Welcome to the web site of Elisabeth Larsen’s group Laboratory of Embryonic Stem Cell Research

Institute of Medical Microbiology, Section for Molecular Biology, is located at the National Hospital at Gaustad, Oslo.

From left: Gaute Nesse, Elisabeth Larsen, Rune Ougland and Sabrina Gruber (click to enlarge image)

Research projects

Our aim is to model human diseases using induced pluripotent stem cells (iPSC).

Currently we are working on reprogramming cells from patients suffering from Huntington disease to iPSC. Also, we are in the process of reprogramming fibroblasts from patients with different genetic imprinting disorders. Furthermore, by using embryonic stem cells derived from knockout animals lacking enzymes involved in epigenetic regulation, we try to elucidate mechanisms regulating pluripotency and self-renewal.

We do have a close collaboration with professor Arne Klungland (the National Hospital, Oslo, Norway), professor Jennie Lee (Harvard Medical School, Boston, USA) and professor Mary Donohoe (Weill Cornell Medical College, New York, USA).