Tone Berge

  • Researcher at the Neuroscience Research Unit and Associate Professor at OsloMEt - Oslo metropolitan University; PhD, MSc
  • +47 230 79027

Background:

Tone Berge has a Master and PhD degree in Biochemistry from the Institute of Biosciences, University of Oslo, where she studied the hematopoietic transcription factor c-Myb. She used in vitro techniques as well as yeast and mammalian cells to define the optimal DNA binding sites for c-Myb. At the Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, she has performed postdoctoral research on T cells signaling, studying the adapter protein TSAd, encoded by the SH2D2A gene. Her main task was to characterize SH2D2A-deficient mice.

Project/Research interest:

Tone Berges main focus is to use molecular immunology technology to get mechanistic insight into disease mechanisms behind multiple sclerosis (MS). Berge and her students are performing molecular studies in order to understand the biological significance behind MS susceptibility gene variants identified through genome-wide approaches. In addition, how MS susceptibility genes interact with common environmental risk factors is under study in the lab. Berge is also collaborating on genome-wide approaches comparing epigenetics, transcriptomics and proteomics between samples from MS patients and healthy controls, and a co-worker in two EU funded projects (Sys4MS and MultipleMS), where Harbo is the Norwegian PI. Berge is currently the main supervisor of PhD student Anna Erikson and co-supervisor of PhD student Ina S. Brorson. She is also supervising several Bachelor projects.

Research interest:

  • Autoimmunity
  • Vitamin D and MS
  • Molecular immunology
  • T cell activation
  • Transcriptional reulation

Methodology:

  • Transfection of cell lines
  • Isolation and cultivation of primary, human T cells
  • Western blotting
  • Flow cytometri
  • Quantitative real-time PCR
  • Vector design and sub-cloning
  • Chromatin immunoprecipitation

Previous students (as main supervisor):

PhD student Pankaj Kumar Keshari, thesis defense 23.05.17 - Genetic and molecular studies of multiple sclerosis associated genes.
PhD student Ingvild Sørum Leikfoss, thesis defense: 30.10.15 - Characterization of multiple sclerosis susceptibility genes, genetic and molecular studies in T cells.

Master students: Ingrid Mo, master exam: 09.11.17; Fernanda Kropf Correia, master exam: 07.11.17; Ina Skaara Brorson, master exam: 14.01.15; Anna Eriksson, master exam: 18.12.14

Previous students (as co supervisor):

PhD student Marte Wendel Gustavsen (main supervisor Hanne F. Harbo), thesis defence: 13.12.15 - Genetic, clinical and environmental aspects of multiple sclerosis.

 

 

Publications 2020

Cellerino M, Ivaldi F, Pardini M, Rotta G, Vila G, Bäcker-Koduah P, Berge T, Laroni A, Lapucci C, Novi G, Boffa G, Sbragia E, Palmeri S, Asseyer S, Høgestøl E, Campi C, Piana M, Inglese M, Paul F, Harbo HF, Villoslada P, Kerlero de Rosbo N, Uccelli A (2020)
Impact of treatment on cellular immunophenotype in MS: A cross-sectional study
Neurol Neuroimmunol Neuroinflamm, 7 (3)
DOI 10.1212/NXI.0000000000000693, PubMed 32139439

Publications 2019

Berge T, Eriksson A, Brorson IS, Høgestøl EA, Berg-Hansen P, Døskeland A, Mjaavatten O, Bos SD, Harbo HF, Berven F (2019)
Quantitative proteomic analyses of CD4+ and CD8+ T cells reveal differentially expressed proteins in multiple sclerosis patients and healthy controls
Clin Proteomics, 16, 19
DOI 10.1186/s12014-019-9241-5, PubMed 31080378

Publications 2018

Rhead B, Brorson IS, Berge T, Adams C, Quach H, Moen SM, Berg-Hansen P, Celius EG, Sangurdekar DP, Bronson PG, Lea RA, Burnard S, Maltby VE, Scott RJ, Lechner-Scott J, Harbo HF, Bos SD, Barcellos LF (2018)
Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients
PLoS One, 13 (10), e0206511
DOI 10.1371/journal.pone.0206511, PubMed 30379917

Publications 2016

Keshari PK, Harbo HF, Myhr KM, Aarseth JH, Bos SD, Berge T (2016)
Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood
BMC Genet, 17, 59
DOI 10.1186/s12863-016-0367-4, PubMed 27080863

Publications 2015

Bos SD, Page CM, Andreassen BK, Elboudwarej E, Gustavsen MW, Briggs F, Quach H, Leikfoss IS, Bjølgerud A, Berge T, Harbo HF, Barcellos LF (2015)
Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
PLoS One, 10 (3), e0117403
DOI 10.1371/journal.pone.0117403, PubMed 25734800

Leikfoss IS, Keshari PK, Gustavsen MW, Bjølgerud A, Brorson IS, Celius EG, Spurkland A, Bos SD, Harbo HF, Berge T (2015)
Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
PLoS One, 10 (7), e0132957
DOI 10.1371/journal.pone.0132957, PubMed 26203907

Wedding IM, Kroken M, Henriksen SP, Selmer KK, Fiskerstrand T, Knappskog PM, Berge T, Tallaksen CM (2015)
Friedreich ataxia in Norway - an epidemiological, molecular and clinical study
Orphanet J Rare Dis, 10, 108
DOI 10.1186/s13023-015-0328-4, PubMed 26338206

Publications 2014

Eriksen AB, Berge T, Gustavsen MW, Leikfoss IS, Bos SD, Spurkland A, Harbo HF, Blomhoff HK (2014)
Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
J Neuroimmunol, 278, 11-8
DOI 10.1016/j.jneuroim.2014.11.019, PubMed 25595247

Granum S, Sundvold-Gjerstad V, Gopalakrishnan RP, Berge T, Koll L, Abrahamsen G, Sørlie M, Spurkland A (2014)
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192
Sci Signal, 7 (355), ra118
DOI 10.1126/scisignal.2005384, PubMed 25492967

Gustavsen MW, Viken MK, Celius EG, Berge T, Mero IL, Berg-Hansen P, Aarseth JH, Myhr KM, Søndergaard HB, Sellebjerg F, Oturai AB, Hillert J, Alfredsson L, Olsson T, Kockum I, Lie BA, Harbo HF (2014)
Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
J Neuroimmunol, 274 (1-2), 174-9
DOI 10.1016/j.jneuroim.2014.06.024, PubMed 25037176

Publications 2013

Berge T, Leikfoss IS, Harbo HF (2013)
From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A
Int J Mol Sci, 14 (3), 4476-97
DOI 10.3390/ijms14034476, PubMed 23439554

Mero IL, Gustavsen MW, Sæther HS, Flåm ST, Berg-Hansen P, Søndergaard HB, Jensen PE, Berge T, Bjølgerud A, Muggerud A, Aarseth JH, International Multiple Sclerosis Genetics Consortium, Myhr KM, Celius EG, Sellebjerg F, Hillert J, Alfredsson L, Olsson T, Oturai AB, Kockum I, Lie BA, Andreassen BK, Harbo HF (2013)
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles
PLoS One, 8 (3), e58352
DOI 10.1371/journal.pone.0058352, PubMed 23472185

Publications 2012

Berge T, Grønningsæter IH, Lorvik KB, Abrahamsen G, Granum S, Sundvold-Gjerstad V, Corthay A, Bogen B, Spurkland A (2012)
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice
PLoS One, 7 (10), e48239
DOI 10.1371/journal.pone.0048239, PubMed 23144743

Publications 2010

Berge T, Sundvold-Gjerstad V, Granum S, Andersen TC, Holthe GB, Claesson-Welsh L, Andreotti AH, Inngjerdingen M, Spurkland A (2010)
T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells
PLoS One, 5 (3), e9761
DOI 10.1371/journal.pone.0009761, PubMed 20305788

Kolltveit KM, Schreurs O, Ostrem J, Søland TM, Khuu C, Berge T, Messelt E, Hayashi K, Granum S, Spurkland A, Schenck K (2010)
Expression of the T-cell-specific adapter protein in oral epithelium
Eur J Oral Sci, 118 (2), 159-67
DOI 10.1111/j.1600-0722.2010.00719.x, PubMed 20487005

Publications 2008

Granum S, Andersen TC, Sørlie M, Jørgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V (2008)
Modulation of Lck function through multisite docking to T cell-specific adapter protein
J Biol Chem, 283 (32), 21909-19
DOI 10.1074/jbc.M800871200, PubMed 18541536

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