The group has the following main areas of interest:
Intra tumor heterogeneity of breast cancer. Breast cancer is a heterogeneous disease, while classification studies focus on inter tumor heterogeneity, these studies focus on the regional or cell-to-cell variation within a tumor.
- Intra tumor heterogeneity; from single cell analysis to diagnostic tools (PI: Hege G. Russnes)
- The relevance of clonal heterogeneity to treatment response in adjuvant treated breast cancer (PI: Hege G. Russnes)
Molecular classification of breast cancer. Through studies of alterations on the DNA, RNA and protein level, tumors from large cohorts of patients are analyzed. This is part of larger collaborative studies in the K. G. Jebsen Center for breast cancer research as well as of projects managed in the OSBREAC group (Oslo Breast Cancer Research Consortium).
- EMITebc (Establishment of Molecular profiling for Individual Treatment decisions in Early Breast Cancer) (PI: Bjørn Naume)
- CARMA (Copy Aberration Regional Mapping Analysis)(PI: Ole Christian Lingjærde)
- CANCAN (Cancer specific copynumber alteration analysis)(PI: Hege G. Russnes)
Circulating biomarkers for breast cancer. Both detection of tumorcells, cell-free DNA and other molecular markers in blood or bonemarrow are promising diagnostic tools in treatment monitoring and follow up of cancer patients.
- Cell-free tumor DNA in blood; non-invasive monitoring of therapy response and disease progression in breast cancer patients (PI: Hege G. Russnes)
Tumor evolution. Knowledge about molecular alterations during tumor evolution can give a key to better prognostication and more targeted therapeutic intervention. Several pilot projects with focus on both the step from pre-invasive to invasive disease as well as the metastatic process.
Immune profiling of lymph nodes: The sentinel node is the first lymph node draining the lymph from the breast, and is likely to be the site of an active immune response against primary breast tumour. Our focus is to map the immune composition and immune activation in lymph nodes and its interaction with the immune response in the primary tumour and to lymph node metastasis.
- Immune profiling of sentinel nodes from breast cancer patients (PI: Hege Russnes)
- Immune profiling of sentine nodes in subtypes of breast cancer patients
- Functional studies of immune activation in metastatic and non-metastatic lymph nodes
Several collaborations in clinical trials, EU projects and institutional projects.
Kreftforeningen, Helse Sør-Øst, Norges Forskningsråd, Radiumhosplitalets Legater