Finn P Reinholt Electron Microscopy and Connective Tissue Research
Tissue distributions of molecular components and their interactions are keys to understand function and disease mechanisms. Our group is striving for optimum instrumentation and protocols in morphological research. The methodological developments are particularly directed towards reproducible quantitative methods to enable studies of tissues close to the native state with a combination of light and electron microscopy. The methods are used to study the molecular composition and cell/matrix interactions in connective tissues, particularly bone and cartilage in animal models aiming at increased understanding of serious chronic diseases of skeletal tissues, like osteoporosis and osteoarthritis. Another challenge includes the mechanisms involved in the development of fibrosis in transplanted organs, a process central to the loss of long term function of such organs.