Terje Rootwelt

  • Professor II
  • +47-22894581

Publications 2020

Nordstrand SEH, Juvodden HT, Viste R, Rootwelt T, Karlsen TI, Thorsby PM, Swanson D, Nilsen KB, Hansen BH, Knudsen-Heier S (2020)
Obesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign
Sleep, 43 (5)
DOI 10.1093/sleep/zsz277, PubMed 31724727

Publications 2019

Nordstrand SEH, Hansen BH, Rootwelt T, Karlsen TI, Swanson D, Nilsen KB, Knudsen S (2019)
Psychiatric symptoms in patients with post-H1N1 narcolepsy type 1 in Norway
Sleep, 42 (4)
DOI 10.1093/sleep/zsz008, PubMed 30649483

Publications 2018

Nordstrand SH, Hansen BH, Kamaleri Y, Nilsen KB, Rootwelt T, Karlsen TI, Knudsen S (2018)
Changes in quality of life in individuals with narcolepsy type 1 after the H1N1-influenza epidemic and vaccination campaign in Norway: a two-year prospective cohort study
Sleep Med, 50, 175-180
DOI 10.1016/j.sleep.2018.05.037, PubMed 30075393

Publications 2016

Lundman E, Gaup HJ, Bakkeheim E, Olafsdottir EJ, Rootwelt T, Storrøsten OT, Pettersen RD (2016)
Implementation of newborn screening for cystic fibrosis in Norway. Results from the first three years
J Cyst Fibros, 15 (3), 318-24
DOI 10.1016/j.jcf.2015.12.017, PubMed 26795017

Publications 2014

Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662

Wanschers BF, Szklarczyk R, van den Brand MA, Jonckheere A, Suijskens J, Smeets R, Rodenburg RJ, Stephan K, Helland IB, Elkamil A, Rootwelt T, Ott M, van den Heuvel L, Nijtmans LG, Huynen MA (2014)
A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability
Hum Mol Genet, 23 (23), 6356-65
DOI 10.1093/hmg/ddu357, PubMed 25008109

Publications 2012

Almaas R, Hankø E, Mollnes TE, Rootwelt T (2012)
Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons
Brain Res, 1458, 12-7
DOI 10.1016/j.brainres.2012.04.007, PubMed 22546346

Dalen ML, Liu X, Elstad M, Løberg EM, Saugstad OD, Rootwelt T, Thoresen M (2012)
Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat
Pediatr Res, 71 (3), 247-52
DOI 10.1038/pr.2011.43, PubMed 22337259

Publications 2011

Bremer S, Ohlsson A, Brodtkorb E, Rootwelt H, Rootwelt T, Woldseth B, Mørkrid L (2011)
A novel mucopolysaccharidosis type I associated splice site mutation and IDUA splice variants
Mol Genet Metab, 104 (3), 289-94
DOI 10.1016/j.ymgme.2011.07.012, PubMed 21831683

Publications 2010

Brodtkorb E, Strand J, Backe PH, Lund AM, Bjørås M, Rootwelt T, Rootwelt H, Woldseth B, Eide L (2010)
Four novel mutations identified in Norwegian patients result in intermittent maple syrup urine disease when combined with the R301C mutation
Mol Genet Metab, 100 (4), 324-32
DOI 10.1016/j.ymgme.2010.04.017, PubMed 20570198

Dalen ML, Alme TN, Bjørås M, Munkeby BH, Rootwelt T, Saugstad OD (2010)
Reduced expression of DNA glycosylases in post-hypoxic newborn pigs undergoing therapeutic hypothermia
Brain Res, 1363, 198-205
DOI 10.1016/j.brainres.2010.09.080, PubMed 20883672

Dalen ML, Alme TN, Munkeby BH, Løberg EM, Pripp AH, Mollnes TE, Rootwelt T, Saugstad OD (2010)
Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation
J Perinat Med, 38 (5), 545-56
DOI 10.1515/JPM.2010.081, PubMed 20629493

Gjerstad L, Helseth E, Rootwelt T, Dietrichs E, Enström K (2010)
Nevrologi og nevrokirurgi: fra barn til voksen : undersøkelse-diagnose-behandling
Vett og viten, Høvik (5. rev. utg.), 702 s.
BIBSYS 101176449, ISBN 978-82-412-0686-3

Rønnestad A, Rootwelt T, Hansen TWR (2010)
Nevrologiske tilstander hos nyfødte
In Nevrologi og nevrokirurgi. Fra barn til voksen. (Gjerstad L, Helseth E, Rosales A, eds.), Vett og Viten, 1361 Høvik, 5, 159-76
PublikaID 119, ISBN 978-82-412-0686-3

Steenweg ME, Jakobs C, Errami A, van Dooren SJ, Adeva Bartolomé MT, Aerssens P, Augoustides-Savvapoulou P, Baric I, Baumann M, Bonafé L, Chabrol B, Clarke JT, Clayton P, Coker M, Cooper S, Falik-Zaccai T, Gorman M, Hahn A, Hasanoglu A, King MD, de Klerk HB, Korman SH, Lee C, Meldgaard Lund A, Mejaski-Bosnjak V et al. (2010)
An overview of L-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study
Hum Mutat, 31 (4), 380-90
DOI 10.1002/humu.21197, PubMed 20052767

Publications 2009

Strømme P, Suren P, Kanavin OJ, Rootwelt T, Woldseth B, Abdelnoor M, Magnus P (2009)
Parental consanguinity is associated with a seven-fold increased risk of progressive encephalopathy: a cohort study from Oslo, Norway
Eur J Paediatr Neurol, 14 (2), 138-45
DOI 10.1016/j.ejpn.2009.03.007, PubMed 19446480

Publications 2008

Dalen ML, Frøyland E, Saugstad OD, Mollnes TE, Rootwelt T (2008)
Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation
Brain Res, 1259, 80-9
DOI 10.1016/j.brainres.2008.12.055, PubMed 19146835

Frøyland E, Skjaeret C, Wright MS, Dalen ML, Cvancarova M, Kasi C, Rootwelt T (2008)
Inflammatory receptors and pathways in human NT2-N neurons during hypoxia and reoxygenation. Impact of acidosis
Brain Res, 1217, 37-49
DOI 10.1016/j.brainres.2008.04.038, PubMed 18502402

Publications 2007

Larsen AC, Kvissel AK, Hafte TT, Avellan CI, Eikvar S, Rootwelt T, Ørstavik S, Skålhegg BS (2007)
Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates
FEBS J, 275 (2), 250-62
DOI 10.1111/j.1742-4658.2007.06195.x, PubMed 18070107

Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE (2007)
CD59 efficiently protects human NT2-N neurons against complement-mediated damage
Scand J Immunol, 66 (2-3), 345-51
DOI 10.1111/j.1365-3083.2007.01959.x, PubMed 17635812

Sandvig HV, Gustavsen A, Solberg R, Simonsen S, Bjerre A, Kyte A, Rootwelt T (2007)
[Dialysis treatment of infants with end stage failure]
Tidsskr Nor Laegeforen, 127 (23), 3069-72
PubMed 18049497

Stromme P, Kanavin OJ, Abdelnoor M, Woldseth B, Rootwelt T, Diderichsen J, Bjurulf B, Sommer F, Magnus P (2007)
Incidence rates of progressive childhood encephalopathy in Oslo, Norway: a population based study
BMC Pediatr, 7, 25
DOI 10.1186/1471-2431-7-25, PubMed 17597517

Strømme P, Magnus P, Kanavin ØJ, Rootwelt T, Woldseth B, Abdelnoor M (2007)
Mortality in childhood progressive encephalopathy from 1985 to 2004 in Oslo, Norway: a population-based study
Acta Paediatr, 97 (1), 35-40
DOI 10.1111/j.1651-2227.2007.00579.x, PubMed 18076719

Publications 2006

Frøyland E, Pedersen ED, Kvissel AK, Almaas R, Pharo A, Skålhegg BS, Mollnes TE, Rootwelt T (2006)
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250

Hankø E, Hansen TW, Almaas R, Rootwelt T (2006)
Recovery after short-term bilirubin exposure in human NT2-N neurons
Brain Res, 1103 (1), 56-64
DOI 10.1016/j.brainres.2006.05.083, PubMed 16814266

Jacobs CM, Trinh MD, Rootwelt T, Lømo J, Paulsen RE (2006)
Dexamethasone induces cell death which may be blocked by NMDA receptor antagonists but is insensitive to Mg2+ in cerebellar granule neurons
Brain Res, 1070 (1), 116-23
DOI 10.1016/j.brainres.2005.10.093, PubMed 16403471

Pedersen ED, Frøyland E, Kvissel AK, Pharo AM, Skålhegg BS, Rootwelt T, Mollnes TE (2006)
Expression of complement regulators and receptors on human NT2-N neurons--effect of hypoxia and reoxygenation
Mol Immunol, 44 (9), 2459-68
DOI 10.1016/j.molimm.2006.10.022, PubMed 17116331

Woldseth B, Rootwelt T (2006)
[Mitochondrial beta-oxidation defects]
Tidsskr Nor Laegeforen, 126 (6), 756-9
PubMed 16541168

Publications 2005

Frøyland E, Wibrand F, Almaas R, Dalen I, Lindstad JK, Rootwelt T (2005)
Acidosis during reoxygenation has an early detrimental effect on neuronal metabolic activity
Pediatr Res, 57 (4), 488-93
DOI 10.1203/01.PDR.0000155946.82230.2E, PubMed 15695602

Hankø E, Hansen TW, Almaas R, Paulsen R, Rootwelt T (2005)
Synergistic protection of a general caspase inhibitor and MK-801 in bilirubin-induced cell death in human NT2-N neurons
Pediatr Res, 59 (1), 72-7
DOI 10.1203/01.pdr.0000191135.63586.08, PubMed 16326984

Saugstad OD, Ramji S, Rootwelt T, Vento M (2005)
Response to resuscitation of the newborn: early prognostic variables
Acta Paediatr, 94 (7), 890-5
DOI 10.1111/j.1651-2227.2005.tb02007.x, PubMed 16188811

Publications 2004

Hankø E, Hansen TW, Almaas R, Lindstad J, Rootwelt T (2004)
Bilirubin induces apoptosis and necrosis in human NT2-N neurons
Pediatr Res, 57 (2), 179-84
DOI 10.1203/01.PDR.0000148711.11519.A5, PubMed 15611354

Kvissel AK, Ørstavik S, Øistad P, Rootwelt T, Jahnsen T, Skålhegg BS (2004)
Induction of Cbeta splice variants and formation of novel forms of protein kinase A type II holoenzymes during retinoic acid-induced differentiation of human NT2 cells
Cell Signal, 16 (5), 577-87
DOI 10.1016/j.cellsig.2003.08.014, PubMed 14751543

Saugstad OD, Rootwelt T (2004)
[Children as research subjects]
Tidsskr Nor Laegeforen, 124 (8), 1141; author reply 1141-2
PubMed 15114401

Publications 2003

Almaas R, Pytte M, Lindstad JK, Wright M, Saugstad OD, Pleasure D, Rootwelt T (2003)
Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation
J Neurochem, 84 (5), 1018-27
DOI 10.1046/j.1471-4159.2003.01593.x, PubMed 12603826

Burwinkel B, Rootwelt T, Kvittingen EA, Chakraborty PK, Kilimann MW (2003)
Severe phenotype of phosphorylase kinase-deficient liver glycogenosis with mutations in the PHKG2 gene
Pediatr Res, 54 (6), 834-9
DOI 10.1203/01.PDR.0000088069.09275.10, PubMed 12930917

Saugstad OD, Ramji S, Irani SF, El-Meneza S, Hernandez EA, Vento M, Talvik T, Solberg R, Rootwelt T, Aalen OO (2003)
Resuscitation of newborn infants with 21% or 100% oxygen: follow-up at 18 to 24 months
Pediatrics, 112 (2), 296-300
DOI 10.1542/peds.112.2.296, PubMed 12897277

Publications 2002

Almaas R, Saugstad OD, Pleasure D, Rootwelt T (2002)
Neuronal formation of free radicals plays a minor role in hypoxic cell death in human NT2-N neurons
Pediatr Res, 51 (2), 136-43
DOI 10.1203/00006450-200202000-00004, PubMed 11809906

Publications 2000

Almaas R, Saugstad OD, Pleasure D, Rootwelt T (2000)
Effect of barbiturates on hydroxyl radicals, lipid peroxidation, and hypoxic cell death in human NT2-N neurons
Anesthesiology, 92 (3), 764-74
DOI 10.1097/00000542-200003000-00020, PubMed 10719955

Hansen TW, Finne PH, Grønn M, Rønnestad A, Rootwelt T (2000)
[To get a premature baby]
Tidsskr Nor Laegeforen, 120 (30), 3815-6
PubMed 11215967

Holmström H, Rootwelt T (2000)
[Thromboembolic diseases in children]
Ugeskr Laeger, 162 (8), 1060-7
PubMed 10741243

Rootwelt T (2000)
[Intracranial arachnoidal cysts]
Tidsskr Nor Laegeforen, 120 (1), 126-7
PubMed 10815507

Saugstad OD, Rootwelt T, Aalen OO (2000)
[Resuscitation of newborn infants with room air or oxygen]
Tidsskr Nor Laegeforen, 120 (1), 25-8
PubMed 10815474

Publications 1999

Holmström H, Rootwelt T (1999)
[Thromboembolic diseases in children]
Tidsskr Nor Laegeforen, 119 (20), 3006-12
PubMed 10504851

Rootwelt T (1999)
[Magnesium and leg cramps during pregnancy]
Tidsskr Nor Laegeforen, 119 (27), 4093
PubMed 10613105

Publications 1998

Feet BA, Medbö S, Rootwelt T, Ganes T, Saugstad OD (1998)
Hypoxemic resuscitation in newborn piglets: recovery of somatosensory evoked potentials, hypoxanthine, and acid-base balance
Pediatr Res, 43 (5), 690-6
DOI 10.1203/00006450-199805000-00019, PubMed 9585017

Rootwelt T, Dunn M, Yudkoff M, Itoh T, Almaas R, Pleasure D (1998)
Hypoxic cell death in human NT2-N neurons: involvement of NMDA and non-NMDA glutamate receptors
J Neurochem, 71 (4), 1544-53
DOI 10.1046/j.1471-4159.1998.71041544.x, PubMed 9751188

Saugstad OD, Rootwelt T, Aalen O (1998)
Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study
Pediatrics, 102 (1), e1
DOI 10.1542/peds.102.1.e1, PubMed 9651453

Publications 1997

Almaas R, Rootwelt T, Oyasaeter S, Saugstad OD (1997)
Ascorbic acid enhances hydroxyl radical formation in iron-fortified infant cereals and infant formulas
Eur J Pediatr, 156 (6), 488-92
DOI 10.1007/s004310050645, PubMed 9208249

Almaas R, Sundar TB, Rootwelt T, Oyasaeter S, Saugstad OD (1997)
Plasma hypoxanthine reacts more abruptly to changes in oxygenation than base deficit and uric acid in newborn piglets
J Perinat Med, 25 (4), 353-60
DOI 10.1515/jpme.1997.25.4.353, PubMed 9350606

Feet BA, Yu XQ, Rootwelt T, Oyasaeter S, Saugstad OD (1997)
Effects of hypoxemia and reoxygenation with 21% or 100% oxygen in newborn piglets: extracellular hypoxanthine in cerebral cortex and femoral muscle
Crit Care Med, 25 (8), 1384-91
DOI 10.1097/00003246-199708000-00028, PubMed 9267954

Moen A, Yu XQ, Rootwelt T, Saugstad OD (1997)
Acute effects on systemic and pulmonary hemodynamics of intratracheal instillation of porcine surfactant or saline in surfactant-depleted newborn piglets
Pediatr Res, 41 (4 Pt 1), 486-92
DOI 10.1203/00006450-199704000-00006, PubMed 9098849

Rootwelt T (1997)
[Glucose--friend or foe of the hypoxic-ischemic brain?]
Tidsskr Nor Laegeforen, 117 (5), 664-7
PubMed 9102957

Publications 1996

Moen A, Rootwelt T, Robertson B, Curstedt T, Hall C, Saugstad OD (1996)
Hemodynamics and tissue blood flow after porcine surfactant replacement in surfactant-depleted newborn piglets
Pediatr Res, 40 (2), 215-24
DOI 10.1203/00006450-199608000-00006, PubMed 8827769

Rootwelt T, Kjos RR, Stiris TA, Whitelaw A (1996)
[Brachial plexus injuries in newborn infants]
Tidsskr Nor Laegeforen, 116 (20), 2445-8
PubMed 8928105

Rootwelt T, Odden JP, Hall C, Saugstad OD (1996)
Regional blood flow during severe hypoxemia and resuscitation with 21% or 100% O2 in newborn pigs
J Perinat Med, 24 (3), 227-36
DOI 10.1515/jpme.1996.24.3.227, PubMed 8827571

Publications 1995

Hukkanen M, Konttinen YT, Santavirta S, Nordsletten L, Madsen JE, Almaas R, Oestreicher AB, Rootwelt T, Polak JM (1995)
Effect of sciatic nerve section on neural ingrowth into the rat tibial fracture callus
Clin Orthop Relat Res (311), 247-57
PubMed 7634582

Odden JP, Rootwelt T, Stiris T, Hall C, Bratlid D (1995)
Retinal and choroidal blood flow response to hyperoxemia after severe hypoxemia in the newborn piglet
Biol Neonate, 67 (3), 208-15
DOI 10.1159/000244165, PubMed 7640321

Rootwelt T (1995)
Resuscitation with 21 \% or 100 \% oxygen: a study of hypoxemia and resuscitation in newborn pigs and a preliminary clinical trial in newborn infants
Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Rikshospitalet, [Oslo], 1 b. (flere pag.)
BIBSYS 951876090, ISBN 82-7722-036-7

Rootwelt T, Almaas R, Oyasaeter S, Moen A, Saugstad OD (1995)
Release of xanthine oxidase to the systemic circulation during resuscitation from severe hypoxemia in newborn pigs
Acta Paediatr, 84 (5), 507-11
DOI 10.1111/j.1651-2227.1995.tb13683.x, PubMed 7633144

Publications 1994

Haberland A, Rootwelt T, Saugstad OD, Schimke I (1994)
Modulation of the xanthine oxidase/xanthine dehydrogenase ratio by reaction of malondialdehyde with NH2-groups
Eur J Clin Chem Clin Biochem, 32 (4), 267-72
DOI 10.1515/cclm.1994.32.4.267, PubMed 8038267

Nordsletten L, Madsen JE, Almaas R, Rootwelt T, Halse J, Konttinen YT, Hukkanen M, Santavirta S (1994)
The neuronal regulation of fracture healing. Effects of sciatic nerve resection in rat tibia
Acta Orthop Scand, 65 (3), 299-304
DOI 10.3109/17453679408995457, PubMed 8042482


Publications 1993

Ramji S, Ahuja S, Thirupuram S, Rootwelt T, Rooth G, Saugstad OD (1993)
Resuscitation of asphyxic newborn infants with room air or 100% oxygen
Pediatr Res, 34 (6), 809-12
DOI 10.1203/00006450-199312000-00023, PubMed 8108199

Rootwelt T, Odden JP, Hall C, Ganes T, Saugstad OD (1993)
Cerebral blood flow and evoked potentials during reoxygenation with 21 or 100% O2 in newborn pigs
J Appl Physiol (1985), 75 (5), 2054-60
DOI 10.1152/jappl.1993.75.5.2054, PubMed 8307859

Rootwelt T, Oyasaeter S, Saugstad OD (1993)
Transport of hypoxanthine from plasma to cerebrospinal fluid and vitreous humor in newborn pigs
J Perinat Med, 21 (3), 211-7
DOI 10.1515/jpme.1993.21.3.211, PubMed 8229612

Stoltenberg L, Rootwelt T, Oyasaeter S, Rognum TO, Saugstad OD (1993)
Hypoxanthine, xanthine, and uric acid concentrations in plasma, cerebrospinal fluid, vitreous humor, and urine in piglets subjected to intermittent versus continuous hypoxemia
Pediatr Res, 34 (6), 767-71
DOI 10.1203/00006450-199312000-00013, PubMed 8108190

Publications 1992

Rootwelt T, Løberg EM, Moen A, Oyasaeter S, Saugstad OD (1992)
Hypoxemia and reoxygenation with 21% or 100% oxygen in newborn pigs: changes in blood pressure, base deficit, and hypoxanthine and brain morphology
Pediatr Res, 32 (1), 107-13
DOI 10.1203/00006450-199207000-00021, PubMed 1635835

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