Johan Bodegård
- Epidemiologist; MD PhD
Johan Bodegård completed his thesis on the Oslo Ischemia Study cohort in 2006. After working as an MD at Akershus University Hospital for some years he has now moved on the AstraZeneca where he holds a position as an epidemiologist. Dr. Bodegård has been instrumental to the collection of mortality and morbidity data and has contributed to a large number of Oslo Ischemia Study publications.
Publications 2024
Usefulness of Heart Failure Categories Based on Left Ventricular Ejection Fraction
J Am Heart Assoc, 13 (8), e032257
DOI 10.1161/JAHA.123.032257, PubMed 38591322
Characteristics, treatment and disease burden among stage 3-4 chronic kidney disease patients with and without type 2 diabetes in Finland during 2016-2022
Nephrol Dial Transplant (in press)
DOI 10.1093/ndt/gfae242, PubMed 39510970
Are there lost opportunities in chronic kidney disease? A region-wide cohort study
BMJ Open, 14 (4), e074064
DOI 10.1136/bmjopen-2023-074064, PubMed 38643002
Heart failure outcomes by left ventricular ejection fraction in a contemporary region-wide patient cohort
ESC Heart Fail, 11 (3), 1377-1388
DOI 10.1002/ehf2.14685, PubMed 38311878
Dapagliflozin treatment of patients with chronic kidney disease without diabetes across different albuminuria levels (OPTIMISE-CKD)
Clin Kidney J, 17 (8), sfae100
DOI 10.1093/ckj/sfae100, PubMed 39165293
Mortality, Health Care Burden, and Treatment of CKD: A Multinational, Observational Study (OPTIMISE-CKD)
Kidney360, 5 (3), 352-362
DOI 10.34067/KID.0000000000000374, PubMed 38297439
Publications 2023
Mortality, Outcomes, Costs, and Use of Medicines Following a First Heart Failure Hospitalization: EVOLUTION HF
JACC Heart Fail, 11 (10), 1320-1332
DOI 10.1016/j.jchf.2023.04.017, PubMed 37354145
Prevalence, outcomes and costs of a contemporary, multinational population with heart failure
Heart, 109 (7), 548-556
DOI 10.1136/heartjnl-2022-321702, PubMed 36781285
History of heart failure and chronic kidney disease and risk of all-cause death after COVID-19 during the first three waves of the pandemic in comparison with influenza outbreaks in Sweden: a registry-based, retrospective, case-control study
BMJ Open, 13 (4), e069037
DOI 10.1136/bmjopen-2022-069037, PubMed 37117003
Publications 2022
Patients with type 1 and type 2 diabetes hospitalized with COVID-19 in comparison with influenza: mortality and cardiorenal complications assessed by nationwide Swedish registry data
Cardiovasc Diabetol, 21 (1), 282
DOI 10.1186/s12933-022-01719-x, PubMed 36522650
Cost of healthcare utilization associated with incident cardiovascular and renal disease in individuals with type 2 diabetes: A multinational, observational study across 12 countries
Diabetes Obes Metab, 24 (7), 1277-1287
DOI 10.1111/dom.14698, PubMed 35322567
Heart Failure Drug Treatment-Inertia, Titration, and Discontinuation: A Multinational Observational Study (EVOLUTION HF)
JACC Heart Fail, 11 (1), 1-14
DOI 10.1016/j.jchf.2022.08.009, PubMed 36202739
Epidemiology of the diabetes-cardio-renal spectrum: a cross-sectional report of 1.4 million adults
Cardiovasc Diabetol, 21 (1), 104
DOI 10.1186/s12933-022-01521-9, PubMed 35689214
Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2·4 million patients from 11 countries: The CaReMe CKD study
Lancet Reg Health Eur, 20, 100438
DOI 10.1016/j.lanepe.2022.100438, PubMed 36090671
Publications 2021
The Oslo Ischaemia Study: cohort profile
BMJ Open, 11 (10), e049111
DOI 10.1136/bmjopen-2021-049111, PubMed 34645662
Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors vs other glucose-lowering drugs in 13 countries across three continents: analysis of CVD-REAL data
Cardiovasc Diabetol, 20 (1), 159
DOI 10.1186/s12933-021-01345-z, PubMed 34332558
Lower heart failure and chronic kidney disease risks associated with sodium-glucose cotransporter-2 inhibitor use in Japanese type 2 diabetes patients without established cardiovascular and renal diseases
Diabetes Obes Metab, 23 Suppl 2, 19-27
DOI 10.1111/dom.14119, PubMed 33835641
Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study
Diabetes Care, 44 (5), 1211-1218
DOI 10.2337/dc20-2839, PubMed 33653822
Novel insights into stroke risk beyond resting and maximal bicycle exercise systolic blood pressure
J Hypertens, 39 (10), 2022-2029
DOI 10.1097/HJH.0000000000002894, PubMed 34102659
Heart failure drug titration, discontinuation, mortality and heart failure hospitalization risk: a multinational observational study (US, UK and Sweden)
Eur J Heart Fail, 23 (9), 1499-1511
DOI 10.1002/ejhf.2271, PubMed 34132001
Publications 2020
Lower cardiorenal risk with sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes without cardiovascular and renal diseases: A large multinational observational study
Diabetes Obes Metab, 23 (1), 75-85
DOI 10.1111/dom.14189, PubMed 32893440
Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study
Diabetes Obes Metab, 22 (9), 1607-1618
DOI 10.1111/dom.14074, PubMed 32363737
Risk factor management of type 2 diabetic patients in primary care in the Scandinavian countries between 2003 and 2015
Prim Care Diabetes, 15 (2), 262-268
DOI 10.1016/j.pcd.2020.09.006, PubMed 33032936
Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study
Lancet Diabetes Endocrinol, 8 (7), 606-615
DOI 10.1016/S2213-8587(20)30130-3, PubMed 32559476
Sodium-glucose cotransporter 2 inhibitors compared with other glucose-lowering drugs in Japan: Subanalyses of the CVD-REAL 2 Study
J Diabetes Investig, 12 (1), 67-73
DOI 10.1111/jdi.13321, PubMed 32530554
Change in Body Weight and Long-Term Risk of Stroke and Death in Healthy Men
Stroke, 51 (5), 1435-1441
DOI 10.1161/STROKEAHA.119.027233, PubMed 32268850
Publications 2019
How representative of a general type 2 diabetes population are patients included in cardiovascular outcome trials with SGLT2 inhibitors? A large European observational study
Diabetes Obes Metab, 21 (4), 968-974
DOI 10.1111/dom.13612, PubMed 30537226
Impact of ischaemic heart disease severity and age on risk of cardiovascular outcome in diabetes patients in Sweden: a nationwide observational study
BMJ Open, 9 (4), e027199
DOI 10.1136/bmjopen-2018-027199, PubMed 30948612
Exercise Systolic Blood Pressure at Moderate Workload Is Linearly Associated With Coronary Disease Risk in Healthy Men
Hypertension, 75 (1), 44-50
DOI 10.1161/HYPERTENSIONAHA.119.13528, PubMed 31735088
SBP above 180 mmHg at moderate exercise workload increases coronary heart disease risk in healthy men during 28-year follow-up
J Hypertens, 37 (5), 949-955
DOI 10.1097/HJH.0000000000001959, PubMed 30325341
Dapagliflozin vs non-SGLT-2i treatment is associated with lower healthcare costs in type 2 diabetes patients similar to participants in the DECLARE-TIMI 58 trial: A nationwide observational study
Diabetes Obes Metab, 21 (12), 2651-2659
DOI 10.1111/dom.13852, PubMed 31379124
Dapagliflozin and cardiovascular mortality and disease outcomes in a population with type 2 diabetes similar to that of the DECLARE-TIMI 58 trial: A nationwide observational study
Diabetes Obes Metab, 21 (5), 1136-1145
DOI 10.1111/dom.13627, PubMed 30609272
Publications 2018
SGLT-2 Inhibitors and Cardiovascular Risk: An Analysis of CVD-REAL
J Am Coll Cardiol, 71 (22), 2497-2506
DOI 10.1016/j.jacc.2018.01.085, PubMed 29852973
Physical fitness is a modifiable predictor of early cardiovascular death: A 35-year follow-up study of 2014 healthy middle-aged men
Eur J Prev Cardiol, 25 (15), 1655-1663
DOI 10.1177/2047487318793459, PubMed 30103630
Cross-sectional and longitudinal analyses of the association between lung function and exercise capacity in healthy Norwegian men
BMC Pulm Med, 18 (1), 118
DOI 10.1186/s12890-018-0655-z, PubMed 30021542
Rates of myocardial infarction and stroke in patients initiating treatment with SGLT2-inhibitors versus other glucose-lowering agents in real-world clinical practice: Results from the CVD-REAL study
Diabetes Obes Metab, 20 (8), 1983-1987
DOI 10.1111/dom.13299, PubMed 29569378
Response by Kosiborod et al to Letters Regarding Article, "Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors)"
Circulation, 137 (9), 989-991
DOI 10.1161/CIRCULATIONAHA.117.031847, PubMed 29483180
Healthcare Cost Development in a Type 2 Diabetes Patient Population on Glucose-Lowering Drug Treatment: A Nationwide Observational Study 2006-2014
Pharmacoecon Open, 2 (4), 393-402
DOI 10.1007/s41669-017-0063-y, PubMed 29623637
Comment on Suissa. Lower Risk of Death With SGLT2 Inhibitors in Observational Studies: Real or Bias? Diabetes Care 2018;41:6-10
Diabetes Care, 41 (6), e104-e105
DOI 10.2337/dc18-0339, PubMed 29784707
Different patterns of second-line treatment in type 2 diabetes after metformin monotherapy in Denmark, Finland, Norway and Sweden (D360 Nordic): A multinational observational study
Endocrinol Diabetes Metab, 1 (4), e00036
DOI 10.1002/edm2.36, PubMed 30815564
Change in Cardiorespiratory Fitness and Risk of Stroke and Death: Long-Term Follow-Up of Healthy Middle-Aged Men
Stroke, 50 (1), 155-161
DOI 10.1161/STROKEAHA.118.021798, PubMed 30580727
Publications 2017
Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis
Lancet Diabetes Endocrinol, 5 (9), 709-717
DOI 10.1016/S2213-8587(17)30258-9, PubMed 28781064
Lower Risk of Heart Failure and Death in Patients Initiated on Sodium-Glucose Cotransporter-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study (Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium-Glucose Cotransporter-2 Inhibitors)
Circulation, 136 (3), 249-259
DOI 10.1161/CIRCULATIONAHA.117.029190, PubMed 28522450
Exercise systolic blood pressure at moderate workload predicts cardiovascular disease and mortality through 35 years of follow-up in healthy, middle-aged men
Blood Press, 26 (4), 229-236
DOI 10.1080/08037051.2017.1291276, PubMed 28276720
Novel oral glucose-lowering drugs are associated with lower risk of all-cause mortality, cardiovascular events and severe hypoglycaemia compared with insulin in patients with type 2 diabetes
Diabetes Obes Metab, 19 (6), 831-841
DOI 10.1111/dom.12889, PubMed 28116795
Dapagliflozin is associated with lower risk of cardiovascular events and all-cause mortality in people with type 2 diabetes (CVD-REAL Nordic) when compared with dipeptidyl peptidase-4 inhibitor therapy: A multinational observational study
Diabetes Obes Metab, 20 (2), 344-351
DOI 10.1111/dom.13077, PubMed 28771923
Long-term predictors of stroke in healthy middle-aged men
Int J Stroke, 13 (3), 292-300
DOI 10.1177/1747493017730760, PubMed 28929941
Weight change patterns and healthcare costs in patients with newly-diagnosed type-2 diabetes in Sweden
Prim Care Diabetes, 11 (3), 217-225
DOI 10.1016/j.pcd.2017.03.001, PubMed 28389199
Publications 2016
Temporal Reduction in Chronotropic Index Predicts Risk of Cardiovascular Death Among Healthy Middle-Aged Men: a 28-Year Follow-Up Study
J Am Heart Assoc, 5 (12)
DOI 10.1161/JAHA.116.004555, PubMed 27881424
Sulphonylurea compared to DPP-4 inhibitors in combination with metformin carries increased risk of severe hypoglycemia, cardiovascular events, and all-cause mortality
Diabetes Res Clin Pract, 117, 39-47
DOI 10.1016/j.diabres.2016.04.055, PubMed 27329021
Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting
Clin Drug Investig, 36 (3), 225-33
DOI 10.1007/s40261-015-0372-9, PubMed 26718960
Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study
Am Heart J, 178, 85-94
DOI 10.1016/j.ahj.2016.05.005, PubMed 27502855
Increased healthcare utilization costs following initiation of insulin treatment in type 2 diabetes: A long-term follow-up in clinical practice
Prim Care Diabetes, 11 (2), 184-192
DOI 10.1016/j.pcd.2016.11.002, PubMed 27894781
Incidence, prevalence and mortality of type 2 diabetes requiring glucose-lowering treatment, and associated risks of cardiovascular complications: a nationwide study in Sweden, 2006-2013
Diabetologia, 59 (8), 1692-701
DOI 10.1007/s00125-016-3971-y, PubMed 27189067
Second line initiation of insulin compared with DPP-4 inhibitors after metformin monotherapy is associated with increased risk of all-cause mortality, cardiovascular events, and severe hypoglycemia
Diabetes Res Clin Pract, 123, 199-208
DOI 10.1016/j.diabres.2016.12.004, PubMed 28056431
Publications 2015
Characteristics of bipolar disorder patients treated with immediate- and extended-release quetiapine in a real clinical setting: a longitudinal, cohort study of 1761 patients
Ther Adv Psychopharmacol, 5 (1), 13-21
DOI 10.1177/2045125314560740, PubMed 25653826
Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational study
Cardiovasc Diabetol, 14, 5
DOI 10.1186/s12933-014-0170-3, PubMed 25589001
Healthcare utilization and costs following newly diagnosed type-2 diabetes in Sweden: A follow-up of 38,956 patients in a clinical practice setting
Prim Care Diabetes, 9 (5), 330-7
DOI 10.1016/j.pcd.2015.01.001, PubMed 25631469
Publications 2014
Population study of disease burden, management, and treatment of bipolar disorder in Sweden: a retrospective observational registry study
Bipolar Disord, 17 (1), 76-85
DOI 10.1111/bdi.12234, PubMed 25056132
Heart rate reserve predicts cardiovascular death among physically unfit but otherwise healthy middle-aged men: a 35-year follow-up study
Eur J Prev Cardiol, 23 (1), 59-66
DOI 10.1177/2047487314553202, PubMed 25281482
Diabetes and CVD risk during angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment in hypertension: a study of 15,990 patients
J Hum Hypertens, 28 (11), 663-9
DOI 10.1038/jhh.2014.43, PubMed 25211055
Association of Changes In Body Weight With Health Care Costs Among Patients With Newly-Diagnosed Type-2 Diabetes In Sweden
Value Health, 17 (7), A338
DOI 10.1016/j.jval.2014.08.660, PubMed 27200610
Publications 2013
Changes in body mass index following newly diagnosed type 2 diabetes and risk of cardiovascular mortality: a cohort study of 8486 primary-care patients
Diabetes Metab, 39 (4), 306-13
DOI 10.1016/j.diabet.2013.05.004, PubMed 23871502
Response to Letter by Morris et al regarding article, "Low heart rates predict incident atrial fibrillation in healthy middle-aged men" by Grundvold et al
Circ Arrhythm Electrophysiol, 6 (6), e102
DOI 10.1161/CIRCEP.113.001154, PubMed 24347602
Low heart rates predict incident atrial fibrillation in healthy middle-aged men
Circ Arrhythm Electrophysiol, 6 (4), 726-31
DOI 10.1161/CIRCEP.113.000267, PubMed 23873309
Low-dose acetylsalicylic acid and gastrointestinal ulcers or bleeding--a cohort study of the effects of proton pump inhibitor use patterns
J Intern Med, 274 (4), 371-80
DOI 10.1111/joim.12103, PubMed 23800296
Seven-year increase in exercise systolic blood pressure at moderate workload predicts long-term risk of coronary heart disease and mortality in healthy middle-aged men
Hypertension, 61 (5), 1134-40
DOI 10.1161/HYPERTENSIONAHA.111.00793, PubMed 23529164
Triglycerides-diabetes association in healthy middle-aged men: modified by physical fitness? A long term follow-up of 1962 Norwegian men in the Oslo Ischemia Study
Diabetes Res Clin Pract, 101 (2), 201-9
DOI 10.1016/j.diabres.2013.06.001, PubMed 23827210
Blood pressure levels and risk of cardiovascular events and mortality in type-2 diabetes: cohort study of 34 009 primary care patients
J Hypertens, 31 (8), 1603-10
DOI 10.1097/HJH.0b013e32836123aa, PubMed 23625112
Publications 2012
Upper normal blood pressures predict incident atrial fibrillation in healthy middle-aged men: a 35-year follow-up study
Hypertension, 59 (2), 198-204
DOI 10.1161/HYPERTENSIONAHA.111.179713, PubMed 22252392
Importance of physical fitness on predictive effect of body mass index and weight gain on incident atrial fibrillation in healthy middle-age men
Am J Cardiol, 110 (3), 425-32
DOI 10.1016/j.amjcard.2012.03.043, PubMed 22579085
Rapidly upsloping ST-segment on exercise ECG: a marker of reduced coronary heart disease mortality risk
Eur J Prev Cardiol, 20 (4), 541-8
DOI 10.1177/2047487312444370, PubMed 22492865
Publications 2011
Low-grade systolic murmurs in healthy middle-aged individuals: innocent or clinically significant? A 35-year follow-up study of 2014 Norwegian men
J Intern Med, 271 (6), 581-8
DOI 10.1111/j.1365-2796.2011.02480.x, PubMed 22061296
HDL-cholesterol and prediction of coronary heart disease: modified by physical fitness? A 28-year follow-up of apparently healthy men
Atherosclerosis, 220 (1), 250-6
DOI 10.1016/j.atherosclerosis.2011.10.009, PubMed 22062589
Publications 2010
Health-care costs of losartan and candesartan in the primary treatment of hypertension
J Hum Hypertens, 25 (2), 130-6
DOI 10.1038/jhh.2010.36, PubMed 20376078
Cardiovascular events in subgroups of patients during primary treatment of hypertension with candesartan or losartan
J Clin Hypertens (Greenwich), 13 (3), 189-97
DOI 10.1111/j.1751-7176.2010.00410.x, PubMed 21366850
Interaction between inflammation and blood viscosity predicts cardiovascular mortality
Scand Cardiovasc J, 44 (2), 107-12
DOI 10.1080/14017430903171248, PubMed 19670036
Publications 2009
Effects of losartan vs candesartan in reducing cardiovascular events in the primary treatment of hypertension
J Hum Hypertens, 24 (4), 263-73
DOI 10.1038/jhh.2009.77, PubMed 19890371
Publications 2006
Cardiovascular long term risk and exercise test findings: 2014 apparently healthy middle aged men followed for 26 years
University of Oslo, Faculty of Medicine, [Oslo], 1 b. (flere pag.)
BIBSYS 060926953, ISBN 82-8072-672-1
Publications 2005
Reasons for terminating an exercise test provide independent prognostic information: 2014 apparently healthy men followed for 26 years
Eur Heart J, 26 (14), 1394-401
DOI 10.1093/eurheartj/ehi278, PubMed 15855193
[Long term prognosis in relation to the presence of systolic heart murmurs in healthy middle-aged men]
Tidsskr Nor Laegeforen, 125 (9), 1157-8
PubMed 15880150
Publications 2004
Possible angina detected by the WHO angina questionnaire in apparently healthy men with a normal exercise ECG: coronary heart disease or not? A 26 year follow up study
Heart, 90 (6), 627-32
DOI 10.1136/hrt.2003.012542, PubMed 15145862
Symptom-limited exercise testing, ST depressions and long-term coronary heart disease mortality in apparently healthy middle-aged men
Eur J Cardiovasc Prev Rehabil, 11 (4), 320-7
DOI 10.1097/01.hjr.0000136460.57921.46, PubMed 15292766
Exercise testing of healthy men in a new perspective: from diagnosis to prognosis
Eur Heart J, 25 (11), 978-86
DOI 10.1016/j.ehj.2004.04.009, PubMed 15172470
[Exercise ECG]
Tidsskr Nor Laegeforen, 124 (3), 339-41
PubMed 14963507
Publications 2003
Fasting blood glucose is independently associated with resting and exercise blood pressures and development of elevated blood pressure
J Hypertens, 21 (7), 1383-9
DOI 10.1097/00004872-200307000-00029, PubMed 12817188
Publications 2002
Early versus late morning measurement of blood pressure in healthy men. A potential source of measurement bias?
Blood Press, 11 (6), 366-70
DOI 10.1080/080370502321095339, PubMed 12523680