Catherine Sem Wegner

  • Postdoc PhD
  • +47 22 78 12 23

The main focus of my research is on pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC) with a mean survival time of 6 moths. For the study of this devastating disease mouse xenograft models using cell line derived or patient derived tissue is examined using functional MRI, intravital microscopy, electron microscopy, histological and molecular methods. We have shown that functional MRI can be used to evaluate the composition of pancreatic tumors in respect to the level of collagen, microvessel density (MVD) and hypoxic fraction of these tumors. This we use to study the effect of stromal depletion in pancreatic cancer.

 

Publications 2019

Gaustad JV, Simonsen TG, Wegner CS, Rofstad EK (2019)
Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts
Front. Oncol., 9, 845

Hansem LMK, Huang R, Wegner CS, Simonsen TG, Gaustad JV, Hauge A, Rofstad EK (2019)
Intratumor Heterogeneity in Interstitial Fluid Pressure in Cervical and Pancreatic Carcinoma Xenografts
Transl Oncol, 12 (8), 1079-1085
DOI 10.1016/j.tranon.2019.05.012, PubMed 31174058

Hauge A, Gaustad JV, Huang R, Simonsen TG, Wegner CS, Andersen LMK, Rofstad EK (2019)
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 104 (3), 666-676
DOI 10.1016/j.ijrobp.2019.03.002, PubMed 30858145

Publications 2018

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2018)
Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy
Transl Oncol, 11 (5), 1128-1136
DOI 10.1016/j.tranon.2018.07.005, PubMed 30036782

Wegner CS, Hauge A, Andersen LMK, Huang R, Simonsen TG, Gaustad JV, Rofstad EK (2018)
Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation
Oncotarget, 9 (30), 21036-21051
DOI 10.18632/oncotarget.24783, PubMed 29765518

Wegner CS, Hauge A, Simonsen TG, Gaustad JV, Andersen LMK, Rofstad EK (2018)
DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts
Neoplasia, 20 (7), 734-744
DOI 10.1016/j.neo.2018.05.006, PubMed 29886124

Publications 2017

Andersen LMK, Wegner CS, Simonsen TG, Huang R, Gaustad JV, Hauge A, Galappathi K, Rofstad EK (2017)
Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
Oncotarget, 8 (29), 48060-48074
DOI 10.18632/oncotarget.18231, PubMed 28624797

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment
J Transl Med, 15 (1), 225
DOI 10.1186/s12967-017-1331-4, PubMed 29100521

Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer
Oncotarget, 8 (62), 105682-105691
DOI 10.18632/oncotarget.22388, PubMed 29285283

Wegner CS, Hauge A, Gaustad JV, Andersen LMK, Simonsen TG, Galappathi K, Rofstad EK (2017)
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
Acta Oncol, 56 (12), 1754-1762
DOI 10.1080/0284186X.2017.1343494, PubMed 28661213

Publications 2016

Rofstad EK, Huang R, Galappathi K, Andersen LM, Wegner CS, Hauge A, Gaustad JV, Simonsen TG (2016)
Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis
Oncotarget, 7 (35), 56986-56997
DOI 10.18632/oncotarget.10931, PubMed 27486768

Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
Cancer Lett, 373 (2), 147-55
DOI 10.1016/j.canlet.2016.01.047, PubMed 26828134

Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
J Transl Med, 14 (1), 161
DOI 10.1186/s12967-016-0920-y, PubMed 27268062

Publications 2015

Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
BMC Cancer, 15, 900
DOI 10.1186/s12885-015-1918-1, PubMed 26573613

Vietri M, Schink KO, Campsteijn C, Wegner CS, Schultz SW, Christ L, Thoresen SB, Brech A, Raiborg C, Stenmark H (2015)
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing
Nature, 522 (7555), 231-5
DOI 10.1038/nature14408, PubMed 26040712

Publications 2014

Wegner CS, Schink KO, Stenmark H, Brech A (2014)
Monitoring phosphatidylinositol 3-phosphate in multivesicular endosome biogenesis
Methods Enzymol, 534, 3-23
DOI 10.1016/B978-0-12-397926-1.00001-9, PubMed 24359945

Publications 2011

Wegner CS, Rodahl LM, Stenmark H (2011)
ESCRT proteins and cell signalling
Traffic, 12 (10), 1291-7
DOI 10.1111/j.1600-0854.2011.01210.x, PubMed 21518165

Publications 2009

Wegner CS, Malerød L, Pedersen NM, Progida C, Bakke O, Stenmark H, Brech A (2009)
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5
Histochem Cell Biol, 133 (1), 41-55
DOI 10.1007/s00418-009-0643-8, PubMed 19830447

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