Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2019 from OUS - Department of Pathology
92 publications found
Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells
BMC Cancer, 19 (1), 596
DOI 10.1186/s12885-019-5803-1, PubMed 31208372
Trends in management and outcome of cystic pancreatic lesions - analysis of 322 cases undergoing surgical resection
Scand J Gastroenterol, 54 (8), 1051-1057
DOI 10.1080/00365521.2019.1642379, PubMed 31322457
Molecular Characterization of the Danish Prion Diseases Cohort With Special Emphasis on Rare and Unique Cases
J Neuropathol Exp Neurol, 78 (11), 980-992
DOI 10.1093/jnen/nlz089, PubMed 31553446
Resident memory CD8 T cells persist for years in human small intestine
J Exp Med, 216 (10), 2412-2426
DOI 10.1084/jem.20190414, PubMed 31337737
BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts
Front Genet, 10, 282
DOI 10.3389/fgene.2019.00282, PubMed 31001324
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes
Clin Cancer Res, 25 (7), 2155-2165
DOI 10.1158/1078-0432.CCR-18-2792, PubMed 30617134
Implications of different guidelines for surveillance after serrated polyp resection in United States of America and Europe
Endoscopy, 51 (8), 750-758
DOI 10.1055/a-0916-8598, PubMed 31195423
18F-Fluciclovine PET/CT in Suspected Residual or Recurrent High-Grade Glioma
Clin Nucl Med, 44 (8), 605-611
DOI 10.1097/RLU.0000000000002641, PubMed 31274605
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128
The β2-Adrenergic Receptor Is a Molecular Switch for Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Mol Cancer Res, 17 (11), 2154-2168
DOI 10.1158/1541-7786.MCR-18-0605, PubMed 31395667
Molecular characterization of carcinosarcomas arising in the uterus and ovaries
Oncotarget, 10 (38), 3614-3624
DOI 10.18632/oncotarget.26942, PubMed 31217897
MGMT promoter methylation is a rare epigenetic change in malignant effusions
Cytopathology, 31 (1), 12-15
DOI 10.1111/cyt.12782, PubMed 31808217
Can we ablate liver lesions close to large portal and hepatic veins with MR-guided HIFU? An experimental study in a porcine model
Eur Radiol, 29 (9), 5013-5021
DOI 10.1007/s00330-018-5996-8, PubMed 30737565
Interfocal heterogeneity challenges the clinical usefulness of molecular classification of primary prostate cancer
Sci Rep, 9 (1), 13579
DOI 10.1038/s41598-019-49964-7, PubMed 31537872
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Hepatology, 69 (2), 622-638
DOI 10.1002/hep.30210, PubMed 30102768
Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates
Cancer Immunol Immunother, 68 (4), 687-697
DOI 10.1007/s00262-019-02302-2, PubMed 30684003
ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†
Ann Oncol, 30 (5), 672-705
DOI 10.1093/annonc/mdz062, PubMed 31046081
"Teratoid" Wilms Tumor: The Extreme End of Heterologous Element Differentiation, Not a Separate Entity
Am J Surg Pathol, 43 (11), 1583-1590
DOI 10.1097/PAS.0000000000001335, PubMed 31600178
Biomarkers of drug resistance in ovarian cancer - an update
Expert Rev Mol Diagn, 19 (6), 469-476
DOI 10.1080/14737159.2019.1618187, PubMed 31075061
Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study
Br J Cancer, 120 (10), 1007-1014
DOI 10.1038/s41416-019-0445-2, PubMed 30967648
Protein kinase C regulates ErbB3 turnover
Exp Cell Res, 382 (2), 111473
DOI 10.1016/j.yexcr.2019.06.018, PubMed 31233741
Results of multigene panel testing in familial cancer cases without genetic cause demonstrated by single gene testing
Sci Rep, 9 (1), 18555
DOI 10.1038/s41598-019-54517-z, PubMed 31811167
Overlapping genetic architecture between Parkinson disease and melanoma
Acta Neuropathol, 139 (2), 347-364
DOI 10.1007/s00401-019-02110-z, PubMed 31845298
Prognostic value of mitotic checkpoint protein BUB3, cyclin B1, and pituitary tumor-transforming 1 expression in prostate cancer
Mod Pathol, 33 (5), 905-915
DOI 10.1038/s41379-019-0418-2, PubMed 31801961
Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro
Aging (Albany NY), 11 (2), 573-589
DOI 10.18632/aging.101761, PubMed 30668541
Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma
Mol Cancer Ther, 19 (3), 895-905
DOI 10.1158/1535-7163.MCT-19-0290, PubMed 31871265
p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance
Sci Rep, 9 (1), 5839
DOI 10.1038/s41598-019-42303-w, PubMed 30967582
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111
Acute atherosis of decidua basalis; characterization of spiral arteries, endothelial status and activation
Placenta, 82, 10-16
DOI 10.1016/j.placenta.2019.04.006, PubMed 31174621
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol, 47 (1), 134-138
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394
Early development of the human placenta and pregnancy complications
J Matern Fetal Neonatal Med, 33 (20), 3538-3545
DOI 10.1080/14767058.2019.1578745, PubMed 30810433
Is Peritoneal Tumor Penetration of Prognostic Importance in Gastrointestinal Stromal Tumors?
Ann Surg Oncol, 26 (13), 4730-4736
DOI 10.1245/s10434-019-07813-x, PubMed 31520212
Breast cancer quantitative proteome and proteogenomic landscape
Nat Commun, 10 (1), 1600
DOI 10.1038/s41467-019-09018-y, PubMed 30962452
Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies
J Reprod Immunol, 132, 42-48
DOI 10.1016/j.jri.2019.03.003, PubMed 30928772
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer
Neoplasia, 21 (4), 353-362
DOI 10.1016/j.neo.2019.01.002, PubMed 30856376
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053
Role of the Wnt signaling pathway in keratoacanthoma
Cancer Rep (Hoboken), 3 (2), e1219
DOI 10.1002/cnr2.1219, PubMed 32672002
MX 2 is a novel regulator of cell cycle in melanoma cells
Pigment Cell Melanoma Res, 33 (3), 446-457
DOI 10.1111/pcmr.12837, PubMed 31660681
Pancreatoduodenectomy with venous resection for ductal adenocarcinoma rarely achieves complete (R0) resection
HPB (Oxford), 22 (1), 50-57
DOI 10.1016/j.hpb.2019.05.005, PubMed 31186199
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721
Treatment of Sinonasal Adenocarcinoma: A Population-Based Prospective Cohort Study
J Neurol Surg B Skull Base, 81 (6), 627-637
DOI 10.1055/s-0039-1694050, PubMed 33381366
Microvessel density in breast cancer: the impact of field area on prognostic informativeness
J Clin Pathol, 72 (4), 304-310
DOI 10.1136/jclinpath-2018-205536, PubMed 30630872
Generation and Characterization of an Abcc1 Humanized Mouse Model (hABCC1flx/flx ) with Knockout Capability
Mol Pharmacol, 96 (2), 138-147
DOI 10.1124/mol.119.115824, PubMed 31189668
Toward Personalized Computer Simulation of Breast Cancer Treatment: A Multiscale Pharmacokinetic and Pharmacodynamic Model Informed by Multitype Patient Data
Cancer Res, 79 (16), 4293-4304
DOI 10.1158/0008-5472.CAN-18-1804, PubMed 31118201
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology, 61 (5), 545-555
DOI 10.1007/s00234-019-02173-5, PubMed 30712139
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293
High level of lncRNA H19 expression is associated with shorter survival in esophageal squamous cell cancer patients
Pathol Res Pract, 215 (11), 152638
DOI 10.1016/j.prp.2019.152638, PubMed 31551175
PDHA1 Gene Knockout In Human Esophageal Squamous Cancer Cells Resulted In Greater Warburg Effect And Aggressive Features In Vitro And In Vivo
Onco Targets Ther, 12, 9899-9913
DOI 10.2147/OTT.S226851, PubMed 31819487
Measurable residual disease monitoring using Wilms tumor gene 1 expression in childhood acute myeloid leukemia based on child-specific reference values
Pediatr Blood Cancer, 66 (6), e27671
DOI 10.1002/pbc.27671, PubMed 30900388
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609
Neurosurgical treatment of pediatric pleomorphic xanthoastrocytomas: long-term follow-up of a single-institution, consecutive series of 12 patients
J Neurosurg Pediatr, 23 (4), 512-516
DOI 10.3171/2018.11.PEDS18449, PubMed 30738389
The Novel Oncolytic Compound LTX-401 Induces Antitumor Immune Responses in Experimental Hepatocellular Carcinoma
Mol Ther Oncolytics, 14, 139-148
DOI 10.1016/j.omto.2019.05.002, PubMed 31211244
Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma
Sci Rep, 9 (1), 2133
DOI 10.1038/s41598-019-38603-w, PubMed 30765891
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
Int J Gynecol Pathol, 38 Suppl 1, S40-S63
DOI 10.1097/PGP.0000000000000491, PubMed 30550483
Virome capture sequencing does not identify active viral infection in unicentric and idiopathic multicentric Castleman disease
PLoS One, 14 (6), e0218660
DOI 10.1371/journal.pone.0218660, PubMed 31242229
Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers
Int J Cancer, 146 (1), 223-235
DOI 10.1002/ijc.32638, PubMed 31444972
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery
Mol Oncol, 13 (5), 1166-1179
DOI 10.1002/1878-0261.12475, PubMed 30854794
Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways
J Oncol, 2019, 7547469
DOI 10.1155/2019/7547469, PubMed 31636669
The Role of Calcitonin in Predicting the Extent of Surgery in Medullary Thyroid Carcinoma: A Nationwide Population-Based Study in Norway
Eur Thyroid J, 8 (3), 159-166
DOI 10.1159/000499018, PubMed 31259158
HMGB1 concentration measurements in trauma patients: assessment of pre-analytical conditions and sample material
Mol Med, 26 (1), 5
DOI 10.1186/s10020-019-0131-0, PubMed 31892315
Genetic Characterization of Myoid Hamartoma of the Breast
Cancer Genomics Proteomics, 16 (6), 563-568
DOI 10.21873/cgp.20158, PubMed 31659109
Fusion of the COL1A1 and FYN Genes in Epithelioid Osteoblastoma
Cancer Genomics Proteomics, 16 (5), 361-368
DOI 10.21873/cgp.20141, PubMed 31467230
Fusion of the Genes PHF1 and TFE3 in Malignant Chondroid Syringoma
Cancer Genomics Proteomics, 16 (5), 345-351
DOI 10.21873/cgp.20139, PubMed 31467228
Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma
Cancer Genomics Proteomics, 16 (4), 293-298
DOI 10.21873/cgp.20134, PubMed 31243110
New reference intervals for cortisol, cortisol binding globulin and free cortisol index in women using ethinyl estradiol
Scand J Clin Lab Invest, 79 (5), 314-319
DOI 10.1080/00365513.2019.1622031, PubMed 31161807
Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1
Leukemia, 33 (8), 1910-1922
DOI 10.1038/s41375-019-0413-0, PubMed 30858550
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006
Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort
Lupus, 28 (7), 818-825
DOI 10.1177/0961203319847275, PubMed 31072277
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
J Transl Med, 17 (1), 96
DOI 10.1186/s12967-019-1846-y, PubMed 30894200
Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced
J Pathol Clin Res, 5 (4), 248-255
DOI 10.1002/cjp2.140, PubMed 31493350
SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma
Gynecol Oncol, 153 (3), 651-660
DOI 10.1016/j.ygyno.2019.03.099, PubMed 30904337
Immune Cell Composition in Human Non-small Cell Lung Cancer
Front Immunol, 9, 3101
DOI 10.3389/fimmu.2018.03101, PubMed 30774636
Children treated for medulloblastoma and supratentorial primitive neuroectodermal tumor in Norway from 1974 through 2013: Unexplainable regional differences in survival
Pediatr Blood Cancer, 66 (10), e27910
DOI 10.1002/pbc.27910, PubMed 31264356
PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings
AJR Am J Roentgenol, 212 (6), 1206-1214
DOI 10.2214/AJR.18.20743, PubMed 30888866
Simulated ablation for detection of cells impacting paracrine signalling in histology analysis
Math Med Biol, 36 (1), 93-112
DOI 10.1093/imammb/dqx022, PubMed 29452382
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment
Nat Commun, 10 (1), 5499
DOI 10.1038/s41467-019-13329-5, PubMed 31796750
In Vivo Adenomyosis Tissue Sampling Using a Transvaginal Ultrasound-guided Core Biopsy Technique for Research Purposes: Safety, Feasibility, and Effectiveness
J Minim Invasive Gynecol, 26 (7), 1357-1362
DOI 10.1016/j.jmig.2019.02.002, PubMed 30738919
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194
Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort
Acta Oncol, 58 (3), 273-282
DOI 10.1080/0284186X.2018.1554260, PubMed 30632866
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018, PubMed 30908936
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells
PLoS One, 14 (3), e0212524
DOI 10.1371/journal.pone.0212524, PubMed 30861002
Kidney Involvement in Patients with Type 1 Autoimmune Pancreatitis
J Clin Med, 8 (2)
DOI 10.3390/jcm8020258, PubMed 30781677
Papilloma of the Fallopian Tube: A Rare Gynecologic Neoplasm Harboring a BRAF (c.1799T>A) Mutation (V600E)
Int J Gynecol Pathol, 38 (5), 459-463
DOI 10.1097/PGP.0000000000000526, PubMed 29851866
Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer
EBioMedicine, 47, 184-194
DOI 10.1016/j.ebiom.2019.08.055, PubMed 31492560
Quality-of-life effects of screening mammography in Norway
Int J Cancer, 146 (8), 2104-2112
DOI 10.1002/ijc.32539, PubMed 31254388
Carotid Plaque Neovascularization Detected With Superb Microvascular Imaging Ultrasound Without Using Contrast Media
Stroke, 50 (11), 3121-3127
DOI 10.1161/STROKEAHA.119.025496, PubMed 31510899
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction
J Med Chem, 62 (11), 5382-5403
DOI 10.1021/acs.jmedchem.9b00003, PubMed 31157974
Potent and specific MTH1 inhibitors targeting gastric cancer
Cell Death Dis, 10 (6), 434
DOI 10.1038/s41419-019-1665-3, PubMed 31164636
Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
Nat Commun, 10 (1), 1522
DOI 10.1038/s41467-019-09320-9, PubMed 30944316
Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET
J Nucl Med, 61 (7), 1050-1057
DOI 10.2967/jnumed.119.237198, PubMed 31806767
Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography
J Cereb Blood Flow Metab, 40 (5), 954-965
DOI 10.1177/0271678X19854541, PubMed 31195936
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
Mol Imaging Biol, 21 (2), 306-316
DOI 10.1007/s11307-018-1230-y, PubMed 29942989