![](https://www.ous-research.no/vaage/images/people/JT-Vaage.jpg)
John T. Vaage
- Department head; Professor
Publications 2024
People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination
Front Immunol, 14, 1235210
DOI 10.3389/fimmu.2023.1235210, PubMed 38299149
Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study
Front Immunol, 15, 1296273
DOI 10.3389/fimmu.2024.1296273, PubMed 38455062
Characterization of the SARS-CoV-2 antibody landscape in Norway in the late summer of 2022: high seroprevalence in all age groups with patterns of primary Omicron infection in children and hybrid immunity in adults
BMC Infect Dis, 24 (1), 841
DOI 10.1186/s12879-024-09670-w, PubMed 39164637
Seroprevalence of SARS-CoV-2 and humoral immune responses to COVID-19 mRNA vaccines among people who use drugs - in the light of tailored mitigating strategies
Harm Reduct J, 21 (1), 120
DOI 10.1186/s12954-024-01023-9, PubMed 38890611
Incidence and outcome of COVID-19 following vaccine and hybrid immunity in patients on immunosuppressive therapy: identification of protective post-immunisation anti-RBD antibody levels in a prospective cohort study
RMD Open, 10 (2)
DOI 10.1136/rmdopen-2023-003545, PubMed 38599653
Publications 2023
Robust spike-specific CD4+ and CD8+ T cell responses in SARS-CoV-2 vaccinated hematopoietic cell transplantation recipients: a prospective, cohort study
Front Immunol, 14, 1210899
DOI 10.3389/fimmu.2023.1210899, PubMed 37503339
Humoral vaccine response and breakthrough infections in kidney transplant recipients during the COVID-19 pandemic: a nationwide cohort study
EClinicalMedicine, 60, 102035
DOI 10.1016/j.eclinm.2023.102035, PubMed 37362086
Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients
EBioMedicine, 97, 104833
DOI 10.1016/j.ebiom.2023.104833, PubMed 37844534
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Cell Rep, 42 (1), 111995
DOI 10.1016/j.celrep.2023.111995, PubMed 36656713
COVID-19 patients treated with convalescent plasma
Tidsskr Nor Laegeforen, 143 (11)
DOI 10.4045/tidsskr.22.0577, PubMed 37589359
Convalescent plasma from Norwegian blood donors to treat COVID-19
Tidsskr Nor Laegeforen, 143 (11)
DOI 10.4045/tidsskr.22.0180, PubMed 37589362
Author Correction: Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 8 (1), 4
DOI 10.1038/s41541-023-00600-6, PubMed 36697432
Humoral Response After 6 or More Successive Doses of SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients-Should We Keep Vaccinating?
Transplantation, 107 (10), e279-e280
DOI 10.1097/TP.0000000000004732, PubMed 37496122
Publications 2022
Four SARS-CoV-2 vaccine doses or hybrid immunity in patients on immunosuppressive therapies: a Norwegian cohort study
Lancet Rheumatol, 5 (1), e36-e46
DOI 10.1016/S2665-9913(22)00330-7, PubMed 36415604
The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls-a prospective cohort study
BMC Med, 20 (1), 378
DOI 10.1186/s12916-022-02587-8, PubMed 36199139
Immune responses to SARS-CoV-2 vaccines in celiac disease
Scand J Gastroenterol, 58 (2), 142-147
DOI 10.1080/00365521.2022.2114809, PubMed 36049123
Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults
Nat Commun, 13 (1), 4165
DOI 10.1038/s41467-022-31888-y, PubMed 35851055
Immunogenicity and Safety of a Third SARS-CoV-2 Vaccine Dose in Patients With Multiple Sclerosis and Weak Immune Response After COVID-19 Vaccination
JAMA Neurol, 79 (3), 307-309
DOI 10.1001/jamaneurol.2021.5109, PubMed 35072702
Fourth dose of the SARS-CoV-2 vaccine in kidney transplant recipients with previously impaired humoral antibody response
Am J Transplant, 22 (11), 2704-2706
DOI 10.1111/ajt.17091, PubMed 35533010
COVID-19 convalescent plasma from Norwegian blood donors
Tidsskr Nor Laegeforen, 142 (9)
DOI 10.4045/tidsskr.22.0057, PubMed 35699539
Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination
Br J Haematol, 197 (6), 697-708
DOI 10.1111/bjh.18149, PubMed 35254660
Immunogenicity and safety of a three-dose SARS-CoV-2 vaccination strategy in patients with immune-mediated inflammatory diseases on immunosuppressive therapy
RMD Open, 8 (2)
DOI 10.1136/rmdopen-2022-002417, PubMed 36328399
Immunogenicity and Safety of Standard and Third-Dose SARS-CoV-2 Vaccination in Patients Receiving Immunosuppressive Therapy
Arthritis Rheumatol, 74 (8), 1321-1332
DOI 10.1002/art.42153, PubMed 35507355
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
Front Immunol, 13, 964525
DOI 10.3389/fimmu.2022.964525, PubMed 36159859
Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
NPJ Vaccines, 7 (1), 174
DOI 10.1038/s41541-022-00586-7, PubMed 36585405
Prevalence of antibodies against SARS-CoV-2 in the Norwegian population, August 2021
Influenza Other Respir Viruses, 16 (6), 1004-1013
DOI 10.1111/irv.13024, PubMed 35770841
Publications 2021
Humoral and cellular immune responses to two and three doses of SARS-CoV-2 vaccines in rituximab-treated patients with rheumatoid arthritis: a prospective, cohort study
Lancet Rheumatol, 4 (3), e177-e187
DOI 10.1016/S2665-9913(21)00394-5, PubMed 34977602
Humoral immunity to SARS-CoV-2 mRNA vaccination in multiple sclerosis: the relevance of time since last rituximab infusion and first experience from sporadic revaccinations
J Neurol Neurosurg Psychiatry, 94 (1), 19-22
DOI 10.1136/jnnp-2021-327612, PubMed 34670844
OBITUARY Erik Thorsby (1938-2021)
HLA, 98 (1), 3-4
DOI 10.1111/tan.14290
Trends in seroprevalence of SARS-CoV-2 and infection fatality rate in the Norwegian population through the first year of the COVID-19 pandemic
Influenza Other Respir Viruses, 16 (2), 204-212
DOI 10.1111/irv.12932, PubMed 34751488
Publications 2019
HLA-DRB3*01:01 exhibits a dose-dependent impact on HPA-1a antibody levels in HPA-1a-immunized women
Blood Adv, 3 (7), 945-951
DOI 10.1182/bloodadvances.2019032227, PubMed 30923048
Publications 2018
Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats
J Immunol, 200 (8), 2847-2859
DOI 10.4049/jimmunol.1701464, PubMed 29531166
Publications 2017
Frontline Science: A hyporesponsive subset of rat NK cells negative for Ly49s3 and NKR-P1B are precursors to the functionally mature NKR-P1B+ subset
J Leukoc Biol, 102 (6), 1289-1298
DOI 10.1189/jlb.1HI0517-177RR, PubMed 28747319
Publications 2016
Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody
Front Immunol, 7, 572
DOI 10.3389/fimmu.2016.00572, PubMed 28003815
Publications 2014
Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut
Eur J Immunol, 45 (2), 501-12
DOI 10.1002/eji.201444710, PubMed 25382546
Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors
Mucosal Immunol, 8 (2), 232-42
DOI 10.1038/mi.2014.60, PubMed 24985083
The tetraspanin CD53 modulates responses from activating NK cell receptors, promoting LFA-1 activation and dampening NK cell effector functions
PLoS One, 9 (5), e97844
DOI 10.1371/journal.pone.0097844, PubMed 24832104
Publications 2013
The role of alloresponsive Ly49+ NK cells in rat islet allograft failure in the presence and absence of cytomegalovirus
Cell Transplant, 23 (11), 1381-94
DOI 10.3727/096368913X670930, PubMed 23866824
Publications 2012
Identification of an MHC class I ligand for the single member of a killer cell lectin-like receptor family, KLRH1
J Immunol, 189 (11), 5178-84
DOI 10.4049/jimmunol.1201983, PubMed 23100519
A novel NKR-P1B(bright) NK cell subset expresses an activated CD25(+)CX(3)CR1(+)CD62L(-)CD11b(-)CD27(-) phenotype and is prevalent in blood, liver, and gut-associated lymphoid organs of rats
J Immunol, 188 (6), 2499-508
DOI 10.4049/jimmunol.1003939, PubMed 22308308
Rat mesenchymal stromal cells inhibit T cell proliferation but not cytokine production through inducible nitric oxide synthase
Front Immunol, 3, 62
DOI 10.3389/fimmu.2012.00062, PubMed 22566943
Mesenchymal stromal cells fail to alleviate experimental graft-versus-host disease in rats transplanted with major histocompatibility complex-mismatched bone marrow
Scand J Immunol, 76 (5), 464-70
DOI 10.1111/j.1365-3083.2012.02758.x, PubMed 22803811
Publications 2011
Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains
Immunogenetics, 63 (12), 809-20
DOI 10.1007/s00251-011-0553-5, PubMed 21720914
Natural killer cell subsets in man and rodents
Tissue Antigens, 78 (2), 81-8
DOI 10.1111/j.1399-0039.2011.01714.x, PubMed 21726202
Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G receptors in rat and mouse
Immunogenetics, 63 (7), 429-36
DOI 10.1007/s00251-011-0520-1, PubMed 21409442
The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages
J Leukoc Biol, 89 (4), 617-23
DOI 10.1189/jlb.1010593, PubMed 21248147
Mycoplasma contamination revisited: mesenchymal stromal cells harboring Mycoplasma hyorhinis potently inhibit lymphocyte proliferation in vitro
PLoS One, 6 (1), e16005
DOI 10.1371/journal.pone.0016005, PubMed 21264307
Publications 2010
Two complementary rat NK cell subsets, Ly49s3+ and NKR-P1B+, differ in phenotypic characteristics and responsiveness to cytokines
J Leukoc Biol, 88 (1), 87-93
DOI 10.1189/jlb.0110039, PubMed 20395458
Partial NK cell tolerance induced by radioresistant host cells in rats transplanted with MHC-mismatched bone marrow
Int Immunol, 22 (12), 973-80
DOI 10.1093/intimm/dxq452, PubMed 21118904
The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells
Eur J Immunol, 40 (12), 3535-43
DOI 10.1002/eji.201040651, PubMed 21108473
Publications 2009
Two major groups of rat NKR-P1 receptors can be distinguished based on chromosomal localization, phylogenetic analysis and Clr ligand binding
Eur J Immunol, 39 (2), 541-51
DOI 10.1002/eji.200838891, PubMed 19130483
Publications 2008
A second prophylactic MHC-mismatched bone marrow transplantation protects against rat acute myeloid leukemia (BNML) without lethal graft-versus-host disease
Transplantation, 85 (1), 102-11
DOI 10.1097/01.tp.0000296856.53493.1f, PubMed 18192919
Publications 2006
The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats
J Immunol, 176 (7), 4133-40
DOI 10.4049/jimmunol.176.7.4133, PubMed 16547249
Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity
Immunogenetics, 58 (11), 905-16
DOI 10.1007/s00251-006-0154-x, PubMed 17028855
Cross-dressing T cells go wild
Nat Med, 12 (6), 611-2
DOI 10.1038/nm0606-611, PubMed 16761002
Publications 2005
Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands
J Immunol, 174 (5), 2702-11
DOI 10.4049/jimmunol.174.5.2702, PubMed 15728478
Killer cell lectin-like receptors and the natural killer cell gene complex
Adv Exp Med Biol, 564, 23-4
DOI 10.1007/0-387-25515-X_7, PubMed 16400803
The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex
Eur J Immunol, 35 (1), 261-72
DOI 10.1002/eji.200425429, PubMed 15593300
Publications 2004
Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut
Eur J Immunol, 34 (12), 3389-400
DOI 10.1002/eji.200425122, PubMed 15517613
cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells
Immunogenetics, 56 (5), 338-42
DOI 10.1007/s00251-004-0695-9, PubMed 15300336
Rat NKp46 activates natural killer cell cytotoxicity and is associated with FcepsilonRIgamma and CD3zeta
J Leukoc Biol, 76 (6), 1200-6
DOI 10.1189/jlb.0903428, PubMed 15356098
Publications 2002
Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c)
Eur J Immunol, 32 (7), 2031-6
DOI 10.1002/1521-4141(200207)32:7<2031::AID-IMMU2031>3.0.CO;2-H, PubMed 12115624
Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands
J Immunol, 169 (1), 22-30
DOI 10.4049/jimmunol.169.1.22, PubMed 12077224
Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells
J Immunol, 168 (10), 5147-54
DOI 10.4049/jimmunol.168.10.5147, PubMed 11994469
Publications 2001
The effect of in vivo depletion of NKR-P1+ or CD8+ lymphocytes on the acute rejection of allogeneic lymphocytes (ALC) in the rat
Scand J Immunol, 54 (4), 341-7
DOI 10.1046/j.1365-3083.2001.00979.x, PubMed 11555400
Rat natural killer cell receptor systems and recognition of MHC class I molecules
Immunol Rev, 181, 149-57
DOI 10.1034/j.1600-065x.2001.1810112.x, PubMed 11513136
A soluble LAT deletion mutant inhibits T-cell activation: reduced recruitment of signalling molecules to glycolipid-enriched microdomains
Cell Signal, 13 (3), 213-20
DOI 10.1016/s0898-6568(01)00131-0, PubMed 11282460
Publications 2000
Characterization and molecular cloning of rat C1qRp, a receptor on NK cells
Eur J Immunol, 30 (12), 3355-62
DOI 10.1002/1521-4141(2000012)30:12<3355::AID-IMMU3355>3.0.CO;2-1, PubMed 11093152
Publications 1999
Oligoclonality of rat intestinal intraepithelial T lymphocytes: overlapping TCR beta-chain repertoires in the CD4 single-positive and CD4/CD8 double-positive subsets
J Immunol, 162 (5), 2683-92
PubMed 10072512
RT1-U: identification of a novel, active, class Ib alloantigen of the rat MHC
J Immunol, 162 (2), 743-52
PubMed 9916694
Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset
Eur J Immunol, 29 (6), 2046-53
DOI 10.1002/(SICI)1521-4141(199906)29:06<2046::AID-IMMU2046>3.0.CO;2-Z, PubMed 10382768
Publications 1998
Role of classical (RT1.A) and nonclassical (RT1.C) MHC class I regions in natural killer cell-mediated bone marrow allograft rejection in rats
Transplantation, 65 (3), 319-24
DOI 10.1097/00007890-199802150-00005, PubMed 9484746
Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells
J Immunol, 160 (1), 219-24
PubMed 9551974
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells
J Exp Med, 187 (7), 1157-61
DOI 10.1084/jem.187.7.1157, PubMed 9529333
Publications 1997
Sequential development of intraepithelial gamma delta and alpha beta T lymphocytes expressing CD8 alpha beta in neonatal rat intestine: requirement for the thymus
Immunology, 92 (4), 447-56
DOI 10.1046/j.1365-2567.1997.00379.x, PubMed 9497485
Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization
Scand J Immunol, 46 (4), 349-57
DOI 10.1046/j.1365-3083.1997.d01-133.x, PubMed 9350285
Cloning, functional activities and in vivo tissue distribution of rat NKR-P1+ TCR alpha beta + cells
Int Immunol, 9 (7), 1043-51
DOI 10.1093/intimm/9.7.1043, PubMed 9237113
The role of natural killer cells in allograft responses to MHC antigens in the rat
Res Immunol, 148 (3), 159-64
DOI 10.1016/s0923-2494(97)84218-6, PubMed 9255867
Positive and negative MHC class I recognition by rat NK cells
Immunol Rev, 155, 91-104
DOI 10.1111/j.1600-065x.1997.tb00942.x, PubMed 9059885
Major histocompatibility complex class I-independent killing of xenogeneic targets by rat allospecific natural killer cells
Transplantation, 63 (1), 119-23
DOI 10.1097/00007890-199701150-00022, PubMed 9000672
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity
J Biol Chem, 272 (9), 5495-500
DOI 10.1074/jbc.272.9.5495, PubMed 9038153
Publications 1996
Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine
Immunology, 89 (4), 494-501
DOI 10.1046/j.1365-2567.1996.d01-783.x, PubMed 9014812
Genes in two MHC class I regions control recognition of a single rat NK cell allodeterminant
Int Immunol, 8 (11), 1779-85
DOI 10.1093/intimm/8.11.1779, PubMed 8943573
Publications 1995
Recruitment of alloreactive natural killer cells to the rat peritoneum by a transfected cell line secreting rat recombinant interleukin-2
J Immunol Methods, 179 (1), 59-69
DOI 10.1016/0022-1759(94)00270-7, PubMed 7868925
Alloreactive natural killer cells in the rat: complex genetics of major histocompatibility complex control
Eur J Immunol, 25 (5), 1249-56
DOI 10.1002/eji.1830250518, PubMed 7774627
Biological properties of rat large granular lymphocytes: MHC control of NK allorecognition
Immunobiological laboratory, Departemnt [i.e. Department]of Anatomy, Institute of Basic Medical Sciences, University of Oslo, [Oslo], 1 b. (flere pag.)
BIBSYS 95180586x, ISBN 82-91061-64-5
Publications 1994
Control of rat natural killer cell-mediated allorecognition by a major histocompatibility complex region encoding nonclassical class I antigens
J Exp Med, 180 (2), 641-51
DOI 10.1084/jem.180.2.641, PubMed 8046337
Publications 1993
Natural killer cell alloreactivity in the rat: I. Potent in vivo recruitment of rat natural killer cells with an interleukin-2-producing cell line in intraperitoneal diffusion chambers
Transplant Proc, 25 (5), 2800-1
PubMed 8212239
Natural killer cell alloreactivity in the rat: II. Predominant role of the RT1.C region in determining target cell susceptibility and specificity
Transplant Proc, 25 (5), 2802-3
PubMed 8212240
Publications 1991
Allospecific recognition of hemic cells in vitro by natural killer cells from athymic rats: evidence that allodeterminants coded for by single major histocompatibility complex haplotypes are recognized
Eur J Immunol, 21 (9), 2167-75
DOI 10.1002/eji.1830210927, PubMed 1716212
Publications 1990
Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors
Int Immunol, 2 (5), 453-60
DOI 10.1093/intimm/2.5.453, PubMed 2150758
T cell receptor-bearing cells among rat intestinal intraepithelial lymphocytes are mainly alpha/beta+ and are thymus dependent
Eur J Immunol, 20 (5), 1193-6
DOI 10.1002/eji.1830200538, PubMed 2162777
Publications 1989
The proliferation and life-span of rat large granular lymphocytes: effects of cytokines
Eur J Immunol, 19 (10), 1895-902
DOI 10.1002/eji.1830191021, PubMed 2583227
Publications 1988
Proliferation of large granular lymphocytes in the rat
Adv Exp Med Biol, 237, 457-61
DOI 10.1007/978-1-4684-5535-9_70, PubMed 3254059