Non-invasive Cardiac Imaging

H.J. Smith
Group leader

Challenges
A specific diagnosis of myocardial disease and early detection of myocardial dysfunction are prerequisites of early and adequate therapeutic intervention. The diagnostic possibilities with the non-invasive modalities of radiology and nuclear medicine are continuously expanding. CT offers detection of coronary artery disease with calcified or non-calcified plaques, PET may reveal myocardial oxygen demand and metabolism, MR visualizes global and regional myocardial function, global and regional strain and strain rate, and presence of edema, infarction, inflammation, replacement fibrosis, iron deposition. Until recently, MR imaging has not been able to detect diffuse myocardial fibrosis or collagen deposition, which may be an early marker of myocardial dysfunction in several cardiomyopathies, post-infarct adverse cardiac remodeling, cardiac failure, cardiac valvular disease and hypertension. A new MR imaging technique, extracellular volume (ECV) imaging, may represent improved detection of diffuse myocardial fibrosis.

Projects
• Early detection of myocardial dysfunction in patients with aortic regurgitation
• Early detection of myocardial dysfunction in hypertensive patients
• Myocardial oxygen demand and metabolism in hypertensive patients
• Myocardial function in arterial switch-operated patients with transposition of the great arteries
• MR detection of diffuse myocardial fibrosis in elderly patients with aortic valve stenosis – a pre- and postoperative study with postoperative histopathological correlation

Contact information:
Group leader Professor Hans-Jørgen Smith Department of Radiology and Nuclear Medicine Oslo University Hospital PO Box 4950 Nydalen NO-0424 Oslo, Norway Mobile: +47 922 97 081 E-mail: h.j.smith@medisin.uio.no