Main research focus

The Neurovascular & Cerebrospinal Fluid Research Group (Division of Clinical Neuroscience, University of Oslo and Oslo University Hospital) teams up with a multidisciplinary group of neurosurgeons and neuroscientists, mathematicians, PhD candidates, Post-Docs and students, to provide a broad collaboration with a common vision; to challenge, discover and improve our current understanding and treatment of complex neurovascular and cerebrospinal fluid (CSF) disorders. We address the close interaction between the cerebral vasculature and the CSF, which we consider to have major impact on cerebral metabolism and metabolic failure. The group has a translational perspective with a strong clinical basis.

 

From the clinical perspective, the following diseases and disease states are targeted:

  • Intracranial aneurysms and subarachnoid hemorrhage, including neuro-intensive surveillance and outcome. Cerebral hemodynamics and cerebral revascularization. Pathophysiology and treatment of chronic subdural hematomas.
  • Cerebrospinal fluid diseases and role of cerebrospinal fluid in metabolic function of central nervous system, particularly in neurodegeneration and dementia, CSF disturbances, vascular disease and cerebral bleeds, inflammatory disease and neuro-oncology.
  • Brain Monitoring. Neurosurgical pathophysiology, intracranial pressure and arterial blood pressure dynamics.
  • Pathophysiology of neuroinflammation in relation to neurosurgical diseases.

 

Projects

  • Cerebrospinal fluid
    Efflux pathways. Glymphatic function. Meningeal lymphatic function. Imaging of CSF flow and CSF tracer transport, and CSF molecular clearance function. Pathophysiology of CNS diseases with CSF disturbance: Hydrocephalus. Normal pressure hydrocephalus. Idiopathic intracranial hypertension. Spontaneous intracranial hypotension. Idiopathic CSF obstruction from cysts. Chiari malformation.
  • Neurovascular
    Subarachnoid hemorrhage: Bleeding risks. Complications (Vasospasms. Hydrocephalus. Fatigue). Rehabilitation. Outcome. Vascular compression syndromes. Trigeminal neuralgia.
  • Neuro-inflammation
    Cerebral abscesses: Pathophysiology. Subdural hematoma: pathophysiology and role of neuroinflammation.
  • Brain monitoring
    Invasive and non-invasive intracranial pressure (ICP).

Cooperation

The group has a comprehensive research cooperation, both nationally and internationally, the most important partners listed below.

National

  • Simula Research Laboratory, UiO
  • Department of Physical Medicine and Rehabilitation, OUH
  • Department of Radiology, OUH
  • The Intervention Centre, OUH
  • Department of Informatics, UiO
  • Department of Mathematics, UiO
  • Department of Neurology, OUH
  • Division of Emergencies and Critical Care, OUH
  • Sunnaas Rehabilitation Hospital
  • Institute of Basic Medical Sciences, UiO

International

  • University of Gothenburg, Sweden
  • University of Kupio, Finland
  • University of Copenhagen, Denmark
 
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