Brooke N. Wolford

  • Researcher; PhD

View information about Brooke’s research at PubMed, ORCiD, or her personal website.

Brooke is also employed at NTNU.
 

Publications 2026

Bjarkø VV, Wolford BN, Haug EB, Stene LC, Carlsson S, Langhammer A, Birkeland KI, Berg TJ, Sørgjerd EP, Lyssenko V, Brumpton BM, Vie GÅ, Åsvold BO (2026)
Temporal changes and genetic susceptibility to type 2 diabetes (1984-2019; HUNT): a longitudinal, population-based study
Lancet Diabetes Endocrinol, 14 (3), 223-232
DOI 10.1016/S2213-8587(25)00322-5, PubMed 41619756

Enarsson M, Gustafsson S, Lampa E, Rudholm Feldreich T, Beigrezaei S, Butterworth AS, Elmståhl S, Engström G, Hveem K, Johansson M, Lind L, Nilsson PM, Perola M, Schulze MB, Simell B, Sipsma H, Wolford BN, Åsvold BO, Assimes TL, Schillemans T, Brooke H, Sundström J, Ärnlöv J (2026)
The proteomic profile of leisure time physical activity across two decades: implications for future cardiovascular risk and mortality
Eur J Prev Cardiol (in press)
DOI 10.1093/eurjpc/zwag016, PubMed 41505439

Publications 2025

Alam MS, Wolford BN, Hveem K, Lundin KEA, Withoff S, Jonkers IH, Sollid LM, Hjort R, Ness-Jensen E (2025)
Genetic differences between diagnosed and undiagnosed Celiac disease: a population-based study
Hum Genet, 144 (11-12), 1071-1078
DOI 10.1007/s00439-025-02778-2, PubMed 41020987

Bezzina Wettinger S, Karaduzovic-Hadziabdic K, Attard R, Farrugia R, Wolford BN, Chierici M, Jurman G, Alexiou P, Peñalvo JL, Costa RS, Basílio J, Sabovčik F, Vitorino R, Schmid JA, Shigdel R, Vilne B, Hatzigeorgiou AG, Sopic M, Devaux Y, Magni P, Tellez-Plaza M, Kreil DP, Gruca A (2025)
Bottlenecks in advancing and applying multiomic data integration-common data resources as rate-limiting drivers-the high-impact use case of atherosclerotic cardiovascular disease
Brief Bioinform, 26 (5)
DOI 10.1093/bib/bbaf526, PubMed 41071609

Ibrahimi E, Wolford BN (2025)
Ten essential tips for robust statistics in cell biology
Nat Cell Biol, 27 (11), 1884-1886
DOI 10.1038/s41556-025-01801-y, PubMed 41174003

Kelsey PT, Selbæk G, Lövheim H, Åsvold BO, Hveem K, Wolford BN, Skjellegrind HK (2025)
Helicobacter pylori and Alzheimer's disease risk: The HUNT study
J Alzheimers Dis, 108 (3), 1177-1184
DOI 10.1177/13872877251386015, PubMed 41091896

Nordestgaard LT, Wolford BN, de Gonzalo-Calvo D, Sopić M, Devaux Y, Matic L, Wettinger SB, Schmid JA, Amigó N, Masana L, Catapano AL, Kardassis D, Magni P, EU-AtheroNET COST Action CA21153 (2025)
Multiomics in atherosclerotic cardiovascular disease
Atherosclerosis, 408, 120414
DOI 10.1016/j.atherosclerosis.2025.120414, PubMed 40663987

Pujol Gualdo N, Džigurski J, Rukins V, Pajuste FD, Wolford BN, Võsa M, Golob M, Haug L, Alver M, Läll K, Peters M, Brumpton BM, Estonian Biobank Research Team, Palta P, Mägi R, Laisk T (2025)
Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses
Nat Med, 31 (5), 1626-1634
DOI 10.1038/s41591-025-03543-8, PubMed 40069456

Wolford BN, Zhao QY, Wu KH, Yu X, Richter CE, Bhatta L, Brumpton BM, Desch KC, Thibord F, Klarin D, Johnson AD, Trégouët DA, Damrauer SM, Smith NL, Lo Faro V, Tsuo K, Daly MJ, Neale BM, Zhou W, Willer CJ, Shavit JA, Surakka I (2025)
Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish
Blood Adv, 9 (19), 4850-4859
DOI 10.1182/bloodadvances.2024015790, PubMed 40554366

Wu KH, Wolford BN, Du J, Yu X, Douville NJ, Mathis MR, Graham SE, Surakka I, Hornsby WE, Bian J, Zhao L, Willer CJ, Shi X (2025)
Integrating large scale genetic and clinical information to predict cases of heart failure
Commun Med (Lond), 5 (1), 493
DOI 10.1038/s43856-025-01198-7, PubMed 41272270

Publications 2024

Jermy B, Läll K, Wolford BN, Wang Y, Zguro K, Cheng Y, Kanai M, Kanoni S, Yang Z, Hartonen T, Monti R, Wanner J, Youssef O, Estonian Biobank research team, FinnGen, Lippert C, van Heel D, Okada Y, McCartney DL, Hayward C, Marioni RE, Furini S, Renieri A, Martin AR, Neale BM et al. (2024)
A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk
Nat Commun, 15 (1), 5007
DOI 10.1038/s41467-024-48938-2, PubMed 38866767

Moksnes MR, Hansen AF, Wolford BN, Thomas LF, Rasheed H, Simić A, Bhatta L, Brantsæter AL, Surakka I, Zhou W, Magnus P, Njølstad PR, Andreassen OA, Syversen T, Zheng J, Fritsche LG, Evans DM, Warrington NM, Nøst TH, Åsvold BO, Flaten TP, Willer CJ, Hveem K, Brumpton BM (2024)
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
Commun Biol, 7 (1), 432
DOI 10.1038/s42003-024-06101-z, PubMed 38594418

Monti R, Eick L, Hudjashov G, Läll K, Kanoni S, Wolford BN, Wingfield B, Pain O, Wharrie S, Jermy B, McMahon A, Hartonen T, Heyne H, Mars N, Lambert S, Genes and Health Research Team, Hveem K, Inouye M, van Heel DA, Mägi R, Marttinen P, Ripatti S, Ganna A, Lippert C (2024)
Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning
Am J Hum Genet, 111 (7), 1431-1447
DOI 10.1016/j.ajhg.2024.06.003, PubMed 38908374

Wolford BN, Åsvold BO (2024)
Bidirectional Mendelian Randomization to Elucidate the Relationship Between Healthy Sleep, Brains, and Hearts
J Am Heart Assoc, 13 (18), e037394
DOI 10.1161/JAHA.124.037394, PubMed 39258560

Øvretveit K, Ingeström EML, Spitieris M, Tragante V, Wade KH, Thomas LF, Wolford BN, Wisløff U, Gudbjartsson DF, Holm H, Stefansson K, Brumpton BM, Hveem K (2024)
Polygenic risk scores associate with blood pressure traits across the lifespan
Eur J Prev Cardiol, 31 (6), 644-654
DOI 10.1093/eurjpc/zwad365, PubMed 38007706

Publications 2023

Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, Dikilitas O, Pattee JW, Judy RL, Pauls-Verges F, Nielsen JB, Wolford BN, Brumpton BM et al. (2023)
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Nat Genet, 55 (11), 1831-1842
DOI 10.1038/s41588-023-01510-y, PubMed 37845353

Surakka I, Wu KH, Hornsby W, Wolford BN, Shen F, Zhou W, Huffman JE, Pandit A, Hu Y, Brumpton B, Skogholt AH, Gabrielsen ME, Walters RG, TOPMed Stroke Working Group, Million Veteran Program (MVP), Hveem K, Kooperberg C, Zöllner S, Wilson PWF, Sutton NR, Daly MJ, Neale BM, Willer CJ, Global Biobank Meta-analysis Initiative (GBMI) (2023)
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries
Cell Genom, 3 (8), 100345
DOI 10.1016/j.xgen.2023.100345, PubMed 37601974

Wang Y, Namba S, Lopera E, Kerminen S, Tsuo K, Läll K, Kanai M, Zhou W, Wu KH, Favé MJ, Bhatta L, Awadalla P, Brumpton B, Deelen P, Hveem K, Lo Faro V, Mägi R, Murakami Y, Sanna S, Smoller JW, Uzunovic J, Wolford BN, Global Biobank Meta-analysis Initiative, Willer C, Gamazon ER et al. (2023)
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Cell Genom, 3 (1), 100241
DOI 10.1016/j.xgen.2022.100241, PubMed 36777179

Publications 2022

Aragam KG, Jiang T, Goel A, Kanoni S, Wolford BN, Atri DS, Weeks EM, Wang M, Hindy G, Zhou W, Grace C, Roselli C, Marston NA, Kamanu FK, Surakka I, Venegas LM, Sherliker P, Koyama S, Ishigaki K, Åsvold BO, Brown MR, Brumpton B, de Vries PS, Giannakopoulou O, Giardoglou P et al. (2022)
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Nat Genet, 54 (12), 1803-1815
DOI 10.1038/s41588-022-01233-6, PubMed 36474045

Surakka I, Wolford BN, Ritchie SC, Hornsby WE, Sutton NR, Elvenstad Gabrielsen M, Skogholt AH, Thomas L, Inouye M, Hveem K, Willer CJ (2022)
Sex-Specific Survival Bias and Interaction Modeling in Coronary Artery Disease Risk Prediction
Circ Genom Precis Med, 16 (1), e003542
DOI 10.1161/CIRCGEN.121.003542, PubMed 36580301

Sutton NR, Malhotra R, St Hilaire C, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y (2022)
Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification
Arterioscler Thromb Vasc Biol, 43 (1), 15-29
DOI 10.1161/ATVBAHA.122.317332, PubMed 36412195

Thibord F, Klarin D, Brody JA, Chen MH, Levin MG, Chasman DI, Goode EL, Hveem K, Teder-Laving M, Martinez-Perez A, Aïssi D, Daian-Bacq D, Ito K, Natarajan P, Lutsey PL, Nadkarni GN, de Vries PS, Cuellar-Partida G, Wolford BN, Pattee JW, Kooperberg C, Braekkan SK, Li-Gao R, Saut N, Sept C et al. (2022)
Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors
Circulation, 146 (16), 1225-1242
DOI 10.1161/CIRCULATIONAHA.122.059675, PubMed 36154123

Zhou W, Kanai M, Wu KH, Rasheed H, Tsuo K, Hirbo JB, Wang Y, Bhattacharya A, Zhao H, Namba S, Surakka I, Wolford BN, Lo Faro V, Lopera-Maya EA, Läll K, Favé MJ, Partanen JJ, Chapman SB, Karjalainen J, Kurki M, Maasha M, Brumpton BM, Chavan S, Chen TT, Daya M et al. (2022)
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease
Cell Genom, 2 (10), 100192
DOI 10.1016/j.xgen.2022.100192, PubMed 36777996

Zhuang Y, Wolford BN, Nam K, Bi W, Zhou W, Willer CJ, Mukherjee B, Lee S (2022)
Incorporating family disease history and controlling case-control imbalance for population-based genetic association studies
Bioinformatics, 38 (18), 4337-4343
DOI 10.1093/bioinformatics/btac459, PubMed 35876838

Publications 2021

Duda M, Sovacool KL, Farzaneh N, Nguyen VK, Haynes SE, Falk H, Furman KL, Walker LA, Diao R, Oneka M, Drotos AC, Woloshin A, Dotson GA, Kriebel A, Meng L, Thiede SN, Lapp Z, Wolford BN (2021)
Teaching Python for Data Science: Collaborative development of a modular & interactive curriculum
J Open Source Educ, 4 (46)
DOI 10.21105/jose.00138, PubMed 35187422

Fan Y, Wolford BN, Lu H, Liang W, Sun J, Zhou W, Rom O, Mahajan A, Surakka I, Graham SE, Liu Z, Kim H, Ramdas S, Fritsche LG, Nielsen JB, Gabrielsen ME, Hveem K, Yang D, Song J, Garcia-Barrio MT, Zhang J, Liu W, Zhang K, Willer CJ, Chen YE (2021)
Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
iScience, 24 (11), 103196
DOI 10.1016/j.isci.2021.103196, PubMed 34746691

Moksnes MR, Røsjø H, Richmond A, Lyngbakken MN, Graham SE, Hansen AF, Wolford BN, Gagliano Taliun SA, LeFaive J, Rasheed H, Thomas LF, Zhou W, Aung N, Surakka I, Douville NJ, Campbell A, Porteous DJ, Petersen SE, Munroe PB, Welsh P, Sattar N, Smith GD, Fritsche LG, Nielsen JB, Åsvold BO et al. (2021)
Genome-wide association study of cardiac troponin I in the general population
Hum Mol Genet, 30 (21), 2027-2039
DOI 10.1093/hmg/ddab124, PubMed 33961016

Roychowdhury T, Lu H, Hornsby WE, Crone B, Wang GT, Guo DC, Sendamarai AK, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb GM, Patel HJ, Eliason J, Eagle KA et al. (2021)
Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm
Am J Hum Genet, 108 (9), 1578-1589
DOI 10.1016/j.ajhg.2021.06.016, PubMed 34265237

Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB et al. (2021)
Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer
Nat Commun, 12 (1), 7354
DOI 10.1038/s41467-021-27675-w, PubMed 34916535

Publications 2020

Børte S, Zwart JA, Skogholt AH, Gabrielsen ME, Thomas LF, Fritsche LG, Surakka I, Nielsen JB, Zhou W, Wolford BN, Vigeland MD, Hagen K, Kristoffersen ES, Nyholt DR, Chasman DI, Brumpton BM, Willer CJ, Winsvold BS (2020)
Mitochondrial genome-wide association study of migraine - the HUNT Study
Cephalalgia, 40 (6), 625-634
DOI 10.1177/0333102420906835, PubMed 32056457

Klarin D, Verma SS, Judy R, Dikilitas O, Wolford BN, Paranjpe I, Levin MG, Pan C, Tcheandjieu C, Spin JM, Lynch J, Assimes TL, Åldstedt Nyrønning L, Mattsson E, Edwards TL, Denny J, Larson E, Lee MTM, Carrell D, Zhang Y, Jarvik GP, Gharavi AG, Harley J, Mentch F, Pacheco JA et al. (2020)
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program
Circulation, 142 (17), 1633-1646
DOI 10.1161/CIRCULATIONAHA.120.047544, PubMed 32981348

Norton EL, Hornsby WE, Wu X, Wolford BN, Graham SE, Willer CJ, Yang B (2020)
Aortic progression and reintervention in patients with pathogenic variants after a thoracic aortic dissection
J Thorac Cardiovasc Surg, 162 (5), 1436-1448.e6
DOI 10.1016/j.jtcvs.2020.01.094, PubMed 32199657

Zhou W, Brumpton B, Kabil O, Gudmundsson J, Thorleifsson G, Weinstock J, Zawistowski M, Nielsen JB, Chaker L, Medici M, Teumer A, Naitza S, Sanna S, Schultheiss UT, Cappola A, Karjalainen J, Kurki M, Oneka M, Taylor P, Fritsche LG, Graham SE, Wolford BN, Overton W, Rasheed H, Haug EB et al. (2020)
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Nat Commun, 11 (1), 3981
DOI 10.1038/s41467-020-17718-z, PubMed 32769997

Publications 2019

Wolford BN, Hornsby WE, Guo D, Zhou W, Lin M, Farhat L, McNamara J, Driscoll A, Wu X, Schmidt EM, Norton EL, Mathis MR, Ganesh SK, Douville NJ, Brummett CM, Kitzman J, Chen YE, Kim K, Deeb GM, Patel H, Eagle KA, Milewicz DM, J Willer C, Yang B (2019)
Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection
Circ Genom Precis Med, 12 (6), e002476
DOI 10.1161/CIRCGEN.118.002476, PubMed 31211624

Publications 2018

Kycia I, Wolford BN, Huyghe JR, Fuchsberger C, Vadlamudi S, Kursawe R, Welch RP, Albanus RD, Uyar A, Khetan S, Lawlor N, Bolisetty M, Mathur A, Kuusisto J, Laakso M, Ucar D, Mohlke KL, Boehnke M, Collins FS, Parker SCJ, Stitzel ML (2018)
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression
Am J Hum Genet, 102 (4), 620-635
DOI 10.1016/j.ajhg.2018.02.020, PubMed 29625024

Nielsen JB, Thorolfsdottir RB, Fritsche LG, Zhou W, Skov MW, Graham SE, Herron TJ, McCarthy S, Schmidt EM, Sveinbjornsson G, Surakka I, Mathis MR, Yamazaki M, Crawford RD, Gabrielsen ME, Skogholt AH, Holmen OL, Lin M, Wolford BN, Dey R, Dalen H, Sulem P, Chung JH, Backman JD, Arnar DO et al. (2018)
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology
Nat Genet, 50 (9), 1234-1239
DOI 10.1038/s41588-018-0171-3, PubMed 30061737

Taylor DL, Knowles DA, Scott LJ, Ramirez AH, Casale FP, Wolford BN, Guan L, Varshney A, Albanus RD, Parker SCJ, Narisu N, Chines PS, Erdos MR, Welch RP, Kinnunen L, Saramies J, Sundvall J, Lakka TA, Laakso M, Tuomilehto J, Koistinen HA, Stegle O, Boehnke M, Birney E, Collins FS (2018)
Interactions between genetic variation and cellular environment in skeletal muscle gene expression
PLoS One, 13 (4), e0195788
DOI 10.1371/journal.pone.0195788, PubMed 29659628

Wolford BN, Willer CJ, Surakka I (2018)
Electronic health records: the next wave of complex disease genetics
Hum Mol Genet, 27 (R1), R14-R21
DOI 10.1093/hmg/ddy081, PubMed 29547983

Zhou W, Nielsen JB, Fritsche LG, Dey R, Gabrielsen ME, Wolford BN, LeFaive J, VandeHaar P, Gagliano SA, Gifford A, Bastarache LA, Wei WQ, Denny JC, Lin M, Hveem K, Kang HM, Abecasis GR, Willer CJ, Lee S (2018)
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies
Nat Genet, 50 (9), 1335-1341
DOI 10.1038/s41588-018-0184-y, PubMed 30104761

Publications 2017

Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, Lin M, Brummett CM, Preuss MH, Refsgaard L, Bottinger EP, Graham SE, Surakka I, Chu Y, Skogholt AH, Dalen H, Boyle AP, Oral H, Herron TJ, Kitzman J, Jalife J et al. (2017)
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development
Am J Hum Genet, 102 (1), 103-115
DOI 10.1016/j.ajhg.2017.12.003, PubMed 29290336

Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU, National Institutes of Health Intramural Sequencing Center (NISC) Comparative Sequencing Program, Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL (2017)
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus
Diabetes, 66 (9), 2521-2530
DOI 10.2337/db17-0464, PubMed 28684635

Varshney A, Scott LJ, Welch RP, Erdos MR, Chines PS, Narisu N, Albanus RD, Orchard P, Wolford BN, Kursawe R, Vadlamudi S, Cannon ME, Didion JP, Hensley J, Kirilusha A, NISC Comparative Sequencing Program, Bonnycastle LL, Taylor DL, Watanabe R, Mohlke KL, Boehnke M, Collins FS, Parker SC, Stitzel ML (2017)
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
Proc Natl Acad Sci U S A, 114 (9), 2301-2306
DOI 10.1073/pnas.1621192114, PubMed 28193859

Publications 2016

Scott LJ, Erdos MR, Huyghe JR, Welch RP, Beck AT, Wolford BN, Chines PS, Didion JP, Narisu N, Stringham HM, Taylor DL, Jackson AU, Vadlamudi S, Bonnycastle LL, Kinnunen L, Saramies J, Sundvall J, Albanus RD, Kiseleva A, Hensley J, Crawford GE, Jiang H, Wen X, Watanabe RM, Lakka TA et al. (2016)
The genetic regulatory signature of type 2 diabetes in human skeletal muscle
Nat Commun, 7, 11764
DOI 10.1038/ncomms11764, PubMed 27353450