Trude Golimo Simonsen

  • Post doc Ph.D.
  • +47 22 78 12 20
Education: M.Sc.
Research interests/projects: Intravital microscopy
 

Publications 2019

Hansem LMK, Huang R, Wegner CS, Simonsen TG, Gaustad JV, Hauge A, Rofstad EK (2019)
Intratumor Heterogeneity in Interstitial Fluid Pressure in Cervical and Pancreatic Carcinoma Xenografts
Transl Oncol, 12 (8), 1079-1085 (in press)
DOI 10.1016/j.tranon.2019.05.012, PubMed 31174058

Hauge A, Gaustad JV, Huang R, Simonsen TG, Wegner CS, Andersen LMK, Rofstad EK (2019)
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 104 (3), 666-676
DOI 10.1016/j.ijrobp.2019.03.002, PubMed 30858145

Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2019)
Pharmacokinetic analysis of DCE-MRI data of locally advanced cervical carcinoma with the Brix model
Acta Oncol, 58 (6), 828-837
DOI 10.1080/0284186X.2019.1580386, PubMed 30810443

Publications 2018

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2018)
Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy
Transl Oncol, 11 (5), 1128-1136
DOI 10.1016/j.tranon.2018.07.005, PubMed 30036782

Simonsen TG, Lund KV, Hompland T, Kristensen GB, Rofstad EK (2018)
DCE-MRI-Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 102 (4), 1193-1201
DOI 10.1016/j.ijrobp.2018.04.035, PubMed 29859790

Wegner CS, Hauge A, Andersen LMK, Huang R, Simonsen TG, Gaustad JV, Rofstad EK (2018)
Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation
Oncotarget, 9 (30), 21036-21051
DOI 10.18632/oncotarget.24783, PubMed 29765518

Wegner CS, Hauge A, Simonsen TG, Gaustad JV, Andersen LMK, Rofstad EK (2018)
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts
Neoplasia, 20 (7), 734-744
DOI 10.1016/j.neo.2018.05.006, PubMed 29886124

Publications 2017

Andersen LMK, Wegner CS, Simonsen TG, Huang R, Gaustad JV, Hauge A, Galappathi K, Rofstad EK (2017)
Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
Oncotarget, 8 (29), 48060-48074
DOI 10.18632/oncotarget.18231, PubMed 28624797

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2017)
The Effect of Sunitinib Treatment in Human Melanoma Xenografts: Associations with Angiogenic Profiles
Transl Oncol, 10 (2), 158-167
DOI 10.1016/j.tranon.2016.12.007, PubMed 28167241

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts
BMC Cancer, 17 (1), 411
DOI 10.1186/s12885-017-3404-4, PubMed 28606060

Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts
J Transl Med, 15 (1), 241
DOI 10.1186/s12967-017-1347-9, PubMed 29183378

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer
Oncotarget, 8 (62), 105682-105691
DOI 10.18632/oncotarget.22388, PubMed 29285283

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment
J Transl Med, 15 (1), 225
DOI 10.1186/s12967-017-1331-4, PubMed 29100521

Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2017)
Pretreatment late-phase DCE-MRI predicts outcome in locally advanced cervix cancer
Acta Oncol, 56 (5), 675-681
DOI 10.1080/0284186X.2017.1294762, PubMed 28447564

Wegner CS, Hauge A, Gaustad JV, Andersen LMK, Simonsen TG, Galappathi K, Rofstad EK (2017)
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
Acta Oncol, 56 (12), 1754-1762
DOI 10.1080/0284186X.2017.1343494, PubMed 28661213

Publications 2016

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2016)
Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression
Oncotarget, 7 (47), 76806-76815
DOI 10.18632/oncotarget.12695, PubMed 27756886

Rofstad EK, Huang R, Galappathi K, Andersen LM, Wegner CS, Hauge A, Gaustad JV, Simonsen TG (2016)
Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis
Oncotarget, 7 (35), 56986-56997
DOI 10.18632/oncotarget.10931, PubMed 27486768

Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
Cancer Lett, 373 (2), 147-55
DOI 10.1016/j.canlet.2016.01.047, PubMed 26828134

Simonsen TG, Gaustad JV, Rofstad EK (2016)
Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma
Transl Oncol, 9 (3), 211-8
DOI 10.1016/j.tranon.2016.04.003, PubMed 27267839

Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
J Transl Med, 14 (1), 161
DOI 10.1186/s12967-016-0920-y, PubMed 27268062

Publications 2015

Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
BMC Cancer, 15, 900
DOI 10.1186/s12885-015-1918-1, PubMed 26573613

Lund KV, Simonsen TG, Hompland T, Kristensen GB, Rofstad EK (2015)
Short-term pretreatment DCE-MRI in prediction of outcome in locally advanced cervical cancer
Radiother Oncol, 115 (3), 379-85
DOI 10.1016/j.radonc.2015.05.001, PubMed 25998804

Simonsen TG, Gaustad JV, Rofstad EK (2015)
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
J Exp Clin Cancer Res, 34, 150
DOI 10.1186/s13046-015-0264-0, PubMed 26667022

Publications 2014

Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2014)
Thrombospondin-1 domain-containing peptide properdistatin improves vascular function in human melanoma xenografts
Microvasc Res, 98, 159-65
DOI 10.1016/j.mvr.2014.02.005, PubMed 24555949

Publications 2013

Gaustad JV, Pozdniakova V, Hompland T, Simonsen TG, Rofstad EK (2013)
Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts
J Exp Clin Cancer Res, 32, 93
DOI 10.1186/1756-9966-32-93, PubMed 24245934

Publications 2012

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
A novel application of dorsal window chambers: repetitive imaging of tumor-associated lymphatics
Microvasc Res, 83 (3), 360-5
DOI 10.1016/j.mvr.2012.02.003, PubMed 22342351

Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts
BMC Cancer, 12, 388
DOI 10.1186/1471-2407-12-388, PubMed 22947392

Gaustad JV, Simonsen TG, Roa AM, Rofstad EK (2012)
Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply
Microvasc Res, 85, 10-5
DOI 10.1016/j.mvr.2012.11.002, PubMed 23154277

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Vascular abnormalities associated with acute hypoxia in human melanoma xenografts
Radiother Oncol, 105 (1), 72-8
DOI 10.1016/j.radonc.2012.08.018, PubMed 23022175

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
Tumor-line specific causes of intertumor heterogeneity in blood supply in human melanoma xenografts
Microvasc Res, 85, 16-23
DOI 10.1016/j.mvr.2012.11.001, PubMed 23149341

Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts
PLoS One, 7 (6), e40006
DOI 10.1371/journal.pone.0040006, PubMed 22768196

Publications 2010

Simonsen TG, Gaustad JV, Rofstad EK (2010)
Development of hypoxia in a preclinical model of tumor micrometastases
Int J Radiat Oncol Biol Phys, 76 (3), 879-88
DOI 10.1016/j.ijrobp.2009.09.045, PubMed 20159362

Publications 2009

Egeland TA, Simonsen TG, Gaustad JV, Gulliksrud K, Ellingsen C, Rofstad EK (2009)
Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images
Radiat Res, 172 (3), 339-47
DOI 10.1667/RR1787.1, PubMed 19708783

Gaustad JV, Simonsen TG, Brurberg KG, Huuse EM, Rofstad EK (2009)
Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries
Neoplasia, 11 (3), 277-85
DOI 10.1593/neo.81400, PubMed 19242609

Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, Simonsen TG (2009)
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts
Neoplasia, 11 (11), 1243-51
DOI 10.1593/neo.91152, PubMed 19881960

Publications 2008

Gaustad JV, Brurberg KG, Simonsen TG, Mollatt CS, Rofstad EK (2008)
Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging
Neoplasia, 10 (4), 354-62
DOI 10.1593/neo.08162, PubMed 18392132

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