/critrevoncog.v12.i3-4.100, PubMed 17425511 -
The order of genetic events associated with colorectal cancer progression inferred from meta-analysis of copy number changes
Genes Chromosomes Cancer, 45 (1), 31-41
DOI 10.1002/gcc.20261, PubMed 16145679 -
Monitoring of disseminated tumor cells in bone marrow in high-risk breast cancer patients treated with high-dose chemotherapy
Int J Cancer, 118 (11), 2877-81
DOI 10.1002/ijc.21709, PubMed 16381016 -
Gene expression profiling of whole-blood samples from women exposed to hormone replacement therapy
Mol Cancer Ther, 5 (4), 868-76
DOI 10.1158/1535-7163.MCT-05-0329, PubMed 16648556 -
Experimental validation of data mined single nucleotide polymorphisms from several databases and consecutive dbSNP builds
Pharmacogenet Genomics, 16 (3), 207-17
DOI 10.1097/01.fpc.0000194422.12770.fb, PubMed 16495780 -
Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
Breast Cancer Res, 8 (2), R15
DOI 10.1186/bcr1387, PubMed 16563180 -
Quality of life and its relation to cancer-related stress in women of families with hereditary cancer without demonstrated mutation
Qual Life Res, 15 (3), 461-70
DOI 10.1007/s11136-005-3008-3, PubMed 16547785 -
Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol
Ann N Y Acad Sci, 1090, 108-12
DOI 10.1196/annals.1378.011, PubMed 17384252 -
RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability
Carcinogenesis, 27 (8), 1593-9
DOI 10.1093/carcin/bgi360, PubMed 16474176 -
Radiation-induced effects on gene expression: an in vivo study on breast cancer
Radiother Oncol, 80 (2), 230-5
DOI 10.1016/j.radonc.2006.07.007, PubMed 16890317 -
Novel patterns of genome rearrangement and their association with survival in breast cancer
Genome Res, 16 (12), 1465-79
DOI 10.1101/gr.5460106, PubMed 17142309 -
Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells
J Cell Physiol, 208 (3), 527-37
DOI 10.1002/jcp.20686, PubMed 16688778 -
Peripheral T-cell lymphoma with involvement of the expanded mantle zone
Virchows Arch, 449 (1), 78-87
DOI 10.1007/s00428-005-0123-z, PubMed 16633785 -
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53
Blood, 109 (6), 2589-96
DOI 10.1182/blood-2006-02-004234, PubMed 17105820 -
A daily glass of red wine induces a prolonged reduction in plasma viscosity: a randomized controlled trial
Blood Coagul Fibrinolysis, 17 (6), 471-6
DOI 10.1097/01.mbc.0000240920.72930.63, PubMed 16905951 -
Discovery and validation of breast cancer subtypes
BMC Genomics, 7, 231
DOI 10.1186/1471-2164-7-231, PubMed 16965636 -
Advances in the genetics and epigenetics of gene regulation and human disease
Genome Biol, 7 (8), 325
DOI 10.1186/gb-2006-7-8-325, PubMed 16934107 -
A new perspective on Renn and Klinke's approach to risk evaluation and management
Reliab. Eng. Syst. Saf., 91 (4), 421-432
DOI 10.1016/j.ress.2005.02.006 -
Genetic variation in putative regulatory loci controlling gene expression in breast cancer
Proc Natl Acad Sci U S A, 103 (20), 7735-40
DOI 10.1073/pnas.0601893103, PubMed 16684880 -
Multilocus analysis of SNP and metabolic data within a given pathway
BMC Genomics, 7, 5
DOI 10.1186/1471-2164-7-5, PubMed 16412218 -
Severity of illness and the use of paracetamol in febrile preschool children; a case simulation study of parents' assessments
Fam Pract, 23 (6), 618-23
DOI 10.1093/fampra/cml046, PubMed 17035288 -
A quality assessment survey of SNP genotyping laboratories
Hum Mutat, 27 (7), 711-4
DOI 10.1002/humu.20346, PubMed 16786507 -
On the proposed association of the ATM variants 5557G>A and IVS38-8T>C and bilateral breast cancer
Int J Cancer, 119 (3), 724-5
DOI 10.1002/ijc.21876, PubMed 16496408 -
ADAMTS1, CRABP1, and NR3C1 identified as epigenetically deregulated genes in colorectal tumorigenesis
Cell. Oncol., 28 (5-6), 259-272 -
Interaction between p53 staining and high-dose chemotherapy in breast cancer
Clin Cancer Res, 12 (7 Pt 1), 2289
DOI 10.1158/1078-0432.CCR-06-0129, PubMed 16609046 -
Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma
Cancer Res, 66 (1), 107-12
DOI 10.1158/0008-5472.CAN-05-2485, PubMed 16397222 -
Evaluation of MetriGenix custom 4D arrays applied for detection of breast cancer subtypes
BMC Cancer, 6, 59
DOI 10.1186/1471-2407-6-59, PubMed 16536878 -
Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study
Lancet Oncol, 7 (5), 402-6
DOI 10.1016/S1470-2045(06)70624-6, PubMed 16648044 -
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
Clin Cancer Res, 12 (4), 1157-67
DOI 10.1158/1078-0432.CCR-05-1029, PubMed 16489069 -
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review
Am J Epidemiol, 165 (2), 115-25
DOI 10.1093/aje/kwj365, PubMed 17053044 -
Statistical dissection of genetic pathways involved in prostate carcinogenesis
Genes Chromosomes Cancer, 45 (2), 154-63
DOI 10.1002/gcc.20279, PubMed 16235241 -
Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
Mol Cancer, 5, 33
DOI 10.1186/1476-4598-5-33, PubMed 16952311 -
The frequent BRCA1 mutation 1135insA has multiple origins: a haplotype study in different populations
BMC Med Genet, 7, 15
DOI 10.1186/1471-2350-7-15, PubMed 16509964 -
Intraoperative, radio-guided sentinel lymph node mapping in 110 nonsmall cell lung cancer patients
Ann Thorac Surg, 82 (1), 237-42
DOI 10.1016/j.athoracsur.2006.01.094, PubMed 16798221 -
Increased mRNA expression levels of ERCC1, OGG1 and RAI in colorectal adenomas and carcinomas
BMC Cancer, 6, 208
DOI 10.1186/1471-2407-6-208, PubMed 16914027 -
Association between cigarette smoking, APC mutations and the risk of developing sporadic colorectal adenomas and carcinomas
BMC Cancer, 6, 71
DOI 10.1186/1471-2407-6-71, PubMed 16545110 -
FISH mapping of i(7q) in acute leukemias and myxoid liposarcoma reveals clustered breakpoints in 7p11.2: implications for formation and pathogenetic outcome of the idic(7)(p11.2)
Cytogenet Genome Res, 114 (2), 126-30
DOI 10.1159/000093327, PubMed 16825763 -
A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1
Genomics, 89 (3), 354-61
DOI 10.1016/j.ygeno.2006.11.003, PubMed 17188460 -
Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study
BMC Cancer, 6, 175
DOI 10.1186/1471-2407-6-175, PubMed 16817948 -
Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
BMC Cancer, 6, 67
DOI 10.1186/1471-2407-6-67, PubMed 16542436 -
Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours
J Pathol, 209 (4), 492-500
DOI 10.1002/path.1998, PubMed 16721726 -
Estimated prevalence of hereditary cancers and the need for surveillance in a Norwegian county, Telemark
Scand J Gastroenterol, 41 (1), 71-9
DOI 10.1080/00365520510023891, PubMed 16373279 -
The novel p21 polymorphism p21G251A is associated with locally advanced breast cancer
Clin Cancer Res, 12 (20 Pt 1), 6000-4
DOI 10.1158/1078-0432.CCR-05-2822, PubMed 17062672 -
Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer
Mol Cancer Ther, 5 (11), 2914-8
DOI 10.1158/1535-7163.MCT-06-0126, PubMed 17121939 -
Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
BMC Genomics, 7, 127
DOI 10.1186/1471-2164-7-127, PubMed 16729877 -
International Agency for Research on Cancer workshop on 'Expression array analyses in breast cancer taxonomy'
Breast Cancer Res, 8 (6), 303
DOI 10.1186/bcr1609, PubMed 17096863 -
ATM variants and cancer risk in breast cancer patients from Southern Finland
BMC Cancer, 6, 209
DOI 10.1186/1471-2407-6-209, PubMed 16914028 -
A marginal zone phenotype in follicular lymphoma with t(14;18) is associated with secondary cytogenetic aberrations typical of marginal zone lymphoma
J Pathol, 209 (2), 258-64
DOI 10.1002/path.1981, PubMed 16583359 -
Analysis of SNP-expression association matrices
J Bioinform Comput Biol, 4 (2), 259-74
DOI 10.1142/s0219720006001953, PubMed 16819783 -
The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals
BMC Cancer, 6, 176
DOI 10.1186/1471-2407-6-176, PubMed 16820046 -
Precursor lesions in testis and dysgenetic gonads
Hum Pathol, 37 (6), 773; author reply 774
DOI 10.1016/j.humpath.2006.01.006, PubMed 16733221 -
Effect of the codon 72 polymorphism (c.215G > C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma (vol 24, pg 21, 2004)
Hum. Mutat., 27 (2), 209-210
DOI 10.1002/humu.20298 -
Molecular cytogenetic analysis of leukemic mantle cell lymphoma with a cryptic t(11;14)
Cancer Genet Cytogenet, 165 (2), 172-5
DOI 10.1016/j.cancergencyto.2005.08.012, PubMed 16527613
Publications 2005
-
Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors
J Neuropathol Exp Neurol, 64 (1), 74-81
DOI 10.1093/jnen/64.1.74, PubMed 15715087 -
Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression
Mol Pharmacol, 69 (1), 207-15
DOI 10.1124/mol.105.015396, PubMed 16189297 -
Perspectives on risk: review and discussion of the basis for establishing a unified and holistic approach
Reliab. Eng. Syst. Saf., 90 (1), 1-14
DOI 10.1016/j.ress.2004.10.008 -
High-resolution gene copy number and expression profiling of human chromosome 22 in ovarian carcinomas
Genes Chromosomes Cancer, 42 (3), 228-37
DOI 10.1002/gcc.20128, PubMed 15578687 -
Chromosome 7 abnormalities are common in chordomas
Cancer Genet Cytogenet, 160 (1), 15-21
DOI 10.1016/j.cancergencyto.2004.11.016, PubMed 15949565 -
Chromosome abnormalities in juxtaglomerular cell tumors
Cancer, 104 (3), 504-10
DOI 10.1002/cncr.21205, PubMed 15968688 -
Adenomas and follicular carcinomas of the thyroid display two major patterns of chromosomal changes
J Pathol, 206 (3), 305-11
DOI 10.1002/path.1772, PubMed 15852498 -
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
Proc Natl Acad Sci U S A, 102 (10), 3738-43
DOI 10.1073/pnas.0409462102, PubMed 15701700 -
Proceedings of the Fourth International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement
Clin Cancer Res, 11 (2 Pt 2), 861s-4s
PubMed 15701878 -
Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers
Int J Cancer, 117 (6), 988-91
DOI 10.1002/ijc.21273, PubMed 15986445 -
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study
J Clin Oncol, 23 (30), 7491-6
DOI 10.1200/JCO.2004.00.7138, PubMed 16234515 -
Psychological distress in women at risk of hereditary breast/ovarian or HNPCC cancers in the absence of demonstrated mutations
Fam Cancer, 4 (2), 121-6
DOI 10.1007/s10689-004-7995-y, PubMed 15951962 -
GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer
Cancer Lett, 229 (1), 85-91
DOI 10.1016/j.canlet.2005.04.019, PubMed 15946795 -
Identification of two molecular groups of seminomas by using expression and tissue microarrays
Clin Cancer Res, 11 (16), 5722-9
DOI 10.1158/1078-0432.CCR-05-0533, PubMed 16115909 -
Macrophage scavenger receptor 1 999C>T (R293X) mutation and risk of prostate cancer
Cancer Epidemiol Biomarkers Prev, 14 (2), 397-402
DOI 10.1158/1055-9965.EPI-04-0202, PubMed 15734964 -
TP53 mutations are associated with a particular pattern of genomic imbalances in breast carcinomas
J Pathol, 207 (1), 14-9
DOI 10.1002/path.1812, PubMed 16007576 -
Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers
Gynecol Oncol, 100 (1), 83-8
DOI 10.1016/j.ygyno.2005.07.110, PubMed 16137751 -
Evaluation of arrayed primer extension for TP53 mutation detection in breast and ovarian carcinomas
Biotechniques, 39 (5), 755-61
DOI 10.2144/000112000, PubMed 16312222 -
TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival
BMC Cancer, 5, 134
DOI 10.1186/1471-2407-5-134, PubMed 16229746 -
Gene expression profiling of breast cancer in relation to estrogen receptor status and estrogen-metabolizing enzymes: clinical implications
Clin Cancer Res, 11 (2 Pt 2), 878s-83s
PubMed 15701881 -
Effects of anastrozole on the intratumoral gene expression in locally advanced breast cancer
J Steroid Biochem Mol Biol, 95 (1-5), 105-11
DOI 10.1016/j.jsbmb.2005.04.028, PubMed 16023338 -
Spatio-temporal variability of richness estimators: coastal marine fish communities as examples
Oecologia, 144 (2), 308-17
DOI 10.1007/s00442-005-0049-9, PubMed 15800740 -
The loss of NKX3.1 expression in testicular--and prostate--cancers is not caused by promoter hypermethylation
Mol Cancer, 4 (1), 8
DOI 10.1186/1476-4598-4-8, PubMed 15691383 -
Genomics in breast cancer-therapeutic implications
Nat Clin Pract Oncol, 2 (1), 26-33
DOI 10.1038/ncponc0072, PubMed 16264853 -
Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer
Breast Cancer Res Treat, 94 (2), 145-52
DOI 10.1007/s10549-005-7697-7, PubMed 16261413 -
Breast and other cancers in 1445 blood relatives of 75 Nordic patients with ataxia telangiectasia
Br J Cancer, 93 (2), 260-5
DOI 10.1038/sj.bjc.6602658, PubMed 15942625 -
Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts
Radiother Oncol, 77 (3), 231-40
DOI 10.1016/j.radonc.2005.09.020, PubMed 16297999 -
Variation in gene expression patterns in effusions and primary tumors from serous ovarian cancer patients
Mol Cancer, 4, 26
DOI 10.1186/1476-4598-4-26, PubMed 16042759 -
Early detection of breast cancer based on gene-expression patterns in peripheral blood cells
Breast Cancer Res, 7 (5), R634-44
DOI 10.1186/bcr1203, PubMed 16168108 -
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
Cancer Res, 65 (13), 5588-98
DOI 10.1158/0008-5472.CAN-05-0153, PubMed 15994931 -
Immunohistochemistry identifies carriers of mismatch repair gene defects causing hereditary nonpolyposis colorectal cancer
J Clin Oncol, 23 (21), 4705-12
DOI 10.1200/JCO.2005.05.180, PubMed 16034045 -
Mutation screening of the TP53 gene by temporal temperature gradient gel electrophoresis
Methods Mol Biol, 291, 207-16
DOI 10.1385/1-59259-840-4:207, PubMed 15502225 -
Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?
Semin Cancer Biol, 15 (1), 3-12
DOI 10.1016/j.semcancer.2004.09.006, PubMed 15613283 -
Genetic and epigenetic changes of components affecting the WNT pathway in colorectal carcinomas stratified by microsatellite instability
Neoplasia, 7 (2), 99-108
DOI 10.1593/neo.04448, PubMed 15802015 -
Analysis of SNP-expression association matrices
Proc IEEE Comput Syst Bioinform Conf, 135-43
DOI 10.1109/csb.2005.14, PubMed 16447971 -
Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC)
Genes Chromosomes Cancer, 44 (2), 123-38
DOI 10.1002/gcc.20219, PubMed 15942939 -
Microinvasive germ cell tumor of the testis
Virchows Arch, 447 (3), 610-25
DOI 10.1007/s00428-005-1257-8, PubMed 15968545 -
PIK3CA mutations in advanced ovarian carcinomas
Hum Mutat, 25 (3), 322
DOI 10.1002/humu.9316, PubMed 15712344 -
Protein expression and prognostic value of genes in the erb-b signaling pathway in advanced ovarian carcinomas
Am J Clin Pathol, 124 (3), 392-401
DOI 10.1309/BL7E-MW66-LQX6-GFRP, PubMed 16191507 -
A comparison of bilateral breast cancers in BRCA carriers
Cancer Epidemiol Biomarkers Prev, 14 (6), 1534-8
DOI 10.1158/1055-9965.EPI-05-0070, PubMed 15941968 -
NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer
Cell. Oncol., 27 (3), 169-173 -
NMD microarray analysis for rapid genome-wide screen of mutated genes in cancer
Cell Oncol, 27 (3), 169-73
DOI 10.1155/2005/478316, PubMed 16037637 -
t(14;22)(q32;q11) in non-Hodgkin lymphoma and myeloid leukaemia: molecular cytogenetic investigations
Br J Haematol, 130 (6), 845-51
DOI 10.1111/j.1365-2141.2005.05688.x, PubMed 16156854 -
G-banding and molecular cytogenetic analyses of marginal zone lymphoma
Br J Haematol, 130 (6), 890-901
DOI 10.1111/j.1365-2141.2005.05706.x, PubMed 16156859 -
Prognostic and predictive value of changes in tumour cell proliferation in locally advanced breast cancer primarily treated with doxorubicin
Oncol Rep, 13 (3), 525-30
PubMed 15706428
Publications 2004
-
Tumor karyotype predicts clinical outcome in colorectal cancer patients
J Clin Oncol, 22 (13), 2623-34
DOI 10.1200/JCO.2004.11.014, PubMed 15226330 -
Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study
Breast Cancer Res, 6 (3), R199-214
DOI 10.1186/bcr771, PubMed 15084244 -
Molecular cytogenetic characterization of tenosynovial giant cell tumors
Neoplasia, 6 (5), 578-83
DOI 10.1593/neo.04202, PubMed 15548367 -
Genome characteristics of primary carcinomas, local recurrences, carcinomatoses, and liver metastases from colorectal cancer patients
Mol Cancer, 3, 6
DOI 10.1186/1476-4598-3-6, PubMed 14977426 -
Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance
Gastroenterology, 127 (1), 17-25
DOI 10.1053/j.gastro.2004.03.068, PubMed 15236168 -
Evaluation of genomic changes in a large series of malignant ovarian germ cell tumors--relation to clinicopathologic variables
Cancer Genet Cytogenet, 155 (1), 25-32
DOI 10.1016/j.cancergencyto.2004.02.010, PubMed 15527899 -
Genome signatures of colon carcinoma cell lines
Cancer Genet Cytogenet, 155 (2), 119-31
DOI 10.1016/j.cancergencyto.2004.03.014, PubMed 15571797 -
Ratio of female to male offspring of women tested for BRCA1 and BRCA2 mutations
J Med Genet, 41 (8), e103
DOI 10.1136/jmg.2004.019687, PubMed 15286163 -
A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines
Mol Cancer, 3, 28
DOI 10.1186/1476-4598-3-28, PubMed 15476557 -
CGH-Explorer: a program for analysis of array-CGH data
Bioinformatics, 21 (6), 821-2
DOI 10.1093/bioinformatics/bti113, PubMed 15531610 -
Genomic aberrations in carcinomas of the uterine corpus
Genes Chromosomes Cancer, 40 (3), 229-46
DOI 10.1002/gcc.20038, PubMed 15139002 -
Analysis of testicular cancer data using a frailty model with familial dependence
Stat Med, 23 (4), 617-32
DOI 10.1002/sim.1614, PubMed 14755393 -
Costs and benefits of diagnosing familial breast cancer
Ann Oncol, 15 Suppl 1, I55-I59
DOI 10.1093/annonc/mdh659, PubMed 15280189 -
Towards evidence-based management of inherited breast and breast-ovarian cancer
Hered Cancer Clin Pract, 2 (1), 11-6
DOI 10.1186/1897-4287-2-1-11, PubMed 20233478 -
BRCA1 testing with definitive results: a prospective study of psychological distress in a large clinic-based sample
Fam Cancer, 3 (1), 21-8
DOI 10.1023/B:FAME.0000026820.32469.4a, PubMed 15131402 -
Ethnic variation in the prevalence of AZF deletions in testicular cancer
Mutat Res, 554 (1-2), 45-51
DOI 10.1016/j.mrfmmm.2004.03.001, PubMed 15450403 -
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
Int J Cancer, 110 (2), 266-70
DOI 10.1002/ijc.20114, PubMed 15069692 -
Single-track sequencing for genotyping of multiple SNPs in the N-acetyltransferase 1 (NAT1) gene
BMC Biotechnol, 4, 28
DOI 10.1186/1472-6750-4-28, PubMed 15563733 -
The effect of climatic forcing on population synchrony and genetic structuring of the Canadian lynx
Proc Natl Acad Sci U S A, 101 (16), 6056-61
DOI 10.1073/pnas.0307123101, PubMed 15067131 -
Snow conditions may create an invisible barrier for lynx
Proc Natl Acad Sci U S A, 101 (29), 10632-4
DOI 10.1073/pnas.0308674101, PubMed 15249676 -
The impact of an early truncating founder ATM mutation on immunoglobulins, specific antibodies and lymphocyte populations in ataxia-telangiectasia patients and their parents
Clin Exp Immunol, 137 (1), 179-86
DOI 10.1111/j.1365-2249.2004.02492.x, PubMed 15196260 -
Alternative splicing and mutation status of CHEK2 in stage III breast cancer
Oncogene, 23 (52), 8535-44
DOI 10.1038/sj.onc.1207928, PubMed 15361853 -
Molecular portraits of breast cancer: tumour subtypes as distinct disease entities
Eur J Cancer, 40 (18), 2667-75
DOI 10.1016/j.ejca.2004.08.021, PubMed 15571950 -
Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making
Cancer, 101 (8), 1786-93
DOI 10.1002/cncr.20527, PubMed 15386312 -
Assessment of clonal relationships in ipsilateral and bilateral multiple breast carcinomas by comparative genomic hybridisation and hierarchical clustering analysis
Br J Cancer, 91 (4), 775-82
DOI 10.1038/sj.bjc.6602021, PubMed 15266323 -
Cell-type-specific responses to chemotherapeutics in breast cancer
Cancer Res, 64 (12), 4218-26
DOI 10.1158/0008-5472.CAN-04-0107, PubMed 15205334 -
Mutation of GATA3 in human breast tumors
Oncogene, 23 (46), 7669-78
DOI 10.1038/sj.onc.1207966, PubMed 15361840 -
Ecology: living in synchrony on Greenland coasts?
Nature, 427 (6976), 697-8; discussion 698
DOI 10.1038/427697a, PubMed 14973473 -
TP53 mutations in early-stage ovarian carcinoma, relation to long-term survival
Br J Cancer, 90 (3), 678-85
DOI 10.1038/sj.bjc.6601537, PubMed 14760384 -
Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
Hum Mutat, 24 (1), 21-34
DOI 10.1002/humu.20055, PubMed 15221786 -
Different gene expression patterns in invasive lobular and ductal carcinomas of the breast
Mol Biol Cell, 15 (6), 2523-36
DOI 10.1091/mbc.e03-11-0786, PubMed 15034139 -
[Polymorphisms of CYP1B1 and COMT in breast and endometrial cancer]
Mol Biol (Mosk), 38 (3), 386-93
PubMed 15285606
Publications 2003
-
Comparative cytogenetic and DNA flow cytometric analysis of 242 primary breast carcinomas
Cancer Genet Cytogenet, 147 (1), 62-7
DOI 10.1016/s0165-4608(03)00190-0, PubMed 14580772 -
ATM variants 7271T>G and IVS10-6T>G among women with unilateral and bilateral breast cancer
Br J Cancer, 89 (8), 1513-6
DOI 10.1038/sj.bjc.6601289, PubMed 14562025 -
Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer
Hum Mutat, 21 (5), 542-50
DOI 10.1002/humu.10206, PubMed 12673797 -
Uptake of BRCA1 genetic testing in adult sisters and daughters of known mutation carriers in Norway
J Genet Couns, 12 (5), 405-17
DOI 10.1023/a:1025864703405, PubMed 14758817 -
Molecular cytogenetic characterization of desmoid tumors
Cancer Genet Cytogenet, 146 (1), 1-7
DOI 10.1016/s0165-4608(03)00122-5, PubMed 14499689 -
Overexpression of cyclin A overrides the effect of p53 alterations in breast cancer patients with long follow-up time
Breast Cancer Res Treat, 80 (2), 199-206
DOI 10.1023/A:1024527220362, PubMed 12908823 -
TP53 and breast cancer
Hum Mutat, 21 (3), 292-300
DOI 10.1002/humu.10174, PubMed 12619115 -
Genetic profiling of breast cancer: from molecular portraits to clinical utility
Int J Biol Markers, 18 (1), 54-6
DOI 10.1177/172460080301800109, PubMed 12699064 -
Genetic profiling of colorectal cancer liver metastases by combined comparative genomic hybridization and G-banding analysis
Genes Chromosomes Cancer, 36 (2), 189-97
DOI 10.1002/gcc.10162, PubMed 12508247 -
Genetic tumor markers with prognostic impact in Dukes' stages B and C colorectal cancer patients
J Clin Oncol, 21 (5), 820-9
DOI 10.1200/JCO.2003.05.190, PubMed 12610180 -
Chromosomal abnormalities in inflammatory pseudotumor of the urinary bladder
Cancer Genet Cytogenet, 143 (2), 169-71
DOI 10.1016/s0165-4608(02)00846-4, PubMed 12781452 -
TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer
Clin Cancer Res, 9 (15), 5582-8
PubMed 14654539 -
ABI3 mediates expression of the peroxiredoxin antioxidant AtPER1 gene and induction by oxidative stress
Plant Mol Biol, 53 (3), 313-26
DOI 10.1023/b:plan.0000006937.21343.2a, PubMed 14750521 -
Seed 1-cysteine peroxiredoxin antioxidants are not involved in dormancy, but contribute to inhibition of germination during stress
Plant Physiol, 133 (3), 1148-57
DOI 10.1104/pp.103.025916, PubMed 14526116 -
The Norwegian founder mutations in BRCA1: high penetrance confirmed in an incident cancer series and differences observed in the risk of ovarian cancer
Eur J Cancer, 39 (15), 2205-13
DOI 10.1016/s0959-8049(03)00548-3, PubMed 14522380 -
Amplification and overexpression of COPS3 in osteosarcomas potentially target TP53 for proteasome-mediated degradation
Oncogene, 22 (34), 5358-61
DOI 10.1038/sj.onc.1206671, PubMed 12917637 -
8q24 Copy number gains and expression of the c-myc mRNA stabilizing protein CRD-BP in primary breast carcinomas
Int J Cancer, 104 (1), 54-9
DOI 10.1002/ijc.10794, PubMed 12532419 -
CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression
Anticancer Res, 23 (3A), 2179-83
PubMed 12894594 -
Genome profiles of bilateral dysgerminomas, a unilateral gonadoblastoma, and a metastasis from a 46, XY phenotypic female
Hum Pathol, 34 (9), 946-9
DOI 10.1016/s0046-8177(03)00345-9, PubMed 14562293 -
Lack of parental origin specificity of altered alleles at 11p15 in testicular germ cell tumors
Cancer Genet Cytogenet, 147 (1), 1-8
DOI 10.1016/s0165-4608(03)00160-2, PubMed 14580764 -
How to approach modelling in a risk analysis
SAFETY AND RELIABILITY, VOLS 1 AND 2, 969-976 -
X chromosome inactivation in cervical cancer patients
Cancer Genet Cytogenet, 146 (1), 73-6
DOI 10.1016/s0165-4608(03)00152-3, PubMed 14499700 -
BUB1 infrequently mutated in human breast carcinomas
Hum Mutat, 22 (5), 420
DOI 10.1002/humu.9194, PubMed 14517964 -
Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas
Scand J Gastroenterol, 38 (3), 298-306
DOI 10.1080/00365520310000618, PubMed 12737446 -
Cytogenetic characterization of tumors of the vulva and vagina
Genes Chromosomes Cancer, 38 (2), 137-48
DOI 10.1002/gcc.10263, PubMed 12939741 -
Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17)
Cancer Genet Cytogenet, 144 (2), 119-24
DOI 10.1016/s0165-4608(03)00025-6, PubMed 12850374 -
CD7 expression by CD34+ cells in CML patients, of prognostic significance?
Eur J Haematol, 71 (4), 266-75
DOI 10.1034/j.1600-0609.2003.00133.x, PubMed 12950236 -
Smoking and relation to other risk factors in postmenopausal women with coronary artery disease, with particular reference to whole blood viscosity and beta-cell function
J Intern Med, 253 (2), 232-9
DOI 10.1046/j.1365-2796.2003.01110.x, PubMed 12542565 -
ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region
J Immunol, 170 (7), 3707-16
DOI 10.4049/jimmunol.170.7.3707, PubMed 12646636 -
Telomerase activity and genetic alterations in primary breast carcinomas
Neoplasia, 5 (2), 170-8
DOI 10.1016/s1476-5586(03)80009-x, PubMed 12659690 -
Gene expression patterns in ovarian carcinomas
Mol Biol Cell, 14 (11), 4376-86
DOI 10.1091/mbc.e03-05-0279, PubMed 12960427 -
Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays
Neoplasia, 5 (5), 397-404
DOI 10.1016/s1476-5586(03)80042-8, PubMed 14670177 -
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome
J Clin Oncol, 21 (24), 4586-91
DOI 10.1200/JCO.2003.07.067, PubMed 14673046 -
NKX3.1 expression is lost in testicular germ cell tumors
Am J Pathol, 163 (6), 2149-54
DOI 10.1016/S0002-9440(10)63571-7, PubMed 14633588 -
The testicular germ cell tumour genome
APMIS, 111 (1), 136-50; discussion 50-1
DOI 10.1034/j.1600-0463.2003.11101181.x, PubMed 12752254 -
Repeated observation of breast tumor subtypes in independent gene expression data sets
Proc Natl Acad Sci U S A, 100 (14), 8418-23
DOI 10.1073/pnas.0932692100, PubMed 12829800 -
Multiplex single-tube screening for mutations in the Nijmegen Breakage Syndrome (NBS1) gene in Hodgkin's and non-Hodgkin's lymphoma patients of Slavic origin
Eur J Hum Genet, 11 (5), 416-9
DOI 10.1038/sj.ejhg.5200972, PubMed 12734548 -
Direct isolation of recombinant human antibodies against group B Neisseria meningitidis from scFv expression libraries
J Immunol Methods, 283 (1-2), 247-59
DOI 10.1016/j.jim.2003.09.015, PubMed 14659916 -
The inframe MSH2 codon 596 deletion is linked with HNPCC and associated with lack of MSH2 protein in tumours
Fam Cancer, 2 (1), 9-13
DOI 10.1023/a:1023362205205, PubMed 14574162 -
Multicentric mammary carcinoma: evidence of monoclonal proliferation
Cancer, 97 (3), 715-7; author reply 717
DOI 10.1002/cncr.11109, PubMed 12548617 -
Intratumoural mRNA expression of genes from the oestradiol metabolic pathway and clinical and histopathological parameters of breast cancer
Breast Cancer Res, 6 (2), R46-55
DOI 10.1186/bcr746, PubMed 14979917 -
Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy
Eur J Cancer, 39 (4), 438-46
DOI 10.1016/s0959-8049(02)00732-3, PubMed 12751373
Publications 2002
-
ATM mutations in Finnish breast cancer patients
J Med Genet, 39 (3), 192-6
DOI 10.1136/jmg.39.3.192, PubMed 11897822 -
Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002
Breast Cancer Res, 4 (6), 249-52
DOI 10.1186/bcr551, PubMed 12473172 -
Mismatch detection using heteroduplex analysis
Curr Protoc Hum Genet, Chapter 7, Unit 7.3
DOI 10.1002/0471142905.hg0703s33, PubMed 18428333 -
Chromosomal aberrations in benign and malignant bilharzia-associated bladder lesions analyzed by comparative genomic hybridization
BMC Cancer, 2, 5
DOI 10.1186/1471-2407-2-5, PubMed 11914143 -
Mantle cell lymphoma with Homer-Wright rosettes
Virchows Arch, 442 (2), 179-82
DOI 10.1007/s00428-002-0739-1, PubMed 12596071 -
Expression array technology in the diagnosis and treatment of breast cancer
Mol Interv, 2 (2), 101-9
DOI 10.1124/mi.2.2.101, PubMed 14993355 -
Genome profiling of breast cancer cells selected against in vitro shows copy number changes
Genes Chromosomes Cancer, 33 (3), 304-9
DOI 10.1002/gcc.10032, PubMed 11807988