Trine Ranheim

  • Research Scientist MSc, PhD
  • +47 23 07 33 58

Publications 2018

Sokolova M, Sahraoui A, Høyem M, Øgaard J, Lien E, Aukrust P, Yndestad A, Ranheim T, Scholz H (2018)
NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction
Am J Physiol Endocrinol Metab, 315 (5), E912-E923
DOI 10.1152/ajpendo.00461.2017, PubMed 30016155

Publications 2017

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T (2017)
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477

Bermudez B, Dahl TB, Medina I, Groeneweg M, Holm S, Montserrat-de la Paz S, Rousch M, Otten J, Herias V, Varela LM, Ranheim T, Yndestad A, Ortega-Gomez A, Abia R, Nagy L, Aukrust P, Muriana FJG, Halvorsen B, Biessen EAL (2017)
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function
Arterioscler Thromb Vasc Biol, 37 (6), 1157-1167
DOI 10.1161/ATVBAHA.116.308187, PubMed 28408371

Dhondup Y, Sjaastad I, Sandanger Ø, Aronsen JM, Ahmed MS, Attramadal H, Finsen AV, Zhang L, Ranheim T, Alfsnes K, Aukrust P, Christensen G, Yndestad A, Vinge LE (2017)
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice
Mediators Inflamm, 2017, 9450439
DOI 10.1155/2017/9450439, PubMed 28490840

Publications 2016

Paramel Varghese G, Folkersen L, Strawbridge RJ, Halvorsen B, Yndestad A, Ranheim T, Krohg-Sørensen K, Skjelland M, Espevik T, Aukrust P, Lengquist M, Hedin U, Jansson JH, Fransén K, Hansson GK, Eriksson P, Sirsjö A (2016)
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
J Am Heart Assoc, 5 (5)
DOI 10.1161/JAHA.115.003031, PubMed 27207962

Sokolova M, Vinge LE, Alfsnes K, Olsen MB, Eide L, Kaasbøll OJ, Attramadal H, Torp MK, Fosshaug LE, Rashidi A, Lien E, Finsen AV, Sandanger Ø, Aukrust P, Ranheim T, Yndestad A (2016)
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts
Biochim Biophys Acta Mol Cell Biol Lipids, 1862 (2), 234-245
DOI 10.1016/j.bbalip.2016.11.003, PubMed 27845246

Publications 2015

Cero FT, Hillestad V, Sjaastad I, Yndestad A, Aukrust P, Ranheim T, Lunde IG, Olsen MB, Lien E, Zhang L, Haugstad SB, Løberg EM, Christensen G, Larsen KO, Skjønsberg OH (2015)
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice
Am J Physiol Lung Cell Mol Physiol, 309 (4), L378-87
DOI 10.1152/ajplung.00342.2014, PubMed 26071556

Dhondup Y, Sjaastad I, Scott H, Sandanger Ø, Zhang L, Haugstad SB, Aronsen JM, Ranheim T, Holmen SD, Alfsnes K, Ahmed MS, Attramadal H, Gullestad L, Aukrust P, Christensen G, Yndestad A, Vinge LE (2015)
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice
PLoS One, 10 (10), e0139715
DOI 10.1371/journal.pone.0139715, PubMed 26461521

Sandanger Ø, Gao E, Ranheim T, Bliksøen M, Kaasbøll OJ, Alfsnes K, Nymo SH, Rashidi A, Ohm IK, Attramadal H, Aukrust P, Vinge LE, Yndestad A (2015)
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective
Biochem Biophys Res Commun, 469 (4), 1012-20
DOI 10.1016/j.bbrc.2015.12.051, PubMed 26706279

Publications 2014

Astrup E, Ranheim T, Damås JK, Davì G, Santilli F, Jensenius M, Vitale G, Aukrust P, Olano JP, Otterdal K (2014)
Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
BMC Infect Dis, 14, 70
DOI 10.1186/1471-2334-14-70, PubMed 24507453

Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A (2014)
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172, PubMed 25398010

Ohm IK, Alfsnes K, Belland Olsen M, Ranheim T, Sandanger Ø, Dahl TB, Aukrust P, Finsen AV, Yndestad A, Vinge LE (2014)
Toll-like receptor 9 mediated responses in cardiac fibroblasts
PLoS One, 9 (8), e104398
DOI 10.1371/journal.pone.0104398, PubMed 25126740

Ohm IK, Gao E, Belland Olsen M, Alfsnes K, Bliksøen M, Øgaard J, Ranheim T, Nymo SH, Holmen YD, Aukrust P, Yndestad A, Vinge LE (2014)
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension
PLoS One, 9 (8), e104407
DOI 10.1371/journal.pone.0104407, PubMed 25126943

Publications 2013

Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Alfsnes K, Finsen AV, Dahl CP, Askevold ET, Florholmen G, Christensen G, Fitzgerald KA, Lien E, Valen G, Espevik T, Aukrust P, Yndestad A (2013)
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury
Cardiovasc Res, 99 (1), 164-74
DOI 10.1093/cvr/cvt091, PubMed 23580606

Sandanger Ø, Ranheim T, Vinge LE, Bliksøen M, Valen G, Aukrust P, Yndestad A (2013)
A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury? Reply
Cardiovasc Res, 99 (1), 226-7
DOI 10.1093/cvr/cvt130, PubMed 23708737

Publications 2012

Askevold ET, Gullestad L, Aakhus S, Ranheim T, Tønnessen T, Solberg OG, Aukrust P, Ueland T (2012)
Secreted Wnt modulators in symptomatic aortic stenosis
J Am Heart Assoc, 1 (6), e002261
DOI 10.1161/JAHA.112.002261, PubMed 23316316

Bliksøen M, Mariero LH, Ohm IK, Haugen F, Yndestad A, Solheim S, Seljeflot I, Ranheim T, Andersen GØ, Aukrust P, Valen G, Vinge LE (2012)
Increased circulating mitochondrial DNA after myocardial infarction
Int J Cardiol, 158 (1), 132-4
DOI 10.1016/j.ijcard.2012.04.047, PubMed 22578950

Dahl TB, Bermudez B, Ranheim T, Otterdal K, Holm S, Biessen EAL, Halvorsen B, Aukrust P (2012)
Unraveling the role of nicotinamide phosphoribosyltransferase on lipids in atherosclerosis
Clin. Lipidol., 7 (6), 697-707

Hol J, Otterdal K, Breland UM, Stang E, Pedersen TM, Hagelsteen K, Ranheim T, Kasprzycka M, Halvorsen B, Haraldsen G, Aukrust P (2012)
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies
PLoS One, 7 (7), e40673
DOI 10.1371/journal.pone.0040673, PubMed 22815786

Smedbakken LM, Halvorsen B, Daissormont I, Ranheim T, Michelsen AE, Skjelland M, Sagen EL, Folkersen L, Krohg-Sørensen K, Russell D, Holm S, Ueland T, Fevang B, Hedin U, Yndestad A, Gullestad L, Hansson GK, Biessen EA, Aukrust P (2012)
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization
Atherosclerosis, 224 (1), 266-73
DOI 10.1016/j.atherosclerosis.2012.06.071, PubMed 22840692

Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Øie E, Vinge LE, Sjaastad I, Sandanger Ø, Ranheim T, Dickstein K, Kjekshus J, Damås JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P (2012)
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure
PLoS One, 7 (3), e33038
DOI 10.1371/journal.pone.0033038, PubMed 22427939

Publications 2011

Dahl T, Ranheim T, Holm S, Berge R, Aukrust P, Halvorsen B (2011)
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages
Eur J Clin Invest, 41 (10), 1098-104
DOI 10.1111/j.1365-2362.2011.02515.x, PubMed 21426336

Publications 2010

Dahl TB, Haukeland JW, Yndestad A, Ranheim T, Gladhaug IP, Damås JK, Haaland T, Løberg EM, Arntsen B, Birkeland K, Bjøro K, Ulven SM, Konopski Z, Nebb HI, Aukrust P, Halvorsen B (2010)
Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease
J Clin Endocrinol Metab, 95 (6), 3039-47
DOI 10.1210/jc.2009-2148, PubMed 20392873

Michelsen AE, Rathcke CN, Skjelland M, Holm S, Ranheim T, Krohg-Sørensen K, Klingvall MF, Brosstad F, Oie E, Vestergaard H, Aukrust P, Halvorsen B (2010)
Increased YKL-40 expression in patients with carotid atherosclerosis
Atherosclerosis, 211 (2), 589-95
DOI 10.1016/j.atherosclerosis.2010.02.035, PubMed 20347092

Publications 2009

Cameron J, Ranheim T, Halvorsen B, Kulseth MA, Leren TP, Berge KE (2009)
Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C
Atherosclerosis, 209 (1), 163-6
DOI 10.1016/j.atherosclerosis.2009.08.039, PubMed 19765707

Holla ØL, Kulseth MA, Berge KE, Leren TP, Ranheim T (2009)
Nonsense-mediated decay of human LDL receptor mRNA
Scand J Clin Lab Invest, 69 (3), 409-17
DOI 10.1080/00365510802707163, PubMed 19148831

Holla ØL, Nakken S, Mattingsdal M, Ranheim T, Berge KE, Defesche JC, Leren TP (2009)
Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses
Mol Genet Metab, 96 (4), 245-52
DOI 10.1016/j.ymgme.2008.12.014, PubMed 19208450

Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA (2009)
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR
Acta Biochim Biophys Sin (Shanghai), 41 (3), 246-55
DOI 10.1093/abbs/gmp008, PubMed 19280064

Publications 2008

Cameron J, Holla OL, Laerdahl JK, Kulseth MA, Ranheim T, Rognes T, Berge KE, Leren TP (2008)
Characterization of novel mutations in the catalytic domain of the PCSK9 gene
J Intern Med, 263 (4), 420-31
DOI 10.1111/j.1365-2796.2007.01915.x, PubMed 18266662

Cameron J, Holla ØL, Berge KE, Kulseth MA, Ranheim T, Leren TP, Laerdahl JK (2008)
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
FEBS J, 275 (16), 4121-33
DOI 10.1111/j.1742-4658.2008.06553.x, PubMed 18631360

Cameron J, Ranheim T, Kulseth MA, Leren TP, Berge KE (2008)
Berberine decreases PCSK9 expression in HepG2 cells
Atherosclerosis, 201 (2), 266-73
DOI 10.1016/j.atherosclerosis.2008.02.004, PubMed 18355829

Ranheim T, Mattingsdal M, Lindvall JM, Holla OL, Berge KE, Kulseth MA, Leren TP (2008)
Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
J Cell Physiol, 217 (2), 459-67
DOI 10.1002/jcp.21519, PubMed 18570182

Publications 2007

Holla ØL, Cameron J, Berge KE, Ranheim T, Leren TP (2007)
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
BMC Cell Biol, 8, 9
DOI 10.1186/1471-2121-8-9, PubMed 17328821

Tveten K, Holla ØL, Ranheim T, Berge KE, Leren TP, Kulseth MA (2007)
4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor
FEBS J, 274 (8), 1881-93
DOI 10.1111/j.1742-4658.2007.05735.x, PubMed 17408384

Publications 2006

Cameron J, Holla ØL, Ranheim T, Kulseth MA, Berge KE, Leren TP (2006)
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
Hum Mol Genet, 15 (9), 1551-8
DOI 10.1093/hmg/ddl077, PubMed 16571601

Holla ØL, Cameron J, Berge KE, Kulseth MA, Ranheim T, Leren TP (2006)
Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene
Scand J Clin Lab Invest, 66 (4), 317-28
DOI 10.1080/00365510600672775, PubMed 16777760

Ranheim T, Halvorsen B (2006)
[Lox-1--an actor in cardiovascular disease?]
Tidsskr Nor Laegeforen, 126 (6), 753-5
PubMed 16541167

Ranheim T, Kulseth MA, Berge KE, Leren TP (2006)
Model system for phenotypic characterization of sequence variations in the LDL receptor gene
Clin Chem, 52 (8), 1469-79
DOI 10.1373/clinchem.2006.068627, PubMed 16740646

Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA (2006)
Analysis of alternatively spliced isoforms of human LDL receptor mRNA
Clin Chim Acta, 373 (1-2), 151-7
DOI 10.1016/j.cca.2006.05.031, PubMed 16828075

Publications 2005

Haugen F, Ranheim T, Harsem NK, Lips E, Staff AC, Drevon CA (2005)
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression
Am J Physiol Endocrinol Metab, 290 (2), E326-33
DOI 10.1152/ajpendo.00020.2005, PubMed 16144822

Ranheim T, Halvorsen B (2005)
Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus
Mol Nutr Food Res, 49 (3), 274-84
DOI 10.1002/mnfr.200400109, PubMed 15704241

Sørensen S, Ranheim T, Bakken KS, Leren TP, Kulseth MA (2005)
Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress
J Biol Chem, 281 (1), 468-76
DOI 10.1074/jbc.M507071200, PubMed 16257961

Publications 2004

Ranheim T, Haugen F, Staff AC, Braekke K, Harsem NK, Drevon CA (2004)
Adiponectin is reduced in gestational diabetes mellitus in normal weight women
Acta Obstet Gynecol Scand, 83 (4), 341-7
DOI 10.1111/j.0001-6349.2004.00413.x, PubMed 15005780

Publications 2003

Grove S, Johansen R, Dannevig BH, Reitan LJ, Ranheim T (2003)
Experimental infection of Atlantic halibut Hippoglossus hippoglossus with nodavirus: tissue distribution and immune response
Dis Aquat Organ, 53 (3), 211-21
DOI 10.3354/dao053211, PubMed 12691192

Hollung K, Reseland JE, Ranheim T, Haugen F, Drevon CA (2003)
[The importance of adipose tissue for development of obesity and diabetes mellitus type 2]
Tidsskr Nor Laegeforen, 123 (3), 311-4
PubMed 12640896

Staff AC, Ranheim T, Halvorsen B (2003)
Augmented PLA2 activity in pre-eclamptic decidual tissue--a key player in the pathophysiology of 'acute atherosis' in pre-eclampsia?
Placenta, 24 (10), 965-73
DOI 10.1016/S0143-4004(03)0175-9, PubMed 14580379

Publications 2002

Gedde-Dahl A, Kulseth MA, Ranheim T, Drevon CA, Rustan AC (2002)
Reduced secretion of triacylglycerol in CaCo-2 cells transfected with intestinal fatty acid-binding protein
Lipids, 37 (1), 61-8
DOI 10.1007/s11745-002-0864-8, PubMed 11876264

Johans R, Ranheim T, Hansen MK, Taksdal T, Totland GK (2002)
Pathological changes in juvenile Atlantic halibut Hippoglossus hippoglossus persistently infected with nodavirus
Dis Aquat Organ, 50 (3), 161-9
DOI 10.3354/dao050161, PubMed 12219972

Johansen R, Ranheim T, Hansen MK, Taksdal T, Totland GK (2002)
Pathological changes in juvenile Atlantic halibut Hippoglossus hippoglossus persistently infected with nodavirus
Dis. Aquat. Org., 50 (3), 161-169

Publications 2001

Halvorsen B, Staff AC, Henriksen T, Sawamura T, Ranheim T (2001)
8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells
Hypertension, 37 (4), 1184-90
DOI 10.1161/01.HYP.37.4.1184, PubMed 11304522

Ranheim T, Staff AC, Henriksen T (2001)
VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery
Acta Obstet Gynecol Scand, 80 (2), 93-8
DOI 10.1034/j.1600-0412.2001.080002093.x, PubMed 11167201

Publications 2000

Staff AC, Ranheim T, Henriksen T, Halvorsen B (2000)
8-Iso-prostaglandin f(2alpha) reduces trophoblast invasion and matrix metalloproteinase activity
Hypertension, 35 (6), 1307-13
DOI 10.1161/01.HYP.35.6.1307, PubMed 10856282

Publications 1999

Berge K, Tronstad KJ, Abdi-Dezfuli F, Ranheim T, Mahesparan R, Bjerkvig R, Berge RK (1999)
Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture
Adv Exp Med Biol, 466, 205-10
PubMed 10709646

Kulseth MA, Kolset SO, Ranheim T (1999)
Stimulation of serglycin and CD44 mRNA expression in endothelial cells exposed to TNF-alpha and IL-1alpha
Biochim Biophys Acta, 1428 (2-3), 225-32
DOI 10.1016/S0304-4165(99)00096-3, PubMed 10434040

Staff AC, Halvorsen B, Ranheim T, Henriksen T (1999)
Elevated level of free 8-iso-prostaglandin F2alpha in the decidua basalis of women with preeclampsia
Am J Obstet Gynecol, 181 (5 Pt 1), 1211-5
DOI 10.1016/S0002-9378(99)70110-9, PubMed 10561647

Staff AC, Ranheim T, Khoury J, Henriksen T (1999)
Increased contents of phospholipids, cholesterol, and lipid peroxides in decidua basalis in women with preeclampsia
Am J Obstet Gynecol, 180 (3 Pt 1), 587-92
DOI 10.1016/S0002-9378(99)70259-0, PubMed 10076133

Publications 1998

Halvorsen B, Ranheim T, Nenseter MS, Huggett AC, Drevon CA (1998)
Effect of a coffee lipid (cafestol) on cholesterol metabolism in human skin fibroblasts
J Lipid Res, 39 (4), 901-12
PubMed 9555953

Publications 1997

Ranheim T, Dumke C, Schueler KL, Cartee GD, Attie AD (1997)
Interaction between BTBR and C57BL/6J genomes produces an insulin resistance syndrome in (BTBR x C57BL/6J) F1 mice
Arterioscler Thromb Vasc Biol, 17 (11), 3286-93
PubMed 9409324

Rustan AC, Halvorsen B, Huggett AC, Ranheim T, Drevon CA (1997)
Effect of coffee lipids (cafestol and kahweol) on regulation of cholesterol metabolism in HepG2 cells
Arterioscler Thromb Vasc Biol, 17 (10), 2140-9
DOI 10.1161/01.ATV.17.10.2140, PubMed 9351383

Rustan AC, Halvorsen B, Ranheim T, Drevon CA (1997)
Cafestol (a coffee lipid) decreases uptake of low-density lipoprotein (LDL) in human skin fibroblasts and liver cells
Ann N Y Acad Sci, 827, 158-62
DOI 10.1111/j.1749-6632.1997.tb51830.x, PubMed 9329750

Publications 1995

Gedde-Dahl A, Ranheim T, Drevon CA, Skrede S, Berge RK, Rustan AC (1995)
Tetradecylthioacetic acid (a 3-thia fatty acid) decreases triacylglycerol secretion in CaCo-2 cells
J Lipid Res, 36 (3), 535-43
PubMed 7775865

Ranheim T, Halvorsen B, Huggett AC, Blomhoff R, Drevon CA (1995)
Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells
J Lipid Res, 36 (10), 2079-89
PubMed 8576635

Publications 1994

Ranheim T, Gedde-Dahl A, Rustan AC, Drevon CA (1994)
Effect of chronic incubation of CaCo-2 cells with eicosapentaenoic acid (20:5, n-3) and oleic acid (18:1, n-9) on triacylglycerol production
Biochem J, 303 ( Pt 1), 155-61
DOI 10.1042/bj3030155, PubMed 7945235

Ranheim T, Gedde-Dahl A, Rustan AC, Drevon CA (1994)
Fatty acid uptake and metabolism in CaCo-2 cells: eicosapentaenoic acid (20:5(n-3)) and oleic acid (18:1(n-9)) presented in association with micelles or albumin
Biochim Biophys Acta, 1212 (3), 295-304
DOI 10.1016/0005-2760(94)90203-8, PubMed 8199200

Publications 1992

Ranheim T, Gedde-Dahl A, Rustan AC, Drevon CA (1992)
Influence of eicosapentaenoic acid (20:5, n-3) on secretion of lipoproteins in CaCo-2 cells
J Lipid Res, 33 (9), 1281-93
PubMed 1402397

Publications 1988

Davies CL, Ranheim T, Malik Z, Rofstad EK, Moan J, Lindmo T (1988)
Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
Br J Cancer, 58 (3), 306-13
DOI 10.1038/bjc.1988.209, PubMed 3179182

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