Publications 2023

Foldvari Z, Knetter C, Yang W, Gjerdingen TJ, Bollineni RC, Tran TT, Lund-Johansen F, Kolstad A, Drousch K, Klopfleisch R, Leisegang M, Olweus J (2023)
A systematic safety pipeline for selection of T-cell receptors to enter clinical use
NPJ Vaccines, 8 (1), 126
DOI 10.1038/s41541-023-00713-y, PubMed 37607971

Giannakopoulou E, Lehander M, Virding Culleton S, Yang W, Li Y, Karpanen T, Yoshizato T, Rustad EH, Nielsen MM, Bollineni RC, Tran TT, Delic-Sarac M, Gjerdingen TJ, Douvlataniotis K, Laos M, Ali M, Hillen A, Mazzi S, Chin DWL, Mehta A, Holm JS, Bentzen AK, Bill M, Griffioen M, Gedde-Dahl T et al. (2023)
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Nat Cancer, 4 (10), 1474-1490
DOI 10.1038/s43018-023-00642-8, PubMed 37783807

Meyer S, Blaas I, Bollineni RC, Delic-Sarac M, Tran TT, Knetter C, Dai KZ, Madssen TS, Vaage JT, Gustavsen A, Yang W, Nissen-Meyer LSH, Douvlataniotis K, Laos M, Nielsen MM, Thiede B, Søraas A, Lund-Johansen F, Rustad EH, Olweus J (2023)
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Cell Rep, 42 (1), 111995
DOI 10.1016/j.celrep.2023.111995, PubMed 36656713

Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K et al. (2023)
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745

Publications 2022

Bollineni RC, Tran TT, Lund-Johansen F, Olweus J (2022)
Chasing neoantigens; invite naïve T cells to the party
Curr Opin Immunol, 75, 102172
DOI 10.1016/j.coi.2022.102172, PubMed 35279483

Pataskar A, Champagne J, Nagel R, Kenski J, Laos M, Michaux J, Pak HS, Bleijerveld OB, Mordente K, Navarro JM, Blommaert N, Nielsen MM, Lovecchio D, Stone E, Georgiou G, de Gooijer MC, van Tellingen O, Altelaar M, Joosten RP, Perrakis A, Olweus J, Bassani-Sternberg M, Peeper DS, Agami R (2022)
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Nature, 603 (7902), 721-727
DOI 10.1038/s41586-022-04499-2, PubMed 35264796

Pataskar A, Champagne J, Nagel R, Kenski J, Laos M, Michaux J, Pak HS, Bleijerveld OB, Mordente K, Navarro JM, Blommaert N, Nielsen MM, Lovecchio D, Stone E, Georgiou G, de Gooijer MC, van Tellingen O, Altelaar M, Joosten RP, Perrakis A, Olweus J, Bassani-Sternberg M, Peeper DS, Agami R (2022)
Author Correction: Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Nature, 608 (7922), E20
DOI 10.1038/s41586-022-05097-y, PubMed 35840685

Riise J, Meyer S, Blaas I, Chopra A, Tran TT, Delic-Sarac M, Hestdalen ML, Brodin E, Rustad EH, Dai KZ, Vaage JT, Nissen-Meyer LSH, Sund F, Wader KF, Bjornevik AT, Meyer PA, Nygaard GO, König M, Smeland S, Lund-Johansen F, Olweus J, Kolstad A (2022)
Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination
Br J Haematol, 197 (6), 697-708
DOI 10.1111/bjh.18149, PubMed 35254660

Publications 2021

Ali M, Giannakopoulou E, Li Y, Lehander M, Virding Culleton S, Yang W, Knetter C, Odabasi MC, Bollineni RC, Yang X, Foldvari Z, Böschen ML, Taraldsrud E, Strønen E, Toebes M, Hillen A, Mazzi S, de Ru AH, Janssen GMC, Kolstad A, Tjønnfjord GE, Lie BA, Griffioen M, Lehmann S, Osnes LT et al. (2021)
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Nat Biotechnol, 40 (4), 488-498
DOI 10.1038/s41587-021-01089-x, PubMed 34873326

Mazzarella L, Enblad G, Olweus J, Malmberg KJ, Jerkeman M (2021)
Advances in immune therapies in hematological malignancies
J Intern Med, 292 (2), 205-220
DOI 10.1111/joim.13395, PubMed 34624160

Publications 2020

Ask EH, Tschan-Plessl A, Gjerdingen TJ, Sætersmoen ML, Hoel HJ, Wiiger MT, Olweus J, Wahlin BE, Lingjærde OC, Horowitz A, Cashen AF, Watkins M, Fehniger TA, Holte H, Kolstad A, Malmberg KJ (2020)
A Systemic Protein Deviation Score Linked to PD-1⁺ CD8⁺ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma
Med, 2 (2), 180-195.e5
DOI 10.1016/j.medj.2020.10.006, PubMed 35590201

Bartok O, Pataskar A, Nagel R, Laos M, Goldfarb E, Hayoun D, Levy R, Körner PR, Kreuger IZM, Champagne J, Zaal EA, Bleijerveld OB, Huang X, Kenski J, Wargo J, Brandis A, Levin Y, Mizrahi O, Alon M, Lebon S, Yang W, Nielsen MM, Stern-Ginossar N, Altelaar M, Berkers CR et al. (2020)
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature, 590 (7845), 332-337
DOI 10.1038/s41586-020-03054-1, PubMed 33328638

Publications 2019

Ali M, Foldvari Z, Giannakopoulou E, Böschen ML, Strønen E, Yang W, Toebes M, Schubert B, Kohlbacher O, Schumacher TN, Olweus J (2019)
Induction of neoantigen-reactive T cells from healthy donors
Nat Protoc, 14 (6), 1926-1943
DOI 10.1038/s41596-019-0170-6, PubMed 31101906

Olweus J, Lund-Johansen F (2019)
Finding Neo (antigens, that is)
Blood, 134 (2), 108-109
DOI 10.1182/blood.2019001334, PubMed 31296544

Publications 2018

Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte JA, Malmberg KJ (2018)
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors
Cancer Immunol Res, 6 (4), 467-480
DOI 10.1158/2326-6066.CIR-17-0207, PubMed 29459477

Publications 2017

Karpanen T, Olweus J (2017)
The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
Front Immunol, 8, 1718
DOI 10.3389/fimmu.2017.01718, PubMed 29321773

Olweus J (2017)
Manufacture of CAR-T cells in the body
Nat Biotechnol, 35 (6), 520-521
DOI 10.1038/nbt.3898, PubMed 28591119

Taraldsrud E, Fevang B, Jørgensen SF, Moltu K, Hilden V, Taskén K, Aukrust P, Myklebust JH, Olweus J (2017)
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency
J Autoimmun, 81, 110-119
DOI 10.1016/j.jaut.2017.04.004, PubMed 28476239

Publications 2016

Henriksen EK, Jørgensen KK, Kaveh F, Holm K, Hamm D, Olweus J, Melum E, Chung BK, Eide TJ, Lundin KE, Boberg KM, Karlsen TH, Hirschfield GM, Liaskou E (2016)
Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease
J Hepatol, 66 (1), 116-122
DOI 10.1016/j.jhep.2016.09.002, PubMed 27647428

Mensali N, Ying F, Sheng VO, Yang W, Walseng E, Kumari S, Fallang LE, Kolstad A, Uckert W, Malmberg KJ, Wälchli S, Olweus J (2016)
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA
Oncoimmunology, 5 (5), e1138199
DOI 10.1080/2162402X.2016.1138199, PubMed 27467957

Strønen E, Toebes M, Kelderman S, van Buuren MM, Yang W, van Rooij N, Donia M, Böschen ML, Lund-Johansen F, Olweus J, Schumacher TN (2016)
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
DOI 10.1126/science.aaf2288, PubMed 27198675

Taraldsrud E, Aukrust P, Jørgensen S, Lingjærde OC, Olweus J, Myklebust JH, Fevang B (2016)
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
Clin Immunol, 175, 69-74
DOI 10.1016/j.clim.2016.11.014, PubMed 27919819

Publications 2015

Karpanen T, Olweus J (2015)
T-cell receptor gene therapy--ready to go viral?
Mol Oncol, 9 (10), 2019-42
DOI 10.1016/j.molonc.2015.10.006, PubMed 26548533

Kolstad A, Olweus J (2015)
"In situ" vaccination for systemic effects in follicular lymphoma
Oncoimmunology, 4 (7), e1014773
DOI 10.1080/2162402X.2015.1014773, PubMed 26140239

Liaskou E, Klemsdal Henriksen EK, Holm K, Kaveh F, Hamm D, Fear J, Viken MK, Hov JR, Melum E, Robins H, Olweus J, Karlsen TH, Hirschfield GM (2015)
High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires
Hepatology, 63 (5), 1608-19
DOI 10.1002/hep.28116, PubMed 26257205

Olweus J (2015)
Cancer immunotherapy--Converting immune failure to clinical response
Mol Oncol, 9 (10), 1891-3
DOI 10.1016/j.molonc.2015.10.017, PubMed 26563645

Tadesse FG, Mensali N, Fallang LE, Walseng E, Yang W, Olweus J, Wälchli S (2015)
Unpredicted phenotypes of two mutants of the TcR DMF5
J Immunol Methods, 425, 37-44
DOI 10.1016/j.jim.2015.06.006, PubMed 26079729

Walseng E, Wälchli S, Fallang LE, Yang W, Vefferstad A, Areffard A, Olweus J (2015)
Soluble T-cell receptors produced in human cells for targeted delivery
PLoS One, 10 (4), e0119559
DOI 10.1371/journal.pone.0119559, PubMed 25875651

Publications 2014

Kolstad A, Kumari S, Walczak M, Madsbu U, Hagtvedt T, Bogsrud TV, Kvalheim G, Holte H, Aurlien E, Delabie J, Tierens A, Olweus J (2014)
Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma
Blood, 125 (1), 82-9
DOI 10.1182/blood-2014-07-592162, PubMed 25293773

Lossius A, Johansen JN, Vartdal F, Robins H, Jūratė Šaltytė B, Holmøy T, Olweus J (2014)
High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+ T cells
Eur J Immunol, 44 (11), 3439-52
DOI 10.1002/eji.201444662, PubMed 25103993

Taraldsrud E, Fevang B, Aukrust P, Beiske KH, Fløisand Y, Frøland S, Rollag H, Olweus J (2014)
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin Exp Immunol, 175 (3), 439-48
DOI 10.1111/cei.12239, PubMed 24237110

Publications 2013

Kumari S, Wälchli S, Fallang LE, Yang W, Lund-Johansen F, Schumacher TN, Olweus J (2013)
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes
Proc Natl Acad Sci U S A, 111 (1), 403-8
DOI 10.1073/pnas.1306549111, PubMed 24344295

Wälchli S, Kumari S, Fallang LE, Sand KM, Yang W, Landsverk OJ, Bakke O, Olweus J, Gregers TF (2013)
Invariant chain as a vehicle to load antigenic peptides on human MHC class I for cytotoxic T-cell activation
Eur J Immunol, 44 (3), 774-84
DOI 10.1002/eji.201343671, PubMed 24293164

Publications 2012

Olweus J, Kolstad A (2012)
[Can the immune system target cancer?]
Tidsskr Nor Laegeforen, 132 (7), 784-5
DOI 10.4045/tidsskr.12.0156, PubMed 22511078

Publications 2011

Abrahamsen IW, Kjellevoll S, Greve-Isdahl M, Mensali N, Wälchli S, Kumari S, Loland BF, Egeland T, Kolstad A, Olweus J (2011)
T cells raised against allogeneic HLA-A2/CD20 kill primary follicular lymphoma and acute lymphoblastic leukemia cells
Int J Cancer, 130 (8), 1821-32
DOI 10.1002/ijc.26209, PubMed 21630262

Wälchli S, Løset GÅ, Kumari S, Johansen JN, Yang W, Sandlie I, Olweus J (2011)
A practical approach to T-cell receptor cloning and expression
PLoS One, 6 (11), e27930
DOI 10.1371/journal.pone.0027930, PubMed 22132171

Publications 2010

Abrahamsen IW, Stronen E, Wälchli S, Johansen JN, Kjellevoll S, Kumari S, Komada M, Gaudernack G, Tjonnfjord G, Toebes M, Schumacher TN, Lund-Johansen F, Olweus J (2010)
Targeting B cell leukemia with highly specific allogeneic T cells with a public recognition motif
Leukemia, 24 (11), 1901-9
DOI 10.1038/leu.2010.186, PubMed 20844564

Publications 2009

Rölle A, Olweus J (2009)
Dendritic cells in cytomegalovirus infection: viral evasion and host countermeasures
APMIS, 117 (5-6), 413-26
DOI 10.1111/j.1600-0463.2009.02449.x, PubMed 19400865

Stronen E, Abrahamsen IW, Gaudernack G, Wälchli S, Munthe E, Buus S, Johansen FE, Lund-Johansen F, Olweus J (2009)
Dendritic cells engineered to express defined allo-HLA peptide complexes induce antigen-specific cytotoxic T cells efficiently killing tumour cells
Scand J Immunol, 69 (4), 319-28
DOI 10.1111/j.1365-3083.2008.02223.x, PubMed 19284496

Publications 2007

Villa I, Kvale EO, Lund-Johansen F, Olweus J (2007)
Assay for monitoring in vitro selective depletion strategies in allogeneic stem cell transplantation
Cytotherapy, 9 (6), 600-10
DOI 10.1080/14653240701510573, PubMed 17882725

Publications 2006

Kvale EO, Fløisand Y, Lund-Johansen F, Rollag H, Farkas L, Ghanekar S, Brandtzaeg P, Jahnsen FL, Olweus J (2006)
Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Blood, 109 (8), 3369-76
DOI 10.1182/blood-2006-06-031484, PubMed 17158235

Publications 2005

Kvale EØ, Dalgaard J, Lund-Johansen F, Rollag H, Farkas L, Midtvedt K, Jahnsen FL, Brinchmann JE, Olweus J (2005)
CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection
Blood, 107 (5), 2022-9
DOI 10.1182/blood-2005-05-2016, PubMed 16269620

Publications 1999

Frostad S, Bjerknes R, Hervig T, Nesthus I, Olweus J, Bruserud Ø Ø (1999)
Malignancy: Insulin-like Growth Factor-1 (IGF-1) is a Costimulator of the Expansion of Lineage Committed Cells Derived from Peripheral Blood Mobilized CD34+ Cells in Multiple Myeloma Patients
Hematology, 4 (3), 217-229
PubMed 11399566

Frostad S, Bjerknes R, Hervig T, Nesthus I, Olweus J, Bruserud Ø (1999)
Insulin-like Growth Factor-1 (IGF-1) is a Costimulator of the Expansion of Lineage Committed Cells Derived from Peripheral Blood Mobilized CD34(+) Cells in Multiple Myeloma Patients
Hematology, 4 (3), 217-29
DOI 10.1080/10245332.1999.11746445, PubMed 27420550

Lund-Johansen F, Houck D, Hoffman R, Davis K, Olweus J (1999)
Primitive human hematopoietic progenitor cells express receptors for granulocyte-macrophage colony-stimulating factor
Exp Hematol, 27 (4), 762-72
DOI 10.1016/s0301-472x(98)00081-2, PubMed 10210334

Lund-Johansen F, Olweus J (1999)
[Dendritic cells--strong candidates for immunotherapy]
Tidsskr Nor Laegeforen, 119 (17), 2510-4
PubMed 10425906

Publications 1998

Frostad S, Bjerknes R, Abrahamsen JF, Olweus J, Bruserud O (1998)
Insulin-like growth factor-1 (IGF-1) has a costimulatory effect on proliferation of committed progenitors derived from human umbilical cord CD34+ cells
Stem Cells, 16 (5), 334-42
DOI 10.1002/stem.160334, PubMed 9766813

Olweus J (1998)
Early events in human myelopoiesis
APMIS Suppl, 78, 1-36
PubMed 9645190

Olweus J (1998)
Early events in human myelopoiesis
APMIS, 106 78, 5-36

Olweus J (1998)
Early events in human myelopoiesis
In APMIS, Supplementum, Blackwell Munksgaard, Oxford, no. 78, 1 b. (flere pag.)
BIBSYS 981928331, ISBN 87-16-15697-8

Publications 1997

Olweus J, BitMansour A, Warnke R, Thompson PA, Carballido J, Picker LJ, Lund-Johansen F (1997)
Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin
Proc Natl Acad Sci U S A, 94 (23), 12551-6
DOI 10.1073/pnas.94.23.12551, PubMed 9356487

Yin AH, Miraglia S, Zanjani ED, Almeida-Porada G, Ogawa M, Leary AG, Olweus J, Kearney J, Buck DW (1997)
AC133, a novel marker for human hematopoietic stem and progenitor cells
Blood, 90 (12), 5002-12
PubMed 9389720

Publications 1996

Civin CI, Almeida-Porada G, Lee MJ, Olweus J, Terstappen LW, Zanjani ED (1996)
Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo
Blood, 88 (11), 4102-9
PubMed 8943843

Olweus J, Terstappen LW, Thompson PA, Lund-Johansen F (1996)
Expression and function of receptors for stem cell factor and erythropoietin during lineage commitment of human hematopoietic progenitor cells
Blood, 88 (5), 1594-607
PubMed 8781415

Olweus J, Thompson PA, Lund-Johansen F (1996)
Granulocytic and monocytic differentiation of CD34hi cells is associated with distinct changes in the expression of the PU.1-regulated molecules, CD64 and macrophage colony-stimulating factor receptor
Blood, 88 (10), 3741-54
PubMed 8916938

Publications 1995

Olweus J, Lund-Johansen F, Terstappen LW (1995)
CD64/Fc gamma RI is a granulo-monocytic lineage marker on CD34+ hematopoietic progenitor cells
Blood, 85 (9), 2402-13
PubMed 7537112

Waller EK, Olweus J, Lund-Johansen F, Huang S, Nguyen M, Guo GR, Terstappen L (1995)
The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors
Blood, 85 (9), 2422-35
PubMed 7537114

Publications 1994

Olweus J, Lund-Johansen F, Terstappen LW (1994)
Expression of cell surface markers during differentiation of CD34+, CD38-/lo fetal and adult bone marrow cells
Immunomethods, 5 (3), 179-88
DOI 10.1006/immu.1994.1054, PubMed 7540098

Publications 1993

Lund-Johansen F, Olweus J (1993)
Use of monoclonal antibodies to study hematopoietic cell function
J Hematother, 2 (3), 395-412
DOI 10.1089/scd.1.1993.2.395, PubMed 7922002

Lund-Johansen F, Olweus J, Symington FW, Arli A, Thompson JS, Vilella R, Skubitz K, Horejsi V (1993)
Activation of human monocytes and granulocytes by monoclonal antibodies to glycosylphosphatidylinositol-anchored antigens
Eur J Immunol, 23 (11), 2782-91
DOI 10.1002/eji.1830231110, PubMed 8223854

Olweus J, Lund-Johansen F, Horejsi V (1993)
CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells
J Immunol, 151 (2), 707-16
PubMed 8335905

Terstappen LW, Gandour D, Huang S, Lund-Johansen F, Manion K, Nguyen M, Mickaels R, Olweus J, Töpker S (1993)
Assessment of hematopoietic cell differentiation by multidimensional flow cytometry
J Hematother, 2 (3), 431-47
DOI 10.1089/scd.1.1993.2.431, PubMed 7522894

Publications 1992

Lund-Johansen F, Olweus J (1992)
Signal transduction in monocytes and granulocytes measured by multiparameter flow cytometry
Cytometry, 13 (7), 693-702
DOI 10.1002/cyto.990130705, PubMed 1451600

Lund-Johansen F, Olweus J, Horejsi V, Skubitz KM, Thompson JS, Vilella R, Symington FW (1992)
Activation of human phagocytes through carbohydrate antigens (CD15, sialyl-CD15, CDw17, and CDw65)
J Immunol, 148 (10), 3221-9
PubMed 1349618

Publications 1991

Lund-Johansen F, Olweus J, Aarli A, Bjerknes R (1991)
The IgG FcRII and the PI-linked IgG FcRIII trigger cytoplasmic calcium fluxes independently in human granulocytes
Scand J Immunol, 33 (3), 261-6
DOI 10.1111/j.1365-3083.1991.tb01771.x, PubMed 1826373

Westby J, Hexeberg E, Olweus J, Myking OL, Lekven J, Grong K (1991)
Blood flow regulation during acute regional ischemia in feline hearts: importance of postjunctional alpha 1- and alpha 2-adrenoceptors
J Cardiovasc Pharmacol, 18 (4), 487-95
DOI 10.1097/00005344-199110000-00003, PubMed 1724524

Publications 1990

Lund-Johansen F, Olweus J, Aarli A, Bjerknes R (1990)
Signal transduction in human monocytes and granulocytes through the PI-linked antigen CD14
FEBS Lett, 273 (1-2), 55-8
DOI 10.1016/0014-5793(90)81049-t, PubMed 1699812